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Replication and pathogenesis of plus strand RNA viruses and double strand RNA viruses

Planned Research

Project AreaMatrix of Infection Phenomena
Project/Area Number 18073002
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2006-2008, 2010)
Microbial Chemistry Research Foundation (2009)

Principal Investigator

NOMOTO Akio  The University of Tokyo, 微生物化学研究所, 所長 (70112670)

Co-Investigator(Kenkyū-buntansha) TANIGUCHI Kouki  藤田保健衛生大学, 医学部, 教授 (40094213)
Co-Investigator(Renkei-kenkyūsha) OHKA Seii  独立行政法人国立がん研究センター研究所, がん幹細胞研究分野, 研究員 (80313097)
MUNAKATA Tsubasa  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (50420237)
TANAKA Yoshikazu  北海道大学, 創成研究機構, 特任助教 (20374225)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥184,000,000 (Direct Cost: ¥184,000,000)
Fiscal Year 2010: ¥36,800,000 (Direct Cost: ¥36,800,000)
Fiscal Year 2009: ¥36,800,000 (Direct Cost: ¥36,800,000)
Fiscal Year 2008: ¥36,800,000 (Direct Cost: ¥36,800,000)
Fiscal Year 2007: ¥36,800,000 (Direct Cost: ¥36,800,000)
Fiscal Year 2006: ¥36,800,000 (Direct Cost: ¥36,800,000)
Keywordsウイルス / 感染症 / リバースジェネティックス / プラス鎖RNA / マイナス鎖 / RNA / 二本鎖RNA
Research Abstract

Reverse genetics systems for poliovirus, Aichivirus, and hepatitis C virus were established. For these viruses, interaction between viral and host molecules were investigated to give an insight into molecular mechanisms of viral replication and pathogenesis. As for rotavirus whose reverse genetics is not completely established, mainly antigenic structure and cleavage region of viral VP4 were studied. At the same time, we made an effort to establish better reverse genetics system for rotavirus.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (123 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (43 results) (of which Peer Reviewed: 37 results) Presentation (76 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Uniformity of rotavirus strain nomenclature proposed by the rotavirus classification working group (RCWG)2011

    • Author(s)
      J.Matthijnssens, et al.
    • Journal Title

      Archives of Virology

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2A protease is not a prerequisite for poliovirus replication.2010

    • Author(s)
      Hiroko Igarashi, Yasuko Yoshino, Miwako Miyazawa, Hitoshi Horie, Seii Ohka, Akio Nomoto.
    • Journal Title

      J.Virol. 84(12)

      Pages: 5947-5957

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2A protease is not a prerequisite for poliovirus replication2010

    • Author(s)
      H.Igarashi, et al.
    • Journal Title

      J.Virol.

      Volume: 84 Pages: 5947-5957

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poliomyelitis2010

    • Author(s)
      S.Koike, et al.
    • Journal Title

      The Picornaviruses

      Pages: 339-351

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rotavirus non-structural protein1-suppresses virus induced cellular apoptosis to facilitate viral growth by activating the cell-survival pathways during early stages of infection2010

    • Author(s)
      P.Bagchi, et al.
    • Journal Title

      J.Virol.

      Volume: 84 Pages: 6834-6845

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms2010

    • Author(s)
      S.Kobayashi, et al.
    • Journal Title

      European Journal of Pediatrics

      Volume: 169 Pages: 1287-1291

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overall linkage map of the nonstructural proteins of Aichi virus2010

    • Author(s)
      K.Ishikawa, et al.
    • Journal Title

      Virus Res

      Volume: 147 Pages: 77-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons2009

    • Author(s)
      S.Ohka, et al.
    • Journal Title

      J.Virol.

      Volume: 83 Pages: 4995-5004

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Translation initiation from the ribosomal A site or P site, depending on the conformation of RNA pseudoknot I in dicistrovirus RNAs2009

    • Author(s)
      N.Kamoshita, et al.
    • Journal Title

      Mol.Cell

      Volume: 35 Pages: 181-190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular chaperone heat shock protein-90 positively regulates rotavirus infection2009

    • Author(s)
      D.Dipanjan, et al.
    • Journal Title

      Virology

      Volume: 391 Pages: 325-333

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Osteopontin on Diarrhea Duration and Innate Immunity in Suckling Mice Infected with a Murine Rotavirus2009

    • Author(s)
      Y.Maeno, et al.
    • Journal Title

      Viral Immunol

      Volume: 22 Pages: 139-144

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A major peroxiredoxin-induced activation of Yapl transcription factor is mediated by reduction-sensitive disulfide bonds and reveals a low level of transcriptional activation2009

    • Author(s)
      T. Tachibana, et.al.
    • Journal Title

      J. Biol. Chem 284

      Pages: 4464-4472

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colorimetric detection of loop-mediated isothermal amplification reaction by using hydroxy naphthol blue2009

    • Author(s)
      M. Goto, et.al.
    • Journal Title

      Bio Techniques 46

      Pages: 167-172

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-dependent and-independent axonal retrograde transport of poliovirus in motor neurons2009

    • Author(s)
      S. Ohka, et.al.
    • Journal Title

      J. Virol (印刷中)(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aichi virus 2A protein is involved in viral RNA replication.2008

    • Author(s)
      Sasaki J, Taniguchi K.
    • Journal Title

      J.Virol. 82(19)

      Pages: 9765-9769

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization epitopes on VP4.2008

    • Author(s)
      Komoto S, Kugita M, Sasaki J, Taniguchi K.
    • Journal Title

      J.Virol. 82(13)

      Pages: 6753-6757

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and poliovirus RNAs2008

    • Author(s)
      T. Nishimura, M. Saito, T. Takano, A. Nomoto, M. Kohara, & K. Tsukiyama-Kohara
    • Journal Title

      Comparat Immunol Microbiol Infect Dis. 31

      Pages: 435-448

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Aichi virus 2A protein is involved in viral RNA replication2008

    • Author(s)
      J. Sasaki, K. Taniguchi, et al
    • Journal Title

      J Virol. 82(19)

      Pages: 9765-9769

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Interaction between polypeptide 3ABC and the 5'-terminal structural elements of the genome of Aichi virus: implication for negative-strand RNA synthesis2008

    • Author(s)
      S. Nagashima, K. Taniguchi, et al
    • Journal Title

      J Virol. 82(13)

      Pages: 6161-6171

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization epitopes on VP42008

    • Author(s)
      S. Komoto, K. Taniguchi, et al
    • Journal Title

      J Virol. 82(13)

      Pages: 6753-6757

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and poliovirus RNAs2008

    • Author(s)
      T. Nishimura, et.al.
    • Journal Title

      Comparat Immunol Microbiol Infect Dis 31

      Pages: 435-448

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization epitopes on VP42008

    • Author(s)
      S. Komoto, et.al.
    • Journal Title

      J. Virol 82

      Pages: 6753-6757

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between polypeptide 3ABC and the 5'-terminal structural elements of the genome of Aichi virus : implication for negative-strand RNA synthesis2008

    • Author(s)
      S. Nagashima, et.al.
    • Journal Title

      J. Virol 82

      Pages: 6161-6171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aichi virus 2A protein is involved in viral RNA replication2008

    • Author(s)
      J. Sasaki, et.al.
    • Journal Title

      J. Virol 82

      Pages: 9765-9769

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of rotavirus antigenemia and extraintestinal manifestations in children with rotavirus gastroenteritis2008

    • Author(s)
      K. Sugata, et.al.
    • Journal Title

      Pediatrics 122

      Pages: 392-397

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of Rotavirus VP6 Genogroup by Reverse Transcription-Polymerase Chain Reaction2008

    • Author(s)
      Y-P. Lin, et.al.
    • Journal Title

      J. Clin. Micorbiol 46

      Pages: 3330-3337

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and poliovirus RNAs2008

    • Author(s)
      T. Nishimura, et. al.
    • Journal Title

      Comparat. Immunol. Microbiol. Infect. Dis. (in press)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation recombinant rotavirus having antigenic mosaic of cross-reactive neutralization epitopes on VP42008

    • Author(s)
      S. Komoto, et. al.
    • Journal Title

      J. Virol 82(in press)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein.2007

    • Author(s)
      Tsubasa Munakata, Yuqiong Liang, Seungtaek Kim, David R.McGivern, John Huibregtse, Akio Nomoto, Stanley M.Lemon.
    • Journal Title

      PLoS pathogens 3(9)

      Pages: 1335-1347

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.2007

    • Author(s)
      Seii Ohka, Hiroko Igarashi, Noriyo Nagata, Mai Sakai, Satoshi Koike, Tomonori Nochi, Hiroshi Kiyono, Akio Nomoto.
    • Journal Title

      J.Virol. 81(15)

      Pages: 7902-7912

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficienin alpha/beta interferon receptor2007

    • Author(s)
      S. Ohka, et. al.
    • Journal Title

      J. Virol. 81

      Pages: 7902-7912

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus induces E6AP-dependent degradation of the reinblastoma protein2007

    • Author(s)
      T. Munakata, et. al.
    • Journal Title

      PLoS pathogens 3

      Pages: 1335-1347

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular aspect of poliovirus pathogenesis2007

    • Author(s)
      A. Nomoto
    • Journal Title

      Proc. Jpn. Acad., Ser. B 83

      Pages: 266-275

    • NAID

      130000093892

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary history and global spread of the emerging G12 human rotaviruses2007

    • Author(s)
      M. Rahman, et. al.
    • Journal Title

      J. Virol. 81

      Pages: 2382-2390

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rotavirus-neutralizing antibodies inhibit virus binding to integrins alpha2betal and alpha4beta12007

    • Author(s)
      F. E. Fleming, et. al.
    • Journal Title

      Arch. Virol. 152

      Pages: 1087-1101

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract binding protein in internal initiation of hepatitis C virus and picornavirus RNAs2007

    • Author(s)
      T.Nishimura et al.
    • Journal Title

      Comp. Immunol. Microbiol. Infect. Dis. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evolutionary history and global spread of the emerging G12 human rotaviruses2007

    • Author(s)
      M.Rahman et al.
    • Journal Title

      J. Virol. 81(5)

      Pages: 2382-2390

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reverse genetics system for introduction of site-specific mutations into the double-stranded RNA genome of infectious rotavirus.2006

    • Author(s)
      Komoto S, Sasaki J, Taniguchi K.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103(12)

      Pages: 4646-4651

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and phyloeny of Kakugo virus, a novel insect picorna-like virus that infects the honeybee (Apis mellifera L.), under various colony conditions2006

    • Author(s)
      T.Fujiyuki et al.
    • Journal Title

      J. Virol. 80(23)

      Pages: 11528-11538

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reverse genetics system for introduction of site-specific mutations into the double-stranded RNA genome of infectious rotavirus2006

    • Author(s)
      S.Komoto et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 4646-4651

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reverse genetics systems of segmented double-stranded RNA viruses including rotavirus2006

    • Author(s)
      S.Komoto et al.
    • Journal Title

      Future Virol. 1

      Pages: 833-846

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High-resolution molecular and antigen structure of the VP8^* core of a sialic acid-independent human rotavirus strain2006

    • Author(s)
      N.Monnier et al.
    • Journal Title

      J. Virol. 80

      Pages: 1513-1523

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons

    • Author(s)
      S. Ohka, M. Sakai, S. Bohnert, H. Igarashi, K. Deinhardt, G. Schiavo, & A. Nomoto
    • Journal Title

      J. Virol. (in press)

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] ロタウイルス感染と中枢神経障害の関係について:1症例の検討から2010

    • Author(s)
      前野芳正, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動神経初代培養細胞の分離培養系におけるポリオウイルス感染2010

    • Author(s)
      大岡静衣、金田祥平、藤井輝夫、五十嵐博子、野本明男
    • Organizer
      第58回日本ウイルス学会
    • Place of Presentation
      徳島あわぎんホール
    • Year and Date
      2010-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動神経初代培養細胞の分離培養系におけるポリオウイルス感染2010

    • Author(s)
      大岡静衣, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪酸合成酵素を介したパルミチン酸によるC型肝炎ウイルスの複製制御2010

    • Author(s)
      棟方翼, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポリオウイルスの血液脳関門透過機構2010

    • Author(s)
      二瓶浩一, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] VP4上のトリプシン切断領域にフューリン認識配列を導入した組換えロタウイルスの作製2010

    • Author(s)
      河本聡志, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 造血幹細胞移植患児で観察された長期間、低レベルロタウイルス抗原血症の病態解明2010

    • Author(s)
      菅田健, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ファージディスプレイ法による、ヒト型ノロウイルス抗体の単離2010

    • Author(s)
      守口匡子, ら
    • Organizer
      第58回 日本ウイルス学会
    • Place of Presentation
      徳島 あわぎんホール
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Palmitate regulates HCV replication.2010

    • Author(s)
      Tsubasa Munakata, Akio Nomoto, Michinori Kohara.
    • Organizer
      The 17th International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Palmitate regulates HCV replication2010

    • Author(s)
      T.Munakata, et al.
    • Organizer
      The 17^<th> International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      横浜 パシフィコ横浜
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] ワクチンの新たな展開2010

    • Author(s)
      野本明男
    • Organizer
      フォーラム2010:衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京 星薬科大学
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanisms of poliovirus dissemination pathways2010

    • Author(s)
      Akio Nomoto
    • Organizer
      BIT's 1^<st> World Congress of Virus and Infections-2010
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 感染研究の中の真菌2010

    • Author(s)
      野本明男
    • Organizer
      第31回 関東医真菌懇話会
    • Place of Presentation
      東京 千代田放送会館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interphase cyclin-dependent kinases regulate hepatitis C virus replication2009

    • Author(s)
      棟方翼, ら
    • Organizer
      第32回 日本分子生物学会年会
    • Place of Presentation
      神奈川 パシフィコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] トランスフェリンレセプターにおけるウイルス粒子結合部位の解析2009

    • Author(s)
      二瓶浩一, ら
    • Organizer
      第32回 日本分子生物学会年会
    • Place of Presentation
      神奈川 パシフィコ横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型肝炎ウイルスの増殖はサイクリン依存性リン酸化酵素阻害剤で抑制できる2009

    • Author(s)
      棟方翼, ら
    • Organizer
      首都大学東京バイオコンファレンス2009
    • Place of Presentation
      東京 首都大学東京
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫不全児におけるロタウイルス感染症の病態解明:院内感染リスクの高い小児病棟内での状況把握2009

    • Author(s)
      菅田健, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] IRES依存性翻訳開始における開始コドンAUGと開始tRNAの果たす役割2009

    • Author(s)
      鴨下信彦, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] サイクリン依存性リン酸化酵素阻害剤によるC型肝炎ウイルスの複製制御2009

    • Author(s)
      棟方翼, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] カニクイザルを用いたポリオウイルス経口感染実験2009

    • Author(s)
      大岡静衣, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rotavirus NSP1 suppresses viru-induced cellular apoptosis to facilitate viral growth during early stages of infection2009

    • Author(s)
      Mamta Chawla-Sarkar, et al.
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular chaperone Hsp90 positively regulates rotavirus infection2009

    • Author(s)
      Mamta Chawla-Sarkar, et al.
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] アイチウイルス3CDによる2AのN末端の切断2009

    • Author(s)
      佐々木潤、石川球美子、前野芳正、河本聡志、守口匡子、谷口孝喜
    • Organizer
      第57回日本ウイルス学会
    • Place of Presentation
      東京都市センターホテル
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] アイチウイルス3CDによる2AのN末端の切断2009

    • Author(s)
      佐々木潤, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] ロタウイルス感染による末梢血単核球MMP-9mRNAの動態2009

    • Author(s)
      前野芳正, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京 都市センターホテル
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新しい群に属すると考えられるブタロタウイルスSKA-1株の全塩基配列決定2009

    • Author(s)
      和久田光毅, ら
    • Organizer
      第57回 日本ウイルス学会
    • Place of Presentation
      東京都市センターホテル
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anti-hepatitis C virus activity of cyclin-dependent kinase inhibitors2009

    • Author(s)
      Tsubasa Munakata, et al.
    • Organizer
      The 16^<th> International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Nice, France
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cleavage at the N-terminus of 2A by 3CD of Aichi virus2009

    • Author(s)
      Jun Sasaki, et al.
    • Organizer
      第9回 あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫 淡路夢舞台国際会議場
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Proteolytic cleavage at the conserved Arginine-241 of Rotavirus VP4 is not essential for virus replication in cell culture2009

    • Author(s)
      Satoshi Komoto, et al.
    • Organizer
      第9回 あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫 淡路夢舞台国際会議場
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 野生型開始tRNAと延長tRNAを用いたPSIV IGR IRES依存症の翻訳開始機構の解析2009

    • Author(s)
      鴨下信彦, ら
    • Organizer
      第11回 RNAミーティング(第11回 日本RNA学会)
    • Place of Presentation
      新潟 朱鷺メッセ 新潟コンベンションセンター
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリオウイルスの新規侵入経路の発見2008

    • Author(s)
      二瓶浩一、坂井麻依、三瓶雅迪、神代浩司、大岡静衣、野本明男
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ダイシストロニック型分泌蛋白質発現ポリオウイルスベクターの開発2008

    • Author(s)
      千葉妃織, ら
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] ジシストロウイルスの翻訳開始機構2008

    • Author(s)
      鴨下信彦, ら
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] TLR3によるC型肝炎ウイルスの認識2008

    • Author(s)
      棟方翼, ら
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ロタウイルスワクチン-過去から現在、そして未来へ「これからの予防接種はどうなるか」2008

    • Author(s)
      谷口孝喜
    • Organizer
      第40回日本小児感染症学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] VP4上の交叉反応性中和エピトープの抗原モザイクを有する組換えロタウイルスの作製2008

    • Author(s)
      河本聡志、釘田雅則、油井晶子、佐々木潤、守口匡子、前野芳正、石川球美子、谷口孝喜
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ロタウイルスのリバースジェネティクスとその展望2008

    • Author(s)
      谷口孝喜
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アイチウイルス2Aタンパク質の性状解析2008

    • Author(s)
      石川球美子, ら
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2b型HCV MA株のNS5A領域を有するキメラウイルスの作製2008

    • Author(s)
      岡本有加, ら
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリオウイルス感染神経芽細胞腫由来細胞中で翻訳を持続する宿主遺伝子2008

    • Author(s)
      鴨下信彦, ら
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞におけるアイチウイルスゲノムの複製部位2008

    • Author(s)
      佐々木潤, ら
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] TLR3はC型肝炎ウイルス感染を制御する2008

    • Author(s)
      棟方翼, ら
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Induction of hepatic TLR3 by E2F1 during hepatitis C viral infection2008

    • Author(s)
      T. Munakata, et.al.
    • Organizer
      The 15^<th> international symposium on hepatitis C virus and related viruses
    • Place of Presentation
      Marriott Rivercenter, San Antonio, Texas, USA
    • Year and Date
      2008-10-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interaction between the P3 proteins and the 5'-terminal structural elements of the aenome of Aichi virus2008

    • Author(s)
      J. Sasaki, et.al.
    • Organizer
      the 8th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路夢舞台国際会議場
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Anti-hepatitis C virus acvtivity of cyclin-dependent kinase inhibitors.2008

    • Author(s)
      Tsubasa Munakata, Makoto Inada, Akio Nomoto.
    • Organizer
      第8回あわじしま感染症\免疫フォーラム
    • Place of Presentation
      兵庫県淡路夢舞台国際会議場
    • Year and Date
      2008-09-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Anti-hepatitis C virus acvtivity of cyclin-dependent kinase inhibitors2008

    • Author(s)
      T. Munakata, et.al.
    • Organizer
      第8回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫県淡路夢舞台国際会議場
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization enitones on VP42008

    • Author(s)
      S. Komoto, et.al.
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路夢舞台国際会議場
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Poliovirus capsid protein causes cytopathic effect in mammalian cells2008

    • Author(s)
      N. Matsuda, et.al.
    • Organizer
      IUMS 2008 XIV International Congress of Virology
    • Place of Presentation
      Istanbul Convention and Exhibition Center, Turkey
    • Year and Date
      2008-08-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Receptor(hPVR/CD155)-dependent and-independent axonal retrograde transport of poliovirus2008

    • Author(s)
      S. Ohka, et.al.
    • Organizer
      IUMS 2008 XIV International Congress of Virology
    • Place of Presentation
      Istanbul Convention and Exhibition Center, Turkey
    • Year and Date
      2008-08-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Negative feed-back regulation of hepatitis C virus replication by TLR32008

    • Author(s)
      T. Munakata, et.al.
    • Organizer
      RIMS 2008 XIV International Congress of Virology
    • Place of Presentation
      Istanbul Convention and Exhibition Center, Turkey
    • Year and Date
      2008-08-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] ジシストロウイルスIRESは、遺伝子間領域のシュードノットIの異なる構造に基づき、2通りの方法で翻訳を開始する2008

    • Author(s)
      鴨下信彦, ら
    • Organizer
      第10回RNAミーティング
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2008-07-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rotavirus vaccine : update and development2008

    • Author(s)
      K. Taniguchi
    • Organizer
      4th Asian Congress of Pediatric Infectious Diseases
    • Place of Presentation
      JW Marrriott Hotel Surabaya, Indonesia
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] ロタウイルス抗原血症とウイルス血症.「Common Diseaseの最新知見」2008

    • Author(s)
      谷口孝喜
    • Organizer
      第49回日本臨床ウイルス学会
    • Place of Presentation
      愛知県名鉄犬山ホテル
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Poliovirus receptor(hPVR/CD155)-dependent and-independent axonalretrograde transport of poliovirus in motor neurons2008

    • Author(s)
      S. Ohka, et.al.
    • Organizer
      Europic 2008
    • Place of Presentation
      Sitges, Barcelona, Spain
    • Year and Date
      2008-05-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation of recombinant rotavirus having an antigenic mosaic of crossreactive neutralization epitopes on VP42008

    • Author(s)
      S. Komoto, et.al.
    • Organizer
      The 42nd Joint Working Conference on Viral Diseases. The Japan-United States Cooperative Medical Science Program
    • Place of Presentation
      長崎大学医学部Ryojun Hall
    • Year and Date
      2008-05-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウイルスの病原性発現機構2008

    • Author(s)
      野本明男
    • Organizer
      第82回日本感染症学会
    • Place of Presentation
      島根県民会館サンラポーむらくも
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] トール様受容体3はC型肝炎ウイルスにより活性化されるRb/E2F経路の下流の標的遺伝子である2007

    • Author(s)
      棟方 翼, ら.
    • Organizer
      第30回 日本分子生物学会年会・第80回 日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular pathogenesis of poliovirus infection2007

    • Author(s)
      A. Nomoto
    • Organizer
      2nd Nagasaki Symposium on Tropical and Emerging Infectious Diseases
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] アイチウイルス非構造タンパク質間における網羅的な相互作用解析2007

    • Author(s)
      石川球美子、佐々木潤、前野芳正、守口匡子、河本聡志、谷口孝喜
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2007-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] C型肝炎ウイルスのRNAポリメラーゼNS5Bが癌抑制遺伝子産物Rbを分解する時に関与する宿主因子の同定2007

    • Author(s)
      棟方 翼, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] ポリオウイルス感染による神経細胞変性効果(CPE)発現機構の研究2007

    • Author(s)
      松田 法恵, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] ポリオウイルスの運動神経軸索逆行性輸送機構2007

    • Author(s)
      大岡 静衣, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] アイチウイルスLタンパク質がポリプロテイン細胞内局在におよぼす影響の解析2007

    • Author(s)
      佐々木 潤, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] アイチウイルス非構造タンパク質間における網羅的な相互作用解析2007

    • Author(s)
      石川 球美子, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遺伝子型2a/2b間でのキメラウイルスの作製および性状解析2007

    • Author(s)
      伊逹 朋子, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] ロタウイルスは末梢血単核球に感染するか2007

    • Author(s)
      前野 芳正, ら
    • Organizer
      第55回 日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Toll-like receptor 3 is a downstream target of Rb/E2F pathway activated during hepatitis C virus infection and replication2007

    • Author(s)
      棟方 翼, ら
    • Organizer
      第7回 あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路島
    • Year and Date
      2007-09-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of neutralization epitopes on an outer protein VP4 of rotavirus with the aid of murine and human neutralizing antibodies and reverse genetics system2007

    • Author(s)
      K. Taniguchi, et. al.
    • Organizer
      The 7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路島
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] ロタウイルスのリバースジェネティクス「環境水系の感染症」2007

    • Author(s)
      谷口 孝喜
    • Organizer
      第48回 日本臨床ウイルス学会
    • Place of Presentation
      富山
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hepatitis C virus(HCV)regulation of the retinoblastoma protein2007

    • Author(s)
      S. Lemon, et. al.
    • Organizer
      Eighth International Symposium on POSITIVE-STRAND RNA VIRUSES
    • Place of Presentation
      Washington DC
    • Year and Date
      2007-05-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] ロタウイルス感染症-最近の3つの話題-「小児感染症の多様な病態と治療」2007

    • Author(s)
      谷口 孝喜
    • Organizer
      第110回 日本小児科学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction of toll-like receptor 3 by hepatitis C virus through RB/E2F pathway.2007

    • Author(s)
      Tsubasa Munakata, Akio Nomoto.
    • Organizer
      Eighth International Symposium on POSITIVE-STRAND RNA VIRUSES
    • Place of Presentation
      Washington DC
    • Related Report
      2010 Final Research Report
  • [Presentation] Induction of toll-like receptor 3 by hepatitis C virus through RB/E2F pathway2007

    • Author(s)
      T. Munakata, et. al.
    • Organizer
      Eighth International Symposium on POSITIVE-STRAND RNA VIRUSES
    • Place of Presentation
      Washington DC
    • Related Report
      2007 Annual Research Report
  • [Presentation] 2A<SUP>pro</SUP>を欠損した自己複製型ポリオウイルス変異株の解析2006

    • Author(s)
      五十嵐博子、大岡静衣、野本明男
    • Organizer
      第54回日本ウイルス学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] ポリオウイルス経口感染モデルマウスにおける経口感染伝播機構の解析2006

    • Author(s)
      大岡静衣、五十嵐博子、永田典代、坂井麻依、小池智、野地智法、清野宏、野本明男
    • Organizer
      第54回日本ウイルス学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] A molecular mechanism underlying down regulation of the Rb tumor suppressor by hepatitis C virus.2006

    • Author(s)
      Tsubasa Munakata, Stanley M.Lemon, Akio Nomoto.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto International Conference Center
    • Related Report
      2010 Final Research Report
  • [Book] Poliomyelitis.(The Picornaviruses, Chapter 21)2010

    • Author(s)
      Satoshi Koike, Akio Nomoto.
    • Publisher
      ASM Press
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.bikaken.or.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://microbiology.m.u-tokyo.ac.jp

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 血液脳関門を透過する薬物輸送体、ペプチド及びその用途2011

    • Inventor(s)
      野本明男、二瓶浩一
    • Industrial Property Rights Holder
      (財)微生物化学研究会、(株)イムノフューチャー
    • Industrial Property Number
      2011-021224
    • Filing Date
      2011-02-02
    • Related Report
      2010 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2018-03-28  

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