| Budget Amount *help |
¥174,000,000 (Direct Cost: ¥174,000,000)
Fiscal Year 2010: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2009: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2008: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2007: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2006: ¥34,800,000 (Direct Cost: ¥34,800,000)
|
|---|
| Research Abstract |
(1) We have identified the interaction between Shigella effectors secreted via the type III secretion system (T3SS) and their targeting host factors, and elucidated their roles in promoting bacterial infection of intestinal epithelium. Based on our results, we have proposed the bacterial infection strategy involving in promoting the initial stage of infection.
(2) We have identified the effector proteins secreted via T3SS of Vibrio parahaemolyticus, and revealed their intracellular functions. Also, the analysis of the regulation mechanism of the T3SS genes revealed a possibility of a novel therapeutic means against bacterial diarrhea.
|
