| Budget Amount *help |
¥90,000,000 (Direct Cost: ¥90,000,000)
Fiscal Year 2010: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2009: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2008: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2007: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2006: ¥18,000,000 (Direct Cost: ¥18,000,000)
|
|---|
| Research Abstract |
Parasites are good model system for the study of biological adaptation in eukaryotic organisms. Especially, to study the fundamental functions such as energy metabolisms common among the living beings and to understand a mechanism of the biological reactions, parasite is one of the best systems.
By the study using Ascaris suum which resides in the host small intestine where oxygen tension is quite low, we found that NADH-fumarate reductase system (Fumarate respiration) plays an important role in the adaptation to hypoxic environment. Further analysis revealed that fumarate respiration functions in the host human cells in hypoxic condition as well as other helminthes
|
