Study of replication, life cycle, and pathogenesis of retrovirus (HIV)

• Project Area: Matrix of Infection Phenomena
• Project/Area Number: 18073008
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: KOYANAGI Yoshio Kyoto University, ウイルス研究所, 教授 (80215417)
• Co-Investigator(Kenkyū-buntansha): MATANO Tetsuro 国立感染症研究所, エイズ研究センター, センター長 (00270653)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥182,000,000 (Direct Cost: ¥182,000,000); Fiscal Year 2010: ¥36,400,000 (Direct Cost: ¥36,400,000); Fiscal Year 2009: ¥36,400,000 (Direct Cost: ¥36,400,000); Fiscal Year 2008: ¥36,400,000 (Direct Cost: ¥36,400,000); Fiscal Year 2007: ¥36,400,000 (Direct Cost: ¥36,400,000); Fiscal Year 2006: ¥36,400,000 (Direct Cost: ¥36,400,000)
• Keywords: HIV / 動物モデル / テトラスパニン / テザリン / 中和抗体 / SIV / CTL / 宿主制御因子 / ヒト化マウス / エイズワクチン / 宿主因子 / CD4陽性ヘルパーT細胞 / CXCR4 / ヒト化マウ / MHC / エイズ / ウイルス抑制 / CD63 / ワクチン

Research Abstract

It has been extensively investigated on HIV and SIV replication, life cycle and pathogenesis. We show how tetraspanin and tetherin inhibit HIV infection and virus possesses accessary machinery to escapes from the inhibition. Furthermore, we show that neutralizing antibody has a role on anti-viral response of CD4+ T cells in acute phase and number of anti-viral CTL epitopes increases in chronic phase in SIV infected macaques. These data indicates the insight of HIV/SIV life cycle and pathogenesis and opens the road for its therapy.

Research Products

• [Journal Article] 9人中8番目Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity. (2011)
  • Author(s): Yamamoto SP, Koyanagi Y, Suzuki Y.
  • Journal Title: Microbes Infect 13 Pages: 339-349
  • Peer Reviewed
• [Journal Article] 11人中11番目A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice (2011)
  • Author(s): Sato K, Misawa N, Koyanagi Y.
  • Journal Title: Blood 117 Pages: 5663-5673
  • Peer Reviewed
• [Journal Article] 11人中11番目Identification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility. (2011)
  • Author(s): Kobayashi T, Ode H, Koyanagi Y.
  • Journal Title: J Virol 85 Pages: 932-945
  • Peer Reviewed
• [Journal Article] 14人中13番目Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. (2011)
  • Author(s): Saito A, Nomaguchi M, Matano T, Akari H
  • Journal Title: Microbes Infect 13 Pages: 58-64
  • Peer Reviewed
• [Journal Article] I dentification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility (2011)
  • Author(s): Kobayashi T, Ode H, Yoshida T, Sato K, Gee P, Yamamoto SP, Ebina H, Strebel K, Sato, Koyanagi Y.
  • Journal Title: Journal of Virology Volume: 85 Pages: 932-945
  • NAID: 120002723154
  • Peer Reviewed
• [Journal Article] Huwel, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity (2011)
  • Author(s): Yamamoto SP, Okawa K, Nakano T, Sano K, Ogawa K, Masuda T, Morikawa Y, Koyanagi Y, Suzuki Y
  • Journal Title: Microbes and Infection Volume: 13 Pages: 339-349
  • Peer Reviewed
• [Journal Article] Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications (2011)
  • Author(s): Saito A, Nomaguchi M, Iijima S, Kuroishi A, Yoshida T, Lee Y-J, Hayakawa T, Kono K, Nakayama EE, Shioda T, Yasutomi Y, Adachi A, Matano T, Akari H
  • Journal Title: Microbes and Infection Volume: 13 Pages: 58-64
  • NAID: 120002723147
  • Peer Reviewed
• [Journal Article] Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/ IL-2R gamma null mice infected with CCR5-tropic HIV-1. (2010)
  • Author(s): Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y.
  • Journal Title: Vaccine 28S2
  • Peer Reviewed
• [Journal Article] 10人中7番目HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency. (2010)
  • Author(s): Hoshino S, Koyanagi Y, Kano S, Itabe H, Ishizaka Y.
  • Journal Title: J Leukoc Biol 87 Pages: 1133-1143
  • Peer Reviewed
• [Journal Article] 9人中9番目Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice. (2010)
  • Author(s): Sato K, Izumi T, Koyanagi Y.
  • Journal Title: J Virol 84 Pages: 9546-9556
  • Peer Reviewed
• [Journal Article] Takaori-Kondo 13人中11番目A.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication. (2010)
  • Author(s): Izumi T, Koyanagi Y, Uchiyama T
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 20798-20803
  • Peer Reviewed
• [Journal Article] 7人中7番目Broadening of CD8+ cell responses in vaccine-based simian immunodeficiency virus controllers. (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Matano T.
  • Journal Title: AIDS 24 Pages: 2777-2787
  • Peer Reviewed
• [Journal Article] 8人中8番目A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins. (2010)
  • Author(s): Inagaki N, Takeuchi H, M, Matano T.
  • Journal Title: Retrovirology 7
  • Peer Reviewed
• [Journal Article] Neutralizing antibodies in SIV control: co-impact with T cells. (2010)
  • Author(s): Yamamoto H, Matano T
  • Journal Title: Vaccine 28S
  • Peer Reviewed
• [Journal Article] 11人中10番目Diversity of MHC class I genes in Burmese-origin rhesus macaques. (2010)
  • Author(s): Naruse TK, Matano T, Kimura A
  • Journal Title: Immunogenetics 62 28S Pages: 601-611
  • Peer Reviewed
• [Journal Article] Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice (2010)
  • Author(s): Sato K, Izumi T, Misawa N, Kobayashi T, Yamashita Y, Ohmichi M, Ito M, Takaori-Kondo A, Koyanagi Y.
  • Journal Title: Journal of Virology Volume: 84 Pages: 9546-9556
  • Peer Reviewed
• [Journal Article] T cell-based functional cDNA library screening identified SEC14-like 1a carboxy-terminal domain as a negative regulator of human immunodeficiency virus replication (2010)
  • Author(s): Urano E, Ichikawa R, Morikawa Y, Yoshida T, Koyanagi Y, Komano J.
  • Journal Title: Vaccine Volume: 28S2
  • Peer Reviewed
• [Journal Article] HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency (2010)
  • Author(s): Hoshino S, Konishi M, Mori M, Shimura M, Nishitani C, Kuroki Y, Koyanagi Y, Kano S, Itabe H, Ishizaka Y.
  • Journal Title: Journal of Leukocyte Biology Volume: 87 Pages: 1133-1143
  • Peer Reviewed
• [Journal Article] HIV-1 Vif interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication (2010)
  • Author(s): Izumi T, Io K, Matsui M, Shirakawa K, Shinohara M, Nagai Y, Kawahara M, Kobayashi M, Kondoh H, Misawa N, Koyanagi Y, Uchiyama T, Takaori-Kondo A.
  • Journal Title: Proceedings of the National Academy of Sciences, USA Volume: 107 Pages: 20798-20803
  • Peer Reviewed
• [Journal Article] Broadening of CD8^+ cell responses in vaccine-based simian immunodeficiency virus controllers (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Journal Title: AIDS Volume: 24 Pages: 2777-2787
  • Peer Reviewed
• [Journal Article] A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins (2010)
  • Author(s): Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T
  • Journal Title: Retrovirology Volume: 7 Pages: 90-90
  • Peer Reviewed
• [Journal Article] Neutralizing antibodies in SIV control : co-impact with T cells (2010)
  • Author(s): Yamamoto H, Matano T
  • Journal Title: Vaccine Volume: 28S
  • Peer Reviewed
• [Journal Article] Diversity of MHC class I genes in Burmese-origin rhesus macaques (2010)
  • Author(s): Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A
  • Journal Title: Immunogenetics Volume: 28S Pages: 601-611
  • Peer Reviewed
• [Journal Article] Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2R□null mice infected with CCR5-tropic HIV-1. (2010)
  • Author(s): Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y.
  • Journal Title: Vaccine Volume: 28S2
  • Peer Reviewed
• [Journal Article] Small intestine CD4^+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load (2010)
  • Author(s): Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K, Miura Y, Koyanagi Y, Nakajima A, Blumberg RS, Takahashi H, Hayami M, Igarashi T, Miura T
  • Journal Title: Journal of General Virology Volume: 91 Pages: 773-781
  • Peer Reviewed
• [Journal Article] 11人中11番目Selective infection of CD4+ effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-1-infected humanized NOD/SCID/IL-2R gammanull mice. (2009)
  • Author(s): Nie C, Sato K, Koyanagi Y.
  • Journal Title: Virology 394 Pages: 64-72
  • Peer Reviewed
• [Journal Article] N-linked glycan-dependent interaction of CD63 with CXCR4 at the Golgi apparatus induces downregulation of CXCR4. (2009)
  • Author(s): Yoshida T, Ebina H, Koyanagi Y.
  • Journal Title: Microbiol Immunol 53 Pages: 629-635
  • NAID: 10027687909
  • Peer Reviewed
• [Journal Article] Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species. (2009)
  • Author(s): Sato K, Yamamoto SP, Misawa N, Yoshida T, Miyazawa T, Koyanagi Y.
  • Journal Title: Retrovirology 6
  • NAID: 120004770243
  • Peer Reviewed
• [Journal Article] Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species. (2009)
  • Author(s): Sato K, Yamamoto SP, Misawa N, Yoshida T, Miyazawa T, Koyanagi Y
  • Journal Title: Retrovirology Volume: 6 Pages: 53-53
  • NAID: 120004770243
  • Peer Reviewed
• [Journal Article] MDM2 is a novel E3 ligase for HIV-1 Vif (2009)
  • Author(s): Izumi T, Takaori-Kondo A, Shirakawa K, Higashitsuji H, Itoh K, Io K, Matsui M, Iwai K, Kondoh H, Sato T, Tomonaga M, Ikeda S, Akari H, Koyanagi Y, Fujita J, Uchiyama T
  • Journal Title: Retrovirology Volume: 6 Pages: 1-1
  • NAID: 120004770229
  • Peer Reviewed
• [Journal Article] Efficient transduction of cytotoxic and anti-HIV-1 genes by a gene-regulatable lentiviral vector (2009)
  • Author(s): Shinoda Y, Hieda K, Koyanagi Y, Suzuki Y
  • Journal Title: Virus Genes Volume: 39 Pages: 165-175
  • NAID: 120001822418
  • Peer Reviewed
• [Journal Article] N-linked glycan-dependent interaction of CD63 with CXCR4 at the Golgi apparatus induces downregulation of CXCR4 (2009)
  • Author(s): Yoshida T, Ebina H, Koyanagi
  • Journal Title: Microbiology and Immunology Volume: 53 Pages: 629-635
  • NAID: 10027687909
  • Peer Reviewed
• [Journal Article] HIV-1 productive infection in CD4+ effector memory T lymphocytes and CD4+ T lymphocyte depletion in humanized NOD/SCID/IL2Rγnull mice (2009)
  • Author(s): Nie C, Sato K, Misawa N, Kitayama H, Fujino H, Hiramatsu H, Heike T, Nakahata T, Tanaka Y, Ito M, Koyanagi Y
  • Journal Title: Virology Volume: 394 Pages: 64-72
  • Peer Reviewed
• [Journal Article] Impact of cytotoxic-T-lymphocyte memory induction without virus-specific CD4+ T-cell help on control of a simian immunodeficiency virus challenge in rhesus macaques (2009)
  • Author(s): Tsukamoto T, Takeda A, Yamamoto T, Yamamoto H, Kawada M, Matano T
  • Journal Title: Journal of Virology Volume: 83 Pages: 9339-9346
  • Peer Reviewed
• [Journal Article] Polyfunctional CD4^+ T-cell induction in neutralizing antibody-triggered control of simian immunodeficiency virus infection (2009)
  • Author(s): Yamamoto T, Iwamoto N, Yamamoto H, Tsukamoto T, Kuwano T, Takeda A, Kawada M, Tsunetsugu-Yokota Y, Matano T
  • Journal Title: Journal of Virology Volume: 83 Pages: 5514-5524
  • Peer Reviewed
• [Journal Article] Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Simian Immunodeficiency Virus Control (2009)
  • Author(s): Yamamoto T, Iwamoto N, Yamamoto H, Tsukamoto T, Kuwano T, Takeda A, Kawada M, Tsunetsugu-Yokota Y, Matano T.
  • Journal Title: J. Virol
  • Peer Reviewed
• [Journal Article] 7人中7番Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (2008)
  • Author(s): Sato K, Aoki J, Koyanagi Y.
  • Journal Title: J Virol 82 Pages: 1021-1033
  • Peer Reviewed
• [Journal Article] 9人中9番目A CD63 mutant inhibits T-cell tropic HIV-1 entry by disrupting CXCR4trafficking to the plasma membrane. (2008)
  • Author(s): Yoshida T, Kawano Y, Koyanagi Y.
  • Journal Title: Traffic 9 Pages: 540-558
  • Peer Reviewed
• [Journal Article] Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction. (2008)
  • Author(s): Kitayama H, Miura Y, Ando Y, Hoshino S, Ishizaka Y, Koyanagi Y.
  • Journal Title: J.Virol 82 Pages: 2528-2542
  • Peer Reviewed
• [Journal Article] 10人中10番目Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques. (2008)
  • Author(s): Takeda A., Igarashi H, Matano T.
  • Journal Title: Vaccine 26 Pages: 6839-6843
  • Peer Reviewed
• [Journal Article] 10人中4番目Potent specific immune responses induced by prime-boost-boost strategies based on DNA, adenovirus, and Sendai virus vectors expressing gag gene of Chinese HIV-1 subtype B. (2008)
  • Author(s): Yu S, Feng X, Shu T, Matano T.
  • Journal Title: Vaccine 26 Pages: 6124-6131
  • Peer Reviewed
• [Journal Article] 10人中10番目Gag-specific cytotoxic T lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial. (2008)
  • Author(s): Kawada M, Tsukamoto T, Matano T.
  • Journal Title: J Virol 82 Pages: 10199-10206
  • Peer Reviewed
• [Journal Article] Anti-HIV adaptive immunity: determinants for viral persistence. (2008)
  • Author(s): Yamamoto H, Matano T.
  • Journal Title: Rev Med Virol 18 Pages: 293-303
  • Peer Reviewed
• [Journal Article] Host factorsinvolved in resistance to retroviralinfection. (2008)
  • Author(s): Takeuchi H, Matano T.
  • Journal Title: Microbiol.Immunol. 52 Pages: 318-325
  • Peer Reviewed
• [Journal Article] 7人中7番目Antigen-specific T-cell induction by vaccination with a recombinant Sendai virus vector even in the presence of vector-specific neutralizing antibodies in rhesus macaques. (2008)
  • Author(s): Moriya C, Horiba S, Matano T.
  • Journal Title: Biochem Biophys Res Commun 371 Pages: 850-854
  • Peer Reviewed
• [Journal Article] 10人中10番目Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope. (2008)
  • Author(s): Tsukamoto T, Dohki S, Matano T.
  • Journal Title: AIDS 22 Pages: 993-994
  • Peer Reviewed
• [Journal Article] Transmission of simian immunodeficiency virus carrying multiple cytotoxic-T-lymphocyte escape mutations with diminished replicative ability can result in AIDS progression in rhesus macaques. (2008)
  • Author(s): Seki S, Kawada M, Takeda A, Igarashi H, Sata, T, Matano T.
  • Journal Title: J Virol 82 Pages: 5093-5098
  • Peer Reviewed
• [Journal Article] 12人中12番目Abrogation of AIDS vaccine-induced cytotoxic T lymphocyte efficacy in vivo due to a change in viral epitope flanking sequences. (2008)
  • Author(s): Moriya C, Igarashi H, Matano T.
  • Journal Title: Microbes Infect 10 Pages: 285-292
  • Peer Reviewed
• [Journal Article] Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (2008)
  • Author(s): Sato K, 他5名, Koyanagi Y(7番目)
  • Journal Title: Journal of Virology 82 Pages: 1021-1033
  • Peer Reviewed
• [Journal Article] A CD63 mutant inhibits T-cell tropic HIV-1 entry by disrupting CXCR4 trafficking to the plasma membrane. (2008)
  • Author(s): Yoshida T, Kawano Y, 他6名, Koyanagi Y(9番目)
  • Journal Title: Traffic 9 Pages: 540-558
  • Peer Reviewed
• [Journal Article] Gag-specific cytotoxic T lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial. (2008)
  • Author(s): Kawada M, 他8名、Matano, T(10番)
  • Journal Title: Journal of Virology. 82 Pages: 10199-10206
  • Peer Reviewed
• [Journal Article] A novel CD4-conjugated ultraviolet light-activated photocatalyst inactivates HIV-1 and SIV efficiently (2008)
  • Author(s): Yamaguchi K, Sugiyama T, Kato S, Kondo Y, Ageyama N, Kanekiyo M, Iwata M, Koyanagi Y, Yamamoto N, Honda M.
  • Journal Title: J. Med. Virol. 80 Pages: 1322-1331
  • Peer Reviewed
• [Journal Article] Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells (2008)
  • Author(s): Urano E, Kariya Y, Futahashi Y, Ichikawa R, Hamatake M, Fukazawa H, Morikawa Y, Yoshida T, Koyanagi Y, Yamamoto N, and Komano J.
  • Journal Title: FEBS Let 582 Pages: 4053-4058
  • Peer Reviewed
• [Journal Article] A CD63 mutant inhibits T-cell tropic HIV-1 entry by disrupting CXCR4 trafficking to the plasma membrane (2008)
  • Author(s): Yoshida T, Kawano Y, Sato K, Ando Y, Aoki J, Miura Y, Komano J, Tanaka Y, Koyanagi Y.
  • Journal Title: Traffic 9 Pages: 540-558
  • Peer Reviewed
• [Journal Article] Primary target cells of herpes simplex virus type 1 in the hippocampus (2008)
  • Author(s): Ando Y, Kitayama H, Kawaguchi Y, Koyanagi Y.
  • Journal Title: Microbes Infect 10 Pages: 1514-1523
  • Peer Reviewed
• [Journal Article] Anti-HIV adaptive immunity : determinants for viral persistence (2008)
  • Author(s): Yamamoto H, Matano T.
  • Journal Title: Rev Med Virol. 18 Pages: 293-303
  • Peer Reviewed
• [Journal Article] Transmission of simian immunodeficiency virus carrying multiple cytotoxic T-lymphocyte escape mutations with diminished replicative ability can result in AIDS progression in rhesus macaques (2008)
  • Author(s): Seki S, Kawada M, Takeda A, Igarashi H, Sata T, Matano T.
  • Journal Title: J. Virol. 82 Pages: 5093-5098
  • Peer Reviewed
• [Journal Article] Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques (2008)
  • Author(s): Takeda A, Igarashi H, Kawada M, Tsukamoto T, Yamamoto H, Inoue M, Iida A, Shu T, Hasegawa M, Matano T.
  • Journal Title: Vaccine 26 Pages: 6839-6843
  • Peer Reviewed
• [Journal Article] Potent specific immune responses induced by prime-boost-boost strategies based on DNA, adenovirus, and Sendai virus vectors expressing gag gene of Chinese HIV-1 subtype B (2008)
  • Author(s): Yu S, Feng X, Shu T, Matano T, Hasegawa M, Wang X, Ma H, Li H, Li Z, Zeng Y.
  • Journal Title: Vaccine 26 Pages: 6124-6131
  • Peer Reviewed
• [Journal Article] Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial (2008)
  • Author(s): Kawada M, Tsukamoto T, Yamamoto H, Iwamoto N, Kurihara K, Takeda A, Moriya C, Takeuchi H, Akari H, Matano T.
  • Journal Title: J. Virol. 82 Pages: 10199-10206
  • Peer Reviewed
• [Journal Article] Host factors involved in resistance to retroviral infection (2008)
  • Author(s): Takeuchi H, Matano T.
  • Journal Title: Microbiol Immunol 52 Pages: 318-325
  • NAID: 40016123018
  • Peer Reviewed
• [Journal Article] Antigen-specific T-cell induction by vaccination with a recombinant Sendai virus vector even in the presence of vector-specific neutralizing antibodies in rhesus macaques (2008)
  • Author(s): Moriya C, Horiba S, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Matano T.
  • Journal Title: Biochem Biophys Res Commun. 371 Pages: 850-854
  • Peer Reviewed
• [Journal Article] Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope (2008)
  • Author(s): Tsukamoto T, Dohki S, Deno T, Kawada M, Takeda A, Yasunami M, Naruse T, Kimura A, Takiguchi M, Matano T.
  • Journal Title: AIDS 22 Pages: 993-994
  • Peer Reviewed
• [Journal Article] A CD63 mutant inhibits T-cell tropic HIV-1 entry by disrupting CXCR4 trafficking to the plasma membrane (2008)
  • Author(s): Yoshida T, Kawano Y, Sato K, Ando Y, Aoki J, Miura Y, Komano J, Tanaka Y, Koyanagi Y
  • Journal Title: Traffic 9 Pages: 540-558
  • Peer Reviewed
• [Journal Article] Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins (2008)
  • Author(s): Sato K, Aoki J, Misawa N, Daikoku E, Sano K, Tanaka Y, Koyanagi Y
  • Journal Title: Journal of Virology 82 Pages: 1021-1033
  • Peer Reviewed
• [Journal Article] Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction (2008)
  • Author(s): Kitayama H, Miura Y, Ando Y, Hoshino S, Ishizaka Y, Koyanagi Y
  • Journal Title: Journal of Virology 82 Pages: 2528-2542
  • Peer Reviewed
• [Journal Article] Significant virus replication in Langerhans cells following application of HIV to abraded skin: Relevance to occupational transmission of HTV (2008)
  • Author(s): Kawamura T, Koyanagi Y, Nakamura Y, Ogawa Y, Yamashita A, Iwamoto T, Ito M, Blauvelt A, Shimada S.
  • Journal Title: Journal of Immunology 180 Pages: 3297-3304
  • Peer Reviewed
• [Journal Article] Human immunodeficiency virus type-1 vulnerates nascent neuronal cells (2008)
  • Author(s): Kitayama H, Miura Y, Ando Y, Koyanagi Y
  • Journal Title: Microbiology and Immunology 52 Pages: 78-88
  • NAID: 10025691204
• [Journal Article] Transmission of simian immunodeficiency virus carrying multiple cytotoxic-T-lymphocyte escape mutations with diminished replicative ability can result in AIDS progression in rhesus macaques (2008)
  • Author(s): Seki S, Kawada M, Takeda A, Igarashi H, Sata T, Matano T
  • Journal Title: Journal of Virology (印刷中)
  • Peer Reviewed
• [Journal Article] 10人中10番目Vaccine-based, long-term, stable control of simian/human immunodeficiency virus 89.6PD replication in rhesus macaques. (2007)
  • Author(s): Yamamoto H, Kawada M, Matano T.
  • Journal Title: J Gen Virol 88 Pages: 652-659
  • Peer Reviewed
• [Journal Article] 7人中7番目Induction of CD8+ cells able to suppress CCR5-tropic simian immunodeficiency virus SIVmac239replication by controlled infection of CXCR4-tropic simian-human immunodeficiency virus in vaccinated rhesus macaques (2007)
  • Author(s): Tsukamoto T, Yuasa M, Matano T.
  • Journal Title: J Virol 81 Pages: 11640-1164
  • Peer Reviewed
• [Journal Article] 7人中7番目Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after non-sterile protection by a cytotoxic T lymphocyte-based vaccine. (2007)
  • Author(s): Kawada M., Tsukamoto T, Matano T.
  • Journal Title: J Virol 81 Pages: 5202-5211
  • Peer Reviewed
• [Journal Article] Post-infection immunodeficiency virus control by neutralizing antibodies. (2007)
  • Author(s): Yamamoto H, Kawada M, Takeda A, Igarashi H, Matano T.
  • Journal Title: PLoS ONE 2
  • Peer Reviewed
• [Journal Article] Long-term control of simian immunodeficiency virus replication with central memory CD4^+ T-cell preservation after non-sterile protection by a cytotoxic T lymphocyte-based vaccine. (2007)
  • Author(s): Kawada M, 他5名, Matano T(7番目)
  • Journal Title: Journal of Virology 81 Pages: 5202-5211
  • Peer Reviewed
• [Journal Article] Post-infection immunodeficiency virus control by neutralizing antibodies. (2007)
  • Author(s): Yamamoto H,他3名、 Matano, T(5番目)
  • Journal Title: PLoS ONE 2:e540
  • Peer Reviewed
• [Journal Article] Vpr in plasma of HIV-1-positive patients is correlated with the HIV-1 RNA titers (2007)
  • Author(s): Hoshino S, Sun B, Konishi M, Shimura M, Segawa T, Hagiwara Y, Koyanagi Y, Iwamoto A, Mimaya JI, Terunuma H, Kano S, Ishizaka Y
  • Journal Title: AIDS Research and Human Retroviruses 23 Pages: 391-397
  • Peer Reviewed
• [Journal Article] Separate elements are required for ligand-dependent and-independen tinternalization of metastatic potentiator CXCR4 (2007)
  • Author(s): Futahashi, Y, Komano J, Urano E, Aoki T, Hamatake M, Miyauchi K, Yoshida T, Koyanagi Y, Matsuda Z, Yamamoto N
  • Journal Title: Cancer Science 98 Pages: 373-379
  • Peer Reviewed
• [Journal Article] Autonomous proliferation of HTLV-CD4+ T cell clones derived from human T cell leukemia virus type I (HTLV-I)-associated myelopathy patients (2007)
  • Author(s): Miyano-Kurosaki N, Kira J, Barnor JS, Maeda N, Misawa N, Kawano Y, Tanaka Y, Yamamoto N, Koyanagi Y
  • Journal Title: Microbiology and Immunology 51 Pages: 235-242
  • NAID: 10020281540
  • Peer Reviewed
• [Journal Article] Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after non-sterile protection by a cytotoxic T lymphocyte-based vaccine (2007)
  • Author(s): Kawada M., Tsukamoto T, Yamamoto H, Takeda A, Igarashi H, Watkins DI, Matano T
  • Journal Title: Journal of Virology 81 Pages: 5202-5211
  • Peer Reviewed
• [Journal Article] Induction of CD8+ cells able to suppress CCR5-tropic simian immunodeficiency virus SIVmac239 replication by controlled infection of CXCR4-tropic simian-human immunodeficiency virus in vaccinated rhesus macaques (2007)
  • Author(s): Tsukamoto T, Yuasa M, Yamamoto H, Kawada M, Takeda A, Igarashi H, Matano T
  • Journal Title: Journal of Virology 81 Pages: 11640-11649
  • Peer Reviewed
• [Journal Article] Post-infection immunodeficiency virus control by neutralizing antibodies (2007)
  • Author(s): Yamamoto H, Kawada M, Takeda A, Igarashi H, Matano T
  • Journal Title: PLoS ONE 2 Pages: 540-540
  • Peer Reviewed
• [Journal Article] Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4 (2007)
  • Author(s): Futahashi, Y, Komano J, Urano E, Aoki T, Hamatake M, Miyauchi K, Yoshida T, Koyanagi Y, Matsuda Z, Yamamoto N
  • Journal Title: Cancer Science 98 Pages: 373-379
  • NAID: 10019481681
• [Journal Article] Long-Term Control of Simian Immunodeficienry Virus Replication with Central Memory CD4+ T-Cell Preservation after Nonsterile Protection by a Cytotoxic T-Lyinphocyte-Based Vaccine (2007)
  • Author(s): Kawada M, Tsukamoto T, Yamamoto H, Takeda A, Igarashi H, Watkins DI, Matano T
  • Journal Title: Journal of Virology 81 Pages: 5202-5211
• [Journal Article] Vaccine-based, long-term, stable control of simian/human immunodeficiency virus 89.6PD replication in rhesus macaques (2007)
  • Author(s): Yamamoto H, Kawada M, Tsukamoto T, Takeda A, Igarashi H, Miyazawa M, Naruse T, Yasunami M, Kimura A, Matano T
  • Journal Title: Journal of General Virology 88 Pages: 652-659
• [Journal Article] 8人中8番目Involvement of multiple epitope-specific cytotoxic T-lymphocyte responses in vaccine-based control of simian immunodeficiency virus replication in rhesus macaques. (2006)
  • Author(s): Kawada M, Igarashi H, Matano T.
  • Journal Title: J Virol 80 Pages: 1949-1958
  • Peer Reviewed
• [Journal Article] Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection (2006)
  • Author(s): Eda Y, Murakami T, Ami Y, Nakasone T, Takizawa M, Someya K, Kaizu M, Izumi Y, Yoshino N, Matsushita S, Higuchi H, Matsui H, Shinohara K, Takeuchi H, Koyanagi Y, Yamamoto N, Honda M
  • Journal Title: Journal of Virology 80 Pages: 5563-5570
• [Journal Article] De novo HTLV-I infection of human lymphocytes in nonobese diabetic-SCID, common γ-chain knocked-out mice (2006)
  • Author(s): Miyazato P, Yasunaga J, Taniguchi Y, Koyanagi Y, Mitsuya H, Matsuoka M
  • Journal Title: Journal of Virology 80 Pages: 10683-10691
• [Journal Article] the mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models(review)
  • Author(s): Sato K, Koyanagi Y
  • Journal Title: Exp Biol Med 印刷中
  • Peer Reviewed
• [Journal Article] A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohis tiocytosis in humanized mice
  • Author(s): Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y
  • Journal Title: Blood Volume: (in press)
  • Peer Reviewed
• [Journal Article] The mouse is out of the bag : insights and perspectives on HIV-1-infected humanized mouse models (review)
  • Author(s): Sato K, Koyanagi Y
  • Journal Title: Experimental Biology and Medicine Volume: (in press)
  • Peer Reviewed
• [Presentation] Mutagenesis and molecular modeling studies reveal structural insights into human tetherin recognition by HIV-1 Vpu (2011)
  • Author(s): Kobayashi T, Ode H, Yoshida T, Sato K, Peter G, Yamamoto S, Ebina H, Klaus S, Sato H, Koyanagi Y.
  • Organizer: 18th Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Hynes Convention Center(米国)
  • Year and Date: 2011-03-01
• [Presentation] p202 Binds to Retrovirus Pre-integration comlex and attenuates HIV infection when fused with an inflammasome pyrin-binding domain (2011)
  • Author(s): Peter G, Suzuki Y, Suzuki Y, Kobayashi T, Ebina H, Koyanagi Y.
  • Organizer: 18th Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Hynes Convention Center(米国)
  • Year and Date: 2011-02-28
• [Presentation] Dynamics of human-specific virus infection in humanized mice, T lymphocyte dynamics in acute and chronic viral infection (2011)
  • Author(s): Sato K, Misawa N, Koyanagi Y.
  • Organizer: Infectious Disease Research Network
  • Place of Presentation: Wellcome Trust(英国)
  • Year and Date: 2011-01-24
• [Presentation] DNA labeling system by peripheral blood of humanized mouse, T lymphocyte dynamics in acute and chronic viral infection (2011)
  • Author(s): Iwami S, Sato K, Misawa N, Kobayashi T, Rob J.de Boer, Koyanagi Y.
  • Organizer: Infectious Disease Research Network
  • Place of Presentation: Wellcome Trust(英国)
  • Year and Date: 2011-01-24
• [Presentation] 個体内における抗HIV-1因子APOBEC3による遺伝子変異 (2010)
  • Author(s): 小柳義夫, 佐藤佳
  • Organizer: 遺伝子病制御研究所研究集会「感染、炎症、発癌」
  • Place of Presentation: 北海道大学遺伝子病制御研究所(札幌市)(招待講演)
  • Year and Date: 2010-12-20
• [Presentation] Identification of amine acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility (2010)
  • Author(s): Kobayashi T, Yoshida T, Sato K, Peter Gee Yamamoto S, Ebina H, Koyanagi Y.
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-08
• [Presentation] 細胞内DNA修復システムによるレトロウイルスcDNA組込み機能の代償 (2010)
  • Author(s): 蝦名博貴、鈴木康嗣、金村優香、津村斐子、小柳義夫
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-07
• [Presentation] エイズワクチン開発:HIV感染症克服への挑戦 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)
  • Year and Date: 2010-11-26
• [Presentation] Human tetherin transmembrane domain is responsible for HIV-1 Vpu interaction and susceptibility (2010)
  • Author(s): 小林朋子、大出裕高、佐藤佳, Gee Peter、山元誠司、蝦名博貴、佐藤裕徳、小柳義夫
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)
  • Year and Date: 2010-11-26
• [Presentation] エイズワクチン開発:HIV感染症克服への挑戦 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)(招待講演)
  • Year and Date: 2010-11-26
• [Presentation] エイズワクチン開発:国際共同臨床試験プロジェクト (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第13回ヒューマンサイエンス総合研究ワークショップ
  • Place of Presentation: 国際研究交流会館国際会議場(東京都)
  • Year and Date: 2010-11-25
• [Presentation] Remarkable and lethal G-to-A mutations in wild-type HIV-1 provirus by individual APOBEC3 proteins in infected humanized mice model (2010)
  • Author(s): Sato K, Koyanagi Y
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)
  • Year and Date: 2010-11-24
• [Presentation] DNA labeling system by peripheral blood of humanized mouse (2010)
  • Author(s): Iwami S, Sato K, Misawa N, Kobayashi T, Rob J.de Boer, Koyanagi Y.
  • Organizer: 2nd synthetic immunology workshop
  • Place of Presentation: 京都大学芝蘭会館(京都市)
  • Year and Date: 2010-11-17
• [Presentation] ヒト化マウスを用いたEBV関連血球貪食性リンパ組織球症モデルマウスの確立 (2010)
  • Author(s): 佐藤佳, 三沢尚子, Chuanyi Nie, 佐藤賢文, 松岡雅雄, 高橋玲, 伊藤守, 高田賢蔵, 小柳義夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-09
• [Presentation] CD8陽性細胞のSIV複製抑制能と抗原特異的CTLレベルの相関の解析 (2010)
  • Author(s): 岩本南、石井洋、山本浩之、武内寛明、俣野哲朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-09
• [Presentation] HIVのアクセサリー蛋白質Vpuとその阻害蛋白テザリン (2010)
  • Author(s): 小柳義夫、小林朋子
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-08
• [Presentation] HIV-1 Vpu相互作用に必須なtetherin/Bst-2膜貫通領域アミノ酸の同定 (2010)
  • Author(s): 小林朋子、芳田剛、佐藤佳、Peter Gee、山元誠司、蝦名博貴、小柳義夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-08
• [Presentation] サルエイズモデルにおけるHAART実施前後のCTL反応の比較 (2010)
  • Author(s): 高原悠佑、松岡佐織、石井洋、堀池麻里子、三浦智行、五十嵐樹彦、俣野哲朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-08
• [Presentation] HIV cDNAのインテグラーゼ非依存性組込みとウイルス複製 (2010)
  • Author(s): 蝦名博貴、鈴木康嗣、金村優香、津村斐子、小柳義夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-07
• [Presentation] Live cell-based mutagenesis studies reveals the structural insights for human tetherin recognition by HIV-1 Vpu (2010)
  • Author(s): Kobayashi T, Yoshida T, Sato K, Peter Gee, Ebina H, Koyanagi Y.
  • Organizer: 11th Kumamoto AIDS Seminar Global COE Joint International Symposium
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル(阿蘇市)(招待講演)
  • Year and Date: 2010-10-07
• [Presentation] The effect of prophylactic vaccination on CTL dominancy post-SIV exposure in rhesusmacaques (2010)
  • Author(s): Matano T
  • Organizer: 11th Kumamoto AIDS Seminar
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル(阿蘇市)(招待講演)
  • Year and Date: 2010-10-07
• [Presentation] Alteration of CTL dominancy post-viral exposure by prophylactic AIDS vaccination. (2010)
  • Author(s): Ishii H, Matano T
  • Organizer: AIDS Vaccine 2010
  • Place of Presentation: Omni Hotel at CNN Center (アトランタ市)
  • Year and Date: 2010-09-30
• [Presentation] Alteration of CTL dominancy post-viral exposure by prophylactic AIDS vaccination (2010)
  • Author(s): Ishii H, Matano T
  • Organizer: AIDS Vaccine 2010
  • Place of Presentation: Omni Hotel at CNN Center(米国)
  • Year and Date: 2010-09-30
• [Presentation] ヒト化マウス末梢血によるDNAラベリング系の確立-動物実験- (2010)
  • Author(s): 佐藤佳, 岩見真吾, 三沢尚子, 伊藤守, 小柳義夫
  • Organizer: 第20回日本数理生物学会大会
  • Place of Presentation: 北海道大学学術交流会館(札幌市)
  • Year and Date: 2010-09-16
• [Presentation] ヒト化マウス末梢血によるDNAラベリング系の確立-数理モデル- (2010)
  • Author(s): 岩見真吾, 佐藤佳, Rob J.de Boer, 小柳義夫
  • Organizer: 第20回日本数理生物学会大会
  • Place of Presentation: 北海道大学学術交流会館(札幌市)
  • Year and Date: 2010-09-16
• [Presentation] G-to-A mutations in HIV-1 provirus by APOBEC3 proteins contribute to abrogation of virus replication in humanized mice (2010)
  • Author(s): Sato K, Izumi T, Misawa N, Kobayashi T, Ito M, Takaori-Kondo A, Koyanagi Y.
  • Organizer: 第10回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場(淡路市)
  • Year and Date: 2010-09-08
• [Presentation] Functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins (2010)
  • Author(s): Inagaki N, Takeuchi H, Matano T
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場(淡路市)
  • Year and Date: 2010-09-08
• [Presentation] Investigation of HIV-1 pathogenesis in humanized mice. (2010)
  • Author(s): Sato K, Misawa N, Nie C, Satou Y, Matsuoka M, Ito M, Koyanagi Y.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-26
• [Presentation] Vaccine-based simian immunodeficiency virus controllers acquire broader CD8^+ cell responses able to suppress multiple escape mutant virus replication (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-26
• [Presentation] Vaccine-based SIV control in a group of Burmese rhesus macaques sharing a MHC class I haplotype. (2010)
  • Author(s): Matano T
  • Organizer: 9th International Veterinary Immunology Symposium
  • Place of Presentation: Tower Hall Funabori(東京都)
  • Year and Date: 2010-08-19
• [Presentation] Vaccine-based SIV control in a group of Burmese rhesus macaques sharing a MHC class I haplotype. (2010)
  • Author(s): Matano T
  • Organizer: 9th International Veterinary Immunology Symposium
  • Place of Presentation: Tower Hall Funabori(東京都)(招待講演)
  • Year and Date: 2010-08-19
• [Presentation] Induction of broad CD8 cell responses effective against replication of a variant virus with multiple escape mutations in simian immunodeficiency virus controllers (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Organizer: VIII International AIDS Conference
  • Place of Presentation: Messe Wien(オーストリア)
  • Year and Date: 2010-07-22
• [Presentation] HIV-1 Vpu counteracts the antiviral factor tetherin/BST-2 by binding it in lipid bilayer (2010)
  • Author(s): Kobayashi T, Ode H, Sato H, Koyanagi Y.
  • Organizer: 16th East Asia Joint Conference on Biomedical Research
  • Place of Presentation: National Taiwan University Convention Center(台湾)(招待講演)
  • Year and Date: 2010-07-02
• [Presentation] A novel animal model for active EBV infection in humanized mice (2010)
  • Author(s): Sato K.
  • Organizer: 16th East Asia Joint Conference on Biomedical Research
  • Place of Presentation: National Taiwan University Convention Center(台湾)(招待講演)
  • Year and Date: 2010-07-02
• [Presentation] センダイウイルスベクターを用いたエイズワクチン開発 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪国際交流センター(大阪市)(招待講演)
  • Year and Date: 2010-06-17
• [Presentation] HIV増殖制御宿主因子:BST-2の機能と構造 (2010)
  • Author(s): 小柳義夫、小林朋子、大出裕高、佐藤裕徳
  • Organizer: 第12回白馬シンポジウム
  • Place of Presentation: 徳島大学附属大学病院(徳島市)
  • Year and Date: 2010-06-14
• [Presentation] Modulation of HIV-1 infection at late phase by an integrase-interactor, Huwel (2010)
  • Author(s): Yamamoto SP, Okawa K, Masuda T, Morikawa Y, Koyanagi, Y, Suzuki Y.
  • Organizer: Retroviruses Meeting
  • Place of Presentation: Cold Spring Harbor研究所(米国)
  • Year and Date: 2010-05-27
• [Presentation] Evidence for HIV-1 G-to-A hepermutation in vivo by Apobec3 proteins (2010)
  • Author(s): Sato K, Izumi T, Misawa N, Ito M, Takaori-Kondo A, Koyanagi Y.
  • Organizer: Retroviruses Meeting
  • Place of Presentation: Cold Spring Harbor研究所(米国)
  • Year and Date: 2010-05-27
• [Presentation] Characterization of species-specific interaction between Bst-2 transmembrane domain and HIV-1 Vpu in lipid bilayers of living cells (2010)
  • Author(s): Kobayashi T, Yoshida T, Sato K., Peter Gee, Ebina H, Koyanagi Y
  • Organizer: Retroviruses Meeting
  • Place of Presentation: Cold Spring Harbor研究所(米国)
  • Year and Date: 2010-05-26
• [Presentation] Investigation of HIV-1pathogenesis in humanized mice (2010)
  • Author(s): 小柳義夫
  • Organizer: The 3rd China-Japan Science Forum
  • Place of Presentation: Wuhan会議場(武漢市)
  • Year and Date: 2010-03-16
• [Presentation] Impact of cytotoxic T lymphocyte responses on HIV/SIV replication (2010)
  • Author(s): 俣野哲朗
  • Organizer: The 3rd China-Japan Science Forum
  • Place of Presentation: Wuhan 会議場(武漢市)
  • Year and Date: 2010-03-16
• [Presentation] Investigation of HIV-1 pathogenesis in humanized mice (2010)
  • Author(s): 小柳義夫
  • Organizer: The 3rd China-Japan Science Forum
  • Place of Presentation: Wuhan会議場(武漢市)
  • Year and Date: 2010-03-16
• [Presentation] Impact of cytotoxic T lymphocyte responses on HIV/SIV replication (2010)
  • Author(s): 俣野哲朗
  • Organizer: The 3rd China-Japan Science Forum
  • Place of Presentation: Wuhan会議場(武漢市)
  • Year and Date: 2010-03-16
• [Presentation] Dynamics of cytotoxic T lymphocyte responses in simian immunodeficiency virus controllers (2010)
  • Author(s): 俣野哲朗
  • Organizer: 2nd Symposium of the IMSUT & RCAST Global COE
  • Place of Presentation: 東京大学医科学研究所(東京都)
  • Year and Date: 2010-03-02
• [Presentation] テトラスパニンによるレトロウイルス感染制御 (2009)
  • Author(s): 小柳義夫、佐藤佳
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-12-12
• [Presentation] エイズワクチン開発:霊長類動物モデルの重要性 (2009)
  • Author(s): 俣野哲朗
  • Organizer: 第5回霊長類医科学フォーラム「先端医科学研究の現状」
  • Place of Presentation: つくば国際会議場(つくば市)
  • Year and Date: 2009-12-10
• [Presentation] Epstein-Barr virus is productively replicated in humanized NOD/SCID/IL2γnull mice simulating severe complications observed in patients with fatal EBV infection (2009)
  • Author(s): Sato K, Misawa N, Nie C, Rei Takahashi R, Ito M, Kuzushima K, Takada K, Koyanagi Y
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-03
• [Presentation] 異種動物細胞株を用いたヒトBST-2/Tetherinの機能比較研究 (2009)
  • Author(s): 佐藤佳、山元誠司、三沢尚子、小柳義夫
  • Organizer: 第23回日本エイズ学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-11-28
• [Presentation] HIV-1インテグレース相互作用因子Huwe1によるHIV-1の感染抑制 (2009)
  • Author(s): 山元誠司、大川克也、増田貴夫、森川裕子、小柳義夫、鈴木陽一
  • Organizer: 第23回日本エイズ学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-11-28
• [Presentation] Analysis of a cohort of unvaccinated and vaccinated Burmese rhesus macaques after SIVmac239 challenge (2009)
  • Author(s): Takahashi N, Iwamoto N, Moriya C, Tsukamoto T, Matano T
  • Organizer: The 27th Annual Symposium on Nonhuman Primate Models for AIDS
  • Place of Presentation: Hyatt Harborside Hotel(ボストン市)
  • Year and Date: 2009-10-29
• [Presentation] 致死性EBV感染症モデルマウスの作製と病態解析 (2009)
  • Author(s): 佐藤佳、三沢尚子、Chuanyi Nie、高橋玲、伊藤守、葛島清隆、高田賢藏、小柳義夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-27
• [Presentation] レトロウイルスインテグラーゼ結合性因子Huwe1の同定とHIV-1感染における役割 (2009)
  • Author(s): 山元誠司、大川克也、増田貴夫、森川裕子、小柳義夫、鈴木陽一
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-26
• [Presentation] Bst-2とHIV-1 Vpuの相互作用メカニズムの解析 (2009)
  • Author(s): 小林朋子、芳田剛、佐藤佳、Peter Gee、蝦名博貴、小柳義夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-26
• [Presentation] Rho GTPase familyによるHIV-1複製抑制 (2009)
  • Author(s): 渡部匡史、鈴木陽一、宮澤正顯、小柳義夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-26
• [Presentation] 広範なSIV特異的細胞性免疫誘導機序の解析 (2009)
  • Author(s): 岩本南、塚本徹雄、俣野哲朗
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-26
• [Presentation] 細胞性免疫誘導エイズワクチンの有効性が認められたサルにおけるSIV特異的CTLのエピトープ探索 (2009)
  • Author(s): 高橋尚史、塚本徹雄、岩本南、高原悠佑、成瀬妙子、木村彰方、俣野哲朗
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-26
• [Presentation] ビルマ産アカゲザルSIV感染により誘導されるCTLエピトープの探索 (2009)
  • Author(s): 高原悠佑、武内寛明、石井洋、高橋尚史、三浦智行、五十嵐樹彦、俣野哲朗
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-26
• [Presentation] HIV-1放出抑制分子BST-2の解明 (2009)
  • Author(s): 小柳義夫
  • Organizer: 第50回日本熱帯医学会大会シンポジウム
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2009-10-23
• [Presentation] HIV感染におけるテトラスパニンの意義 (2009)
  • Author(s): 小柳義夫、佐藤佳
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] Impact of single epitope-specific CD8+ T cell memory induction by prophylactic vaccination on immunodeficiency virus control (2009)
  • Author(s): Tsukamoto T, Matano T
  • Organizer: AIDS Vaccine 2009
  • Place of Presentation: Marriott Rive Gauche Conference Center(パリ市)
  • Year and Date: 2009-10-20
• [Presentation] Sendai virus.Satellite Session: Replicating Viral Vectors for use in AIDS Vaccines (2009)
  • Author(s): Matano T
  • Organizer: AIDS Vaccine 2009
  • Place of Presentation: Marriott Rive Gauche Conference Center(パリ市)
  • Year and Date: 2009-10-19
• [Presentation] Sendai virus. Satellite Session : Replicating Viral Vectors for use in AIDS Vaccines (2009)
  • Author(s): Matano T
  • Organizer: AIDS Vaccine 2009
  • Place of Presentation: Marriott Rive Gauche Conference Center(パリ市)
  • Year and Date: 2009-10-19
• [Presentation] Immunogenicity of an intranasal Sendai virus vector vaccine (2009)
  • Author(s): Matano T
  • Organizer: Japan-France Vaccine and Infectious Diseases Workshop
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-10-10
• [Presentation] Effect of vaccine-induced memory T cells on HIV/SIV replication after virus exposure (2009)
  • Author(s): Matano T
  • Organizer: The 9th Awaji International Forum on Infection and Immunity, Awaji
  • Place of Presentation: 淡路国際会議場(淡路市)
  • Year and Date: 2009-09-11
• [Presentation] Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species (2009)
  • Author(s): Sato K, Yamamoto SP, Misawa N, Yoshida T, Miyazawa T, Koyanagi Y
  • Organizer: The 9th Awaji International Forum on Infection and Immunity, Awaji
  • Place of Presentation: 淡路国際会議場(淡路市)
  • Year and Date: 2009-09-10
• [Presentation] Epstein-Barr virus is productively replicated in humanized NOD/SCID/IL2γ^<null> mice simulating severe complications observed in patients with fatal EBV infection (2009)
  • Author(s): Sato K, Misawa N, Nie C, Takahashi R, Ito M, Kuzushima K, Takada K, Koyanagi Y
  • Organizer: The 9th Awaji International Forum on Infection and Immunity, Awaji
  • Place of Presentation: 淡路国際会議場(淡路市)
  • Year and Date: 2009-09-09
• [Presentation] Mapping of cytotoxic T lymphocyte epitopes in rhesus macaques showing vaccine-based control of simian immunodeficiency virus replication (2009)
  • Author(s): Takahashi N, Tsukamoto T, Iwamoto N, Takahara Y, Naruse T, Kimura A, Matano T
  • Organizer: The 9th Awaji International Forum on Infection and Immunity, Awaji
  • Place of Presentation: 淡路国際会議場(淡路市)
  • Year and Date: 2009-09-09
• [Presentation] エイズワクチン開発:HIV感染防御に何が必要か? (2009)
  • Author(s): 俣野哲朗
  • Organizer: 第36回東京大学医科学研究所創立記念シンポジウム「感染防御の最前線」
  • Place of Presentation: 東京大学医科学研究所(東京都)
  • Year and Date: 2009-05-29
• [Presentation] ヒト血液幹細胞移植マウスのウイルス病原性解析への利用 (2009)
  • Author(s): 小柳義夫、佐藤佳、伊藤守
  • Organizer: 第56回日本実験動物学会
  • Place of Presentation: 大宮ソニックシティ(大宮市)
  • Year and Date: 2009-05-14
• [Presentation] Induction of functional T-cell responses in neutralizing antibody-triggered SIV control. (2008)
  • Author(s): Matano T. , 他4名
  • Organizer: The 26th Annual Symposium on Nonhuman Primate Models for AIDS
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2008-12-12
• [Presentation] Induction of functional T-cell responses in neutralizing antibody-triggered SIV control (2008)
  • Author(s): Matano T, Yamamoto T, Iwamoto N, Yamamoto H, Kawada M
  • Organizer: The 26th Annual Symposium on Nonhuman Primate Models for AIDS
  • Place of Presentation: Puerto Rico, Sanjnan
  • Year and Date: 2008-12-12
• [Presentation] Gag特異的CTLクローンのSIV複製抑制能の解析 (2008)
  • Author(s): 石井洋、川田真幹、武内寛明、明里宏文、上野貴将、滝口雅文、俣野哲朗
  • Organizer: 第22回日本エイズ学会
  • Place of Presentation: 大阪市(大阪国際交流センター)
  • Year and Date: 2008-11-28
• [Presentation] レンチウイルスベクターを用いた抗HIV因子のスクリーニングとその解析 (2008)
  • Author(s): 小林朋子、芳田剛、駒野淳、小柳義夫
  • Organizer: 第22回日本エイズ学会
  • Place of Presentation: 大阪市(大阪国際交流センター)
  • Year and Date: 2008-11-27
• [Presentation] CTLエピトープのみ発現する予防エイズワクチンの検討 (2008)
  • Author(s): 塚本徹雄、川田真幹、岩本南、桑野哲矢、井上誠、飯田章博、朱亜峰、長谷川護、俣野哲朗
  • Organizer: 第56回日本ウイルス学会
  • Place of Presentation: 岡山市(岡山コンベンションセンター)
  • Year and Date: 2008-10-28
• [Presentation] サルエイズモデルにおける宿主MHC遺伝子多型の細胞性免疫誘導ワクチン効果への影響の解析 (2008)
  • Author(s): 桑野哲矢、川田真幹、塚本徹雄、岩本南、井上誠、飯田章博、朱亜峰、長谷川護、俣野哲朗
  • Organizer: 第56回日本ウイルス学会
  • Place of Presentation: 岡山市(岡山コンベンションセンター)
  • Year and Date: 2008-10-28
• [Presentation] Small GTPase Rac2によるHIV-1増殖制御 (2008)
  • Author(s): 渡部匡史, 鈴木陽一, 宮澤正顯, 小柳義夫
  • Organizer: 第56回日本ウイルス学会
  • Place of Presentation: 岡山市(岡山コンベンションセンター)
  • Year and Date: 2008-10-27
• [Presentation] HIV-1 pathogenesis : productive infection in CD4+ effecter memory T lymphocytes and CD4+ depletion in humanized mice. (2008)
  • Author(s): Koyanagi Y.
  • Organizer: 第11回京都大学国際シンポジウム
  • Place of Presentation: 上海
  • Year and Date: 2008-10-11
• [Presentation] Impact of vaccine-induced Gag-specific CTL responses on SIV control (2008)
  • Author(s): 俣野哲朗
  • Organizer: The 9th Kumamoto AIDS Seminar
  • Place of Presentation: 熊本市
  • Year and Date: 2008-09-19
• [Presentation] Characterization of pathogenesis and productive infection of HIV-1 in humanized mice (2008)
  • Author(s): Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y.
  • Organizer: The 8th Awaji Symposium, Awaji
  • Place of Presentation: 淡路市(淡路夢舞台国際会議場)
  • Year and Date: 2008-09-09
• [Presentation] Induction of CD8 cells with strong anti-SIV efficacy in macaques passively immunized with neutralizing antibody (2008)
  • Author(s): Iwamoto N, Yamamoto H, Tsukamoto T, Kuwano T, Kawada M, Matano T.
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路市(淡路夢舞台国際会議場)
  • Year and Date: 2008-09-09
• [Presentation] SIV-specific functional T-cell induction after passive neutralizing antibody immunization postinfection (2008)
  • Author(s): Yamamoto T, Iwamoto N, Yamamoto H, Tsukamoto T, Kuwano T, Takeda A, Kawada M, Tsunetsugu-Yokota Y, Matano T.
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路市(淡路夢舞台国際会議場)
  • Year and Date: 2008-09-09
• [Presentation] HIV-1 Vpr in Mitochondria impairs neuronal cell repair (2008)
  • Author(s): Kitayama H, Ando Y, Hoshino S, Ishizaka Y, Koyanagi Y.
  • Organizer: XIV. International Congress of Virology
  • Place of Presentation: Istanbul
  • Year and Date: 2008-08-11
• [Presentation] HIV and AIDS. (2008)
  • Author(s): Koyanagi Y.
  • Organizer: 日中数理生物学コロキュームシンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2008-08-04
• [Presentation] HIV and AIDS (2008)
  • Author(s): Koyanagi, Y.
  • Organizer: 日中数理生物学コロキュームシンポジウム
  • Place of Presentation: 岡山市(岡山大学)
  • Year and Date: 2008-08-04
• [Presentation] エイズ (2008)
  • Author(s): 俣野哲朗
  • Organizer: 第34回日本医学会シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-17
• [Presentation] エイズ (2008)
  • Author(s): 俣野哲朗
  • Organizer: 第34回日本医学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-17
• [Presentation] A CTL-based AIDS vaccine using a Sendai virus vector (2008)
  • Author(s): 俣野哲朗
  • Organizer: The 7th Japan-China International Conference of Virology
  • Place of Presentation: 東京都
  • Year and Date: 2008-06-02
• [Presentation] Identification of cellular interactors to MoMLV integrase using tandem affinity purification-mass spectrometoy analysis (2008)
  • Author(s): Yamamoto S, Ogawa K, Masuda T, Koyanagi Y, Suzuki Y.
  • Organizer: Retroviruses Meeting, Cold Spring Harbor
  • Place of Presentation: Cold Spring Harbor
  • Year and Date: 2008-05-23
• [Presentation] HIV-1 VPR in mitochondria impairs neuronal progenitor cell differentiation (2008)
  • Author(s): Kitayama H, Miura Y, Ando Y, Hoshino S, Ishizaka Y, Koyanagi Y.
  • Organizer: Retroviruses Meeting, Cold Spring Harbor
  • Place of Presentation: Cold Spring Harbor
  • Year and Date: 2008-05-22
• [Presentation] Tetraspanin on HIV-1 virions modulates its infectivity (2008)
  • Author(s): Sato K, Aoki J, Misawa N, Daikoku E, Sano K, Tanaka Y, Koyanagi Y.
  • Organizer: Retroviruses Meeting, Cold Spring Harbor
  • Place of Presentation: Cold Spring Harbor
  • Year and Date: 2008-05-22
• [Presentation] 受容体分子の表面発現を輸送小胞レベルで調節する機構;HIVのコレセプター分子の細胞質膜発現を調節する (2007)
  • Author(s): 芳田剛、河野祐治、安藤良徳、佐藤佳、駒野淳、三浦義治、田中勇悦、小柳義夫
  • Organizer: 第30回日本分子生物学会年会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜市(パシフィコ横浜)
  • Year and Date: 2007-12-13
• [Presentation] CTL誘導エイズワクチン接種サルのエスケープ変異ウイルス感染実験 (2007)
  • Author(s): 川田真幹＼俣野哲朗
  • Organizer: 第21回日本エイズ学会
  • Place of Presentation: 広島市(広島国際会議場)
  • Year and Date: 2007-11-28
• [Presentation] CXCR4トラフィキング過程の可視化と遺伝子導入によるHIV-1感染阻害 (2007)
  • Author(s): 芳田剛、安藤良徳、小柳義夫
  • Organizer: 第55回日本ウイルス学会
  • Place of Presentation: 札幌市(札幌コンベンションセンター)
  • Year and Date: 2007-10-23
• [Presentation] HIV-1 Vpr誘導性ミトコンドリア機能障害による神経細胞軸索伸長の阻害 (2007)
  • Author(s): 北山裕子、安藤良徳、三浦義治、星野重樹、石坂幸人、小柳義夫
  • Organizer: 第55回日本ウイルス学会
  • Place of Presentation: 札幌市(札幌コンベンションセンター)
  • Year and Date: 2007-10-23
• [Presentation] CD8陽性細胞集団のエイズウイルス抑制能を評価する (2007)
  • Author(s): 塚本徹雄、俣野哲朗
  • Organizer: 第55回日本ウイルス学会
  • Place of Presentation: 札幌市(札幌コンベンションセンター
  • Year and Date: 2007-10-23
• [Presentation] Regulation of Human Immunodeficiency Virus Type 1 Infectivity through Incornoration of CD63 (2007)
  • Author(s): Sato K, Daikoku E, Sano K, and Koyanagi Y
  • Organizer: Awaji symposium
  • Place of Presentation: 淡路市(淡路夢舞台国際会議場)
  • Year and Date: 2007-09-01
• [Presentation] High level of HIV-1 viremia and CD4 depletion in human CD34+ cell-engrafted mice (2007)
  • Author(s): Sato K, Misawa N, Ito M, Koyanagi Y
  • Organizer: Retroviruses meeting
  • Place of Presentation: New York (Cold Spring Harbor)
  • Year and Date: 2007-05-22
• [Presentation] Human Immunodeficiency Virus-1 Vpr inhibits neurite outgrowth via caspase-3-independent pathway (2007)
  • Author(s): Kitayama H, Miura Y, Ando Y, Hoshino S, Ishizaka Y, Koyanagi Y.
  • Organizer: Retroviruses meeting
  • Place of Presentation: New York (Cold Spring Harbor)
  • Year and Date: 2007-05-22
• [Presentation] CD63 and its mutants inhibit fusion of CXCR4-containing vesicles to the plasma membrane and block X4 HIV-1 entry (2007)
  • Author(s): Yoshida T, Kawano Y, Ando Y, Sato K, Komano J, Miura Y, Tanaka Y, Koyanagi Y
  • Organizer: Retroviruses meeting
  • Place of Presentation: New York (Cold Spring Harbor)
  • Year and Date: 2007-05-22
• [Book] Humanized Mice Curr ToCurr Top Microbiol Immunol 324(Nomura, Tatsuji; Watanabe, Takeshi; Habu, Sonoko, Eds.) (2008)
  • Author(s): Koyanagi Y, Tanaka Y, Ito M, Yamamoto N
  • Publisher: Humanized mice for human retrovirus infection
• [Book] "Humanized Mice", Current Topics in Microbiology and Immunology (2008)
  • Author(s): Koyanagi Y, Tanaka Y, Ito M, Yamamoto N, (Nomura T, Watanabe T, Habu S, Eds.)
  • Publisher: Springer
• [Book] Curr. Top. Microbiol. Immunol. (2008)
  • Author(s): Koyanagi Y, Tanaka Y, Ito M, and Yamamoto N
  • Publisher: Springer
• [Book] Virus Expression Vectors Sendai virus engineering: From reverse genetics to vector development. (2007)
  • Author(s): Nagai Y, Inoue M, Iida A, Zhu Y-F, Hasegawa M, Kato A, Matano T
  • Total Pages: 390
  • Publisher: Trasworld Research Network
• [Book] Sendai virus engineering: From reverse genetics to vector development. Virus Expression Vectors (2007)
  • Author(s): Nagai Y, Inoue M, Iida A, Zhu Y-F, Hasegawa M, Kato A, Matano T
  • Publisher: Trasworld Research Network
• [Remarks] ホームページ等
  • URL: http://www.virus.kyoto-u.ac.jp/Lab/sait