| Budget Amount *help |
¥182,000,000 (Direct Cost: ¥182,000,000)
Fiscal Year 2010: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2009: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2008: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2007: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2006: ¥36,400,000 (Direct Cost: ¥36,400,000)
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| Research Abstract |
It has been extensively investigated on HIV and SIV replication, life cycle and pathogenesis. We show how tetraspanin and tetherin inhibit HIV infection and virus possesses accessary machinery to escapes from the inhibition. Furthermore, we show that neutralizing antibody has a role on anti-viral response of CD4+ T cells in acute phase and number of anti-viral CTL epitopes increases in chronic phase in SIV infected macaques. These data indicates the insight of HIV/SIV life cycle and pathogenesis and opens the road for its therapy.
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