Molecular analysis of bacterial invasion strategies and intracellular growth of pathogenic streptococci

• Project Area: Matrix of Infection Phenomena
• Project/Area Number: 18073011
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: KAWABATA Shigetada Osaka University, 大学院・歯学研究科, 教授 (50273694)
• Co-Investigator(Kenkyū-buntansha): TERAO Yutaka 大阪大学, 大学院・歯学研究科, 准教授 (50397717) ; NAKATA Masanobu 大阪大学, 大学院・歯学研究科, 助教 (90444497)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥93,000,000 (Direct Cost: ¥93,000,000); Fiscal Year 2010: ¥18,600,000 (Direct Cost: ¥18,600,000); Fiscal Year 2009: ¥18,600,000 (Direct Cost: ¥18,600,000); Fiscal Year 2008: ¥18,600,000 (Direct Cost: ¥18,600,000); Fiscal Year 2007: ¥18,600,000 (Direct Cost: ¥18,600,000); Fiscal Year 2006: ¥18,600,000 (Direct Cost: ¥18,600,000)
• Keywords: レンサ球菌 / 組織侵入 / 増殖 / タンパク質 / 病原因子 / 感染症 / 細菌 / 微生物 / 免疫学 / バイオ関連機器 / SpeB / A群レンサ球菌 / 自然免疫 / 回避機構 / 補体 / C3b / C5a / システインプロテアーゼ

Research Abstract

Streptococcus pyogenes causes pharyngitis, sepsis, and rheumatic fever. Cell-associated streptococcal C5a peptidase (ScpA) protects S. pyogenes from phagocytosis and has been suggested to interrupt host defenses by enzymatically cleaving complement C5a, a major factor in the accumulation of neutrophils at sites of infection. How S. pyogenes recognizes and binds to C5a, however, is unclear. We detected a C5a-binding protein in 8 M urea extracts of S. pyogenes by ligand blotting using biotinylated C5a. Searching of genome databases showed that the C5a-binding protein is identical to the streptococcal plasmin receptor (Plr), also known as streptococcal surface dehydrogenase (SDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In the present study, we identified a novel function of this multifunctional protein. We examined whether the streptococcal Plr/SDH/GAPDH inhibits the biological effects of C5a on human neutrophils. Together, these results indicate that the multifunctional protein Plr/SDH/GAPDH has additional functions that help S. pyogenes escape detection by the host immune system.

Research Products

• [Journal Article] Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (2011)
  • Author(s): Ogawa, T., Terao, Y., Sakata, H., Okuni, H.,Ninomiya, K., Ikebe, K., Maeda, Y., Kawabata, S.
  • Journal Title: FEMS Microbiol. Lett. 318 Pages: 143-151
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. (2011)
  • Author(s): Okahashi, N., Nakata M., Sakurai A., Terao Y., Hoshino T.,Yamaguchi Y., Isoda R., Sumitomo T., Nakano K., Kawabata S., Ooshima T.
  • Journal Title: Microb. Pathog. 50 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. (2011)
  • Author(s): Sumitomo, T., Nakata M., Higashino M., Jin Y., Terao Y., Fujinaga Y., Kawabata S
  • Journal Title: J.Biol.Chem. 286(4) Pages: 2750-2761
  • Peer Reviewed
• [Journal Article] Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier (2011)
  • Author(s): Sumitomo T, et al.
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 2750-2761
  • Peer Reviewed
• [Journal Article] Inhibitory Effects of Oenothera biennis (Evening Primrose) Seed Extract on Streptococcus mutans and S.mutans-Induced Dental Caries in Rats (2011)
  • Author(s): Matsumoto-Nakano M, et al.
  • Journal Title: Caries Research Volume: 45 Pages: 56-63
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation (2011)
  • Author(s): Okahashi N, et al.
  • Journal Title: Microbial Pathogenesis Volume: 50 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis (2011)
  • Author(s): Ogawa T, et al.
  • Journal Title: FEMS Microbiology Letters Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis (2011)
  • Author(s): Ogawa, T., et al.
  • Journal Title: Microbial Pathogenesis Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum envelope protein, FomA, is immunogenic and binds to salivary statherin-derived peptide. (2010)
  • Author(s): Nakagaki, H., Sekine S., Terao Y., Toe M., Tanaka M., Shizukuishi S., Ito H., Kawabata S., McGhee JR., Fujihashi K., Kataoka K.
  • Journal Title: Infect. Immun. 78(3) Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. (2010)
  • Author(s): Okahashi, N., Nakata M., Sakurai A., Terao Y., Hoshino T., Yamaguchi Y., Isoda R., Sumitomo T., Nakano K., Kawabata S., Ooshima T.
  • Journal Title: Biochem. Biophys.Res.Commun. 391 Pages: 1192-1196
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptide (2010)
  • Author(s): Nakagaki H, et al.
  • Journal Title: Infection and Immunity Volume: 78 Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. (2010)
  • Author(s): Okabasbi N, M.Nakata, A.Sakurai, Y.Terao, T.Hoshino, M.Yamaguchi, R.Tsoda, T.Sumitomo, K.Nakano, S.Kawabata, T.Ooshima.
  • Journal Title: Biochem.Biophys.Res.Commun. 391(2) Pages: 1192-1196
  • Peer Reviewed
• [Journal Article] Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. Biochem. (2009)
  • Author(s): Yamaguchi, M., Minamide M., Terao Y., Isoda R., Ogawa T., Yokota S., Hamada S.Kawabata S.
  • Journal Title: Biophys.Res.Commun. 390(1) Pages: 155-160
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of novel gtf regulation-associated genes in Streptococcus mutans. (2009)
  • Author(s): Terao, Y., Isoda R., Murakami, J.Hamada, S.Kawabata, S.
  • Journal Title: Oral Microbiol. Immunol. 24 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. (2009)
  • Author(s): Nakata, M., Koller, T., Moritz, K., Ribardo, D., Jonas, L., McIver, K.S., Sumitomo, T., Terao, Y., Kawabata, S., Podbielski, A.Kreikemeyer, B.
  • Journal Title: Infect. Immun. 77 Pages: 32-44
  • Peer Reviewed
• [Journal Article] Nrc of Streptococcus pneumoniae wuppresses capsule expression and enhances anti-phagocytosis. (2009)
  • Author(s): Yamaguchi, M., Y.Minamide, Y.Terao, R.Isoda, T.Ogawa, S.Yokota, S.Hamada, S.Kawabata.
  • Journal Title: Biochem.Biophys.Res.Commun. 390(1) Pages: 155-160
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans. (2009)
  • Author(s): Terao, Y., R.Isoda, J. Murakami, S.Hamada, S.Kawabata.
  • Journal Title: Oral Microbiol.Immunol. 24(3) Pages: 211-217
  • Peer Reviewed
• [Journal Article] Mode of expression and functional characterzation of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. (2009)
  • Author(s): Nakata, M., T.Koller, K.Moritz, D.Ribardo, L.Jonas, K.S.McIver, T.Sumitomo, Y.Terao, S.Kawabata, A.Podbielski, B.Kreikemeyer.
  • Journal Title: Infect.Immun. 77(1) Pages: 32-44
  • Peer Reviewed
• [Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. (2009)
  • Author(s): Maruyama F, M.Kobata, K.Kurokawa, K.Nihida, A.Sakurai, K.Nakano, R.Nomura, S.Kawabata, T.Ooshima, K.Nakai, M.Hattori, S.Hamada, I.Nakagawa.
  • Journal Title: BMC Genomics 10 Pages: 358-358
  • Peer Reviewed
• [Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49 (2009)
  • Author(s): Masanobu Nakata
  • Journal Title: Infect. Immun. 77 Pages: 32-44
  • Peer Reviewed
• [Journal Article] A群レンサ球菌の病原性発現に関する分子機構 (2009)
  • Author(s): 川端重忠
  • Journal Title: 感染・炎症・免疫 38 Pages: 2-13
  • Peer Reviewed
• [Journal Article] PfbA, a Novel Plasmin-and Fibronectin-binding Protein of Streptococcus pneumoniae Contributes to Fibronectin-dependent Adhesion and Antiphagocytosis. (2008)
  • Author(s): Yamaguchi, M., Terao, Y., Hamada, S.Kawabata, S.
  • Journal Title: J.Biol.Chem. 283 Pages: 36272-36279
  • Peer Reviewed
• [Journal Article] A novel streptococcal leucine zipper protein (Lzp) that binds to binds to human immunoglobulins. (2008)
  • Author(s): Okamoto, S., Terao, Y., Hasuike, K., Hamada, S.Kawabata, S.
  • Journal Title: Biochem. Biophys.Res.Commun. 377 Pages: 1128-1134
  • Peer Reviewed
• [Journal Article] Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. (2008)
  • Author(s): Terao, Y., Mori, Y., Yamaguchi, M., Shimizu, Y., Ooe, K., Hamada, S.Kawabata S.
  • Journal Title: J.Biol.Chem. 283 Pages: 6253-6260
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of histidine triad protein in group A streptococci. (2008)
  • Author(s): Kunitomo, E., Terao, Y., Okamoto, S., Rikimaru, T., Hamada, S.Kawabata, S.
  • Journal Title: Microbes Infect. 10 Pages: 414-423
  • Peer Reviewed
• [Journal Article] Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes. (2008)
  • Author(s): Okamoto, S., Terao, Y., Tamura, Y., Hamada, S.Kawabata, S.
  • Journal Title: FEMS Microbiol.Lett. 281 Pages: 73-80
  • Peer Reviewed
• [Journal Article] Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. (2008)
  • Author(s): Itsuki ,Y., Saeki, M., Nakahara, H., Egusa, H., Irie, Y., Terao, Y., Kawabata, S., Yatani, H.Kamisaki, H.
  • Journal Title: FEBS Lett. 582 Pages: 2365-2370
  • Peer Reviewed
• [Journal Article] Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity (2008)
  • Author(s): Terao, Y., Y. Mori, M. Yamaguchi, Y. Shimizu, K. Ooe, S. Hamada and S. Kawabata
  • Journal Title: J. Biol. Chem. 283 Pages: 6253-6260
• [Journal Article] PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis (2008)
  • Author(s): Yamaguchi, M., Y. Terao, Y. Mori, S. Hamada and S. Kawabata
  • Journal Title: J. Biol. Chem. 283 Pages: 36272-36279
• [Journal Article] Molecular and biological characterization of histidine triad protein in group A streptococci (2008)
  • Author(s): Kunitomo, E., Y. Terao, S. Okamoto, T. Rikimaru, S. Hamada and S. Kawabata
  • Journal Title: Microbes Infect. 10 Pages: 414-423
• [Journal Article] Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes (2008)
  • Author(s): Okamoto, S., Y. Terao, Y. Tamura, S. Hamada and S. Kawabata
  • Journal Title: FEMS Microbiol. Lett. 281 Pages: 73-80
• [Journal Article] A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins (2008)
  • Author(s): Okamoto, S., Y. Terao, K. Hasuike, S. Hamada and S. Kawabata
  • Journal Title: Biochem. Biophys. Res. Commun. 377 Pages: 1128-1134
• [Journal Article] Group A streptococcal cysteine protease degrades C3(C3b)and contributes to evasion of innate immunity (2008)
  • Author(s): Yutaka Terao
  • Journal Title: J.Biol. Chem. 283 Pages: 16253-6260
  • Peer Reviewed
• [Journal Article] PfbA, a novel plasmin-and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis (2008)
  • Author(s): Masaya Yamaguchi
  • Journal Title: J. Biol Chem. 283 Pages: 36272-36279
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of histidine triad protein in group A streptococci (2008)
  • Author(s): Eiji Kunitomo
  • Journal Title: Microbes Infect. 10 Pages: 414-423
  • Peer Reviewed
• [Journal Article] Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse. B lymphocytes (2008)
  • Author(s): Shigefumi Okamoto
  • Journal Title: FEMS Micrnbiol. Lett. 281 Pages: 73-80
  • Peer Reviewed
• [Journal Article] A novel streptococcal leucine zipper protein(Lzp)binds to human imnumoglobulins (2008)
  • Author(s): Shigefumi Okamoto
  • Journal Title: Biochena Biophys. Res. Commun. 377 Pages: 1128-1134
  • Peer Reviewed
• [Journal Article] Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains (2008)
  • Author(s): Yuki Itsuki
  • Journal Title: FEBS Lett. 582 Pages: 2365-2370
  • Peer Reviewed
• [Journal Article] Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. (2008)
  • Author(s): Terao, Y.・Mori, Y.・Yamaguchi, M.・Shimizu, Y.・Ooe, K.・Hamada, S.・Kawabata, S.
  • Journal Title: Journal of Biological Chemistry (印刷中)
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of histidina triad protein in group A streptococci. (2008)
  • Author(s): Kunitomo, E.・Terao, Y.・Okamoto, S.・Rikimaru, T.・Hamada, S.・kawabata, S.
  • Journal Title: Microbes and Infections (印刷中)
  • Peer Reviewed
• [Journal Article] Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes. (2008)
  • Author(s): Okamoto, S.・Terao, Y.・Tamura, Y.・Hamada, S.・Kawabata, S.
  • Journal Title: FEMS Microbiolgy Letters (印刷中)
  • Peer Reviewed
• [Journal Article] Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation. (2007)
  • Author(s): Saeki, M., Irie, Y.Ni, L.Itsuki, Y.Terao, Y., Kawabata, S.Kamisaki Y.
  • Journal Title: J.Biol.Chem., 282 Pages: 11786-11794
  • Peer Reviewed
• [Journal Article] Induction of immune responses by streptococcal water-insoluble alpha-glucans. (2007)
  • Author(s): Okamaoto, S., Terao, Y., Kaminishi, H., Hamada, S.Kawabata S.
  • Journal Title: J.Dent.Res. 86 Pages: 242-248
  • Peer Reviewed
• [Journal Article] Induction of immune responses by streptococcal water-insoluble α-gulucans. (2007)
  • Author(s): Okamaoto, S.・Terao, Y.・Kaminishi, H.・Hamada, S.・Kawabata, S.
  • Journal Title: Journal of Dental Research 86 Pages: 242-248
  • Peer Reviewed
• [Journal Article] Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation. (2007)
  • Author(s): Saeki, M.・Irie, Y.・Ni, L.・Itsuki, Y.・Terao, Y.・Kawabata, S.・Kamisaki, Y.
  • Journal Title: Journal of Biological Chemistry 282 Pages: 11786-11794
  • Peer Reviewed
• [Journal Article] The Streptococcus pyogenes serotype M49 Nra-Rallp3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity region. (2007)
  • Author(s): Kreikemeyer, B・Nakata, M.・Koller, T.・Hildisch, H.・Kourakos, V.・Standar, K.・Kawabata, S.・Glocker, M. O.・Podbielski, A.
  • Journal Title: Infection and Immunity 75 Pages: 5698-5710
  • Peer Reviewed
• [Journal Article] Inflammatory immune responses by water-insoluble α-glucans (2007)
  • Author(s): Okamoto, S., Y.Terao, H.Kaminishi, S.Hamada, S.Kawabata
  • Journal Title: Journal of Dental Research 86・3 Pages: 242-248
• [Journal Article] 劇症型A群レンサ球菌感染症(劇症化の分子機構) (2007)
  • Author(s): 川端重忠, 寺尾 豊
  • Journal Title: BIO Clinica 22・2 Pages: 39-44
• [Journal Article] Role of Streptococcus sanguinis sortase A in bacterial colonization. (2006)
  • Author(s): Yamaguchi, M., Terao, Y., Ogawa, T., Takahashi, T., Hamada, S.Kawabata S.
  • Journal Title: Microbes Infect. 8 Pages: 2791-2796
  • Peer Reviewed
• [Journal Article] Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. (2006)
  • Author(s): Terao, Y., Yamaguchi, M., Hamada, S.Kawabata, S.
  • Journal Title: J.Biol.Chem. 281 Pages: 14215-14223
  • Peer Reviewed
• [Journal Article] Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils (2006)
  • Author(s): Terao, Y., M.Yamaguchi, S.Hamada, S.Kawabata
  • Journal Title: The Journal of Biological Chemistry 281・20 Pages: 14215-14223
• [Journal Article] Role of Streptococcus sanguinis sortase A in bacterial colonization (2006)
  • Author(s): Yamaguchi, M., Y.Terao, T.Ogawa, T.Takahashi, S.Hamada, S.Kawabata
  • Journal Title: Microbes and Infection 8 Pages: 2791-2796
• [Journal Article] 劇症型A群レンサ球菌感染症 (2006)
  • Author(s): 寺尾 豊, 川端重忠
  • Journal Title: Pharma Medica 24・8 Pages: 43-46
• [Journal Article] Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis.
  • Author(s): Ogawa, T., Terao, Y., Okuni, H., Ninomiya, K., Sakata, H., Ikebe, K., Maeda, Y., Kawabata, S.
  • Journal Title: Microb. Pathog. 2011(in press,出版予定)
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans
  • Author(s): Yutaka Terao
  • Journal Title: Oral Microbiol. Immunol. (印刷中)
  • Peer Reviewed
• [Presentation] M6型A群レンサ球菌が産生する線毛形成機構と機能解析 (2010)
  • Author(s): 木村敬次リチャード, 住友倫子, 寺尾豊, 磯田竜太朗, 中田匡宣, 川端重忠
  • Organizer: 第63回日本細菌学会 関西支部総会
  • Place of Presentation: 枚方市
  • Year and Date: 2010-11-20
• [Presentation] Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells. (2010)
  • Author(s): Sumitomo T, Nakata M, Terao Y, Kawabata S.
  • Organizer: The 10th Awaji International Forum on Infection and Immunity.
  • Place of Presentation: Awaji, Hyogo, Japan.
• [Presentation] Nasal cholera toxin activated mucosal dendritic cells, but not CD4+ T cells elicit TI-IgG class switching recombinationby B-1 B cells. (2010)
  • Author(s): Kataoka K, Fujihashi K, Kobayashi R, Gilbert RS, Sekine S, Fukui M, Fukuyama Y, Kawabata S, Ito H, Fujihashi K.
  • Organizer: 14th International Congress on Immunology.
  • Place of Presentation: Kobe Hyogo, Japan.
• [Presentation] Characterization of Streptococcus pyogenes isolated from patients with recurrent pharyngitis. (2010)
  • Author(s): Ogawa T, Terao Y, Ohkuni H, Ninomiya K, Sakata H, Ikebe K, Maeda Y, Kawabata S.
  • Organizer: 88^<th> General Session & Exhibition of the International Association for Dental Research.
  • Place of Presentation: Barcelona, Spain.
• [Presentation] Anticariogenic effects of Oenothera biennis seed extracts on Streptococcus mutans activity. (2010)
  • Author(s): Matsumoto-Nakano M, Nagayama K, Fujita K, Inagaki S, Takashima Y, Kawabata S, Ooshima T.
  • Organizer: The 57th congress of the European Organization for Caries Research.
  • Place of Presentation: Montpellier, France
• [Presentation] Streptococcus pneumoniae evades neutrophil phagocytosis through its surface protein PfbA. (2010)
  • Author(s): Yamaguchi M, Terao Y, Nishino K, Yamaguchi A, Hamada S, Kawabata, S.
  • Organizer: 110th General Meeting of American Society for Microbiology.
  • Place of Presentation: San Diego, USA.
• [Presentation] Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells (2010)
  • Author(s): T.Sumitomo, M.Nakata, Y.Terao, S.Kawabata
  • Organizer: 第62回日本細胞生物学会
  • Place of Presentation: 大阪市
• [Presentation] Streptococcus pneumoniae evades neutrophil phagocytosis through its surface protein PfbA (2010)
  • Author(s): M.Yamaguchi, Y.Terao, K.Nishino, A.Yamaguchi, S.Hamada, S.Kawabata
  • Organizer: 110^<th> General Meeting of the American Society for Microbiology
  • Place of Presentation: San Diego CA, U.S.A.
• [Presentation] 再発性咽頭炎患者より分離されたA群レンサ球菌の分子解析に基づく新規治療法の提案 (2010)
  • Author(s): 小川泰治, 寺尾豊, 大国壽士, 二宮恵子, 坂田宏, 入江正寛, 本間信夫, 中野正大, 明貝路子, 浜田茂幸, 川端重忠
  • Organizer: 第19回レンサ球菌研究会
  • Place of Presentation: 東京都
• [Presentation] Characterization of Streptococcus pyogenes Isolated from Patients with Recurrent Pharyngitis (2010)
  • Author(s): T.Ogawa., Y.Terao, H.Ohkuni, K.Ninomiya, H.Sakata, K.Ikebe, Y.Maeda, S.Kawabata.
  • Organizer: 88^<th> General Session and Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
• [Presentation] Streptococcus pyogenes C6結合タンパクのナノスケール・バイオイメージング解析 (2010)
  • Author(s): 寺尾豊, 浜田茂幸, 川端重忠
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: 福島市
• [Presentation] 病態観察とゲノム情報から展開するA群レンサ球菌の分子解析 (2010)
  • Author(s): 寺尾豊, 川端重忠
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 東京都(招待講演)
• [Presentation] Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells (2010)
  • Author(s): T.Sumitomo, M.Nakata, Y.Terao, S.Kawabata
  • Organizer: 10^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Japan
• [Presentation] Streptococcus pneumoniaeは赤血球に侵入し自然免疫を回避する (2010)
  • Author(s): 山口雅也, 寺尾豊, 八木哲也, 西野邦彦, 山口明人, 川端重忠
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸市
• [Presentation] 新規免疫システムNETsを誘導する肺炎レンサ球菌タンパクの同定 (2010)
  • Author(s): 森有可, 寺尾豊, 山口雅也, 浜田茂幸, 大嶋隆, 川端重忠
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸市
• [Presentation] 難治性咽頭炎の発症メカニズム解析と再発防止へのアプローチ (2010)
  • Author(s): 小川泰治, 寺尾豊, 坂田宏, 川端重忠
  • Organizer: 第80回日本感染症学会 西日本地方会学術集会
  • Place of Presentation: 松山市
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの検索 (2010)
  • Author(s): 住友倫子, 中田匡宣, 東野美晴, 寺尾豊, 川端重忠
  • Organizer: 第7回感染症沖縄フォーラム
  • Place of Presentation: 那覇市
• [Presentation] Streptococcus pyogenesの補体C6結合タンパクの同定と機能解析 (2010)
  • Author(s): 寺尾豊, 浜田茂幸, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜市
• [Presentation] A群レンサ球菌が産生する線毛の細胞壁架橋機構の解析 (2010)
  • Author(s): 中田匡宣, 住友倫子, 磯山竜太朗, 寺尾豊, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜市
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの解析 (2010)
  • Author(s): 住友倫子, 中田匡宣, 東野美晴, 寺尾豊, 川端重忠
  • Organizer: 第83回日木細菌学会総会
  • Place of Presentation: 横浜市
• [Presentation] Streptococcus pneumoniaeと赤血球の相互作用の解析 (2010)
  • Author(s): 山口雅也, 寺尾豊, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜市
• [Presentation] Streptococcus pneumoniaeの自然免疫回避におけるEnolaseの役割 (2010)
  • Author(s): 森有可, 寺尾豊, 山口雅也, 浜田茂幸, 川端重忠
  • Organizer: 第83回日本細菌学会絵会
  • Place of Presentation: 横浜市
• [Presentation] A群レンサ球菌性咽頭炎の再発メカニズムの解析 (2010)
  • Author(s): 小川泰治, 寺尾豊, 大國壽士, 二宮恵子, 坂田宏, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜市
• [Presentation] 宿主細胞間接着分子の破壊に関与するA群レンサ球菌フロテアーゼの検索 (2010)
  • Author(s): 東野美晴, 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第83回日本紬菌学会総会
  • Place of Presentation: 横浜市
• [Presentation] Molecular analysis of Streptococcus pyogenes isolated from patients with recurrent streptococcal pharyngitis. (2009)
  • Author(s): Ogawa T, S.Kawabata.
  • Organizer: Kyungpook-Osaka University International
  • Place of Presentation: Deagu, Korea
  • Year and Date: 2009-12-11
• [Presentation] Streptococous pneumoniaeの好中球に対する抗貪食能のバイオイメージング解析 (2009)
  • Author(s): 山口雅也, 寺尾豊, 浜田茂幸・川端重忠
  • Organizer: 第62回日本細菌学会関西支部総会
  • Place of Presentation: 泉佐野市
  • Year and Date: 2009-11-14
• [Presentation] Neonatal exposure induced commensal-like immune-response against Aggregatibacter actinomycetemcomitans in mice. (2009)
  • Author(s): Isoda R, Terao Y, Nakata M, Sumitomo T, Kawabata S.
  • Organizer: 87th General Session & Exhibition of the International Association for Dental Research.
  • Place of Presentation: Miami, USA.
• [Presentation] FomA specific-salivary secretary-IgA inhibits Fusobacterium nucleatum binding to statherin. (2009)
  • Author(s): Kataoka K, Nakagaki H, Terao Y, Toe M, Sekine S, Fujihashi K, Kawabata S, Shizukuishi S.
  • Organizer: 87th General Session & Exhibition of the International Association for Dental Research.
  • Place of Presentation: Miami, USA.
• [Presentation] Group A Streptococci translocates across epithelial barrier via intercellular junction cleavage. (2009)
  • Author(s): Sumitomo T, Nakata M, Terao Y, Kawabata S.
  • Organizer: 109th General Meeting of American Society for Microbiology.
  • Place of Presentation: Philadelphia, USA.
• [Presentation] Cysteine protease SpeB enables Streptococcus pyogenes to evade neutrophil immunity. (2009)
  • Author(s): Terao Y, Yamaguchi M, Ogawa T, Kawabata S.
  • Organizer: FEMS 2009 3rd Congress of European Microbiologists.
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] Role of Streptococcus pneumoniae PfbA in adhesion to human epithelial cells and resistance to neutrophil phagocytosis. (2009)
  • Author(s): Yamaguchi M, Terao Y, Hamada S, Kawabata S.
  • Organizer: The 9th Awaji International Forum on Infection and Immunity.
  • Place of Presentation: Awaji, Hyogo, Japan.
• [Presentation] Group A streptococci translocates across epithelial barrier via intercellular junction cleavage (2009)
  • Author(s): Sumitomo T., M.Nakata, Y.Terao, S.Kawabata.
  • Organizer: 109^<th> General Meeting of American Society for Microbiology
  • Place of Presentation: Philadelphia, U.S.A.
• [Presentation] Cysteine protease SpeB enables Streptococcus pyogenes to evade neutrophil immunity (2009)
  • Author(s): Terao Y, M.Yamaguchi, T.Ogawa, S.Kawabata.
  • Organizer: 3^<rd> FEMS Congress of European Microbiologists
  • Place of Presentation: Gotenburg, Sweden
• [Presentation] Role of Streptococcus pneumoniae PfbA in adhesion to human epithelial cells and resistance to neutrophil phagocytosis (2009)
  • Author(s): Yamaguchi M., Y.Terao, S.Hamada, S.Kawabata
  • Organizer: 9^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo, Japan
• [Presentation] 菌体表層タンパクPfbAによるStreptococcus pneumoniaeの上皮細胞定着と抗貪食機構のバイオイメージング解析 (2009)
  • Author(s): 山口雅也, 寺尾豊, 森有可, 浜田茂幸, 川端重忠
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 福岡市
• [Presentation] 再発性咽頭炎患者より分離されたA群レンサ球菌の分子生物学的解析 (2009)
  • Author(s): 小川泰治, 寺尾豊, 大國壽士, 二宮恵子, 浜田茂幸, 川端重忠
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 福岡市
• [Presentation] 口腔領域レンサ球菌による宿主上皮細胞への付着侵入と炎症の誘導 (2009)
  • Author(s): 桜井敦朗, 岡橋暢夫, 中田匡宣, 寺尾豊, 丸山史人, 川端重忠, 大嶋隆
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 福岡市
• [Presentation] A群レンサ球菌が産生する線毛の発現機構の解析 (2009)
  • Author(s): 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟市
• [Presentation] ターメリックはStreptococcus mutansの生育を阻害する (2009)
  • Author(s): 泉井秀介, 山口雅也, 寺尾豊, 川端重忠
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟市
• [Presentation] 肺炎球菌表層タンパク質PfbAの機能解析 (2009)
  • Author(s): 川端重忠
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市
• [Presentation] カルポシステインによるヒト肺胞上皮細胞への肺炎レンサ球菌の付着抑制効果 (2009)
  • Author(s): 住友倫子, 川端重忠
  • Organizer: 第52回日本感染症学会中日本地方会
  • Place of Presentation: 名古屋市
• [Presentation] 細胞間隙経路を介したA群レンサ球菌の上皮バリア突破機構の解析 (2009)
  • Author(s): 住友倫子
  • Organizer: 第7回感染症沖縄フォーラム
  • Place of Presentation: 那覇市
• [Presentation] A群レンサ球菌の好中球免疫阻害機構に関するバイオイメージング解析 (2009)
  • Author(s): 寺尾豊
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] A群レンサ球菌線毛の温度感受性発現機構の解析 (2009)
  • Author(s): 中田匡宣
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2009)
  • Author(s): 住友倫子
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Streptococcus pneumoniaeに対する感染防御抗原の検索 (2009)
  • Author(s): 山口雅也
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Streptococcus pneumoniae enolaseは好中球の細胞死を誘導する (2009)
  • Author(s): 森有可
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] 細胞侵入と細胞内増殖におけるサルモネラ異物排出トランスポーターの役割 (2009)
  • Author(s): 坂田博樹
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Streptococcus pneumbniaeによる好中球細胞死の解析 (2008)
  • Author(s): 森有可
  • Organizer: 第61回日本細菌学会関西支部総会
  • Place of Presentation: 京都市
  • Year and Date: 2008-11-08
• [Presentation] 補体系を阻害するするA群レンサ球菌の分子群 (2008)
  • Author(s): 寺尾豊
  • Organizer: 大阪大学蛋白研究所セミナー
  • Place of Presentation: 吹田市
  • Year and Date: 2008-11-07
• [Presentation] 補体免疫を回避するA群レンサ球菌の分子機構 (2008)
  • Author(s): 寺尾豊
  • Organizer: 三学会合同集会「自然免疫の最前線」
  • Place of Presentation: 札幌市
  • Year and Date: 2008-07-10
• [Presentation] 病因論に基づいたA群レンサ球菌ワクチンの基礎的アプローチ (2008)
  • Author(s): 寺尾豊
  • Organizer: 感染病態研究フロンティア
  • Place of Presentation: 吹田市
  • Year and Date: 2008-07-05
• [Presentation] A群レンサ球菌感染症の劇症化メカニズムの解析 (2008)
  • Author(s): 寺尾豊
  • Organizer: 北里研究所学会掌受賞者特別講演会
  • Place of Presentation: 東京都
  • Year and Date: 2008-01-29
• [Presentation] Streptococcus pyogenes degrades complements C3 and C3b to evade of innate immune system. (2008)
  • Author(s): Terao Y, Mori Y, Yamaguchi M, Hamada S, Kawabata S.
  • Organizer: The 8^<th> Awaji International Forum on Infection and Immunity.
  • Place of Presentation: Higashiura, Hyogo, Japan.
• [Presentation] Impact of novel multi-functional protein PfbA on adherence, invasion, and antiphagocytosis by Streptococcus pneumoniae. (2008)
  • Author(s): Yamaguchi M, Terao Y, Mori Y, Hamada S, Kawabata S.
  • Organizer: The International Union of Microbiological Societies 2008.
  • Place of Presentation: Istanbul, Turkey.
• [Presentation] Role of the Streptococcus pyogenes serotype M49 FCT-3 region encoded pilus in virulence. (2008)
  • Author(s): Nakata M, Koller T, McIver KS, Kawabata S, Podbielski A, Kreikemeyer B.
  • Organizer: 17^<th> Lancefield International Symposium on Streptococci and Streptococcal Diseases.
  • Place of Presentation: Porto Heli, Greece.
• [Presentation] Group A streptococcal cysteine protease degrades complement C3 and contributes to evasion of innate immunity in severe streptococcal infections. (2008)
  • Author(s): Terao Y, Mori Y, Yamaguchi M, Hamada S, Kawabata S.
  • Organizer: 108^<th> General Meeting of American Society for Microbiology.
  • Place of Presentation: Boston, USA.
• [Presentation] Group A streptococcal cysteine protease degrades complement C3 and contributes to evasion of innate immunity in severe streptococcal infections (2008)
  • Author(s): Yutaka Terao
  • Organizer: 108^<th> General Meeting of American Society for Microbiology
  • Place of Presentation: Boston, U.S.A.
• [Presentation] Impact of novel multi-functional protein PfbA on adherence, invasion, and antiphagocytosis by Streptococcus pneumoniae (2008)
  • Author(s): Masaya. Yamaguchi
  • Organizer: The International Union of Microbiological Societies 2008
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Streptococcus pyogenes degrades complements C3 and C3b to evade of innate immune system (2008)
  • Author(s): Yutaka Terao
  • Organizer: The 8^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo, Japan
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2008)
  • Author(s): 住友倫子
  • Organizer: 第17回Lancefieldレンサ球菌研究会
  • Place of Presentation: 徳島市
• [Presentation] 補体分解によるA群レンサ球菌の免疫回避機構 (2008)
  • Author(s): 寺尾豊
  • Organizer: 第2回細菌学若手コロッセウム
  • Place of Presentation: 三浦郡
• [Presentation] A群レンサ球菌が産生する線毛の機能解析 (2008)
  • Author(s): 中田匡宣
  • Organizer: 第50回歯科基礎医学会学術大会
  • Place of Presentation: 東京都
• [Presentation] 肺炎レンサ球菌ならびに黄色ブドウ球菌感染症に対するキメラ免疫グロブリンの構築 (2008)
  • Author(s): 寺尾豊
  • Organizer: 第82回日本感染症会総会
  • Place of Presentation: 松江市
• [Presentation] A群レンサ球菌線毛の機能検索と発現機構の解析 (2008)
  • Author(s): 中田匡宣, 住友倫子, 寺尾 豊, 川端 重忠
  • Organizer: 第6回感染症沖縄フォーラム
  • Place of Presentation: 沖縄県中頭郡
• [Presentation] SpeBによるA群レンサ球菌感染症の重症化機構の解析 (2008)
  • Author(s): 寺尾 豊, 山口雅也, 森 有可, 浜田茂幸, 川端重忠
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都市
• [Presentation] A群レンサ球菌線毛の機能解析 (2008)
  • Author(s): 中田匡宣, 住友倫子, 寺尾 豊, 川端重忠
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都市
• [Presentation] Streptococcus pneumoniaeにおけるフラスミン活性獲得機構の解析 (2008)
  • Author(s): 山口雅也, 寺尾 豊, 森 有可, 浜田茂幸, 川端重忠
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都市
• [Presentation] Streptococcus Pneumoniae 感染における好中球の浸潤と組織侵入機構の検索 (2008)
  • Author(s): 森 有可, 山口雅也, 寺尾 豊, 浜田茂幸, 川端重忠
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都市
• [Presentation] Streptococcus sanguinis のSortase Aは歯面付着性および抗貧食能に関与する (2007)
  • Author(s): 山口雅也, 寺尾 豊, 森 有可, 浜田茂幸, 川端重忠
  • Organizer: 大阪大学歯学会第105回例会
  • Place of Presentation: 吹田市
  • Year and Date: 2007-11-22
• [Presentation] A群レンサ球菌pilus発現機構の解析 (2007)
  • Author(s): 中田 匡宣, 住友 倫子, 寺尾 豊, 川端 重忠
  • Organizer: 第60回日本細菌学会関西支部総会
  • Place of Presentation: 吹田市
  • Year and Date: 2007-11-10
• [Presentation] Streptococcus mutans clonal variation revealed by multilocus sequence typing. (2007)
  • Author(s): Lapirattanakul J, Nakano K, Kawabata S, Ooshima T.
  • Organizer: The 2^<nd> Thailand-Japan Joint Forum on Infectious Diseases.
  • Place of Presentation: Bangkok, Thailand.
  • Year and Date: 2007-10-08
• [Presentation] Role of the Streptococcus pyogenes FCT-region components in pilus assembly and virulence. (2007)
  • Author(s): Nakata M, Ribardo DA, McIver KS, Podbielski A, Kreikemeyer B, Kawabata S.
  • Organizer: The ^<7th> Awaji International Forum on Infection and Immunity.
  • Place of Presentation: Higashiura, Hyogo, Japan.
• [Presentation] Plasmin(ogen)-and fibronectin-binding protein of Streptococcus pneumoniae provides bacterial plasmin activity. (2007)
  • Author(s): Yamaguchi M, Terao Y, Mori Y, Hamada S, Kawabata S.
  • Organizer: 107^<th> General Meeting of American Society for Microbiology.
  • Place of Presentation: Toronto, Canada.
• [Presentation] Role of Streptococcus pyogenes FCT-region sortase and other components in pilus assembly and virulence. (2007)
  • Author(s): Nakata M, Ribardo DA, McIver KS, Kawabata S, Podbielski A, Kreikemeyer B.
  • Organizer: 107th General Meeting of American Society for Microbiology.
  • Place of Presentation: Toronto, Canada.
• [Presentation] Inflammatory immune responses by water-insoluble alpha-glucans from Streptococcus sobrinus. (2007)
  • Author(s): Okamoto S, Terao Y, Kaminishi H, Hamada S, Kawabata S.
  • Organizer: The 2^<nd> International Symposium for Interface Oral Health Science.
  • Place of Presentation: Sendai, Miyagi, Japan.
• [Presentation] Streptococcus pneumoniae に対するキメラ免疫グロ-ブリン製剤の構築 (2007)
  • Author(s): 寺尾 豊, 山口雅也, 中田匡宣, 浜田茂幸, 川端重忠
  • Organizer: 第49回歯科基礎医学会学術大会
  • Place of Presentation: 札幌市
• [Presentation] A群レンサ球菌のプロテアーゼ依存性の補体免疫回避機構 (2007)
  • Author(s): 寺尾 豊, 川端重忠
  • Organizer: 第50回日本感染症学会中日本地方会学術集会
  • Place of Presentation: 神戸市
• [Presentation] Multifunctional glyceralaldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. (2006)
  • Author(s): Kawabata S, Terao Y, Hamada S.
  • Organizer: The 2^<nd> FEMS Congress of European Microbiologist.
  • Place of Presentation: Madrid, Spain.
• [Presentation] Identification of a novel plasmin (ogen)- and fibronectin-binding protein in Streptococcus pneumoniae. (2006)
  • Author(s): Yamaguchi M, Terao Y, Mori Y, Hamada S, Kawabata S.
  • Organizer: The 46^<th> Interscience Conference on Antimicrobial Agents and Chemotherapy.
  • Place of Presentation: San Francisco, CA, USA.
• [Book] 口腔微生物学・免疫学第三版 (2010)
  • Author(s): 浜田茂幸, 川端重忠, 西原達次, 菅井基行, 中川一路編
  • Total Pages: 279
  • Publisher: 医歯薬出版社
• [Book] 口腔微生物学・免疫学 第3版 (2010)
  • Author(s): 浜田茂幸, 川端重忠, ら編
  • Total Pages: 279
  • Publisher: 医歯薬出版社
• [Book] A群レンサ球菌のサバイバル・ストラテジー,蛋白質核酸酵素増刊号,54 (2009)
  • Author(s): 寺尾豊, 川端重忠
  • Publisher: 共立出版
• [Book] -感染現像その理解の深化から疾患制御への展望-蛋白質核酸酵素2009年6月増刊号 (2009)
  • Author(s): 木下タロウ、熊ノ郷淳、竹田潔, 松浦善治, 川端重忠(編)
  • Total Pages: 243
  • Publisher: 共立出版
• [Book] 病原性レンサ球菌の病原因子の機能解析.生命歯科医学のカッティング・エッジ(米田俊之編) (2008)
  • Author(s): 寺尾豊, 住友倫子, 中田匡宣, 磯田竜太朗, 川端重忠
  • Publisher: 大阪大学出版会
• [Book] 生命歯科医学のカッティング・エッジ (2008)
  • Author(s): 寺尾豊
  • Total Pages: 11
  • Publisher: 大阪大学出版会
• [Book] Pharma Medica 「劇症型溶血性A群レンサ球感染症」 (2007)
  • Author(s): 寺尾 豊, 川端重忠
  • Total Pages: 4
  • Publisher: メディカルレビュー社
• [Book] BIO Clinica「劇症型A群レンサ球感染症(劇症化分子機構)」 (2007)
  • Author(s): 川端重忠, 寺尾 豊
  • Total Pages: 6
  • Publisher: 北隆館
• [Book] 化学療法の領域「レンサ球菌の新たな理解に向けて.特集 病原体の感染戦略における新たな知見」 (2007)
  • Author(s): 住友倫子, 川端重忠
  • Total Pages: 7
  • Publisher: 医療ジャーナル社
• [Book] 医学のあゆみ「A群レンサ球菌感染症のメカニズム」 (2007)
  • Author(s): 川端重忠, 山口雅也
  • Total Pages: 6
  • Publisher: 医歯薬出版
• [Book] 炎症と疾患「レンサ球菌感染症に対する免疫療法の可能性」 (2007)
  • Author(s): 中田匡宣, 寺尾 豊, 川端重忠
  • Total Pages: 6
  • Publisher: 先端医学社
• [Book] 実験医学増刊号25「口腔感染症」 (2007)
  • Author(s): 寺尾 豊, 川端重忠
  • Total Pages: 6
  • Publisher: 羊土社
• [Book] 蛋白質核酸酵素増刊号
  • Author(s): 寺尾豊
  • Publisher: 共立出版(印刷中)
• [Remarks] ホームページ等
  • URL: http://web.dent.osaka-u.ac.jp/~mcrbio/
• [Remarks]
  • URL: http://web.dent.osaka-u.ac.jp/~mcrbio/kenkyuu.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/admission/course/mcrbio.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/~mcrbio/kenkyuu.html
• [Remarks] ホームページ
  • URL: http://www.dent.osaka-u.ac.jp/~mcrbio/kenkyuu.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/~mcrbio/kenkyuu.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/~mcrbio/