| Budget Amount *help |
¥89,000,000 (Direct Cost: ¥89,000,000)
Fiscal Year 2010: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2009: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2008: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2007: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2006: ¥17,800,000 (Direct Cost: ¥17,800,000)
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| Research Abstract |
We determined the crystal structure of Pasteurella multocida toxin, a member of the dermonecrosis-inducing toxin, from which an enzyme activity of the toxin was predicted. In addition, by analyzing the domain-structure organization, we found that C1 domain of the toxin was involved in its localization to the plasma membrane. Rat monoclonal antibodies against a product of the enzymic action of the toxin were also developed. These antibodies were considered useful for detection of the toxin action both in vitro and in situ.
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