| Budget Amount *help |
¥88,000,000 (Direct Cost: ¥88,000,000)
Fiscal Year 2010: ¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 2009: ¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 2008: ¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 2007: ¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 2006: ¥17,600,000 (Direct Cost: ¥17,600,000)
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| Research Abstract |
We have determined crystal structures of the measles virus attachment protein in complex with the receptor SLAM, thereby shedding a new light on the mechanism of the measles virus-induced membrane fusion and entry. We have also shown that measles virus can infect polarized epithelial cells independently of SLAM. Furthermore, we have revealed how measles virus interacts, via its C and V proteins, with the host interferon system.
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