Infection with parasites and landlord response

• Project Area: Matrix of Infection Phenomena
• Project/Area Number: 18073016
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hyogo Medical University
• Principal Investigator: NAKANISHI Kenji Hyogo College of Medicine, 医学部, 教授 (60172350)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥91,000,000 (Direct Cost: ¥91,000,000); Fiscal Year 2010: ¥18,200,000 (Direct Cost: ¥18,200,000); Fiscal Year 2009: ¥18,200,000 (Direct Cost: ¥18,200,000); Fiscal Year 2008: ¥18,200,000 (Direct Cost: ¥18,200,000); Fiscal Year 2007: ¥18,200,000 (Direct Cost: ¥18,200,000); Fiscal Year 2006: ¥18,200,000 (Direct Cost: ¥18,200,000)
• Keywords: Th2応答 / 好塩基球 / APC / 蠕虫感染 / アジュバント / キチン / IL-33 / Th2/IgE応答 / Th2アジュバント / IL-5/IL13 / 自然型2型ヘルパー細胞 / 抗原提示細胞 / IL-4 / アレルゲン / IgE複合体 / L.major / Th1 / 腸管寄生線虫 / IL-18 / ST2 / 杯細胞 / Nb / IL-13 / 排虫 / Leishmania major(L.major) / Th1宿主応答 / Th2宿主応答 / Strongyloides venezuelensis (Sv) / IL-27 / Strongyloides venezuelensis

Research Abstract

Although intestinal helinth is expelled mainly by the action of Th2 cells, the mechanism how helminth infection induces Th2/IgE response remains uncertain. To our surprise, basophils express MHC class II and CD80/86. They have the capacity to take-up and process protein antigen (Ag), particularly Ag-IgE complex, and to present peptide with MHC class II and produce IL-4. Thus, basophils are APC, which selectively induce Th2 cells. Furthermore Basophil-lacking mice showed diminished capacity to expel Strongyloides venezuelensis (Sv), although they developed Th2 response in response to infection with Sv. Since helminth infection induces Th2 response, we wished to determine the molecules responsible for inducing Th2 response. Here, we demonstrated that chtin is adjuvant. Furthermore, ip injection of chitin promptly induces IL-33, which in turn stimulates ST2-expressing innate type cells (e. g., natural helper cell) to produce IL-5 and IL-13.

Research Products

• [Journal Article] Basophils as APC in Th2 response in allergic inflammation and parasite infection. (2010)
  • Author(s): Nakanishi K.
  • Journal Title: Curr Opin Immunol 22 Pages: 814-820
  • Peer Reviewed
• [Journal Article] Basophils are potent antigen-presenting cells that selectively induce Th2 cells. (2010)
  • Author(s): Nakanishi K.
  • Journal Title: Eur J Immunol. 40 Pages: 1836-1842
  • Peer Reviewed
• [Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. (2010)
  • Author(s): Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.
  • Journal Title: Nat Immunol 11 Pages: 936-944
  • Peer Reviewed
• [Journal Article] Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice. (2010)
  • Author(s): Tarutani M, Imai Y, Yasuda K, Tsutsui H, Nakanishi K, Yamanishi K.
  • Journal Title: J Dermatol Sci Volume: 58 Pages: 28-35
  • NAID: 10027400286
  • Peer Reviewed
• [Journal Article] Importance of IL-18-Induced Super Th1 Cells for the Development of Allergic Inflammation. (2010)
  • Author(s): Nakanishi K, Tsutsui H, Yoshimoto T.
  • Journal Title: Allergol Int Volume: 59 Pages: 137-41
  • NAID: 10029670054
  • Peer Reviewed
• [Journal Article] Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins. (2010)
  • Author(s): Kuroda-Morimoto M, Tanaka H, Hayashi N, Nakahira M, Imai Y, Imamura M, Yasuda K, Yumikura-Futatsugi S, Matsui K, Nakashima T, Sugimura K, Tsutsui H, Sano H, Nakanishi K.
  • Journal Title: Int Immunol Volume: 22 Pages: 561-70
  • NAID: 10027580749
  • Peer Reviewed
• [Journal Article] Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis. (2010)
  • Author(s): Matsuba-Kitamura S, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Taki Y, Muto T, Ikeda T, Mimura O, Nakanishi K.
  • Journal Title: Int Immunol Volume: 22 Pages: 479-89
  • NAID: 10027580386
  • Peer Reviewed
• [Journal Article] Basophils are potent antigen-presenting cells that selectively induce Th2 cells. (2010)
  • Author(s): Nakanishi K.
  • Journal Title: Eur J Immunol Volume: 40 Pages: 1836-42
  • Peer Reviewed
• [Journal Article] Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model. (2010)
  • Author(s): Yoshikawa S, Iijima H, Saito M, Tanaka H, Imanishi H, Yoshimoto N, Yoshimoto T, Futatsugi-Yumikura S, Nakanishi K, Tsujimura T, Nishigami T, Kudo A, Arii S, Nishiguchi S.
  • Journal Title: Hepatol Res Volume: 40 Pages: 823-31
  • NAID: 10026595516
  • Peer Reviewed
• [Journal Article] Erratum to "Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice". (2010)
  • Author(s): Tartutani M, Imai Y, Yasuda K, Tsutsui H, Nakanishi K, Yamanishi K
  • Journal Title: J Dermatol Sci Volume: 59 Pages: 64-71
  • Peer Reviewed
• [Journal Article] Granzyme B is a novel interleukin-18 converting enzyme. (2010)
  • Author(s): Omoto Y, Yamanaka K, Tokime K, Kitano S, Kakeda M, Akeda T, Kurokawa I, Gabazza EC, Tsutsui H, Katayama N, Yamanishi K, Nakanishi K, Mizutani H.
  • Journal Title: J Dermatol Sci Volume: 59 Pages: 129-35
  • NAID: 10027401986
  • Peer Reviewed
• [Journal Article] The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice. (2010)
  • Author(s): Tsutsui H, Imamura M, Fujimoto J, Nakanishi K.
  • Journal Title: Gastroenterol Res Pract Pages: 641865-641865
  • Peer Reviewed
• [Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. (2010)
  • Author(s): Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.
  • Journal Title: Nat Immunol Volume: 11 Pages: 936-44
  • Peer Reviewed
• [Journal Article] Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4^+ T cells. (2009)
  • Author(s): Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y, Nakanishi K.
  • Journal Title: Nat Immunol 10 Pages: 706-712
  • Peer Reviewed
• [Journal Article] Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice (2009)
  • Author(s): Imamura M, Tsutsui H, Yasuda K, Uchiyama R, Yumikura-Futatsugi S, Mitani K, Hayashi S, Akira S, Taniguchi S, Van Rooijen N, Tschopp J, Yamamoto T, Fujimoto J, Nakanishi K
  • Journal Title: J Hepatol 51 Pages: 333-341
  • Peer Reviewed
• [Journal Article] Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4^+ T cells (2009)
  • Author(s): Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y, Nakanishi K.
  • Journal Title: Nat Immunol 10 Pages: 706-712
  • Peer Reviewed
• [Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma (2009)
  • Author(s): Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M.
  • Journal Title: Am J Respir Crit Care Med 180 Pages: 1048-1055
  • Peer Reviewed
• [Journal Article] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. (2008)
  • Author(s): Kondo, Y., Yoshimoto, T., Yasuda, K., Futatsugi-Yumikura, S., Morimoto, M., Hayashi, N., Hoshino, T., Fujimoto, J., Nakanishi, K.
  • Journal Title: Int.Immunol. 20 Pages: 791-800
  • NAID: 10021241671
  • Peer Reviewed
• [Journal Article] Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation. (2008)
  • Author(s): Kosaka, H., Yoshimoto, T., Fujimoto, J., Nakanishi, K.
  • Journal Title: Nat.Med. 14 Pages: 437-441
  • Peer Reviewed
• [Journal Article] IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells : a novel therapeutic way for Th2-mediated allergic inflammation. (2008)
  • Author(s): Yoshimoto, T., Yoshimoto, T., Yasuda, K., Mizuguchi, J., Nakanishi, K.
  • Journal Title: J.Immunol. 179 Pages: 4415-4423
  • Peer Reviewed
• [Journal Article] Interferon-γis a therapeutic target molecule for prevention of postoperative adhesion formation. (2008)
  • Author(s): Kosaka, H., Yoshimoto, T., Fujimoto, J., Nakanishi, K.
  • Journal Title: Nat. Med. 14 Pages: 437-441
  • Peer Reviewed
• [Journal Article] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. (2008)
  • Author(s): Kondo, Y., Yoshimoto, T., Yasuda, K., Futatsugi-Yumikura, S., Morimoto, M., Hayashi, N., Hoshino, T., Fujimoto, J. Nakanishi, K.
  • Journal Title: Int. Immunol. 20 Pages: 791-800
  • NAID: 10021241671
  • Peer Reviewed
• [Journal Article] Demonstration of cooperative contribution of MET-and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings (2008)
  • Author(s): Seki, E., Kondo, Y., Iimuro, Y., Naka, T., Son, G., Kishimoto, T., Fujimoto, J., Tsutsui, H. and Nakanishi, K.
  • Journal Title: J. Hepatol 48 Pages: 237-245
  • Peer Reviewed
• [Journal Article] Protective effbct of IL-18 on kainate-and IL-1β-induced cerebenar ataxia in mice (2008)
  • Author(s): Andoh, T., Kishi, H., Motoki, K., Nakanishi, K., Kuraishi, Y. and Muraguchi, A.
  • Journal Title: J. Immunol 180 Pages: 2322-2328
  • Peer Reviewed
• [Journal Article] Interferon-γ is a therapeutic target molecule for prevention of postoperativeadhesion formation (2008)
  • Author(s): Kosaka, H., Yoshimoto, T., Fujimoto, J. and Nakanishi, K.
  • Journal Title: Nat. Med 14 Pages: 437-441
  • Peer Reviewed
• [Journal Article] Freshly isolated Langerhans cells negatively regulate naive T cell activation in response to peptide antigen through cell-to-cell contact (2008)
  • Author(s): Imai, Y., Hayashi, N., Yasuda, K., Tsutsui, H., Mizutani, H. and Nakanishi, K.
  • Journal Title: J. Dermatol. Sci 51 Pages: 19-29
  • NAID: 10024119334
  • Peer Reviewed
• [Journal Article] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system (2008)
  • Author(s): Kondo, Y., Yoshimoto, T., Yasuda, K., Futatsugi-Yumikura, S., Morimoto, M., Hayashi, N., Hoshino, T., Fujimoto, J. and Nakanishi. K
  • Journal Title: Int. Immunol 20 Pages: 791-800
  • NAID: 10021241671
  • Peer Reviewed
• [Journal Article] Association of serum IL-33 level and the IL-33 genetic variant with Japanese cedar pollinosis (2008)
  • Author(s): Sakishita, M., Yoshimoto, T., Hirota, T., Harada, M., Okubo, K., Osawa, Y., Fujieda, S., Nakamura, Y., Yasuda, K., Nakanishi, K. and Tamari, M.
  • Journal Title: Clin. Exp. Allergy 38 Pages: 1875-1881
  • Peer Reviewed
• [Journal Article] Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta (2008)
  • Author(s): Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T. and Takeda, K.
  • Journal Title: J. Biol. Chem 283 Pages: 12468-12477
  • Peer Reviewed
• [Journal Article] Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium (2008)
  • Author(s): Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., Yamamoto, M. and Takeda, K.
  • Journal Title: J. Immunol 181 Pages: 8521-8527
  • Peer Reviewed
• [Journal Article] T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production. (2007)
  • Author(s): Hayashi, N., Yoshimoto, T., Izuhara, K., Matsui, K., Tanaka, T., Nakanishi, K.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 104 Pages: 14765-14770
  • Peer Reviewed
• [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode infections. (2007)
  • Author(s): Arizono, N., Nakanishi, K., Horii, T., Tanabe, K.
  • Journal Title: Trends Parasitol. 23 Pages: 175-181
  • Peer Reviewed
• [Journal Article] Type 1 cytokine/chemokine production by mouse NK cells following activation on their TLR/MyD88-mediated pathways. (2007)
  • Author(s): Sawaki, J., Tsutsui, H., Hayashi, N., Yasuda, K., Akira, S., Tanizawa, T., Nakanishi, K.
  • Journal Title: Int. Immunol. 19 Pages: 311-320
  • NAID: 10020111348
• [Journal Article] IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. (2007)
  • Author(s): Yoshimoto, T., Yoshimoto, T., Yasuda, K., Mizuguchi, J., Nakanishi, K.
  • Journal Title: J. Immunol. 179 Pages: 4415-4423
  • Peer Reviewed
• [Journal Article] Type 1 cytokine/chemokine production by mouse NK cells following activation on their TLR/MyD88-mediated pathways. (2007)
  • Author(s): Sawaki, J., Tsutsui, H., Hayashi, N., Yasuda, K., Akira, S., Tanizawa, T. and Nakanishi, K.
  • Journal Title: Int. Immunol 19 Pages: 311-320
  • NAID: 10020111348
  • Peer Reviewed
• [Journal Article] Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4^+ Vα24^+Vβ11^+ natural killer T cells. (2007)
  • Author(s): Fujibayashi, Y., Fujimori, Y., Kasumoto, I., Kai, S., Hara, H., Okamura, H., Tsutsui, H., Ogawa, H. and Nakanishi, K.
  • Journal Title: Int. J. Mol. Med. 20 Pages: 241-245
  • Peer Reviewed
• [Journal Article] Role of innate immune response in liver regeneration. (2007)
  • Author(s): Iimuro, Y., Seki, E., Son, G., Tsutsui, H., Nakanishi, K. and Fujimoto, J
  • Journal Title: J. Gastroenterol. Hepatol. 22 Pages: 57-58
  • Peer Reviewed
• [Journal Article] T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production. (2007)
  • Author(s): Hayashi, N., Yoshimoto, T., Izuhara, K., Matsui, K., Tanaka, T. and Nakanishi, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 104 Pages: 14765-14770
  • Peer Reviewed
• [Journal Article] IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. (2007)
  • Author(s): Yoshimoto, T., Yoshimoto, T., Yasuda, K., Mizuguchi, J. and Nakanishi, K
  • Journal Title: J. Immunol. 179 Pages: 4415-4423
  • Peer Reviewed
• [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode infections. (2007)
  • Author(s): Arizono, N., Nakanishi, K., Horii, T., Tanabe, K.
  • Journal Title: Trends in Parasitology 23・4 Pages: 175-181
• [Journal Article] Type 1 cytokine/chemokine production by mouse NK cells following activation on their TLR/MyD88-mediated pathways. (2007)
  • Author(s): Sawaki, J., Tsutsui, H., Hayashi, N., Yasuda, K., Akira, S., Tanizawa, T., Nakanishi, K.
  • Journal Title: Int. Immunol. 19・3 Pages: 311-320
  • NAID: 10020111348
• [Journal Article] Roles of IL-18 in basophils and mast cells. (2006)
  • Author(s): Yoshimoto, T., Nakanishi, K.
  • Journal Title: Allergol.Int. 55 Pages: 105-113
  • NAID: 10019169531
  • Peer Reviewed
• [Journal Article] Contribution of IL-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. (2006)
  • Author(s): Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., Kubo, M., Matsui, K., Sano, H., Nakanishi, K.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 103 Pages: 8816-8821
  • Peer Reviewed
• [Journal Article] Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. (2006)
  • Author(s): Ishikawa, Y., Yoshimoto, T., Nakanishi, K.
  • Journal Title: Int.Immunol. 18 Pages: 847-855
  • NAID: 10020618556
  • Peer Reviewed
• [Journal Article] Contribution of IL-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. (2006)
  • Author(s): Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., Kubo, M., Matsui, K., Sano, H., Nakanishi, K.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 103 Pages: 8816-8821
  • Peer Reviewed
• [Journal Article] Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. (2006)
  • Author(s): Ishikawa, Y., Yoshimoto, T., Nakanishi, K.
  • Journal Title: Int. Immunol. 18 Pages: 847-855
  • NAID: 10020618556
  • Peer Reviewed
• [Journal Article] Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. (2006)
  • Author(s): Omoto, Y., Tokime, K., Yamanaka, K., Habe, K., Morioka, T., Kurokawa, I., Tsutsui, H., Yamanishi, K., Nakanishi, K., Mizutani, H.
  • Journal Title: J. Immunol. 177 Pages: 8315-8319
  • Peer Reviewed
• [Journal Article] Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. (2006)
  • Author(s): Oumoto, Y., Tokime, K., Yamanaka, K., Habe, K., Morioka, T., Kurokawa, I., Tsutsui, H., Yamanishi, K., Nakanishi, K., Mizutani, H.
  • Journal Title: J. Immunol. 177・12 Pages: 8315-8319
• [Journal Article] Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. (2006)
  • Author(s): Ishikawa, Y., Yoshimoto, T., Nakanishi, K.
  • Journal Title: Int. Immunol. 18・6 Pages: 847-855
  • NAID: 10020618556
• [Journal Article] Contribution of interleukin-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. (2006)
  • Author(s): Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., Kubo, M., Matsui, K., Sano, H., Nakanishi, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 103・23 Pages: 8816-8821
• [Journal Article] Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. (2006)
  • Author(s): Inokuchi, T., Moriwaki, Y., Tsutsui, H., Yamamoto, A., Takahashi, S., Tsutsumi, Z., Ka, T., Nakanishi, K., Yamamoto, T.
  • Journal Title: Cytokine. 33・1 Pages: 21-27
• [Presentation] Innate and acquired immunity in expulsion of intestinal nematode. (2010)
  • Author(s): Nakanishi K.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-27
• [Presentation] Innate and acquired immunity in expulsion of intestinal nematode. (2010)
  • Author(s): Nakanishi K.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-27
• [Presentation] Basophils play a pivotal role in the expulsion of gastrointestinal nematode Strongyloides venezuelensis. (2010)
  • Author(s): Matsumoto M, Yasuda K, Kubo M, Yoshimoto T, Nakanishi K.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-27
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis in the absence of adaptive immune system. (2010)
  • Author(s): Yasuda K, Sasaki Y, Kondo Y, Matsumoto M, Yoshimoto T, Nakanishi K.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-27
• [Presentation] Contribution of IL-33 to induction and augment tion of experiment al allergic conjunctivis. (2010)
  • Author(s): Yasuda K, Matsuba-Kitamura S, Yoshimoto T, Futatsugi-Yumikura S, Taki Y, Muto T, Ikeda N, Mimura O, Nakanishi K.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-27
• [Presentation] 好塩基球によるアレルギー性炎症の誘導と増悪. (2010)
  • Author(s): 中西憲司
  • Organizer: 第22回日本アレルギー学会春期臨床大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-05-08
• [Presentation] Basophils are potent antigen-presenting cells which selectively induce Th2 cells.Adaptive and innate immune response to neglected tropical diseases (2010)
  • Author(s): Nakanishi K.
  • Organizer: US-Japan Cooperative Medical Science Program
  • Place of Presentation: San Diego
  • Year and Date: 2010-01-09
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis in the absence of adaptive immune system (2009)
  • Author(s): Yasuda K, Sasaki Y, Kondo Y, Matsumoto M, Yoshimoto T, Nakanishi K.
  • Organizer: 第65回日本寄生虫学会西日本支部大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-07
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis in the absence of adaptive immune system (2009)
  • Author(s): Yasuda K, Sasaki Y, Kondo Y, Matsumoto M, Yoshimoto T, Nakanishi K.
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場、兵庫
  • Year and Date: 2009-09-09
• [Presentation] Contribution of TRIF to LPS-induced liver injury in mice (2009)
  • Author(s): Imamura M, Tsutsui H, Yasuda K, Uchiyama R, Yumikura S, Akira S, Nakanishi, K.
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場、兵庫
  • Year and Date: 2009-09-09
• [Presentation] Parasitology (2009)
  • Author(s): 中西憲司
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場、兵庫
  • Year and Date: 2009-09-08
• [Presentation] Therapeutic approach to Th1-Type bronchial asthma in transiently humanized mice by using human anti-human IL-18 antibody (2009)
  • Author(s): 中西憲司
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: 東京プリンスホテル、東京
  • Year and Date: 2009-07-09
• [Presentation] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adoptive immune system (2009)
  • Author(s): Yasuda K, Kondo Y, Yoshimoto T, Fujimoto J, Nakanishi K
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: 東京プリンスホテル、東京
  • Year and Date: 2009-07-09
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis in the absence of adaptive immune system (2009)
  • Author(s): Yasuda K, Sasaki Y, Kondo Y, Matsumoto M, Yoshimoto T, Nakanishi K
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 芝蘭会館、京都
  • Year and Date: 2009-06-26
• [Presentation] Contribution of TRIF to LPS-induced liver injury in mice (2009)
  • Author(s): 今村美智子, 筒井ひろ子, 安田好文, 内山良介, 弓倉静江, 審良静男, 中西憲司
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 芝蘭会館、京都
  • Year and Date: 2009-06-26
• [Presentation] IFN-γ is a therapeutic target molecule for prevention of postoperative adhesion formation (2009)
  • Author(s): Yoshimoto T, Kosaka H, Fujimoto J, Nakanishi K
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 芝蘭会館、京都
  • Year and Date: 2009-06-26
• [Presentation] Contribution of basophils to Th2/IgE response in vivo by production of IL-4 and presentation of MHC class II/peptide complex to CD4^+ T cells (2009)
  • Author(s): Yoshimoto T, Yasuda K, Nakanishi K.
  • Organizer: The First Immune Regulation : Present and Future
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-05-26
• [Presentation] The First International Kishimoto Foundation Symposium "Immune Regulation : Present and Future" (2009)
  • Author(s): Imamura M, Tsutsui H, Uchiyama R, Akira S, Tschopp J, Nakanishi K.
  • Organizer: The First Immune Regulation : Present and Future
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-05-26
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis in the absence of adaptive immune system (2009)
  • Author(s): Yasuda K, Sasaki Y, Kondo Y, Matsumoto M, Yoshimoto T, Nakanishi K
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮ソニックシティ、東京
  • Year and Date: 2009-05-14
• [Presentation] NKT IFN-γ production in response to cancel cauterization induces intestinal adhesion formation by reciprocal regulation of plasminogen activator inhibitor type 1 (PA I) and tissue-type plasminogen activator (tPA). (2009)
  • Author(s): Nakanishi K.
  • Organizer: The 5th International Symposium on CD1/NKT Cells
  • Place of Presentation: Kamakura
  • Year and Date: 2009-03-26
• [Presentation] 術後の腸管癒着も免疫学的機序を基盤に形成される. (2008)
  • Author(s): 中西憲司
  • Organizer: (シンポジウム)「免疫難病・感染症等の先進医療技術」第5回(最終)公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-15
• [Presentation] 術後の腸管癒着も免疫学的機序を基盤に形成される (2008)
  • Author(s): 中西憲司
  • Organizer: 「免疫難病・感染症等の先進医療技術」第5回(最終)公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-15
• [Presentation] 好塩基球はIL-4産生能と抗原提示能の両機能を持ち生体内でTh2応答を誘導, 維持, 増強する. (2008)
  • Author(s): 善本知広, 小坂久, 大橋浩一郎, 中西憲司
  • Organizer: 「免疫難病・感染症等の先進医療技術」第5回(最終)公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-15
• [Presentation] 実験的アレルギー性結膜炎モデルにおけるIL-33の病因論的役割の解明 (2008)
  • Author(s): 松葉沙織, 善本知広, 杉村和久, 伊藤祐二, 北本祥, 森本麻衣, 三村治, 中西憲司
  • Organizer: 免疫難病・感染症等の先進医療技術」第5回(最終)公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-15
• [Presentation] 新規DC免疫法 : 抗原とアジュバントでパルスした樹状細胞はナイーブマウスに迅速かつ顕著なTh2応答を誘導する (2008)
  • Author(s): 今井康友, 安田好文, 今村美智子, 林伸樹, 善本知広, 山西清文, 筒井ひろ子, 水谷仁, 中西憲司
  • Organizer: 「免疫難病・感染症等の先進医療技術」第5回(最終)公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-15
• [Presentation] IFN-γ is a therapeutic target molecule for prevention of postoperative adhesion formation (2008)
  • Author(s): Yoshimoto, T., Kosaka, H., Fujimoto, J. and Nakanishi, K.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hvnernlasia in the lungs in the absence of adantive immune system (2008)
  • Author(s): Kondo, Y., Yoshimoto, T., Yasuda, K., Fuiimoto, J. and Nakanishi, K.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] In vivo administration of IL-33 induces goblet cells capable of expelling Nippostrongylus brasiliensis in the absence of adaptive immune system (2008)
  • Author(s): Yasuda, K., Sasaki, Y., Kondo, Y., Matsumoto, M., Yoshimoto, T. and Nakanishi, K.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Basophils induce and augment Th2 response (2008)
  • Author(s): Nakanishi, K. and Yoshimoto, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] New DC immunization : Intracellular adjubant plus Ag immunization induces prompt and striking Ag-specific Th2 response (2008)
  • Author(s): Imai, Y., Yasuda, K., Hayashi, N., Yoshimoto, T., Mizutani, H., Nakanishi, K.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] ブタクサ花粉特異的実験的アレルギー性結膜炎に対するIL-33の病因的役割の解析 (2008)
  • Author(s): 松葉沙織, 善本知広, 安田好文, 池田誠宏, 三村治, 中西憲司
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] IL-1ファミリーサイトカインと自然型アトピー性炎症 (2008)
  • Author(s): 中西憲司, 善本知広
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] 気道炎症疾患と自然免疫IL-18/IL-33による自然型気管支喘息の誘導 (2008)
  • Author(s): 善本知広, 中西憲司
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] T細胞の異常とアレルギーIL-18によるSuper Th1細胞の誘導とIL-33によるTh2細胞増強作用。 (2008)
  • Author(s): 善本知広, 中西憲司
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-27
• [Presentation] In vivo administration of IL-33 induces goblet cells capable of expelling Nippostrongylus brasiliensis in the absence of adaptive immune system (2008)
  • Author(s): Yasuda, K., Sasaki, Y., Kondo, Y., Matsumoto, M., Yoshimoto, T. and Nakanishi, K.
  • Organizer: The 8^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo
  • Year and Date: 2008-09-07
• [Presentation] 腹腔内術後癒着形成メカニズムの解明と予防 (2008)
  • Author(s): 小坂久, 善本知広, 中西憲司, 藤元治朗
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-16
• [Presentation] IL-33のマウス生体内投与は獲得免疫応答非依存性にNippostrongylus brasiliensis排虫作用を有する杯細胞を誘導する (2008)
  • Author(s): 安田好文, 佐々木由紀, 近藤祐一 松本真琴, 善本知広, 中西憲司
  • Organizer: 第73回日本インターフェロン・サイトカイン学会学術集会(JCS2008)
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-10
• [Presentation] IL-27による新規抗アレルギー作用IL-27による気管支喘息とアレルギー性結膜炎発症の抑制。 (2008)
  • Author(s): 善本知広, 松葉沙織, 中西憲司
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-12
• [Presentation] IL-33とアレルギー炎症IL-33の自然型及び獲得型アレルギー性炎症に対する生理作用 (2008)
  • Author(s): 善本知広
  • Organizer: 理研免疫アレルギーセンター(RCAI)免疫ワークショップ
  • Place of Presentation: 甲府
  • Year and Date: 2008-05-20
• [Presentation] IL-33は獲得免疫応答の関与なしに自然型気管支喘息を誘導する (2008)
  • Author(s): 善本知広
  • Organizer: 第73回日本インターフェロン・サイトカイン学会学術集会(JCS2008)
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-20
• [Presentation] Role of NKT cell-drivenIFN-γ in postoperative adhesion formation (2008)
  • Author(s): Kosaka, H., Yoshimoto, T., Nakanishi, K. and Fujimoto, J.
  • Organizer: Digestive Disease Week and the 109th Annual Meeting of the AGA Institute DDW
  • Place of Presentation: San Diego, U.S.A
  • Year and Date: 2008-05-18
• [Presentation] 術後癒着形成はIFN-γ/STAT1依存性のPAI亢進による (2008)
  • Author(s): 小坂久, 善本知広, 中西憲司, 藤元治朗
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-15
• [Presentation] IL-33のマウス生体内投与はNippostrongylus brasiliensis排虫作用を有する杯細胞を誘導する (2008)
  • Author(s): 安田好文, 佐々木由紀, 近藤祐一, 松本真琴, 善本知広, 中西憲司
  • Organizer: 第77回日本寄生虫学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-03
• [Presentation] IgE抗体産生能を欠くCD40KOマウスハヴェネズエラ糞線虫(Strongyloides venezuelensis : Sv)排虫機能が低下している (2008)
  • Author(s): 佐々木由紀, 安田好文, 善本知広, 中西憲司
  • Organizer: 第77回日本寄生虫学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-03
• [Presentation] Basophils induce and augment Th2 response. (2008)
  • Author(s): Nakanishi, K., Yoshimoto, T.
  • Organizer: (シンポジウム)第38回日本免疫学会総会・学術集会,日本免疫学会総会・学術集会記録
  • Place of Presentation: 京都
• [Presentation] Basophils induce and augment Th2 response. (2008)
  • Author(s): Nakanishi, K., Yoshimoto, T.
  • Organizer: (シンポジウム)第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都. 日本免疫学会総会・学術集会記録
• [Presentation] アレルギー疾患の複数病因論とTh2細胞の誘導機序の多彩さ (2008)
  • Author(s): 中西憲司
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] IL-18 and atopic dermatitis : IL-18might be a therapeutic target molecule for the treatment of infection associated allergic inflammation Sponsered seminar (2008)
  • Author(s): Nakanishi, K.
  • Organizer: International investigative dermatology
  • Place of Presentation: Kyoto
• [Presentation] Psoriasis-like hyperplastic and inflammatory lesions produced by epidemic-specific, inducible activation of Raf in mice (2008)
  • Author(s): Tarutani, M., Imai, Y., Tsuda, T., Nakanishi, K. and Yamanishi, K.
  • Organizer: International Investigative Dermatology 2008(IID2008)
  • Place of Presentation: Kyoto
• [Presentation] 表皮ランゲルハンス細胞はペプチド抗原によるナイーブT細胞の活性化を細胞間相互作用によって抑制する (2008)
  • Author(s): 今井康友, 林伸樹, 安田好文, 筒井ひろ子, 水谷仁, 中西憲司
  • Organizer: 第29回日本炎症・再生医学会
  • Place of Presentation: 東京
• [Presentation] TLRを介したcaspase-1活性化におけるTRIFの必要性 (2008)
  • Author(s): 今村美智子, 安田好文, 審良静男, 筒井ひろ子, 藤元治朗, 中西憲司
  • Organizer: 第73回インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 札幌
• [Presentation] RW特異的T細胞株を用いたアレルギー性結膜炎モデルIL-33の病因的役割の解析 (2008)
  • Author(s): 松葉沙織, 善本知広, 安田好文, 池田誠宏, 三村治, 中西憲司
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
• [Presentation] Requirement of MyD88 and TRIF but not ATP signaling for TLR4-mediated caspase-1 activation (2008)
  • Author(s): Imamura, M., Tsutsui, H., Yasuda, K., Akira, S., Fujimoto, J. and Nakanishi, K.
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo
• [Presentation] HGFを用いた術後腹腔内癒着形成予防法 (2008)
  • Author(s): 小坂久, 善本知広, 中西憲司, 藤元治朗
  • Organizer: 第50回日本消化器病学会大会
  • Place of Presentation: 東京
• [Presentation] Freshly isolated Langerhans cells negatively regulate naive T cell activation in response to peptide antigen through cell-to-cell contact (2008)
  • Author(s): Imai, Y., Hayashi, N., Yasuda, K.,Tsutsui, H. Nakanishi, K.
  • Organizer: The 10^<th> International Symposium on Dendritic Cells
  • Place of Presentation: Kobe
• [Presentation] マウスエンドトキシンショックで認める, 免疫応答を基盤としたPAI-1の発現誘導 (2008)
  • Author(s): 川浩介, 筒井ひろ子, 松本轡之 中西憲司
  • Organizer: 第38回日本免疫会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Requirement of MyD88 and TRIF but not ATP signaling for TLR4-mediated caspase-1 activation (2008)
  • Author(s): Imamura, M., Tsutsui, H., Yasuda, K., Akira, S., Fujimoto, J. and Nakanishi. K.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Regulation of host defense against helminthes and protozoa by IL-18 and IL-27. (2007)
  • Author(s): Nakanishi, K.
  • Organizer: (Symposium) The 7th Awaji International forum on infection and immunity.
  • Place of Presentation: Hyogo.
• [Presentation] Induction of Th2/IgE-independent allergic inflammation by IL-18. (招待講演), 自然免疫の医学・生物学〔III〕 (2007)
  • Author(s): 中西憲司
  • Organizer: 第20回内藤コンファレンス
  • Place of Presentation: 神奈川.
• [Presentation] The role of IL-18 in intrinsic allergic diseases. (2006)
  • Author(s): Nakanishi, K.
  • Organizer: (Symposium) RCAI-JSI International symposium of Immunology
  • Place of Presentation: Yokohama.
• [Presentation] IL-18 protects against Strongyloides venezuelesis infection by activating mucosal mast cell-dependent type-2 innate immunity. (2006)
  • Author(s): Yoshimoto, T., Sasaki, Y., Nakanishi, K.
  • Organizer: 11th international congress of parasitology
  • Place of Presentation: Glasgow, Scotland U.K.
• [Presentation] IL-27 inhibits Th2 responses in vitro and in vivo by suppressing GATA-3 expression; demonstration of its protective role against Leishmaniasis. (2006)
  • Author(s): Yoshimoto, T., Yoshimoto, T., Yasuda, K., Mizuguchi, J., Nakanishi, K.
  • Organizer: 第36回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Book] 臨床粘膜免疫学 (2010)
  • Author(s): 安田好文, 中西憲司
  • Total Pages: 8
  • Publisher: 寄生虫に対する粘膜免疫
• [Patent(Industrial Property Rights)] Th2細胞誘導用組成物およびTh2型疾患の治療組成物,ならびにこれらの利用 (2009)
  • Inventor(s): 善本知広, 中西憲司
  • Filing Date: 2009-10-26
• [Patent(Industrial Property Rights)] Th2細胞誘導用組成物およびTh2型疾患の治療組成物, ならびにこれらの利用 (2009)
  • Inventor(s): 善本知広, 中西憲司
  • Industrial Property Rights Holder: 善本知広, 中西憲司
  • Filing Date: 2009-10-26
  • Overseas
• [Patent(Industrial Property Rights)] Th2細胞誘導用組成物およびTh2型疾患の治療組成物、ならびにこれらの利用. (2008)
  • Inventor(s): 中西憲司、善本知広
  • Industrial Property Rights Holder: 兵庫医科大学
  • Industrial Property Number: 2008-281930
  • Filing Date: 2008-10-31
  • Acquisition Date: 2008-10-31
• [Patent(Industrial Property Rights)] Th2細胞誘導用組成物およびTh2型疾患の治療組成物, ならびにこれらの利用 (2008)
  • Inventor(s): 善本知宏, 中西憲司
  • Industrial Property Rights Holder: 善本知宏, 中西憲司
  • Industrial Property Number: 2008-281930
  • Filing Date: 2008-10-31
• [Patent(Industrial Property Rights)] 実験動物の腸管癒着を形成する方法、腸管癒着実験動物の製造方法、腸管癒着抑制剤のスクリーニング方法及び腸管癒着抑制剤 (2007)
  • Inventor(s): 善本知広、中西憲司、藤元治朗
  • Industrial Property Rights Holder: 科学技術振興機構
  • Industrial Property Number: 2007-033904
  • Filing Date: 2007-02-14
• [Patent(Industrial Property Rights)] 気管支喘息発症モデル動物およびその作製方法、並びにその利用 (2006)
  • Inventor(s): 中西憲司、善本知広
  • Industrial Property Rights Holder: 科学技術振興機構
  • Industrial Property Number: 2006-124354
  • Filing Date: 2006-04-27
  • Acquisition Date: 2006-04-27
• [Patent(Industrial Property Rights)] Th2型アレルギー性疾患治療薬及び感染症治療薬 (2006)
  • Inventor(s): 善本知広, 中西憲司, 善本隆之, 水口純一郎
  • Industrial Property Rights Holder: 科学技術振興機構
  • Industrial Property Number: 2006-305852
  • Filing Date: 2006-11-10