Structural basis for torque generation of biological rotary motors
| Project Area | Innovative nanoscience of supermolecular motor proteins working in biomembranes |
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| Project/Area Number |
18074006
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
IMADA Katsumi Osaka University, 大学院・理学研究科, 教授 (40346143)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMINO Tohru 大阪大学, 大学院・生命機能研究科, 准教授 (20402993)
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| Project Period (FY) |
2006 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥79,800,000 (Direct Cost: ¥79,800,000)
Fiscal Year 2010: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2009: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2008: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2007: ¥19,600,000 (Direct Cost: ¥19,600,000)
Fiscal Year 2006: ¥16,100,000 (Direct Cost: ¥16,100,000)
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| Keywords | 分子モーター / ナノマシン / ナノバイオ / 生物物理 / 分子機械 |
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| Research Abstract |
We determined the crystal structures of MotY and MotB, which are stator proteins of bacterial flagellar motor, and revealed the molecular mechanism of the stator assembly into the motor. We proposed a new model for the arrangement of FliG in the rotor and the cooperative switching mechanism based on the structure and the characterization of a mutant FliG that shows a CW-biased rotation. We also solved the structures of FliI, FliJ and their complex, which are soluble components of the flagellar type III protein export apparatus, and found that the apparatus shares common architecture with F_1-ATPase.
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Report
(7 results)
Research Products
(149 results)
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[Journal Article] Effect of Intracellular pH on the Torque-Speed Relationship of Bacterial Proton-Driven Flagellar Motor2009
Author(s)
Nakamura, S., Kami-ike, N., Yokota, J.P., Kudo, S., Minamino, T., & Namba, K.
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Journal Title
J. Mol. Biol. 386
Pages: 332-338
Related Report
Peer Reviewed
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[Presentation] X-ray analysis of FliJ, a cytoplasmic component of the flagellar type III protein export apparatus2008
Author(s)
Ibuki, T., Shimada, M., Minamino, T., Imada, K., Namba, K.
Organizer
XXI Congress of the International Union of Crystallography
Place of Presentation
Grand Cube Osaka, Japan
Related Report
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