Mechanism of intracellular degradation through selective autophagy
| Project Area | Proteolysis in the Regulation of Biological Processes |
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| Project/Area Number |
18076002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKAI Yasuyoshi Kyoto University, 大学院・農学研究科, 教授 (60202082)
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| Co-Investigator(Kenkyū-buntansha) |
YURIMOTO Hiroya 京都大学, 大学院・農学研究科, 准教授 (00283648)
OKU Masahide 京都大学, 大学院・農学研究科, 助教 (10511230)
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| Project Period (FY) |
2006 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥81,200,000 (Direct Cost: ¥81,200,000)
Fiscal Year 2010: ¥17,200,000 (Direct Cost: ¥17,200,000)
Fiscal Year 2009: ¥17,200,000 (Direct Cost: ¥17,200,000)
Fiscal Year 2008: ¥17,200,000 (Direct Cost: ¥17,200,000)
Fiscal Year 2007: ¥17,200,000 (Direct Cost: ¥17,200,000)
Fiscal Year 2006: ¥12,400,000 (Direct Cost: ¥12,400,000)
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| Keywords | オートファジー / ペルオキシソーム / 液胞 / ペキソファジー / 酵母 / 脂肪滴 / タンパク質分解 / 植物病原性 / メタノール資化性酵母 / 細胞内分解 / 選択性 / オルガネラ |
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| Research Abstract |
We elucidated novel functions of Vac8 in peroxisome degradation (pexophagy) and of Atg8 in regulating the vacuolar morphology. Furthermore, we revealed the molecular mechanisms of an autophagic pathway induced in the lag phase of yeasts and a pexophagy process responsible for infection of a plant pathogen fungus, discovering new physiological functions of autophagy.
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Report
(7 results)
Research Products
(68 results)
