Mechanism underlying selective substrate recognition by the ubiquitin system

• Project Area: Proteolysis in the Regulation of Biological Processes
• Project/Area Number: 18076004
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University (2008-2010); Osaka City University (2006-2007)
• Principal Investigator: IWAI Kazuhiro Osaka University, 大学院・生命機能研究科, 教授 (60252459)
• Co-Investigator(Kenkyū-buntansha): KAWAHARA Hiroyuki 首都大学東京, 大学院・理工学研究科, 教授 (70291151) ; TOKUNAGA Fuminori 大阪大学, 大学院・医学系研究科, 准教授 (00212069)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥186,900,000 (Direct Cost: ¥186,900,000); Fiscal Year 2010: ¥43,700,000 (Direct Cost: ¥43,700,000); Fiscal Year 2009: ¥43,700,000 (Direct Cost: ¥43,700,000); Fiscal Year 2008: ¥43,700,000 (Direct Cost: ¥43,700,000); Fiscal Year 2007: ¥43,700,000 (Direct Cost: ¥43,700,000); Fiscal Year 2006: ¥12,100,000 (Direct Cost: ¥12,100,000)
• Keywords: タンパク質 / 分解 / ユビキチン / 蛋白質 / ストレス / 癌 / 生体分子 / タンパク質分解

Research Abstract

The ubiquitin conjugation system regulates function of substrate proteins by conjugating ubiquitin in a selective manner. In this research projects, we have identified mechanisms underlying release of ubiquitinated substrate from ubiquitin ligases, which leads to degradation of the proteins and delivery of nascent abnormal proteins to the proteasome. We also identified regulation of cell functions by newly identified polyubiqutin chains.

Research Products

• [Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. (2011)
  • Author(s): Ikeda, F., Deribe, Y.L., Skanland, S.S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S.J.L., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, J.P., Rittinger, K., Schaefer, L., Macek, B., Dikic, I.
  • Journal Title: Nature 471 Pages: 637-641
• [Journal Article] SHARPIN is a component of the NF-κB activating linear ubiquitin chain assembly complex. (2011)
  • Author(s): Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., Iwai, K.
  • Journal Title: Nature 471 Pages: 633-636
• [Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type-I interferon induction. (2011)
  • Author(s): Inn, K.-S., Gack, M.U.Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K., (corresponding author) Jung, J.U.
  • Journal Title: Molecular Cell 41 Pages: 354-365
• [Journal Article] A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1. (2011)
  • Author(s): Kagawa, H., Shino, Y., Kobayashi, D., Demizu, S., Shimada.M., Ariga, H.Kawahara, H.
  • Journal Title: PLoS ONE 6
• [Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-I interferon induction. (2011)
  • Author(s): Inn, K.-S., Gack, M.U. Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K., (責任者著), Jung, J.U.
  • Journal Title: Molecular Cell Volume: 41 Pages: 354-365
  • Peer Reviewed
• [Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex. (2011)
  • Author(s): Tokunaga, F., Nakagawa T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., Iwai, K.
  • Journal Title: Nature Volume: (In press)
  • Peer Reviewed
• [Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. (2011)
  • Author(s): Ikeda, F., et al.
  • Journal Title: Nature Volume: (In press)
  • Peer Reviewed
• [Journal Article] BAG-6 is essential for selective elimination of defective proteasomal substrates. (2010)
  • Author(s): Minami, R., Hayakawa, A., Kagawa, H., Yanagi, Y., Yokosawa, H.Kawahara, H.
  • Journal Title: J.Cell Biol. 190 Pages: 637-650
• [Journal Article] Role of dynamic distribution of muscle-specific calpain in physical-stress adaptation and muscular dystrophy in mice. (2010)
  • Author(s): Ojima, K., Y Kawabata, Y., Nakao, H., Nakao, K., Doi, N., Kitamura, F., Ono, Y., Hata, S., Suzuki, H., Kawahara, H., Labeit, S., Toyama-Sorimachi, N., Suzuki, K., Maeda, T., Abe, K., Aiba, A.Sorimachi, H.
  • Journal Title: J.Clinc.Invest. 120 Pages: 2672-2683
• [Journal Article] Crystallization and preliminary X-ray characterization of the Skpl-Fbg3 complex. (2010)
  • Author(s): Kumanomidou, T., Nakagawa, T., Mizushima, T., et al.
  • Journal Title: Acta Crystallogr Sect F Struct Biol Cryst Commun 66 Pages: 95-98
  • Peer Reviewed
• [Journal Article] Involvement of linear polyubiquitination of NEMO in NF-κB activation. (2009)
  • Author(s): Tokunaga, F., Sakata, S.-I., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K.Iwai, K.
  • Journal Title: Nature Cell Biology 11 Pages: 123-132
• [Journal Article] Coordination of PGC-1b and iron uptake in mitochondrial biogenesis and osteoclast activation. (2009)
  • Author(s): Ishii, K., Fumoto, T., Iwai, K., et al.
  • Journal Title: Nature Medicine 15 Pages: 259-266
  • Peer Reviewed
• [Journal Article] Linear polyubiquitination : a new regulator of NF-κB activation. (2009)
  • Author(s): Iwai, K., Tokunaga, F.
  • Journal Title: EMBO Rep 10 Pages: 706-713
  • Peer Reviewed
• [Journal Article] Involvement of linear polyubiquitination of NEMO in NF-KB activation (2009)
  • Author(s): Tokunaga, F., Sakata, S.-I., Saeki, Y.,Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S.,Takao, T., Tanaka, K. and lwai K.
  • Journal Title: Nature Cell Biology 11 Pages: 123-132
• [Journal Article] Involvement of linear polyubiquitinatioh of NEMO in NF-κB activation (2009)
  • Author(s): Tokunaga, F., Sakata, Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato,_M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K., and Iwai K.
  • Journal Title: Nature Cell Biology 11 Pages: 123-132
  • Peer Reviewed
• [Journal Article] Structural basis for specific cleavage of Lys63-linked polyubiquitin chains. (2008)
  • Author(s): Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai, K., Komada, M., Fukai, S.
  • Journal Title: Nature 455 Pages: 358-362
• [Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase.mediated hypoxia inducible factor-α ubiquitination. (2008)
  • Author(s): Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
  • Journal Title: J.Biol.Chem. 283 Pages: 16622-16631
• [Journal Article] Gp78 Cooperates with RMA1 in ER-associated Degradation of CFTRΔF508. (2008)
  • Author(s): Morito, D., Hirao, K., Oda, Y., Hosokawa, N., Tokunaga, F., Cyr, D.M., Tanaka, K., Iwai, K., Nagata K.
  • Journal Title: Mol.Biol.Cell. 19 Pages: 1328-1336
• [Journal Article] Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. (2008)
  • Author(s): Zhou, G., Dada, L.A., Chandel, N.S., Iwai, K., Lecuona, E., Ciechanover, A., Sznajder, J.I.
  • Journal Title: FASEB J. 22 Pages: 1335-1342
• [Journal Article] Structural basis for specific cleavage of Lys63-linked polyubiquitin chains (2008)
  • Author(s): Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai, K., Komada, M., and Fukai, S.
  • Journal Title: Nature 455 Pages: 358-362
• [Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-a ubiquitination (2008)
  • Author(s): Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
  • Journal Title: J. Biol. Chem. 283 Pages: 16622-16631
• [Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-α ubiquitination (2008)
  • Author(s): Miyauchi, Y., Kato, M., Tokunaga, F., and Iwai, K.
  • Journal Title: J. Biol. Chem 283 Pages: 16622-16631
  • Peer Reviewed
• [Journal Article] Structural basis for specific cleavage of Lys63-linked polyubiquitin chains (2008)
  • Author(s): Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai. K., Komada, M., and Fukai, S.
  • Journal Title: Nature 455 Pages: 358-362
  • Peer Reviewed
• [Journal Article] Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of XEF1AO. (2007)
  • Author(s): Minami, R., Shimada, M., Yokosawa, H.Kawahara, H.
  • Journal Title: Biochem.J.(London) 405 Pages: 495-501
• [Journal Article] Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target. (2007)
  • Author(s): Shabek, N., Iwai, K., Ciechanover, A.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 425-431
• [Journal Article] Direct interactions between Nedd8 and uE2 conjugating enzymes contribute up-regulation of cullin-based E3 ligase activity. (2007)
  • Author(s): Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K.Kato, K.
  • Journal Title: Nature Struct.Mol.Biol. 14: Pages: 167-168
• [Journal Article] Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target (2007)
  • Author(s): Shabek, N., lwai, K., Ciechanover, A.
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 425-431
• [Journal Article] Herne induces ubiquitination and degradation of the transcription factor Bachl (2007)
  • Author(s): Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., lkura, M., Asahara, T., Tokunaga, F., Iwai, Igarashi, K.
  • Journal Title: Mol. Cell Biol. 27 Pages: 6962-6971
• [Journal Article] Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of XEF1A0 (2007)
  • Author(s): Minami, R., Shimada, M., Yokosawa, H., Kawahara, H.
  • Journal Title: Biochem. J. (London) 405 Pages: 495-501
• [Journal Article] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development (2007)
  • Author(s): Hamazaki, J., Sasaki, K., Kawahara, H., Hisanaga, S., Tanaka, K., Murata, S.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 6629-6638
• [Journal Article] A neural-specific F-box protein Fbsl functions as a chaperone suppressing glycoprotein aggregation (2007)
  • Author(s): Yoshida, Y., Murakami, A., Iwai, K., Tanaka, K.
  • Journal Title: J. Biol. Chem. 282 Pages: 7137-7144
• [Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity (2007)
  • Author(s): Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K. Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K., Kato, K.
  • Journal Title: Nature Struct. Mol. Biol. 14 Pages: 167-168
• [Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity. (2007)
  • Author(s): Sakata, E., et. al.
  • Journal Title: Nature Struct. Mol. Biol. 14 Pages: 167-168
  • Peer Reviewed
• [Journal Article] Neural-specific F-box protein Fbsl functions as a chaperone suppressing glycoprotein aggregation. (2007)
  • Author(s): Yoshida, Y., Murakami, A., Iwai. K. and Tanaka, K. A
  • Journal Title: J. Biol. Chem. 282 Pages: 7137-7144
  • Peer Reviewed
• [Journal Article] Heme in duces ubiquitination and degradation of the transcription factor Bachl. (2007)
  • Author(s): Zenke-Kawasaki, Y., et. al.
  • Journal Title: Mol. Cell Biol. 27 Pages: 6962-6971
  • Peer Reviewed
• [Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity. (2007)
  • Author(s): Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K., Kato, K.
  • Journal Title: Nat. Struct. Mol. Biol. 14・2 Pages: 167-168
• [Journal Article] A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation. (2007)
  • Author(s): Yoshida, Y., Murakami, A., Iwai, K., Tanaka, K.
  • Journal Title: J. Biol. Chem. 282・10 Pages: 7137-7144
• [Journal Article] Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans. (2006)
  • Author(s): Shimada, M., Kanematsu, K., Tanaka, K., Yokosawa, H.Kawahara, H.
  • Journal Title: Mol.Biol.Cell 17 Pages: 5356-5371
• [Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains. (2006)
  • Author(s): Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S.Tokunaga, F., Tanaka, K.Iwai, K.
  • Journal Title: EMBO J. 25 Pages: 4877-4887
• [Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC) (2006)
  • Author(s): Nakamura, M., Tokunaga, F., Sakata , S.-I., Iwai, K.
  • Journal Title: Biochem. Biophys. Res. Commun. 351 Pages: 340-347
• [Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains (2006)
  • Author(s): Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S. Tokunaga, F., Tanaka, K., lwai, K.
  • Journal Title: EMBO J. 25 Pages: 4877-4887
• [Journal Article] Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans (2006)
  • Author(s): Shimada, M., Kanematsu, K., Tanaka, K., Yokosawa, H., Kawahara, H.
  • Journal Title: Mol. Biol. Cell 17 Pages: 5356-5371
• [Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains. (2006)
  • Author(s): Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S., Tokunaga, F., Tanaka.K., Iwai.K.
  • Journal Title: EMBO J. 25・20 Pages: 4877-4887
• [Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC). (2006)
  • Author(s): Nakamura, M., Tokunaga, F., Sakata, S.-I., Iwai, K.
  • Journal Title: Biochem. Biophys. Res. Commun. 351・2 Pages: 340-347
• [Journal Article] The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. (2006)
  • Author(s): Bayle, J., Lopez, S., Iwai, K., Dubreuil, P., De Sepulveda, P.
  • Journal Title: FEBS Lett. 580・11 Pages: 2609-2614
• [Journal Article] Chemoenzymatic Ubiquitination of Artificial Substrates. (2006)
  • Author(s): Burchak, O.N., Jaquinod, M., Cottin, C., Mugherli, L., Iwai, K., Chatelain, F., Balakirev.M.Y.
  • Journal Title: Chembiochem. 7・11 Pages: 1667-1669
• [Presentation] Linear Polyubiquitination : A Newly Identified Regulator of NF-κB Signaling (2010)
  • Author(s): Iwai, K.
  • Organizer: Biology of the Ubiquitin and the Ubiquitin-Like Systems
  • Place of Presentation: イスラエル(エルサレム市)
  • Year and Date: 2010-03-15
• [Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling. (2010)
  • Author(s): Iwai, K.
  • Organizer: Banbury Center meetings,"SIGNALING THROUGH UBIQUITIN(Invited)
  • Place of Presentation: The Banbury Center, Cold Spring Harbor Laboratory, New York, USA.
• [Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling. (2010)
  • Author(s): Iwai, K.
  • Organizer: 2010 FASEB Summer Research Conferences "Ubiquitin and Cellular Regulation"(Invited)
  • Place of Presentation: Saxtons River, Vermont, USA.
• [Presentation] Linear Polyubiquitination : A Newly Identified Regulator of NF-κB Signaling. (2010)
  • Author(s): Iwai, K.
  • Organizer: BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS Research Conference of the Institute for Advanced Studies, the Israel Science Foundation.(Invited)
  • Place of Presentation: Jerusalem, Israel.
• [Presentation] Linear polyubiquitination : A newly identified regulator of NF-κB signaling. (2010)
  • Author(s): Iwai, K., Sakata, S.-I., Nakagawa, T., Tokunaga, F.
  • Organizer: Keystone Symposium "NF-κB in Inflammation and Disease"
  • Place of Presentation: Santa Fe, New Mexico, USA.
• [Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling. (2010)
  • Author(s): Iwai, K.
  • Organizer: FASEB Summer Research Conferences "Ubiquitin and Cellular Regulation"
  • Place of Presentation: Saxtons River, Vermont, USA(招待講演)
• [Presentation] Physiological function of linear polyubiquitin chain (2009)
  • Author(s): 岩井一宏(Kazuhiro Iwai)
  • Organizer: Keystone Symposium"The Many Faces of Ubiquitin"
  • Place of Presentation: Copper Mountahi Resort, 米国コロラド州
  • Year and Date: 2009-01-13
• [Presentation] polyubiquitination : A newly identified regulator of NF-κB signaling. (2009)
  • Author(s): Iwai, K., Tokunaga, F.Linear
  • Organizer: The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
  • Place of Presentation: Riva Del Garda, Italy.
• [Presentation] Involvement of linear polyubiquitination of NEMO in NF-κB activation (2009)
  • Author(s): Tokunaga, F., Sakata, S.-I., Nakagawa, T., Iwai, K.
  • Organizer: Cold Spring Harbor Laboratory meeting "The Ubiquitin Family"
  • Place of Presentation: Cold Spring Harbor, NY, USA.
• [Presentation] Physiological Function of Linear Polyubiquitin Chain. (2009)
  • Author(s): Iwai, K.
  • Organizer: Keystone Symposium "The Many Faces of Ubiquitin"(Invited)
  • Place of Presentation: Copper Mountain Resort, CO, USA
• [Presentation] Physiological function of linear polyubiquitin chain (2009)
  • Author(s): Iwai K.
  • Organizer: Keystone Symposium "The Many Faces of Ubiquitin"
  • Place of Presentation: Copper Mountain Resort, CO, LISA
• [Presentation] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase.mediated HIF-α ubiquitination. (2008)
  • Author(s): Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
  • Organizer: ZOMESV : The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3 : At the interface between signaling and proteolysis(Invited)
  • Place of Presentation: Yokohama, Japan.
• [Presentation] The COP9/Signalosorne increases the efficiency of pVHL-containing ubiquitin ligase-mediated H1F-a ubiquitination (2008)
  • Author(s): Miyauchi, Y., Kato, M., Tokunaga, F., lwai K.
  • Organizer: ZOMESV
  • Place of Presentation: Yokohama, Japan
• [Presentation] Prevention of TNF-a induced apoptosis by linear polyubiquitination (2008)
  • Author(s): lwai, K.
  • Organizer: The 15^<th> Takeda Science Foundation Symposium on Bioscience "Cell Death: What have we learned and what will we learn?"
  • Place of Presentation: Tokyo, Japan
• [Presentation] Linear ubiquitination of NEMO triggers NF-kB activation (2007)
  • Author(s): Tokunaga, F., et. al.
  • Organizer: EMBO CONFERENCE Ubiquitin and Ubiqutin-like Modifiers in Cellular Reeulation
  • Place of Presentation: Riva Del Garda, Italy
  • Year and Date: 2007-09-24
• [Presentation] Linear ubiquitination of NEMO triggers NF-kB activation. (2007)
  • Author(s): Tokunaga, F., Sakata, S.-I., Kirisako, T., Nakagawa, T., Murata, S.Tanaka, K.Iwai, K.
  • Organizer: The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
  • Place of Presentation: Riva Del Garda, Italy.
• [Presentation] Linear ubiquitination of NEMO triggers NF-KB activation (2007)
  • Author(s): Tokunaga, F., Sakata, S.-I., Kirisako, T., Nakagawa, T., Murata, S. Tanaka, K. and Iwai, K.
  • Organizer: The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
  • Place of Presentation: Riva Del Garda Italy
• [Presentation] Proteasomal ubiquitin receptor RPN-10 controls TRA-2-mediated sex determination in Caenorhabditis elegans. (Invited) (2006)
  • Author(s): Kawahara, H., Shimada, M., Yokosawa, H.
  • Organizer: 4th NIBB-EMBL Symposium
  • Place of Presentation: Okazaki, Japan,
• [Presentation] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role. (2006)
  • Author(s): Kirisako, T., Tokunaga, F., Nakamura, M., Iwai, K.
  • Organizer: The Fourth NIBB-EMBL Symposium,(Invited)
  • Place of Presentation: Okazaki, Japan.
• [Book] M.eds Landes Biosciences (2010)
  • Author(s): Iwai, K.
  • Publisher: FUNCTIONS OF LINEAR UBIQUITIN CHAINS IN THE NF-κB PATHWAY Linear Polyubiquitin in NF-κB Signaling. Conjugation and Deconjugation of Ubiquitin Family Modifiers Groettrup
• [Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers (2010)
  • Author(s): Iwai K.
  • Total Pages: 272
  • Publisher: Groettrup, M.eds Landes Biosciences
• [Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers (2010)
  • Author(s): Iwai, K.
  • Publisher: Landes Biosciences(In Press)
• [Book] J, eds.John Wiley and Sons (2006)
  • Author(s): Lorick, K., Yang, Y., Jensen, J., Iwai, K.Weissman, A.M.
  • Publisher: Studies of the ubiquitin proteasome system. Units 15.9 Current Protocols in Cell Biology Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino
• [Book] A.M. Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12. Current Protocols in Cell Biology Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino J eds. (2006)
  • Author(s): Lorick, K., Yang, Y., Jensen, J., lwai K. and Weissman
  • Publisher: John Wiley and Sons
• [Book] Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12. Current Protocols in Cell Biology (2006)
  • Author(s): Lorick, K., Yang, Y., Jensen, J., Iwai, K., Weissman, A.M.
  • Total Pages: 75
  • Publisher: Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino J, eds. John Wiley and Sons
• [Remarks] ホームページ等
  • URL: http://www.cellbio.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.cellbio.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.cellbio.med.osaka-u.ac.jp/
• [Remarks] ホームページ
  • URL: http://www.cellhio.med.osaka-u.ac.jp/
• [Patent(Industrial Property Rights)] 新規なユビキチンリガーゼ及びその利用 (2010)
  • Inventor(s): 岩井一宏
  • Industrial Property Rights Holder: 大阪大学
  • Filing Date: 2010-08-06
• [Patent(Industrial Property Rights)] 新規なユビキチンリガーゼおよびその利用 (2010)
  • Inventor(s): 岩井一宏
  • Industrial Property Rights Holder: 大阪大学
  • Filing Date: 2010-08-06
  • Overseas
• [Patent(Industrial Property Rights)] 新規なユビキチンリガーゼ及びその利用 (2009)
  • Inventor(s): 岩井一宏
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2009-184878
  • Filing Date: 2009-08-07