Biology of the Ubiquitin System

• Project Area: Proteolysis in the Regulation of Biological Processes
• Project/Area Number: 18076006
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Tsukuba
• Principal Investigator: CHIBA Tomoki University of Tsukuba, 大学院・生命環境科学研究科, 教授 (00311423)
• Co-Investigator(Kenkyū-buntansha): 佐藤 晃嗣 筑波大学, 大学院・生命環境科学研究科, 講師 (00419243)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥82,200,000 (Direct Cost: ¥82,200,000); Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥14,300,000); Fiscal Year 2009: ¥19,900,000 (Direct Cost: ¥19,900,000); Fiscal Year 2008: ¥16,700,000 (Direct Cost: ¥16,700,000); Fiscal Year 2007: ¥18,700,000 (Direct Cost: ¥18,700,000); Fiscal Year 2006: ¥12,600,000 (Direct Cost: ¥12,600,000)
• Keywords: ユビキチン / ユビキチン様タンパク質 / プロテアソーム / タンパク質分解 / コビキチン

Research Abstract

The proteins in the body are in a dynamic state and they are continually degraded as well as synthesized. Selective protein degradation is regulated by an elaborate system called Ubiquitin-system. Ubiquitin is a small molecule that marks the proteins for proteasomal degradation. This selective protein degradation is essential for many cellular events and its impairment cause various diseases such as cancer and neurodegenerative diseases. The summary of this study is twofold. We identified and characterized several enzymes involved in the ubiquitination reaction mediated by Cullin-based ubiquitin ligase complexes (ie; substrate recognition, regulation of conjugation and de-conjugation, etc). Secondly, we generated mutant mice for one of the proteasome regulatory subunit to clarify the function of proteasome regulatory particles.

Research Products

• [Journal Article] Bioluminescence assay for detecting cell surface membrane protein expression. (2010)
  • Author(s): Kato M, Chiba T, Li M, Hanyu Y.
  • Journal Title: Assay & Drug Dev.Tech. Volume: 9 Pages: 31-39
  • Peer Reviewed
• [Journal Article] The mechanism of poly-NEDD8 chain formation in vitro. (2009)
  • Author(s): Ooki Y, Konishi N, Funatsu N, Chiba T.
  • Journal Title: B.B.R.C. 381 Pages: 443-447
  • Peer Reviewed
• [Journal Article] The mechanism of poly-NEDD8 chain formation in vitro (2009)
  • Author(s): Ooki Y, Konishi N, Funatsu N, Chiba T.
  • Journal Title: Biochem.Biophys.Res.Commun. 381 Pages: 443-447
  • Peer Reviewed
• [Journal Article] The mechanism of poly-NEDD8 chain Formation in vitro (2009)
  • Author(s): Ooki Y,Konishi N,Funatsu N,Chiba T
  • Journal Title: B.B.R.C 381 Pages: 443-447
  • Peer Reviewed
• [Journal Article] The mechanism of poly-NEDD8 chain formation in vitro (2009)
  • Author(s): Ooki Y, Konishi N, Funatsu N, Chiba T.
  • Journal Title: Biochem. Biophys. Res. Commun 381 Pages: 443-447
  • Peer Reviewed
• [Journal Article] PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degrada -tion. (2008)
  • Author(s): Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I.
  • Journal Title: Mol Cell Biol. 28 Pages: 7126-7138
  • Peer Reviewed
• [Journal Article] A novel ubiquitin ligase involved in p57^<Kip2> proteolysis regulates osteoblast cell differentiation. (2008)
  • Author(s): Kim M, Nakamoto K, Nishimori S, Tanaka K, Chiba T.
  • Journal Title: EMBO rep. 9 Pages: 878-884
  • Peer Reviewed
• [Journal Article] Allele-selective effect of PA28 in MHC class I antigen processing. (2008)
  • Author(s): Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Udono H.
  • Journal Title: J.Immunol. 181 Pages: 1655-1664
  • Peer Reviewed
• [Journal Article] Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. (2008)
  • Author(s): Koyama S, Hata S, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Witt SH, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H.
  • Journal Title: J Mol Biol. 376 Pages: 1224-1236
  • Peer Reviewed
• [Journal Article] Pandolfi PP,Kitabayashi I.PML activates Transcription by protecting HIPK2 and P300 from SCFFbx3-mediated degrada-Ton (2008)
  • Author(s): Shima Y,Shima T,Chiba T,Irimura T
  • Journal Title: Mol Cell Biol 28 Pages: 7126-7138
  • Peer Reviewed
• [Journal Article] A novel ubiquitin ligase involved in p57kip2 proteolysis regulates Osteoblast cell differentiation (2008)
  • Author(s): Kim M,Nakamoto K,Nishimori S, Tanaka K,Chiba T
  • Journal Title: EMBO rep 9 Pages: 878-884
  • Peer Reviewed
• [Journal Article] PML activates transcription by protecting HIPK2 and p300 from SCFFbx3- mediated degradation (2008)
  • Author(s): Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I
  • Journal Title: Mol Cell Biol 28 Pages: 7126-7138
  • Peer Reviewed
• [Journal Article] A novel ubiquitin ligase involved in p57^KiP2 proteolysis reguates osteoblast cell differentiation (2008)
  • Author(s): Kim M, Nakamoto K, Nishimori S, Tanaka K, Chiba T.
  • Journal Title: EMBO rep. 9 Pages: 878-884
  • Peer Reviewed
• [Journal Article] Hsp90 mediated assembly of the 26S proteasome is involved in MHC class I antigen processing (2008)
  • Author(s): Yamano T, Mizukami S, Murata S, Chiba T, Tanaka K, Udono H.
  • Journal Title: J. Biol. Chem. 283 Pages: 28060-28065
  • Peer Reviewed
• [Journal Article] Allele-selective effect of PA28 in MHC class I antigen processing (2008)
  • Author(s): Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Udono H.
  • Journal Title: J Immunol 181 Pages: 1655-1664
  • Peer Reviewed
• [Journal Article] Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis (2008)
  • Author(s): Koyama S, Hata S, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, be K, Witt SH, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H.
  • Journal Title: J Mol. Biol 376 Pages: 1224-1236
  • Peer Reviewed
• [Journal Article] SCRAPPER- Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release. (2007)
  • Author(s): Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, MacGregor GR, Tanaka K, Setou M.
  • Journal Title: Cell 130 Pages: 943-957
  • Peer Reviewed
• [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. (2007)
  • Author(s): Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, Takahashi S, Kouzmenko A, Nohara K, Chiba T, Fujii-kuriyama Y, Kato S.
  • Journal Title: Nature 446 Pages: 562-566
  • Peer Reviewed
• [Journal Article] TBP-interacting protein 120b(TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. (2007)
  • Author(s): Shiraishi S, Zhou C, Aoki T, Sato N, Chiba T, Tanaka K, Yoshida S, Nabeshima Y, Nabeshima Y, Tamura TA.
  • Journal Title: J Biol Chem. 282 Pages: 9017-9028
  • Peer Reviewed
• [Journal Article] Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity. (2007)
  • Author(s): Sakata E, Yamaguchi Y, Miyauchi Y, Iwai K, Chiba T, Saeki Y, Matsuda N, Tanaka K, Kato K.
  • Journal Title: Nat.Struct.Mol.Biol. 14 Pages: 167-168
  • Peer Reviewed
• [Journal Article] SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Sunaptic Vesicle Release (2007)
  • Author(s): Yao I, (他14名)
  • Journal Title: Cell 130 Pages: 943-957
  • Peer Reviewed
• [Journal Article] Diosin receptor is a ligand-dependent E3 ubiquitin ligase (2007)
  • Author(s): Ohtake F, (他11名)
  • Journal Title: Nature 446 Pages: 562-566
  • Peer Reviewed
• [Journal Article] Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity (2007)
  • Author(s): Satake E,Yamaguchi Y,Miyauchi Y,Iwai K,Chiba T,Saeki Y,Matsuda N,Tanaka K,Kato K
  • Journal Title: Nat.Struct.Mol.Biol 14 Pages: 167-168
  • Peer Reviewed
• [Journal Article] Muscle RING-finger protein-1(MuRF1)as a connector of muscle energy metabolism and protein sy6nthesis (2007)
  • Author(s): Kdyama S, Hata S, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Vvitt SH, Rybin V, Gasch A, Franz T, Labeit s, Sorimachi H.
  • Journal Title: J.Mol.Biol 367 Pages: 1224-1236
  • Peer Reviewed
• [Journal Article] SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synapyic Vesicle Release (2007)
  • Author(s): Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda y, Chiba T, Morane N, Yuasa S, Inokuchi K, Ohtsuka T, MacGregorGr, Tanaka K, Setou M.
  • Journal Title: Cell 130 Pages: 943-957
  • Peer Reviewed
• [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. (2007)
  • Author(s): Ohtake F, Baba A, Takada I, Okada M., Iwasaki K, Miki H, Takahashi S, Kiuzmenko A, Nohara K, Chiba T, Fujii-Kuriyama Y, Kato s.
  • Journal Title: nature 446 Pages: 562-566
  • Peer Reviewed
• [Journal Article] TBP-inreracting protein 120b(TIP120B)/cullin-associated and neddylation-dissociated 2(CAN2)inhibits SCF-dependent ubiquitination of myogenin and accelerates myoginic differentiaton (2007)
  • Author(s): Shiraishi S, Zhou C, Aoki T, Sao N, Chiba T, Tanaka K, Yoshida S, Nabeshima Y, Tanura TA.
  • Journal Title: J.Biol.Chem 282 Pages: 9017-908
  • Peer Reviewed
• [Journal Article] Direst interaction between NEDD8 and ubiquiyin E2 Conjugating enztmes upregulatate Cullinbaded E3 ligase activity (2007)
  • Author(s): Sakata R, Yamaguchi Y, Miyauchi Y, Iwaki K, Chiba T, Saeki Y, Matsuda K, Kato K.
  • Journal Title: Nat Struct Mol Biol 14 Pages: 167-168
  • Peer Reviewed
• [Journal Article] Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity. (2007)
  • Author(s): Sakata E, Yamaguchi Y, Miyauchi Y, Iwai K, Chiba T, Saeki Y, Matsuda N, Tanaka K, Kato K
  • Journal Title: Nat.Struct.Mol.Biol. 14 Pages: 167-168
• [Journal Article] TBP-interacting protein 120b (TIP120B) /cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiaton. (2007)
  • Author(s): Shiraishi S, Zhou C, Aoki T, Sato N, Chiba T, Tanaka K, Yoshida S, Nabeshima Y, Nabeshima Y, Tamura TA
  • Journal Title: J.Biol.Chem. 282 Pages: 9017-9028
• [Journal Article] SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. (2006)
  • Author(s): Lee MH, Lee SW, Lee EJ, Choi SJ, Chung SS, Lee JI, Cho JM, Seol JH, Baek SH, Kim KI, Chiba T, Tanaka K, Bang OS, Chung CH
  • Journal Title: Nat.Cell Biol. 8 Pages: 1424-1431
• [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration in mice. (2006)
  • Author(s): Komatsu M, Waguri S, Chiba T, Murata S, Iwata JI, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K
  • Journal Title: Nature 441 Pages: 880-884
• [Journal Article] 14-3-3eta is a novel regulator of parkin ubiquitin ligase. (2006)
  • Author(s): Sato S, Chiba T, Sakata E, Kato K, Mizuno Y, Hattori N, Tanaka K
  • Journal Title: EMBO J. 25 Pages: 211-221
• [Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography. (2006)
  • Author(s): Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukada H, Hatano T, Fukuda T, Yasoshima Y, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
  • Journal Title: J.Neurosci.Res. 84 Pages: 1350-1357
• [Journal Article] Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. (2006)
  • Author(s): Fujiwara T, Mishima T, Kofuji T, Chiba T, Tanaka K, Yamamoto A, Akagawa K
  • Journal Title: J.Neurosci. 26 Pages: 5767-5776
• [Journal Article] Depletion of HSP90beta induces multiple defects in B cell receptor signaling. (2006)
  • Author(s): Shinozaki F, Minami M, Chiba T, Suzuki M, Yoshimatsu K, Ichikawa Y, Terasawa K, Emori Y, Matsumoto K, Kurosaki T, Nakai A, Tanaka K, Minami Y
  • Journal Title: J.Biol.Chem. 281 Pages: 16361-16369
• [Journal Article] BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of DAXX for ubiquitination by Cul3-based ubiquitin ligase. (2006)
  • Author(s): Kwon JE, La M, Oh KH, Oh YM, Kim GR, Seol JH, Baek SH, Chiba T, Tanaka K, Bang OS, Joe CO, Chung CH
  • Journal Title: J.Biol.Chem. 281 Pages: 12664-12672
• [Journal Article] Excess peroxisomes are degraded by autophagic machinery in mammals. (2006)
  • Author(s): Iwata J, Ezaki J, Komatsu M, Yokota S, Ueno T, Tanida I, Chiba T, Tanaka K, Kominami E
  • Journal Title: J.Biol.Chem. 281 Pages: 4035-4041
• [Journal Article] The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells. (2006)
  • Author(s): Duan X, Hisaeda H, Shen J, Tu L, Imai T, Chou B, Murata S, Chiba T, Tanaka K, Fehling HJ, Koga T, Sueishi K, Himeno K
  • Journal Title: Int.Immunol. 18 Pages: 679-687
  • NAID: 10020619445
• [Journal Article] The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1. (2006)
  • Author(s): Ishii K, Hisaeda H, Duan X, Imai T, Sakai T, Fehling HJ, Murata S, Chiba T, Tanaka K, Hamano S, Sano M, Yano A, Himeno K
  • Journal Title: Microbes.Infect. 8 Pages: 1045-1053
• [Presentation] A mutation in an AdRP causative gene affects its Cullin complex formation. (2010)
  • Author(s): Kigoshi Y, Tsuruta F, Chiba T.
  • Organizer: American Society of Cell Biology Meeting.
  • Place of Presentation: Philadelphia, U.S.A
• [Presentation] Loss of Parkin leads to selective degeneration of spermatogonia in mice. (2010)
  • Author(s): Komatsu T, Satake T, Sato A, Tsuruta F, Chiba T.
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市、神戸ポートアイランド
• [Presentation] The analyses of the poly-NEDD8 chain. (2010)
  • Author(s): Takashima O, Tsuruta F, Funatsu N, Konishi N, Chiba T.
  • Organizer: The 6^<th> International Conferences on COP9 Signalosome, Proteasome and eIF3. ZOMES VI.
  • Place of Presentation: Safed, Israel.
• [Presentation] Loss of Parkin leads to selective degeneration of spermatogonia in mice. (2010)
  • Author(s): Satake T, Komatsu T, Sato A, Tsuruta F, Chiba T.
  • Organizer: EMBO Workshop.Proteolysis & Neurodegeneration
  • Place of Presentation: Madrid, Spain
• [Presentation] Regulation of KLHL7, a BTB-kelch protein by a novel cullin family protein. (2010)
  • Author(s): Kigoshi Y, Tsuruta F, Chiba T.
  • Organizer: EMBO Workshop.Proteolysis & Neurodegeneration
  • Place of Presentation: Madrid, Spain
• [Presentation] The analyses of the poly-NEDD8 chain (2010)
  • Author(s): Takashima O, Tsuruta F, Funatsu N, Konishi N, Chiba T.
  • Organizer: The 6^<th> International Conferences on COP9 Signalosome, Proteasome and elF3.ZOMES VI.
  • Place of Presentation: Safed, Israel
• [Presentation] The analyses of the poly-NEDD8 chain (2010)
  • Author(s): Takashima O, Tsuruta F, Funatsu N, Konishi N, Chiba T.
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市、神戸ポートアイランド
• [Presentation] Ubiquitin ligase SCF^<Fbl12> complex regulates neuronal morphogenesis (2010)
  • Author(s): Tsuruta F, Chiba T.
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市、神戸ポートアイランド
• [Presentation] Regulation of KLHL7 by cullin family proteins. (2010)
  • Author(s): Kigoshi Y, Hayasaka N, Tsuruta F, Chiba T.
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市、神戸ポートアイランド
• [Presentation] A mutation in an AdRP causative gene affects its Cullin complex formation (2010)
  • Author(s): Kigoshi Y, Tsuruta F, Chiba T.
  • Organizer: American Society of Cell Biology Meeting
  • Place of Presentation: Philadelphia, U.S.A
• [Presentation] The mechanism and the function of the poly-NEDD8 chain (2010)
  • Author(s): Takashima O, Ohki Y, Funatsu N, Konishi N, Chiba T.
  • Organizer: The 5^<th> Int.Conf.on Ub, UBL and cancer
  • Place of Presentation: 米国テキサス州
• [Presentation] 試験管内再構築系によるポリNEDD8鎖の解析 (2009)
  • Author(s): 小西なつみ、舩津憲一、高島統、千葉智樹
  • Organizer: 日本生化学会年会
  • Place of Presentation: 神戸市
• [Presentation] NF-κB1、NF-κB2の限定分解におけるプロテアソーム活性の役割 (2009)
  • Author(s): 東山健、千葉智樹
  • Organizer: 日本生化学会年会
  • Place of Presentation: 神戸市
• [Presentation] DDB2と相互作用する脱ユビキチン化酵素の解析 (2009)
  • Author(s): 舩津憲一、芦木拓真、千葉智樹
  • Organizer: 日本生化学会年会
  • Place of Presentation: 神戸市
• [Presentation] Analysis of Cul-10 : a component of a putative ubiquitin ligase complex (2009)
  • Author(s): 木越悠、早坂奈美、千葉智樹
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜市
• [Presentation] The regulation of Cullin by NEDD8 (2009)
  • Author(s): 千葉智樹
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜市
• [Presentation] The mechanism of poly-NEDD8 chain formation (2009)
  • Author(s): Ohki Y, Funatsu N, Konishi N, Chiba T.
  • Organizer: The Ubiquitin Meeting, CSHL meeting
  • Place of Presentation: 米国ニューヨーク州
• [Presentation] ポリNEDD8鎖形成機構の解明 (2008)
  • Author(s): 大木優、船津憲一、小西なつみ、千葉智樹
  • Organizer: 日本生化学会・日本分子生物学会合同年会
  • Place of Presentation: 神戸市
• [Presentation] マウス初期胚における精子ミトコンドリア排除とおーとファジー (2008)
  • Author(s): 佐藤晃嗣、米川博通、林純一、千葉智樹
  • Organizer: 日本生化学会・日本分子生物学会合同年会
  • Place of Presentation: 神戸市
• [Presentation] A novel ubiquitin ligase involved in p57Kip2 proteolysis regulates osteoblast cell differentiation (2008)
  • Author(s): Kim M, Chiba T.
  • Organizer: The 5^<th> International Symposium on the COP9 siganalosome, Proteasome and eIF3
  • Place of Presentation: 横浜市
• [Presentation] The mechanism of poly-NEDD8 chain formation in vitro (2008)
  • Author(s): Ohki Y, Funatsu N, Konishi N, Chiba T.
  • Organizer: The 5^<th> International Symposium on the COP9 siganalosome, Proteasome and eIF3.
  • Place of Presentation: 横浜市
• [Presentation] Elucidation of proteasome activity involved in NF-kappaB processing (2008)
  • Author(s): Higashiyama K, Chiba T.
  • Organizer: The 5^<th> International Symposium on the COP9 siganalosome, Proteasome and elF3
  • Place of Presentation: 横浜市
• [Presentation] NF-kB1、NF-kB2の限定分解における新規プロテアソーム活性の役割 (2008)
  • Author(s): 東山健、千葉智樹
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市
• [Presentation] ポリNEDD8鎖形成機構の解明 (2008)
  • Author(s): 大木優、舩津憲一、小西なつみ、千葉智樹
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市
• [Presentation] マウス初期胚における精子ミトコンドリア排除とオートファジー (2008)
  • Author(s): 佐藤晃嗣、米川博通、林純一、千葉智樹
  • Organizer: 日本分子生物学会、日本生化学会合同年会
  • Place of Presentation: 神戸市
• [Presentation] ユビキチンリガーゼ(SCF複合体)の活動制御機構の解析 (2007)
  • Author(s): 大木・Robertson小西・千葉
  • Organizer: 日本生化学会・分子生物学会 合同年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] StrapによるTGF-βシグナル調整機構の解析 (2007)
  • Author(s): 小林・東條・小西・船津・千葉
  • Organizer: 日本生化学会・分子生物学会 合同年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 筋特異的RINGタクパク質MURF1によるクレアチンキナーゼの分解制御 (2007)
  • Author(s): 小山・泰・Christian小野・尾島ほか
  • Organizer: 日本生化学会・分子生物学会 合同年会
  • Place of Presentation: パシフィコ横浜
• [Remarks] ホームページ等
  • URL: http://tchibalab.org/
• [Remarks]
  • URL: http://www.biol.tsukuba.ac.jp/~tchiba/