| Budget Amount *help |
¥82,200,000 (Direct Cost: ¥82,200,000)
Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2009: ¥19,900,000 (Direct Cost: ¥19,900,000)
Fiscal Year 2008: ¥16,700,000 (Direct Cost: ¥16,700,000)
Fiscal Year 2007: ¥18,700,000 (Direct Cost: ¥18,700,000)
Fiscal Year 2006: ¥12,600,000 (Direct Cost: ¥12,600,000)
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| Research Abstract |
The proteins in the body are in a dynamic state and they are continually degraded as well as synthesized. Selective protein degradation is regulated by an elaborate system called Ubiquitin-system. Ubiquitin is a small molecule that marks the proteins for proteasomal degradation. This selective protein degradation is essential for many cellular events and its impairment cause various diseases such as cancer and neurodegenerative diseases. The summary of this study is twofold. We identified and characterized several enzymes involved in the ubiquitination reaction mediated by Cullin-based ubiquitin ligase complexes (ie; substrate recognition, regulation of conjugation and de-conjugation, etc). Secondly, we generated mutant mice for one of the proteasome regulatory subunit to clarify the function of proteasome regulatory particles.
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