| Budget Amount *help |
¥62,900,000 (Direct Cost: ¥62,900,000)
Fiscal Year 2010: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2009: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2008: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2007: ¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2006: ¥11,100,000 (Direct Cost: ¥11,100,000)
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| Research Abstract |
We searched for the molecules which induce conversion of touch sensation to pain by the modal shift of their sensor functions. We identified μ-opioid, peripheral-type benzodiazepine receptor, and casein kinase 1ε as effectors which are functionally located downstream of N-type calcium channel activation. We also clarified how the modal shift of these molecules affect the excitability of neurons and their intracellular calcium transient [Ca^<2+>]i , and how the inhibitor of each molecule affects the observed changes caused by the modal shift of these molecules.
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