Alteration of cell response and behavior by temporal, special, phylogenetic modal-shifts of taste cell sensors.
Project Area | Molecular interaction and modal shift of cellular sensors |
Project/Area Number |
18077004
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyushu University |
Principal Investigator |
NINOMIYA Yuzo Kyushu University, 歯学研究院, 教授 (50076048)
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Co-Investigator(Kenkyū-buntansha) |
SHIGEMURA Noriatsu 九州大学, 大学院・歯学研究院, 准教授 (40336079)
YOSHIDA Ryusuke 九州大学, 大学院・歯学研究院, 助教 (60380705)
|
Project Period (FY) |
2006 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥64,400,000 (Direct Cost: ¥64,400,000)
Fiscal Year 2010: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2009: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2008: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2007: ¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2006: ¥12,100,000 (Direct Cost: ¥12,100,000)
|
Keywords | セルセンサー / モーダルシフト / 甘味センサー / 塩味センサー / レプチン / T1R2/T1R3 / 鼓策神経 / ENaC / 遺伝子多型 / アミロライド / T1R2 / 1R3 / 鼓索神経 / TIR2 / IR3 |
Research Abstract |
Potential modal-shifts of sensitivities of taste cell sensors were studied by examining cellular and behavior responses to sweet and salty stimuli under various molecular and environmental conditions. The results suggest that as comparable with the action of central nervous system, endocannabinoids, orexigenic mediators, enhanced peripheral sweet taste sensitivities, that opposes the action of leptin, an anorexigenic mediator. Species-specific sweet-suppressing effect of gurmarin occurs its binding to the mouse extracellular domain of T1r3(partially that of T1r2). In addition, molecular based modal-shift was found in sodium-salt sensor ENaC channels where an amino acid change (R616W) in αsubunit may produce variation in amiloride-sensitivity of the channel.
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Report
(7 results)
Research Products
(227 results)
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[Journal Article] Endocannabinoids selectively enhance sweet taste.2010
Author(s)
Yoshida R., Ohkuri T., Jyotaki M., Yasuo T., Horio N., Yasumatsu K., Sanematsu K., Shigemura N., Yamamoto T., Margolskee RF., Ninomiya Y.
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Journal Title
Proc.Natl.Acad.Sci.USA 107:(2)
Pages: 935-939
Related Report
Peer Reviewed
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[Journal Article] Endocannabinoids selectively enhance sweet taste.2010
Author(s)
Yoshida R., Ohkuri T, Jyotaki M., Yasuo T., Horio N., Yasumatsu K., Sanematsu K., Shigemura N., Yamamoto T, Margolskee RF., Ninomiya Y.
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Journal Title
Proc.Natl.Acad.Sci.USA 107(2)
Pages: 935-939
Related Report
Peer Reviewed
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[Journal Article] Discrimi- nation of taste qualities among mouse fungiform taste bud cells.2009
Author(s)
Yoshida R., Miyauchi A., Yasuo T., Jyotaki M., Murata Y., Yasumatsu K., Shigemura N., Yanagawa Y., Obata K., Ueno H., Margolskee RF., Ninomiya Y.
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Journal Title
J Physiol 587:(18)
Pages: 4425-4439
Related Report
Peer Reviewed
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[Journal Article] Discrimination of taste qualities among mouse fungiform taste bud cells2009
Author(s)
Yoshida R., Miyauchi A., Yasuo T., Jyotaki M., Murata Y., Yasumatsu K.,ShigemuraN.,Yanagawa Y., Obata K., Ueno H., Robert F. Margolskee., Ninomiya Y
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Journal Title
J Physiol 587(18)
Pages: 4425-4439
Related Report
Peer Reviewed
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[Journal Article] Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin.2008
Author(s)
Shigemura N., Nakao K., Yasuo T., Murata Y., Yasumatsu K., Nakashima A., Katsukawa H., Sako N., Ninomiya Y.
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Journal Title
Biochem Biophys Res Commun. 367:(2)
Pages: 356-363
Related Report
Peer Reviewed
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[Journal Article] Gurmarin seusitivity of sweet taste response is associated with co-expression patterns of T1r2,Tfr3, and gustducin2008
Author(s)
Shigemura, N.・Nakao, K.・Yasuo, T.・Murata, Y.・Yasumatsu, K.・Nakashima, A.・Katsukawa, H.・Sako, N.・Ninomiya, Y.
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Journal Title
Biochem Biophys Res Commun 367
Pages: 356-363
Related Report
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[Journal Article] Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-triphosphate receptor2007
Author(s)
Hisatsune, C.・Yasumatsu, K.・Takahashi-Iwanaga, H.・Ogawa, N.・Kuroda, Y.・Yoshida, R.・Ninomiya, Y.・Mikoshiba, K.
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Journal Title
J.Biol. Chem. 282
Pages: 37221-37231
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[Journal Article] Trpm5 null mice respond to bitter, sweet and umami compounds.2006
Author(s)
Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Perez CA, Shigemura N, Yoshida R, Mosinger B Jr, Glendinning JI, Ninomiya Y, Margolskee RF
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Journal Title
Chem. Senses 31
Pages: 253-264
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[Journal Article] Induction of salivary kallikreins by the diet containing a sweet-suppressive peptide, gurmarin, in the rat2006
Author(s)
Yamada A, Nakamura Y, Sugita D, Shirosaki S, Ohkuri T, Katsukawa H, Nonaka K, Imoto T, Ninomiya Y
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Journal Title
Biochem Biophys Res Commun. 346
Pages: 386-392
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[Journal Article]
Author(s)
Yasumatsu K, Horio N, Murata Y, Shirosaki S, Ohkuri T, Yoshida R, Ninomiya Y
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Journal Title
Am J Clin Nutr. (In press)
Related Report
Peer Reviewed
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[Presentation] Detecting the taste-specific temporal type by fMRI-salty and sweet-2009
Author(s)
Nakamura Y, Goto TK, Tokumori K, Yoshiura T, Kobayashi K, Nakamura Y, Honda H, Ninomiya Y, Yoshiura K
Organizer
31thAchemS
Place of Presentation
Sarasota, Florida, USA
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[Presentation] Different response properties between Type II and TypeIII taste bud cells in mouse fungifom papillae2009
Author(s)
Yoshida R, Yasuo T, MurataY, Jyotaki M, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y
Organizer
31thAchemS
Place of Presentation
Sarasota, Florida, USA
Related Report
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[Presentation] Gurmarin inhibits the Sweet Receptor by Binding to the Venus Fly Trap Module of T1R32009
Author(s)
Emeline L.Maillet, Laura Pelletier, Timotlty J.Cardozo, Jeniffer Quijada, Prisca Silie, Baobua Zhao, YUzo Ninomiya, Marianna Max, Robert F.Margolskee
Organizer
31thAchemS
Place of Presentation
Sarasota, Florida, USA
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[Presentation] Taste responses of mouse fungiform taste bud cells expressing gustducin or GAD672009
Author(s)
Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, Shigemura N, Yanagawa Y, Obata K, Ueno H, Margolskee RF
Organizer
第7回味覚嗅覚の分子神経機構
Place of Presentation
福岡市
Related Report
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[Presentation] Modulation and transmission of sweet taste information for energy homeostasis2008
Author(s)
Ninomiya Y, Yoshida R, Murata Y, Yasumatsu K, Ohkuri T, Shirosaki S, Sanematsu K, Yasuo T, Nakamura Y, Shigemura N
Organizer
第15回ISOT
Place of Presentation
San Francisco, USA
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[Presentation] Temperature-And Gurmarin-Sensitivity Of The Chorda Tympani Nerve Responses To Sweeteners In The Wild-Type, T1R3-,Ggust-, TRPM5-KO Mice2008
Author(s)
Ohkuri T, Yasumatsu K, Jyotaki M, Kusuhara Y, Yasuo T, Murata Y, Margolskee RF, Ninomiva Y
Organizer
第15回ISOT
Place of Presentation
San Francisco, USA
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[Presentation] Polymorphisms of ENaC asubunit are associated with strain differences in amiloride sensitive NaCl responses in mice.2007
Author(s)
Shigemura, N・Ohkuri, T・Sadamitsu, C・Yasumatsu, K・Yoshida, R・GK, Beauchamp・AA, Bachmanov・Ninomiya, Y
Organizer
AChemS 29th Annual Meeting
Place of Presentation
Sarasota, Florida, SUA
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