| Budget Amount *help |
¥64,400,000 (Direct Cost: ¥64,400,000)
Fiscal Year 2010: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2009: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2008: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2007: ¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2006: ¥12,100,000 (Direct Cost: ¥12,100,000)
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| Research Abstract |
Potential modal-shifts of sensitivities of taste cell sensors were studied by examining cellular and behavior responses to sweet and salty stimuli under various molecular and environmental conditions. The results suggest that as comparable with the action of central nervous system, endocannabinoids, orexigenic mediators, enhanced peripheral sweet taste sensitivities, that opposes the action of leptin, an anorexigenic mediator. Species-specific sweet-suppressing effect of gurmarin occurs its binding to the mouse extracellular domain of T1r3(partially that of T1r2). In addition, molecular based modal-shift was found in sodium-salt sensor ENaC channels where an amino acid change (R616W) in αsubunit may produce variation in amiloride-sensitivity of the channel.
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