| Budget Amount *help |
¥63,700,000 (Direct Cost: ¥63,700,000)
Fiscal Year 2010: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2009: ¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2008: ¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2007: ¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2006: ¥13,100,000 (Direct Cost: ¥13,100,000)
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| Research Abstract |
We showed direct interaction between Na_x channels and alpha subunits of Na^+/K^+-ATPase, which brings about Na-dependent activation of the metabolic state of the glial cells. The metabolic enhancement leading to extensive lactate production was observed in the subfornical organ (SFO). Furthermore, lactate, as well as Na, stimulated the activity of GABAergic neurons in the SFO. These results suggest that the information on a physiological increase in the Na level of body fluids, which is sensed by Na_x in glial cells, is transmitted to neurons by lactate as a mediator to regulate neural activities of the SFO. We further demonstrated that a ganglioneuroma formed in the PNS triggered an autoimmune channelopathy targeting Na_x, the Na-level sensor of body fluids in the brain, leading to essential hypernatremia.
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