| Project Area | Molecular interaction and modal shift of cellular sensors |
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| Project/Area Number |
18077008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Nobuyuki 京都大学, 農学研究科, 助教 (50370135)
INOUE Hana 東京医科大学, 医学部, 助教 (20390700)
LEE Elbert 米国在住 (30425425)
NUMATA Tomohiro 京都大学, 工学研究科, 助教 (20455223)
AKATSUKA Yuhko 鈴鹿医療科学大学, 薬学部薬学科, 准教授 (90321611)
AKITA Tenpei 生理学研究所, 細胞器官研究系, 特任助教 (00522202)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA Toshiaki 生理学研究所, 細胞器官研究系, 特任准教授 (00373283)
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| Project Period (FY) |
2006 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥81,300,000 (Direct Cost: ¥81,300,000)
Fiscal Year 2010: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2009: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2008: ¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 2007: ¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2006: ¥15,300,000 (Direct Cost: ¥15,300,000)
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| Keywords | アニオンチャネル / カチオンチャネル / TRPM7 / モーダルシフト / 蛋白-蛋白相互作用 / メカノセンサー / 容積センサー / ROSセンサー / 分子連関 / ABCF2 |
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| Research Abstract |
Mechano-sensor cation channel TRPM7 and volume-sensor anion channel VSOR play important roles in the cell volume regulation mechanism which determines cell survival and death. The present study showed that TRPM7 exhibits functional modal shifts from a mechano-sensor to an osmo-sensor and a proton-sensor whereas VSOR does so from a volume-sensor to a ROS-sensor and ABC protein-sensor under certain conditions. The present study also showed that TRPM7 interacts with VSOR not only functionally thereby accomplishing cell volume regulation but also molecularly thereby regulating the VSOR activity.
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