| Budget Amount *help |
¥62,200,000 (Direct Cost: ¥62,200,000)
Fiscal Year 2010: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2009: ¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 2008: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2007: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2006: ¥11,700,000 (Direct Cost: ¥11,700,000)
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| Research Abstract |
Microglia sense ATP leaked from damaged neurons by the ATP-sensor P2Y12, and migrate toward the injured site. If they meet UDP, eat-me signal, there, microglia start to phagocytose the damaged cells or debris to remove them from the brain. The UDP sensor is P2Y6. Microglia change their mode from migration to phagocytosis (modal-shift), which was associated with down- and up-regulation of P2Y12 and P2Y6, respectively. By such a modal-shift, microglia maintain the homeostasis of the CNS.
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