Information processing by the interaction of the ATP-sensors and mechano-sensors

• Project Area: Molecular interaction and modal shift of cellular sensors
• Project/Area Number: 18077011
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Yamanashi
• Principal Investigator: KOIZUMI Schuichi University of Yamanashi, 大学院・医学工学総合研究部, 教授 (10280752)
• Co-Investigator(Kenkyū-buntansha): FUJISHITA Kayoko 山梨大学, 大学院・医学工学総合研究部, 助教 (10443102) ; SHIBATA Keisuke 山梨大学, 大学院・医学工学総合研究部, 助教 (50580411) ; OKUBO Satoko 国立医薬品食品衛生研究所, 研究員 (20274954)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥62,200,000 (Direct Cost: ¥62,200,000); Fiscal Year 2010: ¥12,400,000 (Direct Cost: ¥12,400,000); Fiscal Year 2009: ¥12,300,000 (Direct Cost: ¥12,300,000); Fiscal Year 2008: ¥13,400,000 (Direct Cost: ¥13,400,000); Fiscal Year 2007: ¥12,400,000 (Direct Cost: ¥12,400,000); Fiscal Year 2006: ¥11,700,000 (Direct Cost: ¥11,700,000)
• Keywords: ミクログリア / 貪食 / アストロサイト / 神経細胞傷害 / ATP / UDP / ATPセンサー / モーダルシフト / 貪食センサー / P2受容体 / 傷害 / TGF-β / TNF-α / 脳傷害 / サイトカイン / 炎症 / UTP / 神経細胞障害

Research Abstract

Microglia sense ATP leaked from damaged neurons by the ATP-sensor P2Y12, and migrate toward the injured site. If they meet UDP, eat-me signal, there, microglia start to phagocytose the damaged cells or debris to remove them from the brain. The UDP sensor is P2Y6. Microglia change their mode from migration to phagocytosis (modal-shift), which was associated with down- and up-regulation of P2Y12 and P2Y6, respectively. By such a modal-shift, microglia maintain the homeostasis of the CNS.

Research Products

• [Journal Article] New roles of astrocytes (2011)
  • Author(s): Koizumi S.
  • Journal Title: Japanese Journal of Neurosurgery Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] グリア・ニューロン連関 (2011)
  • Author(s): 小泉修一
  • Journal Title: BioClinica Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Synchronized Ca^2+ oscillations in astrocytes. (2010)
  • Author(s): Koizumi, S.
  • Journal Title: FEBS J. 277 Pages: 286-292
• [Journal Article] Synchronized Ca^<2+> oscillations in astrocytes. (2010)
  • Author(s): Koizumi S.
  • Journal Title: FEBS J. Volume: 277 Pages: 286-292
  • Peer Reviewed
• [Journal Article] Synchronized Ca^<2+> oscillations in astrocytes. (2010)
  • Author(s): Koizumi S.
  • Journal Title: FEBS J 277 Pages: 286-292
  • Peer Reviewed
• [Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca^2+ influx and ATP release in primary urothelial cell cultures. (2009)
  • Author(s): Mochizuki, T., Tokabe, T., Araki, I., Fujishita, K., Shibasaki, K., Uchida, K., Naruse, K., Koizumi, S., Takeda, M.and Tominaga, M.
  • Journal Title: J.Biol.Chem. 284 Pages: 21257-21264
• [Journal Article] Grape seed extract (GSE) acting on astrocytes, reveals its neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. (2009)
  • Author(s): Fujishita, K., Ozawa, T., Shibata, K., Tanabe, S., Sato, Y., Hisamoto, M., Okuda, T., Koizumi, S.
  • Journal Title: Cell Mol Neurobiol. 29 Pages: 1121-1129
• [Journal Article] Direct observation of ATP-induced conformational changes in single P2X_4 receptors. (2009)
  • Author(s): Shinozaki, Y., Sumitomo, K., Tsuda, M., Koizumi, S., Inoue, K.and Torimitsu, K.
  • Journal Title: PLoS Biology 7 Pages: 103-103
• [Journal Article] Activation of P2Y_1 receptors in astrocytes interferes the H_2O_2-evoked death promoting signaling cascades. (2009)
  • Author(s): Shinozaki, T., Koizumi, S., Ohno, T., Nagao, T.and Inoue, K.
  • Journal Title: Glia 54(6) Pages: 606-618
• [Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca^<2+> influx and ATPrelease in primary urothelial cell cultures. (2009)
  • Author(s): Mochizuki T
  • Journal Title: J.Bio.Chem 284 Pages: 21257-21264
  • Peer Reviewed
• [Journal Article] Grape seed extract (GSE) acting on astrocytes, reveals its neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. (2009)
  • Author(s): Fujishita K
  • Journal Title: Cell Mol Neurobiol 29 Pages: 1121-1129
  • Peer Reviewed
• [Journal Article] Direct observation of ATP-induced conformational changes in single P2X_4 receptors. (2009)
  • Author(s): Shinozaki Y
  • Journal Title: PLoS Biology 7
  • Peer Reviewed
• [Journal Article] P2Y_6-evoked microglial phagocytosis. (2009)
  • Author(s): Inoue K
  • Journal Title: International Review of Neurobiology 85 Pages: 159-163
  • Peer Reviewed
• [Journal Article] 高速原子間力顕微鏡を用いた受容体の一分子イメージング (2009)
  • Author(s): 篠崎陽一
  • Journal Title: 日薬理誌 133 Pages: 68-72
  • Peer Reviewed
• [Journal Article] 脳内グリア細胞におけるATPセンサーを介した情報伝達 (2009)
  • Author(s): 小泉修一
  • Journal Title: 生化学 81 Pages: 35-38
  • NAID: 10024915713
  • Peer Reviewed
• [Journal Article] 脳内グリア細胞におけるATPセンサーを介した情報伝達 (2009)
  • Author(s): 小泉修一、井上和秀
  • Journal Title: 生化学 81 Pages: 35-38
  • NAID: 10024915713
  • Peer Reviewed
• [Journal Article] Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury (2008)
  • Author(s): Tsuda M, Toyomitsu E, Komatsu T, Masuda T, Kunifusa E, Nasu-Tada K, Koizumi S, Yamamoto K, Ando J, Inoue K.
  • Journal Title: Glia 56 Pages: 579-585
  • Peer Reviewed
• [Journal Article] ATPを介したグリア・ニューロン相互作用 (2008)
  • Author(s): 小泉修一
  • Journal Title: 細胞 40 Pages: 12-16
  • Peer Reviewed
• [Journal Article] ニューロン・ミクログリア相互作用 (2008)
  • Author(s): 小泉修一、井上和秀
  • Journal Title: BioClinica 23 Pages: 97-102
  • Peer Reviewed
• [Journal Article] Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase. (2007)
  • Author(s): Shinozaki, Y., Sato, Y., Koizumi, S., Ohno, Y., Nagao, T.and Inoue, K.
  • Journal Title: Neurosci. 147 Pages: 153-163
• [Journal Article] UDP acting at P2Y_6 receptors is a novel mediator of microglial phagocytosis. (2007)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B.V., Jacobson, K.A., Kohsaka, S., Inoue, K.
  • Journal Title: Nature 446 Pages: 1091-1095
• [Journal Article] アストロサイトを介したニューロン・アストロサイト相互調節 (2007)
  • Author(s): 小泉修一、藤下加代子
  • Journal Title: Brain and Nerve 56 Pages: 707-715
• [Journal Article] (2007)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B.V., Jacobson, K.A., Kohsaka, S. and Inoue, K.
  • Journal Title: Nature 446 Pages: 1091-1095
  • Peer Reviewed
• [Journal Article] UDP acting at P2Y_6 receptors is a novel mediator of microglial phagocytosis (2007)
  • Author(s): Koizumi, S.Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B.V., Jacobson, K.A., Kohsaka, S.and Inoue, K.
  • Journal Title: Nature 446 Pages: 1091-1095
  • Peer Reviewed
• [Journal Article] Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase (2007)
  • Author(s): Shinozaki, Y., Sato, Y., Koizumi, S., Ohno, Y., Nagao, T.and Inoue, K.(2007)
  • Journal Title: Neurosci. 147 Pages: 153-163
  • Peer Reviewed
• [Journal Article] The role of nucleotides in the neuron-glia communication responsible for the brain functions (2007)
  • Author(s): Inoue K, Koizumi S, Tsuda M.
  • Journal Title: J.Neurochem. 102 Pages: 1447-1458
  • Peer Reviewed
• [Journal Article] The role of nucleotides in the neuron-glia communication responsible for the brain functions J.Neurochem.,102,1447-1458 (2007)
  • Author(s): Inoue K, Koizumi S, Tsuda M.
  • Journal Title: J.Neurochem. 102 Pages: 1447-1458
  • Peer Reviewed
• [Journal Article] グリア細胞を標的とする医薬品の創製 (2007)
  • Author(s): 工藤佳久, 小泉修一, 和田圭司, 橋本謙二
  • Journal Title: 日薬理誌 130 Pages: 185-192
  • NAID: 10025739725
• [Journal Article] アストロサイトを介したニューロン・アストロサイト相互調節 (2007)
  • Author(s): 小泉修一, 藤下加代子
  • Journal Title: Brain and Nerve 56 Pages: 707-715
  • Peer Reviewed
• [Journal Article] 4.G蛋白質共役型ATP受容体と痛み. (2006)
  • Author(s): 小泉修一, 藤下加代子, 津田誠, 井上和秀
  • Journal Title: ペインクリニック 27 Pages: 560-568
• [Journal Article] ATPを介した皮膚ケラチノサイト間情報連絡と痛み (2006)
  • Author(s): 小泉修一, 藤下加代子, 津田誠, 井上和秀 (2006)
  • Journal Title: Pain Research 21 Pages: 133-139
• [Journal Article] Retinoic acids increase P2X_2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC12 cells. (2006)
  • Author(s): Tozaki-Saito H., Koizumi, S., Sato, Y., Tsuda, M., Nagao, T., Inoue, K
  • Journal Title: Mol. Pharmacol. 70 (1) Pages: 319-328
• [Journal Article] ATP stimulates interleukin-6 production via P2Y receptors in human H_aC_aT keratinocytes. (2006)
  • Author(s): Yoshida H, Kobayashi D, Ohkubo S, Nakahata N
  • Journal Title: Eur J Pharmacol. 540 Pages: 1-9
• [Journal Article] Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in H_aC_aT keratinocytes. (2006)
  • Author(s): Kobayashi D, Ohkubo S, Nakahata N
  • Journal Title: J Pharmacol Sci. 102 (4) Pages: 368-376
• [Journal Article] Direct observation of ATP-induced conformational changes in single P2X_4 receptors
  • Author(s): Shinozaki, Y., Sumitomo, K., Tsuda, M., Koizumi, S., Inoue, K. and Torimitsu, K.
  • Journal Title: PLoS Biology in press
  • Peer Reviewed
• [Journal Article] Grape seed extract (GSE) acting on astrocytes, reveals its neuronal protection against oxidative stress via interleukin-6-mediated mechanisms.
  • Author(s): Fujishita, K., Ozawa, T., Shibata, K., Tanabe, S., Sato, Y., Hisamoto, M., Okuda, T. and Koizumi, S.
  • Journal Title: Cell Mol Neurobiol. in press
  • Peer Reviewed
• [Journal Article] Grape seed extract (GSE) acting on astrocytes, reveals its neuronal protection against oxidative stress via interleukin-6-mediated mechanisms
  • Author(s): Fujishita, K., Ozawa, T., Shibata, K., Tanabe, S., Sato, Y, Hisamoto, M., Okuda, T. and Koizumi, S.
  • Journal Title: Cell Mol Neurobiol (印刷中)
  • Peer Reviewed
• [Journal Article] Direct observation of ATP-induced conformational changes in single P2X_4 receptors
  • Author(s): Shinozaki, Y., Sumitomo, K., Tsuda, M., Koizumi. S., Inoue, K. and Torimitsu, K.
  • Journal Title: PLoS Biology (印刷中)
  • Peer Reviewed
• [Journal Article] UDP acting at P2Y_6 receptors is a novel mediator of microglial phagocytosis.
  • Author(s): Koizumi.S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B.V., Jacobson, K.A., Kohsaka, S., Inoue, K.
  • Journal Title: Nature (印刷中)
• [Presentation] Astrocytic ATP release and brain functions. (2011)
  • Author(s): Koizumi, S.
  • Organizer: 第84回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-22
• [Presentation] Mechanisms of release of gliotransmitter ATP and neuronal functions. (2010)
  • Author(s): Koizumi, S.
  • Organizer: Asian-Pacific Neurochemical Society
  • Place of Presentation: Phuket, Thai
  • Year and Date: 2010-10-18
• [Presentation] Mechanisms underlying ATP release from astrocytes. (2010)
  • Author(s): Koizumi, S.
  • Organizer: Naito International Conference
  • Place of Presentation: 湘南
  • Year and Date: 2010-10-06
• [Presentation] グリア細胞制御タンパクATP受容体と脳機能 (2010)
  • Author(s): 小泉修一
  • Organizer: 日本薬理学会関東部会
  • Place of Presentation: 静岡
  • Year and Date: 2010-06-05
• [Presentation] グリア細胞と痛み (2010)
  • Author(s): 小泉修一
  • Organizer: 第5回埼玉ペインクリニック研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-01-30
• [Presentation] Mechanisms underlying upregulation of microglial P2Y6 receptors. (2010)
  • Author(s): Koizumi, S., Fujishita, K., Nakao, A.
  • Organizer: Society for Neuroscience Meeting
  • Place of Presentation: San Diego, USA.
• [Presentation] Glia and diseases. (2010)
  • Author(s): Koizumi S
  • Organizer: Japan-France Frontier of Sciences
  • Place of Presentation: France, Poitiers
• [Presentation] Regulation of glial activation by KAMPO -therapeutic strategy for neuropathic pain. (2010)
  • Author(s): Koizumi S
  • Organizer: (シンポジウム)第83回日本薬理学会
  • Place of Presentation: 大阪
• [Presentation] The pathology of neuropathic pain characterized by mechanisms of analgesic effect of Bushimatsu. (2010)
  • Author(s): Shibata K
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
• [Presentation] Mechanisms underlying fluoxetine-evoked increase in BDNF in hippocampal astrocytes. (2010)
  • Author(s): Koizumi S
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
• [Presentation] Loss of UDP-glucose signaling evokes release of MMP-9 in astrocytes. (2010)
  • Author(s): Kinoshita M
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
• [Presentation] Protection of the methylmercury-induced neuronal cell death by astrocytes via interleukin-6-mediated mechanisms. (2010)
  • Author(s): Noguchi Y
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
• [Presentation] Mechanisms underlying upregulation of microglial P2Y6 receptors after kainic acid treatment (2010)
  • Author(s): Fujishita K
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
• [Presentation] 抗うつ薬の有望な標的としてのアストロサイト (2010)
  • Author(s): 小泉修一
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] グリア細胞のATPセンサーによる脳機能制御 (2010)
  • Author(s): 小泉修一
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 盛岡
• [Presentation] ニューロン-グリア連関 (2009)
  • Author(s): 小泉修一
  • Organizer: 第25回脳機能分子研究会
  • Place of Presentation: 京都大学、京都市
  • Year and Date: 2009-12-05
• [Presentation] ニューロン-グリア連関-アストロサイトの情報発信メカニズムを中心として- (2009)
  • Author(s): 小泉修一
  • Organizer: 東京大学新領域特別講義
  • Place of Presentation: 柏市
  • Year and Date: 2009-11-25
• [Presentation] Neuron-to-glia communication in the CNS. (2009)
  • Author(s): Koizumi S
  • Organizer: The 6^<th> Joint Symposium between Univ.Bonn and Waseda Univ.
  • Place of Presentation: Tokyo
  • Year and Date: 2009-06-16
• [Presentation] グリア細胞と疼痛 (2009)
  • Author(s): 小泉修一
  • Organizer: 第17回甲信疼痛治療研究会
  • Place of Presentation: 甲府
  • Year and Date: 2009-06-13
• [Presentation] Glial function and ischemic brain injury. (2009)
  • Author(s): Koizumi, S., Fujishita, K.
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-18
• [Presentation] Analgesic effect of Bushimatsu on neuropathic pain. (2009)
  • Author(s): Shibata, K., Sugawara, K., Fujishita, K. Ozawa, T. Matsukawa, T., Suzuki, T. and Koizumi, S.
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] Microglial proliferation mediated by P2Y_2 receptors after kainate-induced neuronal injury. (2009)
  • Author(s): Tanaka, Y., Fujishita, K. and Koizumi, S.
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] Antidepressants increase BDNF in astrocytes. (2009)
  • Author(s): Ozawa, T., Fujishita, K., Shibata, K and Koizumi, S.
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] Mechanisms underlying upregulation of P2Y_6 receptors in microglia in kainate-induced injury model. (2009)
  • Author(s): Fujishita,K., Nakao,A., Koizumi, S.
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] Contribution of astrocytes to the "French paradox" in the CNS. (2009)
  • Author(s): Koizumi, S., Fujishita, K., Shibata, K., Ozawa, T., Tanabe, S., Sato, Y.
  • Place of Presentation: Paris, France.
• [Presentation] Mechanisms underlying upregulation of P2Y_6 receptors in microglia in kainate-induced injury model. (2009)
  • Author(s): Fujishita, K., Nakao, A., Inoue, K.and Koizumi, S.
  • Place of Presentation: Paris, France.
• [Presentation] Contribution of astrocytes to the "French paradox" in the CNS. (2009)
  • Author(s): Koizumi, S., Fujishita, K., Shibata, K., Ozawa, T.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Chicago, USA.
• [Presentation] Cell-to-cell communication mediated by extracellular nucleotides in the CNS. (2009)
  • Author(s): Koizum, S.
  • Organizer: A lecture in commemoration of receiving prize "Japan Academy Medal" Fukuoka Purine 2009
  • Place of Presentation: Fukuoka.
• [Presentation] Fujishita, K.Glial function and ischemic brain injury.(シンポジウム) (2009)
  • Author(s): Koizumi, S.
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] 神経因性疾痛へのブシ末の鎮痛効果 (2009)
  • Author(s): 小泉修一
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保
• [Presentation] グリア細胞の神経化学 (2009)
  • Author(s): 小泉修一
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保
• [Presentation] 神経細胞-アストロサイトミクログリア三者間相互作用がもたらすミクログリアの食食細胞へのダイナミックなモーダルシフト (2009)
  • Author(s): Koizumi S
  • Organizer: 特定領域研究夏の班会議
  • Place of Presentation: 沖縄
• [Presentation] Cell-to-cell communication mediated by extracellular nucleotides in the CNS. (2009)
  • Author(s): 柴田圭輔
  • Organizer: A lecture in commemoration of receiving prize "Japan Academy Medal" Fukuoka Purine 2009
  • Place of Presentation: Fukuoka
• [Presentation] Neuron-microglia interaction mediated by multiple P2Y receptors. (2009)
  • Author(s): Koizumi S
  • Organizer: IUPS
  • Place of Presentation: Kyoto
• [Presentation] Mechanisms underlying upregulation of P2Y6 receptors in microglia in kainate-induced injury model (2009)
  • Author(s): Fujishita K
  • Organizer: IRS
  • Place of Presentation: Kyoto
• [Presentation] Contribution of astrocytes to the "French paradox" in the CNS. (2009)
  • Author(s): Koizumi S
  • Organizer: Euroglia
  • Place of Presentation: Paris, France.
• [Presentation] Mechanisms underlying upregulation of P2Y_6 receptors in microglia in kainate-induced injury model. (2009)
  • Author(s): Fujishita K
  • Organizer: Euroglia
  • Place of Presentation: Paris, France
• [Presentation] Contribution of astrocytes to the "French paradox" in the CNS. (2009)
  • Author(s): Koizumi S
  • Organizer: Society for Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Glial function and ischemic brain injury (2009)
  • Author(s): Koizumi, S., Fujishita, K.
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] Mechanisms underlying upregulation of P2Y_6 receptors in microglia in kainate-induced injury model (2009)
  • Author(s): Fujishita, K., Nakao, A., Koizumi, S.
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] Microglial proliferation mediated by P2Y_2 receptors after kainate-induced neuronal injury (2009)
  • Author(s): Tanaka, Y., Fujishita, K. and Koizumi, S.
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] Antidepressants increase BDNF in astrocytes (2009)
  • Author(s): Ozawa, T., Fujishita, K., Shibata, K and Koizumi. S.
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] Analgesic effect of Bushimatsu on neuropathic pain (2009)
  • Author(s): Shibata, K., Sugawara, K., Fujishita, K. Ozawa, T. Matsukawa, T., Suzuki, T. and Koizumi. S.
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] グリア細胞による脳機能の制御 (2008)
  • Author(s): 小泉修一
  • Organizer: 山梨神経科学研究会
  • Place of Presentation: 山梨
  • Year and Date: 2008-11-25
• [Presentation] グリア細胞による脳機能の制御 (2008)
  • Author(s): 小泉修一
  • Organizer: 第20回山梨神経科学研究会
  • Place of Presentation: 山梨
  • Year and Date: 2008-11-25
• [Presentation] Astrocyte-to-pericyte communication mediated by ATP. (2008)
  • Author(s): Fujishita, K., Sueishi, K., Takata, F., Kataoka, Y., and Koizumi,S.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-16
• [Presentation] ミクログリアP2Y6受容体発現亢進の分子メカニズム (2008)
  • Author(s): 藤下加代子、中尾篤人、小泉修一
  • Organizer: グリア研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-08
• [Presentation] アストロサイトのATP情報発信 (2008)
  • Author(s): 小泉修一、藤下加代子
  • Organizer: 岡崎生理研研究会
  • Place of Presentation: 岡崎市
  • Year and Date: 2008-09-04
• [Presentation] Extracellular nucleotides regulate two different microglial functions, i.e., phagocytosis and chemotaxis. (2008)
  • Author(s): Koizumi, S.
  • Organizer: OIST シンポジウム
  • Place of Presentation: 沖縄
  • Year and Date: 2008-04-18
• [Presentation] Extracellular nucleotides regulate two different microglial functions, i. e., phagocytosis and chemotaxis (2008)
  • Author(s): Koizumi. S.
  • Organizer: OIST
  • Place of Presentation: 沖縄
  • Year and Date: 2008-04-18
• [Presentation] The "eat-me signal UDP" and microglial phagocytosis. (2008)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S. and Inoue, K.
  • Organizer: 日本薬理学会(シンポジウム)
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] Astrocyte-to-pericyte communication mediated by ATP. (2008)
  • Author(s): Fujishita, K., Sueishi, K., Takata, F., Kataoka, Y., Koizumi, S.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC, USA.
• [Presentation] The "eat-me signal UDP" and microglial phagocytosis mediated by P2Y6 receptors. (2008)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S. and Inoue, K.
  • Organizer: 日米グリアシンポジウム
  • Place of Presentation: Philadelphia
• [Presentation] Microglial nucleotide sensor P2Y6 receptors and brain functions (2008)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y, Kaoru, T., Shinozaki, Y., Fujishita, K., Ohsawa, K, Tsuda, M., Kohsaka, S. and Inoue, K.
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 横浜
• [Presentation] アストロサイトのATP情報発信 (2008)
  • Author(s): 小泉修一、藤下加代子
  • Organizer: 岡崎生理研研究会
  • Place of Presentation: 岡崎
• [Presentation] Astrocyte-to-pericyte communication mediated by ATP (2008)
  • Author(s): Fujishita, K., Sueishi, K., Takata, F., Kataoka, Y., and Koizumi, S.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] The"eat-me signal UDP"and microglial phagocytosis (2008)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S.and Inoue, K.
  • Organizer: 第81回日本薬理学会(シンポジウム)
  • Place of Presentation: 横浜
• [Presentation] The"eat-me signal UDP"and microglial phagocytosis mediated by P2Y6 receptors (2008)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S.and Inoue, K.
  • Organizer: 日米グリアシンポジウム
  • Place of Presentation: Philadelphia(USA)
• [Presentation] 細胞外ヌクレオチドセンサーP2Y6受容体とミクログリアの貪食 (2007)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S. and Inoue, K.
  • Organizer: 日本生化学・分子生物学合同大会(シンポジウム)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] 中枢神経傷害時の細胞外ヌクレオチドとミクログリアの貪食作用 (2007)
  • Author(s): 小泉修一, 重本由香里, 多田薫, 篠崎陽一, 大澤圭子, 津田誠, 高坂新一, 井上和秀
  • Organizer: グリア研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-11-17
• [Presentation] UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. (2007)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S. and Inoue, K.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-08
• [Presentation] "Eat-me signal"UDPとミクログリアの貪食作用 (2007)
  • Author(s): 小泉修一
  • Organizer: 名古屋大学COEシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-07
• [Presentation] "Eat-me-signal"UDPとミクログリアの貪食作用 (2007)
  • Author(s): 小泉修一、重本由香里、多田 薫、篠崎陽一、大澤圭子、津田誠、高坂新一、井上和秀
  • Organizer: 第4回GPCR 研究会(シンポジウム)
  • Place of Presentation: 山梨
  • Year and Date: 2007-05-11
• [Presentation] 中枢神経傷害時の細胞外ヌクレオチドとミクログリアの貪食作用 (2007)
  • Author(s): 小泉修一, 重本由香里, 多田薫, 篠崎陽一, 大澤圭子, 津田誠, 高坂新一, 井上和秀
  • Organizer: 第4回GPCR研究会(シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] 細胞外ヌクレオチドを介した損傷神経細胞-グリア細胞連関 (2007)
  • Author(s): 小泉修一, 重本由香里, 多田薫, 篠崎陽一, 大澤圭子, 津田誠, 高坂新一, 井上和秀
  • Organizer: 生理研研究会
  • Place of Presentation: 岡崎
• [Presentation] ミクログリアの貪食能を規定する新規分子UDP (2007)
  • Author(s): 小泉修一, 重本由香里, 多田薫, 篠崎陽一, 大澤圭子, 津田誠, 高坂新一, 井上和秀
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
• [Presentation] UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis (2007)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S.and Inoue, K.
  • Organizer: 北米神経科学会
  • Place of Presentation: San Diego,(USA)
• [Presentation] 細胞外ヌクレオチドセンサーP2Y_6受容体とミクログリアの貪食 (2007)
  • Author(s): Koizumi, S., Shigemoto-Mogami, Y., Shinozaki, Y., Ohsawa, K., Tsuda, M., Jacobson, K., Kohsaka, S.and Inoue, K.
  • Organizer: 日本生化学・分子生物学合同大会(シンポジウム)
  • Place of Presentation: 横浜
• [Book] ATPを介したグリア・ニューロン相互作用、細胞 (2008)
  • Author(s): 小泉修一
  • Publisher: ニューサイエンス社
• [Book] ニューロン・ミクログリア相互作用、BioClinica (2008)
  • Author(s): 小泉修一、井上和秀
  • Publisher: 北隆館
• [Book] TP を介したグリア・ニューロン相互作用、細胞 (2008)
  • Author(s): 小泉修一
  • Publisher: ニューサイエンス社
• [Book] 細胞 (2008)
  • Author(s): 小泉修一
  • Total Pages: 16
  • Publisher: ATPを介したグリア・ニューロン相互作用
• [Book] BioClinica (2008)
  • Author(s): 小泉修一、井上和秀
  • Total Pages: 12
  • Publisher: ニューロン・ミクログリア相互作用
• [Book] 細胞 (2008)
  • Author(s): 小泉 修一
  • Total Pages: 16
  • Publisher: ATPを介したグリア・ニューロン相互作用
• [Book] Bioclinica (2008)
  • Author(s): 小泉 修一, 井上和秀
  • Total Pages: 12
  • Publisher: ニューロン・ミクログリア相互作用
• [Remarks]
  • URL: http://www.47news.jp/CN/200704/CN2007040501000448.html
• [Remarks] ホームページ
  • URL: http://www.med.yamanashi.ac.jp/clinical_basic/pharmaco/
• [Patent(Industrial Property Rights)] グリア細胞の活性化抑制組成物 (2009)
  • Inventor(s): 小泉修一(山梨大学)、柴田圭輔(山梨大学)、藤下加代子(山梨大学)、菅原健(山梨大学)、松川隆(山梨大学)
  • Industrial Property Rights Holder: 小泉修一(山梨大学)、柴田圭輔(山梨大学)、藤下加代子(山梨大学)、菅原健(山梨大学)、松川隆(山梨大学)
  • Industrial Property Number: 2009-267902
  • Filing Date: 2009-11-25
• [Patent(Industrial Property Rights)] 神経細胞の維持や修復に有用な薬剤 (2009)
  • Inventor(s): 小泉修一(山梨大学)、柴田圭輔(山梨大学)、小澤哲朗(山梨大学)、柴田圭輔(山梨大学)、松川隆(山梨大学)
  • Industrial Property Rights Holder: 小泉修一(山梨大学)、柴田圭輔(山梨大学)、小澤哲朗(山梨大学)、柴田圭輔(山梨大学)、松川隆(山梨大学)
  • Industrial Property Number: 2009-183294
  • Filing Date: 2009-08-06