| Project Area | Molecular interaction and modal shift of cellular sensors |
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| Project/Area Number |
18077015
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
WAKABAYASHI Shigeo National Cardiovascular Center Research Institute, 分子生理部, 部長 (70158583)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Yuko 独立行政法人国立循環器病研究センター, 分子生理部, 室長 (80171908)
NISHITANI Tomoe 独立行政法人国立循環器病研究センター, 分子生理部, 室長 (50393244)
HISAMITSU Takashi 独立行政法人国立循環器病研究センター, 分子生理部, 研究員 (50327946)
YOUSSEF Ben Ammar 独立行政法人国立循環器病研究センター, 分子生理部, 流動研究員 (90463273)
KOBAYASHI SOUSHI 独立行政法人国立循環器病研究センター, 分子生理部, 流動研究員 (50511531)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Soushi 独立行政法人国立循環器病研究センター, 分子生理部, 流動研究員 (50511531)
SHIMADA Naoko 独立行政法人国立循環器病研究センター, 分子生理部, 流動研究員 (60600385)
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| Project Period (FY) |
2006 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥61,500,000 (Direct Cost: ¥61,500,000)
Fiscal Year 2010: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2009: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2008: ¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2007: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2006: ¥12,900,000 (Direct Cost: ¥12,900,000)
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| Keywords | 生理学 / 蛋白質 / 循環器・高血圧 / シグナル伝達 / バイオテクノロジー |
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| Research Abstract |
In the heart, various stress including hypertension and diabetes induce cardiac hypertrophy, but if such adaptations fail, heart failure occurs. Using genetically modified animals and physiological approaches for ion sensor proteins, specifically membrane ion transporters and Ca2+ sensors, we found that there is a close link between the progression of heart diseases and the spatiotemporal "modal shift" of these sensor proteins.
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