| Budget Amount *help |
¥130,910,000 (Direct Cost: ¥100,700,000、Indirect Cost: ¥30,210,000)
Fiscal Year 2022: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2021: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2020: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2019: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2018: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
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| Outline of Final Research Achievements |
In order to observe a "singularity phenomenon" which is an irreversible biological phenomenon induced by a "singularity cell" born or produced in rare cases, we have developed a non-invasive physiological function imaging method and a whole-cell imaging technique. The former, based on photoacoustic imaging technology, was developed to measure physiological functions of individual cells in mice in three dimensions in real time, achieving a spatial resolution of 1 micrometer and a temporal resolution of 10 seconds in a 1 square millimeter field of view. The latter, based on light sheet microscopy, we developed structured light-sheet technology and an incubator for light-sheet microscope, achieving a continuous imaging of all cells every 5 minutes for 24 hours during mouse embryogenesis.
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