| Budget Amount *help |
¥130,130,000 (Direct Cost: ¥100,100,000、Indirect Cost: ¥30,030,000)
Fiscal Year 2022: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2021: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2020: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2019: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2018: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Outline of Final Research Achievements |
We developed a visualization probe to distinguish and observe specific cells in a cell population and a technique to manipulate cell activity spatiotemporally. As an elemental technology for use in visualization probes, Sumire, a fluorescent protein that shows fluorescence by short-wavelength excitation, was developed. As a chemiluminescent probe, we developed a probe that detects the aggregation of tau protein, which causes Alzheimer's disease. In cell manipulation technology, an optogenetic tool using blue photoreceptors was developed to induce tau protein aggregation by light irradiation. In addition, technical assistance was provided to A-03 group and the public recruitment group, and mutual results were obtained.
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