| Co-Investigator(Kenkyū-buntansha) |
高島 明彦 学習院大学, 理学部, 教授 (00154774)
廣島 通夫 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (20392087)
松本 弦 長崎大学, 医歯薬学総合研究科(医学系), 講師 (50415303)
松田 恵子 慶應義塾大学, 医学部(信濃町), 講師 (40383765)
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| Budget Amount *help |
¥117,780,000 (Direct Cost: ¥90,600,000、Indirect Cost: ¥27,180,000)
Fiscal Year 2022: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2021: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2020: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2019: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2018: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Outline of Final Research Achievements |
In this study, we aimed to answer two questions: (1) When and where do "singularity cells," which acquire the ability to propagate and accumulate toxic tau oligomers, arise? (2) When, how, and how rapidly do tau oligomers released from singularity cells propagate to the cerebral cortex?
We established a technique to induce tau supramolecular complexes such as tau oligomers and tau aggregates by light irradiation. We also found candidate probes for the detection of tau oligomers. We identified the effects of intracellular and extracellular tau on neuronal synapses. We established a technique to analyze the dynamics of intracellular tau oligomers at single molecule resolution.
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