| Budget Amount *help |
¥72,930,000 (Direct Cost: ¥56,100,000、Indirect Cost: ¥16,830,000)
Fiscal Year 2022: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2021: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2020: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2019: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Outline of Final Research Achievements |
In nature, various proteins form specific assembly structures spontaneously. In this study, as a protein needle precision design for dynamic supramolecular assemblies, we realized a protein needle with precisely controlled functions as a molecular engine based on the crystal structure of gp5, experimental results from HSAFM, and molecular dynamics calculations. To achieve precise assembly of gp5 on a two-dimensional surface, we modified the protein to have an anisotropic assembly structure. As a result, we constructed a model from theoretical calculations and elucidated the mechanism of new assembly formation by understanding the experimental results of high-speed AFM using mathematical modeling.
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