| Budget Amount *help |
¥93,340,000 (Direct Cost: ¥71,800,000、Indirect Cost: ¥21,540,000)
Fiscal Year 2022: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2021: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2020: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2018: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
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| Outline of Final Research Achievements |
In this study, molecular simulations and NMR experiments were used to analyze the functions of various molecular engines. In collaboration within this group, we clarified the molecular recognition mechanism of TrkA, a biological molecular engine, and its inhibitor, TP1 peptide. In collaboration with group A01-1, molecular simulations of synthesized molecular engines such as synthesized ion channels and ionophores were performed to clarify their functional mechanisms. In collaboration with group B01-1, molecular simulations of the kinesin-microtubule system were performed to elucidate the mechanical response mechanism. In collaboration with groups A01, C01-1, the photointermediates of microbial rhodopsin during a light-activated state were identified and characterized by light-irradiated NMR spectroscopy.
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