| Budget Amount *help |
¥124,150,000 (Direct Cost: ¥95,500,000、Indirect Cost: ¥28,650,000)
Fiscal Year 2022: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2021: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2020: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2019: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2018: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
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| Outline of Final Research Achievements |
We have investigated the non-equilibrium dynamics of molecular engines, such as molecular motor proteins, spanning from single-molecule level to collective group level. We have found the underlying mechanism by which molecular motors govern positional symmetry breaking within a cell-sized space, enabling adhesion-independent migration driven by frictional force with the external environment. Moreover, at single molecule level, we have elucidated the strategy employed by F1-ATPase, a rotary molecular motor renowned as an intracellular energy factory, as it mitigates inefficient energy consumption through a rectifying ratchet system. This rectification mechanism not only achieves exceptional performance but also diminishes energetic cost associated with autonomous control. These findings have the potential to unravel design principles governing the development of novel molecular engines.
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