| Budget Amount *help |
¥171,990,000 (Direct Cost: ¥132,300,000、Indirect Cost: ¥39,690,000)
Fiscal Year 2022: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2021: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2020: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2019: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2018: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
|
|---|
| Outline of Final Research Achievements |
We have established a system to inactivate cofilin, which enters the synapse upon LTP, using a photosensitizing protein. We found that we can erase LTP which was once established,. Next, we showed that fear memory can be eliminated in animals. Using transcriptome analysis, we compared mRNA expression in the peripheral blood of patients with PTSD re-experiencing symptoms with mRNA expression in the hippocampus of mice after fear memory recall, and identified a group of genes that were commonly down-regulated in both groups. Since these genes decrease cAMP levels, we hypothesized that the decreased expression of these genes leads to activation of the cAMP signaling pathway. We proceeded to analyze the mechanism of fear memory by optogenetically manipulating the activity of the fear memory engram in the hippocampus during fear memory recall.
|
