• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Creation of controllable biological rhythm and pattern

Planned Research

Project AreaScience of Soft Robot: interdisciplinary integration of mechatronics, material science, and bio-computing
Project/Area Number 18H05474
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionKyushu University

Principal Investigator

Ito Hiroshi  九州大学, 芸術工学研究院, 准教授 (20512627)

Co-Investigator(Kenkyū-buntansha) 杉 拓磨  広島大学, 統合生命科学研究科(理), 准教授 (70571305)
永井 健  北陸先端科学技術大学院大学, 先端科学技術研究科, 講師 (40518932)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥97,500,000 (Direct Cost: ¥75,000,000、Indirect Cost: ¥22,500,000)
Fiscal Year 2022: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2021: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2020: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2019: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2018: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Keywords概日リズム / パターン / 植物 / クラゲ / 線虫 / イカ / リズム / 集団運動 / シアノバクテリア / ソフトロボット / コントロール / バラ / 蚕 / ケンサキイカ / 生物リズム / 生物パターン
Outline of Final Research Achievements

The group promoted research on biological phenomena that exhibit rhythm and pattern phenomena, expanding the boundaries of existing robots by providing them with controllable functions. As a major achievement, we showed that dynamic pattern formation occurs by mass culture of rotationally moving C. elegans, and that the patterns can be controlled by optogenetic manipulation of the environment. We showed that a physical reservoir computer using squid chromatophores, which have the ability to oscillate, is capable of speech recognition. We also conducted a theoretical study of a scenario in which organisms spontaneously acquire autonomous oscillatory 24-hour cycles, and proposed a theoretical method for reducing periodic fluctuations.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は生物そのものがやわらかいロボットとして機能しうることの実例を動物・植物・微生物を用いて明らかにした。また工学的なアプローチが生物理解そのものに貢献することを実例とともに示した。工学と生物学の融合によって、既存の生物学の枠組みおよびロボット学の枠組みを双方押し広げることに成功した。

Report

(6 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (57 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (32 results) (of which Int'l Joint Research: 9 results,  Invited: 6 results) Book (4 results) Remarks (5 results)

  • [Int'l Joint Research] Universite Grenoble Alpes(フランス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Universite Grenoble Alpes(フランス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Universite Grenoble Alpes(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Universite Grenoble Alpes(フランス)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Root PRR7 Improves the Accuracy of the Shoot Circadian Clock through Nutrient Transport2023

    • Author(s)
      Uemoto Kyohei、Mori Fumito、Yamauchi Shota、Kubota Akane、Takahashi Nozomu、Egashira Haruki、Kunimoto Yumi、Araki Takashi、Takemiya Atsushi、Ito Hiroshi、Endo Motomu
    • Journal Title

      Plant and Cell Physiology

      Volume: 64 Issue: 3 Pages: 352-362

    • DOI

      10.1093/pcp/pcad003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Large-Scale Cultivation of Nematodes to Study Their Collective Behaviors2023

    • Author(s)
      Imamura Ryuki、Nakane Yurina、Jiajing Hu、Ito Hiroshi、Sugi Takuma
    • Journal Title

      Journal of Visualized Experiments

      Volume: 1 Issue: 198 Pages: 10-10

    • DOI

      10.3791/65569

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced precision of circadian rhythm by output system2023

    • Author(s)
      Kaji Hotaka、Mori Fumito、Ito Hiroshi
    • Journal Title

      Journal of Theoretical Biology

      Volume: 574 Pages: 111621-111621

    • DOI

      10.1016/j.jtbi.2023.111621

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase characteristics of vocal tract filter can distinguish speakers2023

    • Author(s)
      Okada Masahiro、Ito Hiroshi
    • Journal Title

      Frontiers in Applied Mathematics and Statistics

      Volume: 9 Pages: 1274846-1274846

    • DOI

      10.3389/fams.2023.1274846

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Artificial temperature-compensated biological clock using temperature-sensitive Belousov?Zhabotinsky gels2023

    • Author(s)
      Yamada Yuhei、Ito Hiroshi、Maeda Shingo
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 22436-22436

    • DOI

      10.1038/s41598-023-41310-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of self-sustained circadian rhythms is facilitated by seasonal change of daylight2022

    • Author(s)
      Seki Motohide、Ito Hiroshi
    • Journal Title

      Proceedings of the Royal Society B: Biological Sciences

      Volume: 289 Issue: 1987 Pages: 20220577-20220577

    • DOI

      10.1098/rspb.2022.0577

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global transcriptional and circadian regulation in a halotolerant cyanobacterium Halothece sp. PCC74182022

    • Author(s)
      Waditee-Sirisattha Rungaroon、Ito Hiroshi、Kageyama Hakuto
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 13190-13190

    • DOI

      10.1038/s41598-022-17406-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of spatial pattern of prickles on stem of Rosa hybrida ‘Red Queen’and mathematical model of the pattern2021

    • Author(s)
      Amikura K, Ito H, & Kitazawa MS
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 13857-13857

    • DOI

      10.1038/s41598-021-93133-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Damped circadian oscillation in the absence of KaiA in Synechococcus2020

    • Author(s)
      Kawamoto Naohiro、Ito Hiroshi、Tokuda Isao T.、Iwasaki Hideo
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 2242-2242

    • DOI

      10.1038/s41467-020-16087-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 個体集団が生み出す動的秩序~線虫の集団運動に よる動的ネットワーク形成2020

    • Author(s)
      杉拓磨 伊藤浩史 永井健
    • Journal Title

      生物物理

      Volume: 60 Pages: 6-12

    • NAID

      130007790196

    • Related Report
      2020 Annual Research Report
  • [Journal Article] C. elegans collectively forms dynamical networks2019

    • Author(s)
      Sugi Takuma、Ito Hiroshi、Nishimura Masaki、Nagai Ken H.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 683-683

    • DOI

      10.1038/s41467-019-08537-y

    • NAID

      120006558249

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生物リズム・パターンのソフトロボティクスへの応用2019

    • Author(s)
      伊藤浩史 杉拓磨 永井健
    • Journal Title

      日本機械学会誌

      Volume: 122 Pages: 32-34

    • Related Report
      2019 Annual Research Report
  • [Presentation] Fabrication of Biological Rhythms and Patterns2023

    • Author(s)
      Hiroshi Ito
    • Organizer
      ReCAPS 10th Anniversary Seminar
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Circadian rhythm of two strains of morning glory with different flowering times2023

    • Author(s)
      Umezu Haruna, Takiko Kozuma, Sota Hase, Eiji Nitasaka, Tokitaka Oyama, Hiroshi Ito
    • Organizer
      Plant and Chronobiology Talks for Youth
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observation of Circadian Rhythms of Non-model Plants via Gene Gun2023

    • Author(s)
      Hiroshi Ito
    • Organizer
      Plant and Chronobiology Talks for Youth
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 概日時計ゆらぎ機能のデザイン2023

    • Author(s)
      梶穂高, 森史, 伊藤浩史
    • Organizer
      時間生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光合成を行わない細菌の概日リズムの可能性2023

    • Author(s)
      鍵山京佳, 伊藤浩史
    • Organizer
      時間生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 開花時刻の異なる2系統のアサガオの概日リズム2023

    • Author(s)
      梅津晏奈, 上妻多紀子, 長谷颯太, 仁田坂英二, 小山時隆, 伊藤浩史
    • Organizer
      時間生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高速分裂するシアノバクテリアの概日リズム2023

    • Author(s)
      富永直, 今井圭子, 伊藤浩史
    • Organizer
      時間生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] What makes cellular clock more precise2023

    • Author(s)
      Hiroshi Ito
    • Organizer
      時間生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Fabrication of biological oscillators and patterns2023

    • Author(s)
      Hiroshi Ito
    • Organizer
      Adaptive Motion of Animals and Machines
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 時計の針とゆらぎ2023

    • Author(s)
      伊藤浩史
    • Organizer
      CyanoClock 4.0
    • Related Report
      2022 Annual Research Report
  • [Presentation] 概日時計のゆらぎ2022

    • Author(s)
      伊藤浩史
    • Organizer
      MIMS研究集会「現象と数理モデル」
    • Related Report
      2021 Annual Research Report
  • [Presentation] 振動子間の非対称な結合強度をスパイク時刻データだけから推定する2021

    • Author(s)
      森史、岩見貴弘、郡宏、伊藤浩史
    • Organizer
      日本物理学会 2021年秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 概日リズムの出力系のゆらぎ2021

    • Author(s)
      梶穂高, 森史, 伊藤浩史
    • Organizer
      第127回日本物理学会九州支部例
    • Related Report
      2021 Annual Research Report
  • [Presentation] 同期している振動子間の非対称な結合強度の推定2021

    • Author(s)
      森史, 岩見貴弘, 郡宏, 伊藤 浩史
    • Organizer
      第127回日本物理学会九州支部例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 数理モデルは概日リズム研究のガイドになる2021

    • Author(s)
      伊藤浩史
    • Organizer
      生物統計と数理生物:似ているようで異なる生物へのアプローチ
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生物リズム、パターンの生まれ方2021

    • Author(s)
      伊藤浩史
    • Organizer
      創造する天然知能としての「わたし」の理論と実践・研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Speech recognition by chromatophores of squid via reservoir computing2021

    • Author(s)
      Ruki Sho, Toma Yamagawa, Honoka Moribe, Kohei Nakajima, Hiroshi Ito
    • Organizer
      MHS
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soft clock: fabrication and control of biological clock2021

    • Author(s)
      Hiroshi Ito
    • Organizer
      MHS
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分裂速度の速いシアノバクテリアの概日リズム2021

    • Author(s)
      國弘暉, 今井圭子, 伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Which clock is master? : inference of asymmetric interaction intensities in coupled oscillators2021

    • Author(s)
      森史, 岩見貴弘, 郡宏, 伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 低温下におけるシロイヌナズナ1細胞の概日リズム2021

    • Author(s)
      中村光洋 , 上妻多紀子, 梅津晏奈, 小山時隆, 伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 時計のゆらぎ2021

    • Author(s)
      伊藤浩史
    • Organizer
      CyanoClock
    • Related Report
      2021 Annual Research Report
  • [Presentation] Frequency-Amplitude relation in circadian rhythm2020

    • Author(s)
      Tetsuhiro Hataekyama, Irina Miahlcescu, Hiroshi Ito
    • Organizer
      日本時間生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 概日リズムの3要素を関係づける2020

    • Author(s)
      伊藤浩史
    • Organizer
      九州山口沖縄リズム研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 体内時計を冷やす2020

    • Author(s)
      伊藤浩史
    • Organizer
      MIMS 現象と数理モデル
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生物リズム・パターンの制御2019

    • Author(s)
      伊藤浩史, 杉拓磨, 永井健
    • Organizer
      自律分散シンポジウム
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Presentation] たよりないものをあつめてたよりがいのあるものを作る2019

    • Author(s)
      伊藤浩史
    • Organizer
      共創学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reconstitution of biological rhythms and pattern with living matter2019

    • Author(s)
      Hiroshi Ito, Takuma Suigi, Ken H Nagai
    • Organizer
      Robo Soft
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individual cyanobacterial circadian rhythms under low temperature conditions2019

    • Author(s)
      Hiroshi Ito
    • Organizer
      European Biological Rhythms Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 理論は実験のガイドになる2019

    • Author(s)
      伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reconstituted cyanobacterial circadian clock in cold conditions2019

    • Author(s)
      Hiroshi Ito
    • Organizer
      Malaysia International Genetics Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 振幅からみた時間生物学2018

    • Author(s)
      伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2018 Annual Research Report
  • [Book] The Science of Soft Robots2023

    • Author(s)
      Ito H and Sugi T
    • Total Pages
      406
    • Publisher
      Springer
    • ISBN
      9789811951732
    • Related Report
      2022 Annual Research Report
  • [Book] 温度ストレスによる生体応答ダイナミクス2023

    • Author(s)
      伊藤浩史
    • Total Pages
      384
    • Publisher
      NTS出版
    • ISBN
      9784860438302
    • Related Report
      2022 Annual Research Report
  • [Book] Cyanobacterial Physiology From Fundamentals to Biotechnology2022

    • Author(s)
      Ito H
    • Total Pages
      252
    • Publisher
      Elsevier
    • ISBN
      9780323961066
    • Related Report
      2022 Annual Research Report
  • [Book] Circadian Rhythms in Bacteria and Microbiomes2021

    • Author(s)
      Ito H, Murayama Y, Kawamoto N, Seki M Iwasaki, H.
    • Total Pages
      349
    • Publisher
      Springer
    • Related Report
      2021 Annual Research Report
  • [Remarks] https://www.design.kyushu-u.ac.jp/~hito/

    • Related Report
      2022 Annual Research Report
  • [Remarks] http://www.design.kyushu-u.ac.jp/~hito/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 伊藤浩史研究室

    • URL

      http://www.design.kyushu-u.ac.jp/~hito/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 杉拓磨ホームページ

    • URL

      http://takumasugi.com/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 永井健ホームページ

    • URL

      https://www.jaist.ac.jp/areas/bb/laboratory/nagai.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-07-20   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi