| Budget Amount *help |
¥69,290,000 (Direct Cost: ¥53,300,000、Indirect Cost: ¥15,990,000)
Fiscal Year 2022: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2021: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2020: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2019: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate (I) the cellulose crystal formation process using cellodextrin phosphorylase (CDP), (II) the degradation mechanism of crystalline cellulose by cellulase using simulation, (III) the evolution of processivity in cellulase, (IV) the structure-function relationship of enzymes degrading plant cell walls, (V) the cellulose degradation mechanism. (V) the mechanism of cellulose degradation. （In (I), we succeeded in synthesizing cellulose under microgravity for the first time in the world. （In (II), we showed that the size of the cellulose-binding domain is important for the activity. （In (III), we showed the convergent evolution of processive cellulases, and in (IV), we showed the structure-function relationship of galactan- and xylan-degrading enzymes. And in (V) we put an end to the 70-year debate on cellulose degradation.
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