| Budget Amount *help |
¥87,620,000 (Direct Cost: ¥67,400,000、Indirect Cost: ¥20,220,000)
Fiscal Year 2022: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2021: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2018: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
The ubiquitin modification, which was originally identified as a signal for protein degradation, is now known to play an essential role in the regulation of diverse cellular functions. Ubiquitin chains formed by covalently linking ubiquitin molecules are closely associated with the diversity of functions. Research aimed at understanding the molecular mechanisms of attachment, recognition, and removal of ubiquitin chains and artificially controlling cellular functions could contribute to therapeutic development for various diseases. In this study, we determined the three-dimensional structures of protein complexes associated with the ubiquitin chain modification to deepen the understanding of novel ubiquitin chain recognition mechanisms and molecular mechanisms involving ubiquitin chains. Furthermore, based on the obtained structural information, we attempted to design compounds that could control the function.
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