Chemical biology for controlling ubiquitin function

• Project Area: New frontier for ubiquitin biology driven by chemo-technologies
• Project/Area Number: 18H05503
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Yoshida Minoru 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617)
• Co-Investigator(Kenkyū-buntansha): PRADIPTA AMBARA 東京工業大学, 物質理工学院, 助教 (90631648) ; 川谷 誠 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (50391925) ; 近藤 恭光 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (80333342)
• Project Period (FY): 2018-06-29 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥175,240,000 (Direct Cost: ¥134,800,000、Indirect Cost: ¥40,440,000); Fiscal Year 2022: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000); Fiscal Year 2021: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000); Fiscal Year 2020: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000); Fiscal Year 2019: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000); Fiscal Year 2018: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
• Keywords: ユビキチンリガーゼ / ユビキチン化誘導キメラ分子 / リガンド化合物 / 化合物アレイ / E3リガンド / UbTACs / ライブラリー合成 / クリック反応 / アグリソーム / スプライシング / ユビキチンデコーダー / アジド / アルキン / ユビキチンデコーダ

Outline of Final Research Achievements

We have established various cellular interaction analysis methods to develop new chemical probes that bind strongly to ubiquitin decoders and shuttle molecules and modulate their functions. Using split-luciferase, chemical arrays, microscale thermophoresis, and TR-FRET methods, we have discovered inhibitors of ubiquitin-decoder interactions and novel ligands for cystic fibrosis-related E3 ubiquitin ligases RFFL and RNF5. We also developed a probe that induces cancer cell-specific ubiquitination of intracellular proteins using a molecule that efficiently reacts with acrolein, which is overproduced in cancer. Furthermore, we have elucidated a novel quality control mechanism that suppresses the expression of aggregation-prone proteins translated from intron-derived sequences resulting from splicing errors.

Academic Significance and Societal Importance of the Research Achievements

タンパク質ユビキチン化は、プロテアソームによるタンパク質分解のみならず、多様なタンパク質機能制御機構であることがわかってきた。この多様な機能を生み出す基盤は、ユビキチン修飾の構造多様性と相互作用する分子の多様性にあるが、その複雑性ゆえに全体像を理解するのは困難であった。本研究では、化学的アプローチにより個々の役割を理解し、疾患のメカニズム解明や治療法の開拓に資する幾つかの化合物を同定することに成功した。また、イントロン配列由来のタンパク質がユビキチン化されて凝集体を造ること、その生産を抑制する品質管理機構の存在も明らかになり、スプライシングとユビキチン修飾系という新たな研究領域が開拓された。

Research Products

• [Journal Article] Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors (2023)
  • Author(s): Motoyama Takayuki、Nogawa Toshihiko、Shimizu Takeshi、Kawatani Makoto、Kashiwa Takeshi、Yun Choong-Soo、Hashizume Daisuke、Osada Hiroyuki
  • Journal Title: ACS Chemical Biology Volume: 18 Issue: 2 Pages: 396-403
  • DOI: 10.1021/acschembio.2c00830
  • Peer Reviewed
• [Journal Article] Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells (2022)
  • Author(s): Sasaki Kazuki、Suzuki Michihiro、Sonoda Takeshi、Schneider-Poetsch Tilman、Ito Akihiro、Takagi Motoki、Fujishiro Shinya、Sohtome Yoshihiro、Dodo Kosuke、Umehara Takashi、Aburatani Hiroyuki、Shin-ya Kazuo、Nakao Yoichi、Sodeoka Mikiko、Yoshida Minoru
  • Journal Title: Cell Chemical Biology Volume: 29 Issue: 7 Pages: 1153-1161
  • DOI: 10.1016/j.chembiol.2022.05.006
  • Peer Reviewed / Open Access
• [Journal Article] Recognition of pathogen-derived sphingolipids in <i>Arabidopsis</i> (2022)
  • Author(s): Kato H.、Nemoto K.、Shimizu M.、Abe A.、Asai S.、Ishihama N.、Matsuoka S.、Daimon T.、Ojika M.、Kawakita K.、Onai K.、Shirasu K.、Yoshida M.、Ishiura M.、Takemoto D.、Takano Y.、Terauchi R.
  • Journal Title: Science Volume: 376 Issue: 6595 Pages: 857-860
  • DOI: 10.1126/science.abn0650
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors (2022)
  • Author(s): 橋本公佑、井手聡一郎、新真由美、中田明子、伊藤昭博、伊藤孝、工藤紀雄、伊藤昭博、伊藤孝、林邦忠、布村一人、津金沢恵子、吉田稔、長岡康夫、住吉孝明
  • Journal Title: ACS Medicinal Chemistry Letters Volume: 13 Issue: 7 Pages: 1077-1082
  • DOI: 10.1021/acsmedchemlett.2c00081
  • Peer Reviewed
• [Journal Article] Filter trapping protocol to detect aggregated proteins in human cell lines. (2022)
  • Author(s): Chhipi-Shrestha JK, Yoshida M, and Iwasaki S
  • Journal Title: STAR Protoc Volume: 3(3) Issue: 3 Pages: 101571-101571
  • DOI: 10.1016/j.xpro.2022.101571
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Isoquercitrin from <i>Apocynum venetum</i> L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice <i>in vivo</i>. (2022)
  • Author(s): Manzoor M, Muroi M, Ogawa N, Kobayashi H, Nishimura H, Chen D, Fasina OB, Wang J, Osada H, Yoshida M, Xiang L, Qi J
  • Journal Title: Food Funct Volume: 13 Issue: 21 Pages: 10923-10936
  • DOI: 10.1039/d2fo02438a
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Second-Generation Click-to-Sense Probe for Intraoperative Diagnosis of Breast Cancer Tissues Based on Acrolein Targeting (2022)
  • Author(s): Pradipta Ambara R.、Michiba Hiroyuki、Kubo Anna、Fujii Motoko、Tanei Tomonori、Morimoto Koji、Shimazu Kenzo、Tanaka Katsunori
  • Journal Title: Bulletin of the Chemical Society of Japan Volume: 95 Issue: 3 Pages: 421-426
  • DOI: 10.1246/bcsj.20210387
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of “click-to-sense” assay with frozen section analysis using simulated surgical margins in breast cancer patients (2022)
  • Author(s): Kubo Anna、Tanei Tomonori、Pradipta Ambara R、Morimoto Koji、Fujii Motoko、Sota Yoshiaki、Miyake Tomohiro、Kagara Naofumi、Shimoda Masafumi、Naoi Yasuto、Motoyama Yuichi、Morii Eiichi、Tanaka Katsunori、Shimazu Kenzo
  • Journal Title: European Journal of Surgical Oncology Volume: 48 Issue: 7 Pages: 1520-1526
  • DOI: 10.1016/j.ejso.2022.04.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite (2022)
  • Author(s): Mendoza, A., Takemoto, Y., Cruzado, KT., Masoud, SS., Nagata, A., Tantipanjaporn, A., Okuda, S., Kawagoe, F., Sakamoto, R., Odagi, M., Mototani, S., Togashi, M., Kawatani, M., Aono, H., Osada, H., Nakagawa, H., Higashi, T., Kittaka, A., Nagasawa, K., Uesugi, M.
  • Journal Title: Cell Chem Biol. Volume: 29 Issue: 4 Pages: 660-669
  • DOI: 10.1016/j.chembiol.2021.08.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of a small molecule that enhances ferroptosis via inhibition of FSP1. (2022)
  • Author(s): Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
  • Journal Title: ACS Chemical Biology Volume: 17 Issue: 2 Pages: 483-491
  • DOI: 10.1021/acschembio.2c00028
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns (2022)
  • Author(s): Chhipi-Shrestha Jagat K.、Schneider-Poetsch Tilman、Suzuki Takehiro、Mito Mari、Khan Khalid、Dohmae Naoshi、Iwasaki Shintaro、Yoshida Minoru
  • Journal Title: Cell Chemical Biology Volume: 29 Issue: 2 Pages: 259-275
  • DOI: 10.1016/j.chembiol.2021.07.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential biosynthesis and roles of two ferrichrome-type siderophores, ASP2397/AS2488053 and ferricrocin, in Acremonium persicinum. (2022)
  • Author(s): Yoshiki Asai, Tomoshige Hiratsuka, Miyu Ueda, Yumi Kawamura, Shumpei Asamizu, Hiroyasu Onaka, Manabu Arioka, Shinichi Nishimura, and Minoru Yoshida
  • Journal Title: ACS Chem. Biol. Volume: 17 Issue: 1 Pages: 207-216
  • DOI: 10.1021/acschembio.1c00867
  • Peer Reviewed
• [Journal Article] Inhibition of amyloid formation of amyloid β(1-42), amylin and insulin by 1,5-diazacyclooctanes, as spermine-acrolein conjugate (2021)
  • Author(s): R. Kunitomi, A. R. Pradipta, H. Kawabe, N. Lobsiger, K. Tanaka, T. Zako
  • Journal Title: Bioorg. Med. Chem. Volume: 46 Pages: 116391-116391
  • DOI: 10.1016/j.bmc.2021.116391
  • Peer Reviewed
• [Journal Article] CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. (2021)
  • Author(s): Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y
  • Journal Title: Journal of Biological Chemistry Volume: 297 Issue: 1 Pages: 100803-100803
  • DOI: 10.1016/j.jbc.2021.100803
  • Peer Reviewed / Open Access
• [Journal Article] New abscisic acid derivatives revealed adequate regulation of stomatal, transcriptional, and developmental responses to conquer drought. (2021)
  • Author(s): Yoshida K, Kondoh Y, Nakano T, Bolortuya B, Kawabata S, Iwahashi F, Nagano E, Osada H
  • Journal Title: ACS Chemical Biology Volume: 16 Issue: 8 Pages: 1566-1575
  • DOI: 10.1021/acschembio.1c00451
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth (2021)
  • Author(s): Takayama Ken-ichi、Honma Teruki、Suzuki Takashi、Kondoh Yasumitsu、Osada Hiroyuki、Suzuki Yutaka、Yoshida Minoru、Inoue Satoshi
  • Journal Title: Cancer Research Volume: 81 Issue: 13 Pages: 3495-3508
  • DOI: 10.1158/0008-5472.can-20-3819
  • Peer Reviewed / Open Access
• [Journal Article] Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. (2021)
  • Author(s): Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A
  • Journal Title: Cancer Science Volume: 112 Issue: 10 Pages: 4303-4316
  • DOI: 10.1111/cas.15079
  • NAID: 120007159906
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock (2021)
  • Author(s): Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-Ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
  • Journal Title: Communications Biology Volume: 4 Issue: 1 Pages: 1165-1165
  • DOI: 10.1038/s42003-021-02701-1
  • Peer Reviewed / Open Access
• [Journal Article] A cesium tolerance-enhancing chemical promotes cesium tolerance in Arabidopsis thaliana by interacting with BETA-GLUCOSIDASE 23. (2021)
  • Author(s): Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R
  • Journal Title: Scientific Reports Volume: 26 Issue: 1 Pages: 21109-21109
  • DOI: 10.1038/s41598-021-00564-4
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment (2021)
  • Author(s): J. Yoshida, T. Ohishi, H. Abe, S. Ohba, H. Inoue, I. Usami, M. Amemiya, R. Oriez, C. Sakashita, S. Dan, M. Sugawara, T. Kawaguchi, J. Ueno, Y. Asano, A. Ikeda, M. Takamatsu, G. Amori, Y. Kondoh, K. Honda, H. Osada, T. Noda, T. Watanabe, T. Shimizu, M. Shibasaki and M. Kawada
  • Journal Title: iScience Volume: 24 Issue: 12 Pages: 103497-103497
  • DOI: 10.1016/j.isci.2021.103497
  • Peer Reviewed / Open Access
• [Journal Article] Improving measures of chemical structural similarity using machine learning on chemical-genetic interactions (2021)
  • Author(s): Safizadeh, H., Simpkins, SW., Nelson, J., Li, SC., Piotrowski, JS., Yoshimura, M., Yashiroda, Y., Hirano, H., Osada, H., Yoshida, M., Boone, C., Myers, CL.
  • Journal Title: Journal of Chemical Information and Modeling Volume: 61 Issue: 9 Pages: 4156-4172
  • DOI: 10.1021/acs.jcim.0c00993
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Splicing modulators: on the way from nature to clinic (2021)
  • Author(s): Schneider-Poetsch Tilman、Chhipi-Shrestha Jagat Krishna、Yoshida Minoru
  • Journal Title: The Journal of Antibiotics Volume: 74 Issue: 10 Pages: 603-616
  • DOI: 10.1038/s41429-021-00450-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 機能低下したミトコンドリアを活性化させる化合物の発見 (2021)
  • Author(s): 小林大貴、吉田稔
  • Journal Title: 実験医学 Volume: 39 Pages: 954-957
• [Journal Article] ケミカルバイオロジーによる新たなミトコンドリア病創薬標的候補の発見 (2021)
  • Author(s): 小林大貴、吉田稔
  • Journal Title: ケモテクノロジーが拓くユビキチンニューフロンティア ニュースレター Volume: 3 Pages: 37-39
• [Journal Article] Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation. (2021)
  • Author(s): Yoshimoto, R., Chhipi-Shrestha, J.K., Schneider-Poetsch, T., Furuno, M., Burroughs, A.M., Noma, S., Suzuki, H., Hayashizaki, Y., Mayeda, A., Nakagawa, S., Kaida, D., Iwasaki, S., Yoshida, M.
  • Journal Title: Cell Chem. Biol. Volume: - Issue: 9 Pages: 1356-1365
  • DOI: 10.1016/j.chembiol.2021.03.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. (2021)
  • Author(s): Nielsen, A. L., Rajabi, N., Kudo, N., Lundo, K., Moreno-Yruela, C., Baek, M., Fontenas, M., Lucidi, A., Madsen, A. S., Yoshida, M., Olsen, C. A.
  • Journal Title: RSC Chem. Biol. Volume: 2(2) Issue: 2 Pages: 612-626
  • DOI: 10.1039/d0cb00036a
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations (2021)
  • Author(s): Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.
  • Journal Title: Nat Chem Biol Volume: 17 Issue: 3 Pages: 335
  • DOI: 10.1038/s41589-020-00676-4
  • Peer Reviewed
• [Journal Article] 機能低下したミトコンドリアを活性化させる化合物の発見. (2021)
  • Author(s): 小林大貴、吉田稔
  • Journal Title: 実験医学 Volume: 39(6) Pages: 954-957
• [Journal Article] Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation (2021)
  • Author(s): Pradipta, A. R., Ahmadi, P., Terashima, K., Muguruma, K., Fujii, M., Ichino, T., Maeda, S., Tanaka, K.
  • Journal Title: Chem. Sci. Volume: - Issue: 15 Pages: 5438-5449
  • DOI: 10.1039/d0sc06083f
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Application of acrolein imines to organic synthesis, biofunctional studies, and clinical practice (2021)
  • Author(s): Pradipta, A. R., Tanaka, K.
  • Journal Title: Chem. Rec. Volume: 21 Issue: 4 Pages: 646-662
  • DOI: 10.1002/tcr.202000146
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns (2020)
  • Author(s): Shrestha Jagat Krishna Chhipi、Schneider-Poetsch Tilman、Suzuki Takehiro、Mito Mari、Khan Khalid、Dohmae Naoshi、Iwasaki Shintaro、Yoshida Minoru
  • Journal Title: bioRxiv Volume: NA
  • DOI: 10.1101/2020.11.23.393835
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genome-wide survey of ribosome collision. (2020)
  • Author(s): Han, P., Shichino, Y., Schneider-Poetsch, T., Mito, M., Hashimoto, S., Udagawa, T., Kohno, K., Yoshida, M., Mishima, Y., Inada, T., Iwasaki, S.
  • Journal Title: Cell Rep. Volume: 31(5) Issue: 5 Pages: 107610-107610
  • DOI: 10.1016/j.celrep.2020.107610
  • Peer Reviewed / Open Access
• [Journal Article] Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis. (2020)
  • Author(s): Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J
  • Journal Title: Aging Volume: 12 Issue: 14 Pages: 13991-14018
  • DOI: 10.18632/aging.103521
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells. (2020)
  • Author(s): Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
  • Journal Title: Biosci Biotechnol Biochem Volume: 84 Issue: 10 Pages: 2113-2120
  • DOI: 10.1080/09168451.2020.1789445
  • Peer Reviewed / Open Access
• [Journal Article] LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells (2020)
  • Author(s): Jo Tomoyasu、Nishikori Momoko、Kogure Yasunori、Arima Hiroshi、Sasaki Katsuhiro、Sasaki Yoshiteru、Nakagawa Tomoko、Iwai Fumie、Momose Shuji、Shiraishi Aki、Kiyonari Hiroshi、Kagaya Noritaka、Onuki Tetsuo、Shin-ya Kazuo、Yoshida Minoru、Kataoka Keisuke、Ogawa Seishi、Iwai Kazuhiro、Takaori-Kondo Akifumi
  • Journal Title: Blood Volume: 136 Issue: 6 Pages: 684-697
  • DOI: 10.1182/blood.2019002654
  • Peer Reviewed / Open Access
• [Journal Article] 血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索. (2020)
  • Author(s): 住吉孝明、平中誠弥、出口芳春、伊藤昭博、吉田稔
  • Journal Title: MEDCHEM NEWS Volume: 30(1) Pages: 43-46
  • NAID: 130008033678
• [Journal Article] A strategy for tumor targeting by higher-order glycan pattern recognition: Synthesis and in vitro and in vivo properties of glycoalbumins conjugated with four different N-glycan molecules (2020)
  • Author(s): Smirnov, I., Sibgatullina, R., Urano, S., Tahara, T., Ahmadi, P., Watanabe, Y., Pradipta, A. R., Kurbangalieva, A., Tanaka, K.
  • Journal Title: Small Volume: 16 Issue: 46 Pages: 2004831-2004831
  • DOI: 10.1002/smll.202004831
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry (2020)
  • Author(s): Muguruma, K., Pradipta, A. R., Ode, Y., Terashima, K., Michiba, H., Fujii, M., Tanaka, K.
  • Journal Title: Bioorg. Med. Chem. Volume: 28 Issue: 24 Pages: 115831-115831
  • DOI: 10.1016/j.bmc.2020.115831
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Methods for acrolein detection: Recent advances and applications (2020)
  • Author(s): Pradipta, A. R., Tanaka, K.
  • Journal Title: J. Idn. Chem. Soc. Volume: 3 Issue: 2 Pages: 73-80
  • DOI: 10.34311/jics.2020.03.2.73
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions (2020)
  • Author(s): Chang Tsung‐Che、Pradipta Ambara R.、Tanaka Katsunori
  • Journal Title: Chirality Volume: 32 Issue: 9 Pages: 1160-1168
  • DOI: 10.1002/chir.23265
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics (2020)
  • Author(s): 16)Kawamura, T., Futamura, Y., Shang, E., Muroi, M., Janning, P., Ueno, M., Wilke, J., Takeda, S., Kondoh, Y., Ziegler, S., Watanabe, N., Waldmann, H., Osada, H.
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 84 Issue: 12 Pages: 2484-2490
  • DOI: 10.1080/09168451.2020.1812375
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins. (2020)
  • Author(s): Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
  • Journal Title: Environ Pollut Volume: 266 Pages: 115179-115179
  • DOI: 10.1016/j.envpol.2020.115179
  • Peer Reviewed
• [Journal Article] Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress (2020)
  • Author(s): Sophonnithiparasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R
  • Journal Title: Heliyon Volume: 6 Issue: 10 Pages: e05200-e05200
  • DOI: 10.1016/j.heliyon.2020.e05200
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells. (2020)
  • Author(s): 20)Ikeda, H., Muroi, M., Kondoh, Y., Ishikawa, S., Kakeya, H., Osada, H., Imoto, M.
  • Journal Title: ACS Chem. Biol. Volume: 15 Issue: 8 Pages: 2195-2204
  • DOI: 10.1021/acschembio.0c00381
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana (2020)
  • Author(s): Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 8691-8691
  • DOI: 10.1038/s41598-020-65614-9
  • NAID: 120006876594
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry (2020)
  • Author(s): Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Watanabe Nobumoto、Osada Hiroyuki
  • Journal Title: BIO-PROTOCOL Volume: 10 Issue: 3
  • DOI: 10.21769/bioprotoc.3517
  • Peer Reviewed / Open Access
• [Journal Article] Measurement of ATPase Activity of Valosin-containing Protein/p97 (2020)
  • Author(s): Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Osada Hiroyuki、Watanabe Nobumoto
  • Journal Title: BIO-PROTOCOL Volume: 10 Issue: 3
  • DOI: 10.21769/bioprotoc.3516
  • Peer Reviewed / Open Access
• [Journal Article] Emerging Technologies for Real‐Time Intraoperative Margin Assessment in Future Breast‐Conserving Surgery. (2020)
  • Author(s): Pradipta AR, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
  • Journal Title: Advanced Science (Weinh) Volume: 10.1002 Issue: 9 Pages: 201901519-201901519
  • DOI: 10.1002/advs.201901519
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms (2020)
  • Author(s): O. A. Lodochnikova, D. R. Chulakova, D. P. Gerasimova, I. A. Litvinov, A. R. Pradipta, K. Tanaka, A. R. Kurbangalieva
  • Journal Title: J. Struct. Chem. Volume: 61 Issue: 1 Pages: 125-131
  • DOI: 10.26902/jsc_id49649
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure (2019)
  • Author(s): Takase Shohei、Kurokawa Rumi、Kondoh Yasumitsu、Honda Kaori、Suzuki Takehiro、Kawahara Teppei、Ikeda Haruo、Dohmae Naoshi、Osada Hiroyuki、Shin-ya Kazuo、Kushiro Tetsuo、Yoshida Minoru、Matsumoto Ken
  • Journal Title: ACS Chemical Biology Volume: 14 Issue: 8 Pages: 1819-1828
  • DOI: 10.1021/acschembio.9b00410
  • Peer Reviewed / Open Access
• [Journal Article] Identification of ryuvidine as a KDM5A inhibitor. (2019)
  • Author(s): Mitsui, E., Yoshida, S., Shinoda, Y., Matsumori, Y., Tsujii, H., Tsuchida, M., Wada, S., Hasegawa, M., Ito, A., Mino, K., Onuki, T., Yoshida, M., Sasaki, R., Mizukami, T.
  • Journal Title: Sci. Rep. Volume: 9(1) Issue: 1 Pages: 9952-9952
  • DOI: 10.1038/s41598-019-46346-x
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1 (2019)
  • Author(s): Feng Ling, Eliot Bradshaw, Minoru Yoshida
  • Journal Title: Scientific Reports Volume: 9 (1) Issue: 1 Pages: 5433-5445
  • DOI: 10.1038/s41598-019-41699-9
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation‐Inhibitory Activity (2019)
  • Author(s): Nomura Yusaku、Thuaud Frederic、Sekine Daisuke、Ito Akihiro、Maeda Satoko、Koshino Hiroyuki、Hashizume Daisuke、Muranaka Atsuya、Cruchter Thomas、Uchiyama Masanobu、Ichikawa Satoshi、Matsuda Akira、Yoshida Minoru、Hirai Go、Sodeoka Mikiko
  • Journal Title: Chemistry A European Journal Volume: 25 Issue: 35 Pages: 8387-8392
  • DOI: 10.1002/chem.201901093
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. (2019)
  • Author(s): Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
  • Journal Title: Journal of Medicinal Chemistry Volume: 62 Issue: 7 Pages: 3407-3427
  • DOI: 10.1021/acs.jmedchem.8b01888
  • Peer Reviewed
• [Journal Article] Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay (2019)
  • Author(s): Murashima Akihiro、Shinjo Keiko、Katsushima Keisuke、Onuki Tetsuo、Kondoh Yasumitsu、Osada Hiroyuki、Kagaya Noritaka、Shin-ya Kazuo、Kimura Hiroshi、Yoshida Minoru、Murakami Shingo、Kondo Yutaka.
  • Journal Title: The Journal of Biochemistry Volume: - Issue: 1 Pages: 1-10
  • DOI: 10.1093/jb/mvz007
  • NAID: 40021952184
  • Peer Reviewed / Open Access
• [Journal Article] Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies (2019)
  • Author(s): Yoshida Kazuko、Kondoh Yasumitsu、Iwahashi Fukumatsu、Nakano Takeshi、Honda Kaori、Nagano Eiki、Osada Hiroyuki
  • Journal Title: ACS Chemical Biology Volume: 14 Issue: 9 Pages: 1964-1971
  • DOI: 10.1021/acschembio.9b00453
  • Peer Reviewed
• [Journal Article] Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors (2019)
  • Author(s): Shu Keitou、Iwamoto Naoya、Honda Kaori、Kondoh Yasumitsu、Hirano Hiroyuki、Osada Hiroyuki、Ohno Hiroaki、Fujii Nobutaka、Oishi Shinya
  • Journal Title: Bioconjugate Chemistry Volume: 30 Issue: 5 Pages: 1395-1404
  • DOI: 10.1021/acs.bioconjchem.9b00154
  • Peer Reviewed
• [Journal Article] Facile Access to Optically Active 2,6‐Dialkyl‐1,5‐Diazacyclooctanes (2019)
  • Author(s): Chulakova Dilyara R.、Pradipta Ambara R.、Lodochnikova Olga A.、Kuznetsov Danil R.、Bulygina Kseniya S.、Smirnov Ivan S.、Usachev Konstantin S.、Latypova Liliya Z.、Kurbangalieva Almira R.、Tanaka Katsunori
  • Journal Title: Chemistry - An Asian Journal Volume: 14 Issue: 22 Pages: 4048-4054
  • DOI: 10.1002/asia.201900938
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis. (2019)
  • Author(s): Shinohara, H., Yasue, N., Onuki, T., Yoshida, M. Matsubayashi, Y.
  • Journal Title: Commun. Biol. Commun Biol. Volume: 2 Issue: 1 Pages: 61-61
  • DOI: 10.1038/s42003-019-0307-8
  • Peer Reviewed / Open Access
• [Journal Article] Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments (2019)
  • Author(s): Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL
  • Journal Title: Nature Protocols Volume: 14 Issue: 2 Pages: 415-440
  • DOI: 10.1038/s41596-018-0099-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol (2019)
  • Author(s): Cornelio Kimberly、Espiritu Rafael Atillo、Hanashima Shinya、Todokoro Yasuto、Malabed Raymond、Kinoshita Masanao、Matsumori Nobuaki、Murata Michio、Nishimura Shinichi、Kakeya Hideaki、Yoshida Minoru、Matsunaga Shigeki
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Biomembranes Volume: 1861 Issue: 1 Pages: 228-235
  • DOI: 10.1016/j.bbamem.2018.07.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent advances in target identification of bioactive natural products. (2019)
  • Author(s): Yoshida M.
  • Journal Title: Biosci Biotechnol Biochem. Volume: 83(1) Issue: 1 Pages: 1-9
  • DOI: 10.1080/09168451.2018.1533804
  • Peer Reviewed
• [Journal Article] Tetramethylrhodamine is an essential scaffold of azide probe in detecting cellular acrolein (2019)
  • Author(s): Pradipta AR, Fujii M, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
  • Journal Title: Bioorg. Med. Chem. Volume: - Issue: 11 Pages: 2228-2234
  • DOI: 10.1016/j.bmc.2019.04.026
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration. (2019)
  • Author(s): Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N
  • Journal Title: J Biol Chem Volume: 294 Issue: 9 Pages: 2988-2996
  • DOI: 10.1074/jbc.ra118.004741
  • Peer Reviewed / Open Access
• [Journal Article] Opening the selectivity pocket in the human lysine deacetylase sirtuin2 - new opportunities, new questions. (2018)
  • Author(s): Robaa D, Monaldi D, W?ssner N, Kudo N, Rumpf T, Schiedel M, Yoshida M, Jung M.
  • Journal Title: Chem Rec. Volume: 18(12) Issue: 12 Pages: 1701-1707
  • DOI: 10.1002/tcr.201800044
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. (2018)
  • Author(s): Mizutani A, Yashiroda Y, Muramatsu Y, Yoshisa H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4003-4014
  • DOI: 10.1111/cas.13805
  • Peer Reviewed / Open Access
• [Journal Article] Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology (2018)
  • Author(s): Tanei Tomonori、Pradipta Ambara R.、Morimoto Koji、Fujii Motoko、Arata Mayumi、Ito Akihiro、Yoshida Minoru、Saigitbatalova Elena、Kurbangalieva Almira、Ikeda Jun-ichiro、Morii Eiichi、Noguchi Shinzaburo、Tanaka Katsunori
  • Journal Title: Advanced Science Volume: 6 Issue: 2 Pages: 1801479-1801479
  • DOI: 10.1002/advs.201801479
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions (2018)
  • Author(s): Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL
  • Journal Title: PLoS Computational Biology Volume: 14 Issue: 10 Pages: e1006532-e1006532
  • DOI: 10.1371/journal.pcbi.1006532
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. (2018)
  • Author(s): Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
  • Journal Title: Oncotarget Volume: 9(74) Issue: 74 Pages: 33871-33883
  • DOI: 10.18632/oncotarget.26049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors (2018)
  • Author(s): Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
  • Journal Title: ACS Med Chem Lett. Volume: 9 Issue: 9 Pages: 884
  • DOI: 10.1021/acsmedchemlett.8b00099
  • Peer Reviewed
• [Journal Article] Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses (2018)
  • Author(s): Yoshihiro Sohtome, Tadahiro Shimazu, Joaquin Barjau, Shinya Fujishiro, Mai Akakabe, Naoki Terayama, Kosuke Dodo, Akihiro Ito, Minoru Yoshida, Yoichi Shinkai, Mikiko Sodeoka
  • Journal Title: Chem. Commun. Volume: 54 Issue: 66 Pages: 9202-9205
  • DOI: 10.1039/c8cc03907k
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine (2018)
  • Author(s): Hirano Tomoya、Fujiwara Takashi、Niwa Hideaki、Hirano Michitake、Ohira Kasumi、Okazaki Yusuke、Sato Shin、Umehara Takashi、Maemoto Yuki、Ito Akihiro、Yoshida Minoru、Kagechika Hiroyuki
  • Journal Title: ChemMedChem Volume: 13 Issue: 15 Pages: 1530-1540
  • DOI: 10.1002/cmdc.201800233
  • Peer Reviewed
• [Journal Article] Along the Central Dogma Controlling Gene Expression with Small Molecules (2018)
  • Author(s): Schneider-Poetsch Tilman、Yoshida Minoru
  • Journal Title: Annual Review of Biochemistry Volume: 87 Issue: 1 Pages: 1-30
  • DOI: 10.1146/annurev-biochem-060614-033923
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. (2018)
  • Author(s): Kudo N, Ito A, Arata M, Nakata A, Yoshida M.
  • Journal Title: Philos Trans R Soc Lond B Biol Sci. Volume: 373(1748) Issue: 1748 Pages: 20170070-20170070
  • DOI: 10.1098/rstb.2017.0070
  • Peer Reviewed / Open Access
• [Journal Article] Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1 (2018)
  • Author(s): Matsumoto Ken、Kose Shingo、Kuwahara Iku、Yoshimura Mami、Imamoto Naoko、Yoshida Minoru
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 6198-6198
  • DOI: 10.1038/s41598-018-24401-3
  • Peer Reviewed / Open Access
• [Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53?dependent transcriptional regulation (2018)
  • Author(s): Kanda Keitaro、Sakamoto Jiro、Matsumoto Yoshihide、Ikuta Kozo、Goto Norihiro、Morita Yusuke、Ohno Mikiko、Nishi Kiyoto、Chiba Tsutomu、Nishi Eiichiro、Seno Hiroshi
  • Journal Title: JCI Insight Volume: 3 Issue: 8 Pages: 1-15
  • DOI: 10.1172/jci.insight.91316
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preparation of Cell Lysates of Fission Yeast for Immunoprecipitation. (2018)
  • Author(s): Akihisa Matsuyama, Atsuko Shirai, Minoru Yoshida
  • Journal Title: Methods in Molecular Biology Volume: 1721 Pages: 125-133
  • DOI: 10.1007/978-1-4939-7546-4_12
  • ISBN: 9781493975457, 9781493975464
  • Peer Reviewed
• [Journal Article] MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action (2018)
  • Author(s): Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
  • Journal Title: Bioinformatics Volume: 34 Issue: 7 Pages: 1251-1252
  • DOI: 10.1093/bioinformatics/btx732
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcriptomic analysis of Arabidopsis thaliana plants treated with the Ky-9 and Ky-72 histone deacetylase inhibitors (2018)
  • Author(s): Nguyen HM, Sako K, Matsui A, Ueda M, Tanaka M, Ito A, Nishino N, Yoshida M, Seki M.
  • Journal Title: Plant Signaling and Behavior Volume: 13 Issue: 3 Pages: e1448333-e1448333
  • DOI: 10.1080/15592324.2018.1448333
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6 (2018)
  • Author(s): Y. Qi, X. Zhao, J. Chen, A. R. Pradipta, J. Wei, H. Ruan, R. P. Hsung, K. Tanaka, L. Zhou
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: - Issue: 6 Pages: 1-16
  • DOI: 10.1080/09168451.2018.1559030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expanding the applicability of metal-labeling of biomolecules by RIKEN click reaction: A case study with 68Ga-PET (2018)
  • Author(s): Y. Nakamoto, A. R. Pradipta, H. Mukai, M. Zouda, Y. Watanabe, A. Kurbangalieva, P. Ahmadi, Y. Manabe, K. Fukase, K. Tanaka
  • Journal Title: ChemBioChem. Volume: 19 Issue: 19 Pages: 2055-2060
  • DOI: 10.1002/cbic.201800335
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cycloaddition reactions of N-alkyl-α,β-unsaturated imines: Facile preparation of azaheterocycles for synthesis and biological applications (2018)
  • Author(s): A. R. Pradipta, L. Latypova, D. Chulakova, I. Smirnov, A. Kurbangalieva, K. Tanaka
  • Journal Title: Heterocycles Volume: 97 Issue: 2 Pages: 668-685
  • DOI: 10.3987/rev-18-sr(t)4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide (2018)
  • Author(s): Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park S-Y, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 2769-2769
  • DOI: 10.1038/s41598-018-20987-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells (2018)
  • Author(s): Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.
  • Journal Title: Cancer Med Volume: 7 Issue: 3 Pages: 883-893
  • DOI: 10.1002/cam4.1339
  • Peer Reviewed / Open Access
• [Journal Article] Halistanol sulfates I and J, new SIRT1?3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria (2017)
  • Author(s): Nakamura Fumiaki、Kudo Norio、Tomachi Yuki、Nakata Akiko、Takemoto Misao、Ito Akihiro、Tabei Hodaka、Arai Daisuke、de Voogd Nicole、Yoshida Minoru、Nakao Yoichi、Fusetani Nobuhiro
  • Journal Title: The Journal of Antibiotics Volume: 71 Issue: 2 Pages: 273-278
  • DOI: 10.1038/ja.2017.145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Tackling Genetic Diseases with Chemical Biology (2023)
  • Author(s): 吉田 稔
  • Organizer: Future Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] 微生物に学ぶ新たな創薬標的研究 (2023)
  • Author(s): 吉田 稔
  • Organizer: 化学・材料インキュベーション研究会
  • Invited
• [Presentation] ケミカルゲノミクスを基盤とした創薬研究 (2023)
  • Author(s): 吉田 稔
  • Organizer: 2022年度【先端モデル動物支援プラットフォーム】成果発表会
  • Invited
• [Presentation] eIF5A ハイプシン化の阻害剤 GC7 はミトコンドリアストレスを誘導する (2023)
  • Author(s): 松本健、黒川留美、Tilman Schneider-Poetsch1、高瀬恵、鈴木健裕 、堂前直、吉田稔
  • Organizer: 2022年度【先端モデル動物支援プラットフォーム】成果発表会
• [Presentation] 生体内の有機合成化学による次世代医療 (2023)
  • Author(s): A. R. Pradipta
  • Organizer: 第6回東工大応用化学系次世代を担う若手シンポジウム
  • Invited
• [Presentation] がん細胞内でのDiels-Alder反応によるプロドラッグ法の検討 (2023)
  • Author(s): 服部海斗, 道場皓之, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] 金属触媒を用いた一酸化炭素挿入による抗がん活性物質の合成研究 (2023)
  • Author(s): 河合雅行, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] 生体内でのルイス酸触媒反応の検討 (2023)
  • Author(s): 熊倉蓮, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] 生体寛容性人工金属触媒によるジアゾ化合物の反応性の検討 (2023)
  • Author(s): 奥村昂也, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] アクロレインをトリガーとしたがん細胞内での水酸基脱保護反応の開発 (2023)
  • Author(s): _橋ゆりあ, 寺島一輝, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] 大出雄大, A. R. Pradipta, 田中克典 (2023)
  • Author(s): 寺島一輝, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] アクロレインとアジドの反応を利用した標的α線治療 (2023)
  • Author(s): 大出雄大, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] 生体内での選択的アミド化反応による薬剤の現地合成 (2023)
  • Author(s): 松浦淳紘, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] がん代謝物をトリガーとした糖転移酵素阻害剤の活性化とがん治療 (2023)
  • Author(s): 笠原隆継, 張宗哲, 浦野清香, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] がん細胞での選択的環化反応による新規タンパク質分解誘導の検討 (2023)
  • Author(s): 松嶋良真, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] がん細胞内での無触媒[4+4]付加環化反応による機能性ポリマーの合成研究 (2023)
  • Author(s): 川口慎司, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] がん細胞で起こる[4+4]付加環化反応の意義とメカニズムの検討 (2023)
  • Author(s): 関口拓真, 吉岡広大, A. R. Pradipta, 田中克典
  • Organizer: 日本化学会第103春季年会
• [Presentation] がん代謝阻害剤の探索と標的同定 (2023)
  • Author(s): 川谷誠
  • Organizer: 先端モデル動物支援プラットフォーム2022年度成果発表会
  • Invited
• [Presentation] Development of Protease Sensor, a novel assay for measuring intracellular DUB activity (2022)
  • Author(s): Kenji Ogawa, Yasue Ichikawa, Akiko Idei, and Minoru Yoshida
  • Organizer: The international symposium in Tokyo 2022 Ubiquitin New Frontier ~from Neo-Biology to Targeted Protein Degradation~
  • Int'l Joint Research
• [Presentation] Identification of a quality control system to cope with aberrant proteins produced by mis-splicing (2022)
  • Author(s): Minoru Yoshida
  • Organizer: The international symposium in Tokyo 2022 Ubiquitin New Frontier ~from Neo-Biology to Targeted Protein Degradation~
  • Int'l Joint Research / Invited
• [Presentation] 化学遺伝学による遺伝病の治療標的分子同定と新規治療法の開発 (2022)
  • Author(s): 吉田 稔
  • Organizer: 第96回日本薬理学会年会
  • Invited
• [Presentation] フェリクロームは高アンモニウム条件下において分裂酵母の適応生育を誘導する (2022)
  • Author(s): 西村慎一、Po-Chang Chiu、中村優里、田渕稔二、八代田陽子、 平井 剛、松山晃久、吉田 稔
  • Organizer: 酵母遺伝学フォーラム第55回研究報告会
• [Presentation] 奇数鎖脂肪酸による分裂酵母の小胞体の異常形態と膜リン脂質組成の攪乱 (2022)
  • Author(s): 星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、 Charles Boone、津川裕司、有田 誠、吉田 稔
  • Organizer: 酵母遺伝学フォーラム第55回研究報告会
• [Presentation] Proteins from translated introns repress global protein synthesis (2022)
  • Author(s): Jagat K. Chhipi-Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki and Minoru Yoshida
  • Organizer: 第23回日本RNA学会年会
• [Presentation] eIF5A ハイプシン化阻害剤 GC7 による細胞増殖抑制の標的経路の解析 (2022)
  • Author(s): 松本 健、堂前 直、吉田 稔
  • Organizer: 第26回がん分子標的治療学会学術集会
• [Presentation] 鎌状赤血球症治療薬創製を目指したヒストンメチル化酵素 G9a 阻害剤の開発 (2022)
  • Author(s): 伊藤昭博、高瀬翔平、寛山隆、白井文幸、西ヶ谷洋輔、角谷龍展、中田明子、 園田健、丹羽英明、梅原崇史、中村幸夫、吉田稔
  • Organizer: 日本ケミカルバイオロジー学会第16回年会
• [Presentation] ヒストンメチル化のケミカルバイオロジーと創薬 (2022)
  • Author(s): 吉田 稔
  • Organizer: 日本ケミカルバイオロジー学会・産学連携委員会 定例会
  • Invited
• [Presentation] Reactivity of endogenous acrolein: Application for proteolysis-induced cancer treatment (2022)
  • Author(s): A. R. Pradipta, K. Tanaka
  • Organizer: The International Symposium in Tokyo 2022: Ubiquitin New Frontier “from Neo-Biology to Targeted Protein Degradation”
  • Int'l Joint Research
• [Presentation] 生体内の有機合成化学による次世代医療 (2022)
  • Author(s): A. R. Pradipta
  • Organizer: 第12回CSJ化学フェスタ2022
  • Invited
• [Presentation] Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy (2022)
  • Author(s): A. R. Pradipta
  • Organizer: The 17th Joint Conference on Chemistry State University of Semarang
  • Int'l Joint Research / Invited
• [Presentation] Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy (2022)
  • Author(s): A. R. Pradipta
  • Organizer: RIKEN _ Taiwan National Chung Hsing University Symposium
  • Int'l Joint Research / Invited
• [Presentation] がんが普遍的に過剰生産するアクロレイン代謝物：生組織でのカスケード反応によるがん診断・治療への応用 (2022)
  • Author(s): A. R. Pradipta
  • Organizer: 有機合成化学協会関東支部「若手研究者のためのセミナー」
  • Invited
• [Presentation] Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy (2022)
  • Author(s): A. R. Pradipta
  • Organizer: The 15th International Conference on Cutting-Edge Organic Chemistry in Asia
  • Int'l Joint Research
• [Presentation] Reactivity of endogenous acrolein: Application for cancer-specific ubiquitination (2022)
  • Author(s): A. R. Pradipta
  • Organizer: 新学術領域「ケモユビキチン」第6回総括班会議
• [Presentation] アクロレインの新規反応性に基づく糖転移酵素阻害剤の活性化 (2022)
  • Author(s): 笠原隆継, T. C. Chang, 浦野清香, A. R. Pradipta, 田中克典
  • Organizer: 第83回有機合成化学協会関東支部シンポジウム
• [Presentation] アクロレインとアジドの環化付加反応に基づく糖転移酵素阻害剤の活性化 (2022)
  • Author(s): 笠原隆継, A. R. Pradipta, 田中克典
  • Organizer: 第12回CSJ化学フェスタ2022
• [Presentation] 生体内一酸化炭素を利用した抗がん活性物質の生体内合成 (2022)
  • Author(s): 河合雅行, A. R. Pradipta, 田中克典
  • Organizer: 第12回CSJ化学フェスタ2022
• [Presentation] がん細胞での[4+4]付加環化反応を用いる機能性ポリマー合成 (2022)
  • Author(s): 川口慎司, A. R. Pradipta, 田中克典
  • Organizer: 第12回CSJ化学フェスタ2022
• [Presentation] がんのアクロレインを用いた薬理活性複素環化合物の合成研究 (2022)
  • Author(s): 奥村昂也, A. R. Pradipta, 田中克典
  • Organizer: 第12回CSJ化学フェスタ2022
• [Presentation] アクロレインとの反応によるタンパク質の分解誘導がん治療 (2022)
  • Author(s): 松嶋良真, A. R. Pradipta, 田中克典
  • Organizer: 第12回CSJ化学フェスタ2022
• [Presentation] がん代謝物との反応を基盤とするプロドラッグ法 (2022)
  • Author(s): 寺島一輝, A. R. Pradipta, 田中克典
  • Organizer: 第16回バイオ関連化学シンポジウム
• [Presentation] がん代謝物との反応を基盤とした標的α線がん治療分子 (2022)
  • Author(s): 大出雄大, A. R. Pradipta, 田中克典
  • Organizer: 創薬懇談会2022
• [Presentation] がん代謝物との反応を基盤とした生体内天然物合成研究 (2022)
  • Author(s): 寺島一輝, A. R. Pradipta, 田中克典
  • Organizer: 創薬懇談会2022
• [Presentation] Peptide/protein-mediated delivery of a ruthenium catalyst for in vivo tumor threapy (2022)
  • Author(s): K. Muguruma, K. Imai, A. R. Pradipta, K. Tanaka
  • Organizer: Peptide Science: Proceeding of the Japanese Peptide Symposium 20225
• [Presentation] Identification of dihydroorotate dehydrogenase inhibitors, indoluidins, that inhibit cancer cell growth (2022)
  • Author(s): Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Kanami Yamazaki, Shingo Dan, Hiroyuki Osada
  • Organizer: 11th annual conference of the International Chemical Biology Society (ICBS)
  • Int'l Joint Research
• [Presentation] ビタミンD代謝産物による脂質ベータ酸化とカルニチン生合成の制御 (2022)
  • Author(s): 竹本靖、Mendoza Aileena、Cruzado Kevin Tana、Masoud Shadi Sedghib、永田亜希子、Tantipanjaporn Ajcharapana、奥田聡、川越文裕、坂本良太、小田木陽、本谷小佑里、冨樫萌香、川谷誠、青野晴美、長田裕之、中川勇人、東達也、橘高敦史、長澤和夫、上杉志成
  • Organizer: 第64回天然有機化合物討論会
• [Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定 (2022)
  • Author(s): 川谷誠、青野晴美、室井誠、大石智一、大庭俊一、川田学、旦慎吾、長田裕之
  • Organizer: 第26回日本がん分子標的治療学会学術集会
• [Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定 (2022)
  • Author(s): 川谷誠、青野晴美、清水猛、平沼佐代子、室井誠、小川直子、大石智一、大庭俊一、川田学、山崎佳波、旦慎吾、長田裕之
  • Organizer: 日本ケミカルバイオロジー学会第16回年会
• [Presentation] がん細胞のフェロトーシスを増強するFSP1阻害剤NPD4928の発見 (2022)
  • Author(s): 吉岡広大、河村達郎、室井誠、近藤恭光、本田香織、川谷誠、青野晴美、Herbert Waldmann、渡邉信元、長田裕之
  • Organizer: 日本ケミカルバイオロジー学会第16回年会
• [Presentation] CFTR関連ユビキチンリガーゼの阻害剤探索と治療的応用 (2022)
  • Author(s): 谷口幸穂、松浦佑大、小野裕司、土井由佳子、近藤恭光、本田香織、長田裕之、井上敬太郎、山口美穂、田代杏樹、青木俊介、福田亮介、沖米田司
  • Organizer: 日本薬学会第142年会
• [Presentation] YAP-TEADの分子間相互作用を標的とした阻害剤探索 (2022)
  • Author(s): 関根咲彩、高瀬翔平、林瀬瑠奈、則次恒太、黒川留美、市川保恵、近藤恭光、小川健司、松本健、長田裕之、吉田稔、伊藤昭博
  • Organizer: 日本薬学会第142年会
• [Presentation] Reactivity of Endogenous Acrolein: Application for Cancer-Specific Ubiquitination (2021)
  • Author(s): A. R. Pradipta
  • Organizer: 新学術領域「ケモユビキチン 」第6回総括班会議
• [Presentation] がん代謝物との環化付加反応によるがん化学療法 (2021)
  • Author(s): A. R. Pradipta, P. Ahmadi, K. Terashima, M. Fujii, K. Tanaka
  • Organizer: 日本ケミカルバイオロジー学会 第15回年会
• [Presentation] がん代謝物との反応を基盤とするプロドラッグ法 (2021)
  • Author(s): A. R. Pradipta, K. Tanaka
  • Organizer: 第79回有機合成化学協会関東支部大岡山シンポジウム
• [Presentation] Thriving in Your Research Career: My Personal Experience - Hints & Tip (2021)
  • Author(s): A. R. Pradipta
  • Organizer: 第12回 Tokyo Tech Indonesian Commitment Award 2021
• [Presentation] Add Perseverance to Your Passion: The Long and Rocky Academia Pathway (2021)
  • Author(s): A. R. Pradipta
  • Organizer: 第11回 CSJ化学フェスタ 2021
• [Presentation] がんが普遍的に過剰生産するアクロレイン代謝物：生組織でのカスケード反応によるがん診断・治療への応用 (2021)
  • Author(s): A. R. Pradipta
  • Organizer: Departemental Talk Kyushu University
• [Presentation] がんが普遍的に過剰生産するアクロレイン代謝物：生組織でのカスケード反応によるがん診断・治療への応用 (2021)
  • Author(s): A. R. Pradipta
  • Organizer: 専門基礎研究塾：有機化学分野
• [Presentation] がんが普遍的に過剰生産するアクロレイン代謝物：生組織でのカスケード反応によるがん診断・治療への応用 (2021)
  • Author(s): A. R. Pradipta
  • Organizer: 物質理工学院研究紹介～ランチセッション～
• [Presentation] がんが普遍的に過剰生産するアクロレイン代謝物：生組織でのカスケード反応によるがん診断・治療への応用 (2021)
  • Author(s): A. R. Pradipta
  • Organizer: 第8回慶應有機化学若手シンポジウム
• [Presentation] 次世代シークエンサーを用いた低分子化合物と結合する非コードRNAの網羅的探索 (2021)
  • Author(s): 藤本颯、近藤恭光、河村達郎、長谷純崇、井本正哉、長田裕之、榊原康文
  • Organizer: 日本ケミカルバイオロジー学会 第15回年会
• [Presentation] YAP-TEAD分子間相互作用を標的とした阻害剤スクリーニング (2021)
  • Author(s): 高瀬翔平、関根咲彩、林瀬瑠奈、則次恒太、市川保恵、近藤恭光、小川健司、長田裕之、吉田稔、伊藤昭博
  • Organizer: 日本ケミカルバイオロジー学会 第15回年会
• [Presentation] YAP-TEAD間相互作用を標的とした低分子阻害剤の探索 (2021)
  • Author(s): 関根咲彩、高瀬翔平、林瀬瑠奈、則次恒太、市川保恵、近藤恭光、小川健司、長田裕之、吉田稔、伊藤昭博
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] ハイプシン化阻害剤 GC7 による細胞増殖抑制の標的経路の解析 (2021)
  • Author(s): 松本健、黒川留美、吉田稔
  • Organizer: 日本ケミカルバイオロジー学会 第15回年会
• [Presentation] 分裂酵母の分泌型シグナル分子を使った細胞間コミュニケーション (2021)
  • Author(s): 吉田稔、西村慎一、八代田陽子
  • Organizer: 第23回酵母合同シンポジウム
• [Presentation] 生理活性天然物が教えてくれた真核生物の新しい遺伝子発現制御機構 (2021)
  • Author(s): 吉田稔
  • Organizer: 日本農芸化学会2021年 度西日本・中四国・関西支部 合同大会
• [Presentation] ケミカルゲノミクスが牽引するがん研究と創薬 (2021)
  • Author(s): 吉田稔
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] eIF5Aハイプシン化阻害剤GC7によるミトコンドリアタンパク質への影響 (2021)
  • Author(s): 松本健、黒川留美、吉田稔
  • Organizer: 第94回日本生化学会大会シンポジウム 神秘の生命物質ポリアミンから探る生命現象と健康への応用
• [Presentation] HP1αクロモドメインを用いたFRET型蛍光プローブによる細胞分裂中のヒストン修飾動態の観察 (2021)
  • Author(s): 佐々木和樹、鈴木律裕、中尾 洋一、吉田 稔
  • Organizer: 第14回日本エピジェネティクス研究会年会
• [Presentation] 天然物化学ゲノミクスによる真核生物セントラルドグマの制御機構解析 (2021)
  • Author(s): 吉田稔
  • Organizer: 第14回日本エピジェネティクス研究会年会
  • Invited
• [Presentation] 細胞分裂過程におけるHP1αクロモドメインとヒストンH3の結合状態の経時観察 (2021)
  • Author(s): 佐々木和樹、鈴木律裕、中尾 洋一、吉田 稔
  • Organizer: 日本農芸化学会2021年度大会
• [Presentation] 分裂酵母のオキシリピンを介した窒素代謝に関わる細胞間コミュニケーションの解明 (2021)
  • Author(s): 橋本莉央、八代田陽子、大澤晋、平井剛、森山裕充、吉田 稔
  • Organizer: 日本農芸化学会2021年度大会
• [Presentation] mTOR経路阻害でリー脳症モデルNdufs4 KOマウス寿命を延長する分子機構 (2021)
  • Author(s): 伊藤孝、小林大貴、吉田稔
  • Organizer: J-mit 特別 オンラインシンポジウム
• [Presentation] 機能低下したミトコンドリアを活性化させる化合物の発見とその応用 (2021)
  • Author(s): 小林大貴、畠山英之、伊藤孝、西村はる菜、横田睦美、鈴木禎史、苫米地由里、白水美香子、長田裕之、三牧正和、後藤雄一、吉田稔
  • Organizer: J-mit 特別 オンラインシンポジウム
• [Presentation] Reactivity of Acrolein Released from Cancer Cells: Application for Selective Cancer Therapy and Diagnosis (2021)
  • Author(s): Pradipta Ambara Rachmat, Ahmadi Peni, Tanaka Katsunori
  • Organizer: 日本化学会第101春季年会
• [Presentation] Reactivity of Endogenous Acrolein: Application for Therapy and Diagnosis (2021)
  • Author(s): Pradipta Ambara Rachmat
  • Organizer: 新学術領域「ケモユビキチン 」第4回総括班会議
• [Presentation] 汚染物質輸送因子Major latex-like proteinの遺伝子発現と結合活性の制御によるウリ科作物汚染の低減化 (2021)
  • Author(s): 藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
  • Organizer: 日本農薬学会第46回大会
• [Presentation] A new paradigm of eukaryotic mitochondrial genetic inheritance revealed from studies on yeast mitochondrial DNA replication (2020)
  • Author(s): Ling Feng, Yoshida Minoru
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns (2020)
  • Author(s): Chhipi Shrestha Jagat Krishna, Schneider-Poetsch Tilman, Suzuki Takehiro, Mito Mari, Khan Khalid, Dohmae Naoshi, Iwasaki Shintaro, Yoshida Minoru
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] Discovery of a small molecule that rescues phenotypes of cells carrying disease- related mitochondrial DNA mutations by inducing metabolic redirection (2020)
  • Author(s): Minoru Yoshida
  • Organizer: Target 2035 | a probe for every protein | Kick-off webinar series
  • Int'l Joint Research / Invited
• [Presentation] Hippo経路におけるYAP-TEAD相互作用を標的とした阻害剤探索 (2020)
  • Author(s): 高瀬翔平、長田裕之、吉田稔、伊藤昭博、
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] エピジェネティクスリーダータンパク質GAS41の阻害剤探索 (2020)
  • Author(s): 高瀬翔平、高橋未帆、園田健、菊地正樹、近藤恭光、梅原崇史、長田裕之、吉田稔、伊藤昭博
  • Organizer: 第93回日本生化学会大会
• [Presentation] 化合物の標的分子同定のためのケミカルゲノミクス基盤の確立 (2020)
  • Author(s): 八代田陽子、Lien Pham、Sheena Li、Urvi Bhojoo、吉村麻美、木村寛美、河村優美、長田裕之、松本健、吉田稔、Jason Moffat、Charles Boone
  • Organizer: 新学術領域研究「化学コミュニケーションのフロンティア」第７回公開シンポジウム
• [Presentation] Reactivity and Application of Acrolein Released from Cancer Cells (2020)
  • Author(s): Pradipta Ambara Rachmat
  • Organizer: The 6th International Symposium on Applied Chemistry
  • Int'l Joint Research / Invited
• [Presentation] がんが風編的に過剰生産するアクロレイン代謝物：ヒト生組織でのカスケード反応による乳がん術中迅速診断の臨床成果 (2020)
  • Author(s): Pradipta Ambara Rachmat, Tanei Tomonori, Morimoto Koji, Shimazu Kenzo, Noguchi Shinzaburo, Tanaka Katsunori
  • Organizer: 第62回天然有機化合物討論会
• [Presentation] Comprehensive detection of RNA targets that bind to chemical compounds using next-generation sequencing and data-driven method. (2020)
  • Author(s): Fujimoto Hayate, Kondoh Yasumitsu, Kawamura Tatsuro, Hase Sumitaka, Imoto Masaya, Osada Hiroyuki, Sakakibara Yasubumi
  • Organizer: RNA 2020 Meeting
  • Int'l Joint Research
• [Presentation] ハイプシン化阻害剤GC7のミトコンドリアへの影響 (2020)
  • Author(s): 松本 健、黒川 留美、Tariq Mohammad、Schneider-Poetsch Tilman、凌 楓、室井 誠、鈴木 健裕、堂前 直、伊藤 昭博、長田 裕之、吉田 稔
  • Organizer: 日本薬学会第140年会
• [Presentation] HP1αクロモドメインを用いた蛍光プローブによる細胞分裂中のクロマチン動態観察 (2020)
  • Author(s): 佐々木 和樹、鈴木 律裕、中尾 洋一、吉田 稔
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] TEAD-YAP相互作用を標的とした化合物の探索 (2020)
  • Author(s): 高瀬 翔平、林瀬 瑠奈、則次 恒太、市川 保恵、小川 健司、吉田 稔、伊藤 昭博
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] 翻訳因子 eIF5Aによる酵母の代謝調節機能の研究 (2020)
  • Author(s): 高橋 匠、近藤 直子、白井 温子、ヒルバート マグパンタイ、松山 晃久、吉田 稔
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] PAF複合体-SAGA複合体を介した窒素カタボライト抑制制御機構の解明 (2020)
  • Author(s): 大澤 晋、八代田 陽子、吉田 稔
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] 分裂酵母における栄養源感受性変異株の探索と解析 (2020)
  • Author(s): 三浦 俊一、八代田 陽子、西村 慎一、松山 晃久、吉田 稔
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] 分裂酵母の窒素シグナリング因子を介した細胞間コミュニケーションにおける受容機構の解明 (2020)
  • Author(s): 橋本 莉央、八代田 陽子、大澤 晋、平井 剛、森山 裕充、吉田 稔
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] Autophagy deficiency boosts the production of kojic acid in the filamentous fungus Aspergillus oryzae (2020)
  • Author(s): Junlin CHEN, Minoru YOSHIDA, Manabu ARIOKA
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] 統合表現型プロファイリングとケミカルプロテオミクスの手法による3量体Giタンパク質調節化合物の発見 (2020)
  • Author(s): 河村達郎、二村友史、Erchang Shang、室井誠、Petra Janning、上野雅佳、Julian Wilke、武田茂樹、近藤恭光、Slava Ziegler、渡辺信元、Herbert Waldmann、長田裕之
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] 天然物ケミカルバイオロジーによる新しい遺伝子発現制御機構の発見 (2020)
  • Author(s): 吉田 稔
  • Organizer: 日本農芸化学会四国支部第56回講演会
  • Invited
• [Presentation] eIF5Aハイプシン化阻害剤GC7によるミトコンドリア制御 (2020)
  • Author(s): 松本 健、黒川 留美、凌 楓、鈴木 健裕、堂前 直、吉田 稔
  • Organizer: 日本ポリアミン学会 第11回年会
• [Presentation] Opening new avenues of chemical biology by bioactive natural products (2020)
  • Author(s): Minoru Yoshida
  • Organizer: The 6th CSRS-ITbM Joint Workshop
• [Presentation] Acrolein Click Chemistry-Mediated Cancer Diagnosis (2020)
  • Author(s): Ambara Rachmat Pradipta
  • Organizer: 令和元年度基礎科学特別研究員成果発表会
• [Presentation] Reactivity of Acrolein Released from Cancer Cells: Application for Selective Cancer Therapy (2020)
  • Author(s): Ambara Rachmat Pradipta, Peni Ahmadi, Motoko Fujii, Katsunori Tanaka
  • Organizer: 日本化学会第100春季年会
• [Presentation] 酵母ケミカルゲノミクス法を用いた化合物の標的同定 (2019)
  • Author(s): 八代田陽子、吉村麻美、野口峻太朗、Sheena Li、木村寛美、河村優美、吉田稔、酒井隆一、Charles Boone
  • Organizer: 「化学コミュニケーションのフロンティア」第6回公開シンポジウム
• [Presentation] A novel translational buffering system that links splicing and cancer (2019)
  • Author(s): Minoru Yoshida
  • Organizer: 第42回日本分子生物学会年会 Symposium on ” Crossroad of Chemical and RNA Biology”
• [Presentation] eIF5Aハイプシン化阻害剤GC7によるミトコンドリアタンパク質の減少 (2019)
  • Author(s): 松本 健、黒川 留美、Tariq Mohammad、Schneider-Poetsch Tilman、凌 楓、室井 誠、鈴木 健裕、堂前 直、伊藤 昭博、長田 裕之、吉田 稔
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] タンキラーゼ阻害剤の創薬研究（３）：新規ジヒドロキナゾリノン誘導体の創出 (2019)
  • Author(s): 鷲塚 健一、白井 文幸 、八代田 陽子 、幸 瞳 、丹羽 英明 、佐藤 心 、安倍 昌子 、大貫 哲男 、眞﨑 唯 、平間 千津子 、深見 竹広 、本間 光貴 、梅原 崇史 、白水 美香子 、吉田 喜香 、水谷 アンナ 、村松 由紀子 、清宮 啓之 、吉田 稔 、小山 裕雄
  • Organizer: 第37回メディシナルケミストリーシンポジウム2019
• [Presentation] タンキラーゼ阻害剤の創薬研究（２）：経口投与で抗腫瘍効果を示すスピロインドリノン誘導体RK582 の創製 (2019)
  • Author(s): 白井 文幸、水谷 アンナ 、八代田 陽子 、津村 武史 、狩野 ゆうこ 、近田 翼 、村松 由紀子 、幸 瞳 、丹羽 英明 、佐藤 心 、鷲塚 健一 、甲田 泰子 、眞﨑 唯 、張 明奎 、永森 晶子 、奥江 雅之 、渡邊 尚志 、北村 弘一 、設楽 永紀 、本間 光貴 、梅原 崇史 、白水 美香子 、深見 竹広 、清宮 啓之 、吉田 稔 、小山 裕雄
  • Organizer: 第37回メディシナルケミストリーシンポジウム2019
• [Presentation] タンキラーゼ阻害剤の創薬研究（１）：細胞増殖阻害活性改善を指向した誘導体合成 (2019)
  • Author(s): 甲田 泰子、白井 文幸 、水谷 アンナ 、八代田 陽子 、津村 武史 、狩野 ゆうこ 、近田 翼 、村松 由紀子 、幸 瞳 、丹羽 英明 、佐藤 心 、吉田 喜香 、眞﨑 唯 、鷲塚 健一 、奥江 雅之 、渡邊 尚志 、北村 弘一 、設楽 永紀 、本間 光貴 、梅原 崇史 、白水 美香子 、深見 竹広 、清宮 啓之 、吉田 稔 、小山 裕雄
  • Organizer: 第37回メディシナルケミストリーシンポジウム2019
• [Presentation] 内因性脂質代謝物N-アシルドーパミンによるHIF-1α 活性化機構 (2019)
  • Author(s): 石倉菜摘、前本佑樹、青木元秀、橘高敦史、上杉志成、吉田稔、伊藤昭博
  • Organizer: 第24回化学生物学研究会
• [Presentation] Opening new drug discovery frontiers through natural products chemical genetics (2019)
  • Author(s): Minoru Yoshida
  • Organizer: 8th annual conference of International Chemical Biology Society (ICBS-2019)
  • Int'l Joint Research / Invited
• [Presentation] Target pathway identification of bioactive compounds by multifaceted approaches (2019)
  • Author(s): Ken Matsumoto, Shohei Takase, Rumi Kurokawa, Minoru Yoshida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Development of fluorescent probes for visualizing an interaction between intra-nucleosomal histone H3 K9 tri-methylation and HP1α chromodomain and live-cell imaging (2019)
  • Author(s): Kazuki Sasaki, Michihiro Suzuki, Akihiro Ito, Yoichi Nakao, Minoru Yoshida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Chemical and genetic regulation of nitrogen catabolite repression by PAF complex in the fission yeast Schizosaccharomyces (2019)
  • Author(s): Shin Ohsawa, Yoko Yahiroda, Minoru Yohida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Development of NanoBiT-based 2- and 3-hybrid system in fission yeast (2019)
  • Author(s): Akihisa Matsuyama, Minoru Yoshida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Comprehensive analysis of the mechanism of action of theonellamides, marine-derived antifungals, based on fission yeast ORFeome (2019)
  • Author(s): Shinichi Nishimura, Akifumi Suganaga, Akihisa Matsuyama, Minoru Yoshida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Identification of a novel compound that alters energy metabolism (2019)
  • Author(s): Hiroki Kobayashi, Hiroyuki Osada, Minoru Yoshida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Mechanism of action of anticancer splicing modulators? Translational buffering linking splicing and cancer (2019)
  • Author(s): Minoru Yoshida
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] Translation factor eIF5A connects protein synthesis and energy metabolism (2019)
  • Author(s): Tilman Schneider-Poetsch, Jagat Shrestha, Shintaro Iwasaki, Minoru Yoshida
  • Organizer: The 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
  • Int'l Joint Research
• [Presentation] A novel compound that alters energy metabolism (2019)
  • Author(s): Hiroki Kobayashi, Hiroyuki Osada, Minoru Yoshida
  • Organizer: The 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
  • Int'l Joint Research
• [Presentation] ワールブルグ効果制御物質の発見 (2019)
  • Author(s): 小林大貴、長田 裕之、吉田 稔
  • Organizer: 第78回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] Translational buffering linking splicing and cancer (2019)
  • Author(s): Minoru Yoshida
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 7th Symposium
  • Int'l Joint Research / Invited
• [Presentation] Conversion of SIRT2 catalytic activity from deacetylase to defatty-acylase by fatty-acyl substrates (2019)
  • Author(s): Norio Kudo, Akihiro Ito, Mayumi Arata, Akiko Nakata, Seiji Matsuoka, Daria Monaldi, Manfred Jung, Minoru Yoshida
  • Organizer: FASEB Conference on The Reversible Protein Acetylation in Health and Disease
  • Int'l Joint Research
• [Presentation] Fatty acyl metabolites as intrinsic inhibitors of SIRT2 deacetylase (2019)
  • Author(s): Minoru Yoshida
  • Organizer: FASEB Conference on The Reversible Protein Acetylation in Health and Disease
  • Int'l Joint Research / Invited
• [Presentation] 分裂酵母同士も「化合物」を使ってコミュニケーションする (2019)
  • Author(s): 吉田 稔
  • Organizer: 微生物ウイーク2019
• [Presentation] PAF complex regulates the cancelation of nitrogen catabolite repression (2019)
  • Author(s): Shin Ohsawa, Yoko Yashiroda, Minoru Yoshida
  • Organizer: 10th International Fission Yeast Meeting (Pombe meeting 2019)
  • Int'l Joint Research
• [Presentation] ウリ科作物の新規汚染低減化法の開発 (2019)
  • Author(s): 藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
  • Organizer: 神戸大学研究基盤センター若手フロンティア研究会２019
• [Presentation] 汚染物質輸送因子の遺伝子発現と結合活性制御によるウリ科作物における作物汚染の低減化 (2019)
  • Author(s): 藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
  • Organizer: 第37回農薬環境科学研究会
• [Presentation] 受容体特異的な3′-alkyl ABAを用いたアブシジン酸受容体機能解析 (2019)
  • Author(s): 由田和津子、近藤恭光、岩橋福松、中野雄司、本田香織、永野栄喜、長田裕之
  • Organizer: 植物化学調節学会第54回大会
• [Presentation] Reduction of pop contamination in Cucurbitaceae family focusing on the transporting factors for POPs by the treatment of pesticides (2019)
  • Author(s): Kentaro Fujita, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Hideyuki Inui
  • Organizer: 39th International Symposium on Halogenated Persistent Organic Pollutants: DioXin 2019
  • Int'l Joint Research
• [Presentation] Identification and characterization of small-molecular compounds that inhibit salicylic acid-mediated signaling pathway in Arabidopsis (2019)
  • Author(s): Nobuaki Ishihama, Yoshiteru Noutoshi, Seung-won Choi, Ivana Saska, Shuta Asai, Kaori Takizawa, Yasumitsu Kondoh, Yuko Nomura, Hirofumi Nakagami, Hiroyuki Osada, Ken Shirasu
  • Organizer: IS-MPMI XVIII Congress
  • Int'l Joint Research
• [Presentation] Selective activation of abscisic acid receptors by 3’-alkyl ABAs (2019)
  • Author(s): Kazuko Yoshida, Yasumitsu Kondoh, Fukumatsu Iwahashi, Takeshi Nakano, Kaori Honda, Eiki Nagano, Hiroyuki Osada.
  • Organizer: Chemical Probe Workshop
  • Int'l Joint Research
• [Presentation] 新規UbTACsのためのリガンド化合物探索とキメラ化法開発 (2019)
  • Author(s): Ambara Rachmat Pradipta
  • Organizer: 新学術領域「ケモユビキチン 」第3回総括班会議
• [Presentation] Synthetic Chemistry for Clinical Trials: Azide-Acrolein Click Reaction for Intraoperative Diagnosis of Breast Cancer Patients (2019)
  • Author(s): Ambara Rachmat Pradipta, Motoko Fujii, Katsunori Tanaka
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology the Seventh Symposium
  • Int'l Joint Research
• [Presentation] 実臨床合成化学：乳癌の術中断端迅速診断 (2019)
  • Author(s): Ambara Rachmat Pradipta, Tomonori Tanei, Motoko Fujii, Koji Morimoto, Shinzaburo Noguchi, Katsunori Tanaka
  • Organizer: 日本化学会第99春季年会
• [Presentation] 実臨床合成化学：乳癌の術中断端迅速診断 (2019)
  • Author(s): Ambara Rachmat Pradipta, Katsunori Tanaka
  • Organizer: 第1回新学術「ケモユビキチン」班会議・第2回ユビキチン研究会
• [Presentation] 受容体特異的な3’-alkyl ABAを用いたABA受容体機能解析 １．構造活性相関 (2019)
  • Author(s): 由田和津子、近藤恭光、岩橋福松、中野雄司、本田香織、永野栄喜、長田裕之
  • Organizer: 日本農芸化学会2019年度大会
• [Presentation] 受容体特異的な3’-alkyl ABAを用いたABA受容体機能解析 ２．ドッキングシミュレーション (2019)
  • Author(s): 近藤恭光、由田和津子、岩橋福松、中野雄司、本田香織、永野栄喜、長田裕之
  • Organizer: 日本農芸化学会2019年度大会
• [Presentation] がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析 (2019)
  • Author(s): 河村 達郎、二村 友史、室井 誠、川谷 誠、SHANG Erchang、JANNING Petra、近藤 恭光、野川 俊彦、ZIEGLER Slava、渡辺 信元、WALDMANN Herbert、長田 裕之
  • Organizer: 日本農芸化学会2019年度大会
• [Presentation] XIAP BIR3ドメインの化学合成と鏡像スクリーニングへの応用 (2019)
  • Author(s): 岩本 直也、周敬棠、本田香織、近藤恭光、長田裕之、井貫晋輔、大野浩章、藤井信孝、大石真也
  • Organizer: 日本薬学会第139年会
• [Presentation] 汚染物質輸送因子の結合活性制御に着目したウリ科作物の汚染低減化 (2019)
  • Author(s): 藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
  • Organizer: 日本農薬学会第44回大会
• [Presentation] Target identification of a small-molecule that inhibits cancer cell-accelerated fibroblast migration (2019)
  • Author(s): Kruthi Suvarna, Kaori Honda, Makoto Muroi, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
  • Organizer: The 5th CSRS-ITbM Joint Workshop
• [Presentation] エネルギー代謝のケミカルバイオロジー (2018)
  • Author(s): 吉田 稔
  • Organizer: 産学協力研究委員会 第170委員会・第189委員会合同シンポジウム
  • Invited
• [Presentation] 天然活性物質の作用機序研究から見えてきたもの (2018)
  • Author(s): 吉田 稔
  • Organizer: 第5回生命科学セミナー
  • Invited
• [Presentation] Power of chemical genetics to uncover eukaryotic gene expression and metabolism (2018)
  • Author(s): Minoru Yoshida
  • Organizer: A3 Lecture（JSPS日中韓フォーサイト事業（A3事業））
  • Int'l Joint Research / Invited
• [Presentation] Acrolein Sensor for Rapid Intraoperative Diagnosis of Breast Cancer (2018)
  • Author(s): Ambara Rachmat Pradipta, Katsunori Tanaka
  • Organizer: The All-RIKEN Workshop 2018
• [Presentation] Acrolein Click Chemistry-Mediated Cancer Imaging and Treatment (2018)
  • Author(s): Ambara Rachmat Pradipta, Katsunori Tanaka
  • Organizer: GlycoTOKYO2018シンポジウム (東京糖鎖研究会)
• [Presentation] Synthetic Chemistry for Clinical Trials: Azide-Acrolein Click Reaction for Intraoperative Diagnosis of Breast Cancer Patients (2018)
  • Author(s): Ambara Rachmat Pradipta, Katsunori Tanaka
  • Organizer: The 14th International Kyoto Conference on New Aspects of Organic Chemistry
  • Int'l Joint Research
• [Presentation] Clinical Organic Synthesis: Rapid Intraoperative Diagnosis of Breast Cancer (2018)
  • Author(s): Ambara Rachmat Pradipta, Motoko Fujii, Katsunori Tanaka
  • Organizer: 日本化学会新領域研究グループ「有機合成化学を起点とするものづくり戦略」最終研究成果発表シンポジウム
• [Presentation] Acrolein Click Chemistry-Mediated Cancer Imaging and Treatment (2018)
  • Author(s): Ambara Rachmat Pradipta, Katsunori Tanaka
  • Organizer: ケミカルプローブ合同合宿セミナー
• [Presentation] 実臨床合成化学：乳癌の術中断端迅速診断 (2018)
  • Author(s): Ambara Rachmat Pradipta, Tomonori Tanei, Motoko Fujii, Koji Morimoto, Shinzaburo Noguchi, Katsunori Tanaka
  • Organizer: 第12回バイオ関連化学シンポジウム
• [Presentation] Acrolein Click Chemistry-Mediated Cancer Imaging and Treatment (2018)
  • Author(s): Ambara Rachmat Pradipta, Katsunori Tanaka
  • Organizer: The 54th International Conference on Medicinal Chemistry: Interfacing Chemical Biology and Drug Discovery
  • Int'l Joint Research
• [Presentation] Acrolein Click Chemistry-Mediated Oxidative Stress Imaging and Theranostics (2018)
  • Author(s): Ambara Rachmat Pradipta
  • Organizer: 日本化学会第98春季年会, Asian International Symposium (Medicinal Chemistry)
  • Invited
• [Presentation] アクロレインのインビボクリック反応性に基づく生体内合成化学治療 (2018)
  • Author(s): Ambara Rachmat Pradipta, Motoko Fujii, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Yasuyoshi. Watanabe, Katsunori Tanaka
  • Organizer: 日本化学会第98春季年会
• [Presentation] ケミカルバイオロジーからアプローチしたTAZの新しい制御機構の解析 (2018)
  • Author(s): 長島俊太、丸山順一、岩佐宏晃、有本-松崎京子、本田 香織、近藤恭光、長田裕之、名和眞希子、石上-湯浅磨里、影近弘之、中浜健一、仁科博史、畑裕
  • Organizer: MBSJ日本分子生物学会
• [Presentation] A small-molecule ligand of VCP inhibits accelerated fibroblast migration by cancer cells (2018)
  • Author(s): Kruthi Suvarna, Kaori Honda, Makoto Muroi, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
  • Organizer: MBSJ日本分子生物学会
• [Presentation] 植物成長促進化合物PPGによる植物カルス形成制御機構の解明 (2018)
  • Author(s): 前川琴美、田中翔太、竹野駿、山上あゆみ、筧 雄介、嶋田幸久、近藤恭光、堂前 直、嶋田勢津子、松井 南、久城哲夫、長田裕之、浅見忠男、篠崎一雄、中野雄司
  • Organizer: 第53回植物化学調節学会年次大会
• [Presentation] 植物免疫阻害剤を用いた植物免疫応答制御因子の探索 (2018)
  • Author(s): 石濱伸明, 能年義輝, 崔 勝媛, Ivana Saska, 浅井秀太, 瀧澤 香, 野村有子, 中神弘史, 近藤恭光, 長田裕之, 白須 賢
  • Organizer: 平成30年度日本植物病理学会関東部会
• [Presentation] Reduction of crop contamination resulting from hydrophobic contaminants by the treatment of pesticides targeting to its transport factors (2018)
  • Author(s): Fujita K, Sakai A, Kondoh Y, Honda K, Osada H, Inui H
  • Organizer: 38th International Symposium on Halogenated Persistent Organic Pollutants & 10th International PCB Workshop
  • Int'l Joint Research
• [Presentation] JBIR-140 の細胞増殖抑制機構の解析 (2018)
  • Author(s): 松本 健、高瀬翔平、近藤恭光、鈴木健裕、堂前直、新家一男、長田裕之、久城哲夫、吉田稔
  • Organizer: 日本ケミカルバイオロジー学会第13回年会
• [Presentation] 高脂溶性汚染物質によって引き起こされる作物汚染の化合物輸送因子を標的とした農薬による低減化 (2018)
  • Author(s): 藤田健太郎、酒井葵衣、近藤恭光、本田香織、長田裕之、乾秀之
  • Organizer: 日本農薬学会第43回大会
• [Presentation] 新規インスリン分泌促進化合物の分子機構の解明 (2018)
  • Author(s): 松永 耕一、牛込剛史、近藤恭光、本田香織、長田裕之、泉 哲郎
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Book] 月刊誌「Precision Medicine」４. 有機合成反応を活用したがん診断 (2023)
  • Author(s): A. R. Pradipta, 田中克典
  • Total Pages: 6
  • Publisher: 株式会社北陸館
• [Remarks] イントロン由来の異常タンパク質が与えるストレス
  • URL: https://www.riken.jp/press/2021/20210914_1/index.html
• [Patent(Industrial Property Rights)] 新規フラノクマリン誘導体及びその用途 (2023)
  • Inventor(s): 川谷誠、長田裕之、青野晴美、平沼佐代子、清水猛
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
  • Overseas