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ヤポネシア人の人口推定を中心とした巨大データ解析

Planned

Project AreaDeciphering Origin and Establishment of Japonesians mainly based on genome sequence data
Project/Area Number 18H05511
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionHokkaido University

Principal Investigator

長田 直樹  北海道大学, 情報科学研究院, 准教授 (70416270)

Co-Investigator(Kenkyū-buntansha) 五條堀 淳  総合研究大学院大学, 先導科学研究科, 講師 (00506800)
河合 洋介  国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (30435515)
藤本 明洋  東京大学, 大学院医学系研究科(医学部), 教授 (30525853)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2020: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2019: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2018: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywordsゲノム / 進化 / 日本人 / 集団遺伝学 / ヤポネシア人 / ゲノム配列 / 人口動態
Outline of Annual Research Achievements

本年度は新学術領域研究「ヤポネシアゲノム」の計画研究班として,以下のような研究を行った.
1)Admixture Graphや,Fstから計算されたQ値を用いて,性染色体の分化様式から性に偏った移住様式を推定する手法を開発し,パイロット的に霊長類(旧世界ザル)ゲノムデータに適用した.その結果,性に偏った移住が現在の集団の遺伝構成に大きな影響を及ぼしたことが明らかになった.また,その手法をヤポネシア人集団と東アジア集団の集団ゲノムデータに適用した.2)ハプロタイプ共有長の情報を用いて,集団間の分岐年代をシミュレーションを用いて推定する手法を確立し,本土日本人集団と古代人を含む他の集団との分岐年代推定に応用した.3)マイクロサテライト配列の多型をゲノムワイドに推定する手法を開発し,手法の正確性や,日本人集団内での多様性について検討した.4)長鎖シークエンス技術を用いて発見された変異についての検証を行った.5)集団内に稀にしか存在しない希少変異の情報を用いて,古代人を含む東アジア集団の関係についての推測を行った.6)約2000人のヤポネシア人集団mtDNAのデータから,Bayesian Skyline Plot法を用いて,旧石器時代から弥生時代にかけての人口動態推定を行った.
また,領域内の他の研究班と,縄文人ゲノム解析や動植物(ハツカネズミやヒグマ)のゲノム解析などにおいて,多方面の共同研究を行った.11編の英語論文,4編の日本語解説記事/著書,22回の学会等発表を行った.

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

本年度は5年間の研究計画の2年目に位置する.研究開始当初にあげた目的を着実に達成しているだけでなく,データ解析の結果から新しい知見が得られ始めている.また,個別の研究テーマの推進だけではなく,領域内での共同研究を円滑に進めるためのデータ共有システムの構築も行い,領域内研究者間の共同研究も進みつつある.さらに,縄文人ゲノム解析や動植物のゲノム解析などにおいて,他研究班との多方面の共同研究を行った.また,研究に参画している大学院生がいくつかの賞を受けるなど,若手研究者の育成も着実に進んでいる.これらの点を考慮し,(1)当初の計画以上に進展している,とした.

Strategy for Future Research Activity

今後は,引き続き,ゲノムワイドデータを用いたヤポネシア人集団の歴史の探索を,他班との協力関係をつづけながら進めていく.また,本課題において新たに開発された手法を用いて,今後新しく得られるデータについての解析を行っていく.具体的には,以下の研究計画をあげる(1)日本人集団の成立にあたっての移住時の性比の偏りについて,ゲノムワイドデータとシミュレーションを用いて検証を行う.(2)ハプロタイプデータを用いた人口動態推定について,領域研究で得られたあらたなデータをもとに行う.(3)希少変異を用いた集団間の関連に関する研究を引き続き行い,古代人集団と東アジア人集団との関連をさらに高解像度で判別する.(4)マイクロサテライトデータを用いた日本人集団の遺伝的構造解析を行う.

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(72 results)

All 2020 2019 2018 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Funded Workshop

  • [Int'l Joint Research] University College Dublin(アイルランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Trinity Collage Dublin(アイルランド)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations2020

    • Author(s)
      Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H.
    • Journal Title

      EBioMedicine.

      Volume: 53 Pages: 102659-102659

    • DOI

      10.1016/j.ebiom.2020.102659

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive analysis of indels in whole-genome microsatellite Regions and microsatellite instability across 21 cancer types2020

    • Author(s)
      Fujimoto A*, Fujita M, Hasegawa T, Wong JH, Maejima K, Oku-Sasaki A, Nakano K, Shiraishi Y, Miyano S, Yamamoto G, Akagi K, Imoto S, and Nakagawa H
    • Journal Title

      Genome Res

      Volume: 30 Pages: 2020-2020

    • DOI

      10.1101/gr.255026.119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pan-cancer analysis of whole genomes.2020

    • Author(s)
      The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
    • Journal Title

      Nature

      Volume: 578 Pages: 82-93

    • DOI

      10.1038/s41586-020-1969-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Implications of HLA diversity among regions for bone marrow donor searches in Japan.2020

    • Author(s)
      Hashimoto S, Nakajima F, Imanishi T, Kawai Y, Kato K, Kimura T, Miyata S, Takanashi M, Nishio M, Tokunaga K, Satake M
    • Journal Title

      HLA

      Volume: in press

    • DOI

      10.1111/tan.13881

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels2020

    • Author(s)
      Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H.
    • Journal Title

      Ann Rheum Dis

      Volume: 79(1) Pages: 164166-164166

    • DOI

      10.1136/annrheumdis-2019-216044

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 港川人のミトコンドリア DNA全塩基配列からわかること2020

    • Author(s)
      水野文月,五條堀淳
    • Journal Title

      学術の動向

      Volume: 25 Pages: 2-2

    • Related Report
      2019 Annual Research Report
  • [Journal Article] eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA.2019

    • Author(s)
      Mizuno Kei、Akamatsu Shusuke、Sumiyoshi Takayuki、Wong Jing Hao、Fujita Masashi et al.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 15017-15017

    • DOI

      10.1038/s41598-019-51459-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan2019

    • Author(s)
      Kanzawa-Kiriyama Hideaki、Jinam Timothy A.、Kawai Yosuke、Sato Takehiro、Hosomichi Kazuyoshi、Tajima Atsushi、Adachi Noboru、Matsumura Hirofumi、Kryukov Kirill、Saitou Naruya、Shinoda Ken-Ichi
    • Journal Title

      AS

      Volume: 127 Issue: 2 Pages: 83-108

    • DOI

      10.1537/ase.190415

    • NAID

      130007696474

    • ISSN
      0918-7960, 1348-8570
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Key metabolic gene for recurrent freshwater colonization and radiation in fishes2019

    • Author(s)
      Ishikawa Asano, Kabeya Naoki, Ikeya Koki, Kakioka Ryo, Cech Jennifer N., Osada Naoki, Leal Miguel C., Inoue Jun, Kume Manabu, Toyoda Atsushi, Tezuka Ayumi, Nagano Atsushi J., Yamasaki Yo Y., Suzuki Yuto, Kokita Tomoyuki, Takahashi Hiroshi et al.
    • Journal Title

      Science

      Volume: 364 Pages: 886-889

    • DOI

      10.1126/science.aau5656

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic diversity and population structure of Glossina morsitans morsitans in the active foci of human African trypanosomiasis in Zambia and Malawi.2019

    • Author(s)
      Yukiko Nakamura, Junya Yamagishi, Kyoko Hayashida, Naoki Osada, Elisha Chatanga, Cornelius Mweempwa, Kalinga Chilongo, John Chisi, Jenelisa Musaya, Ryosuke Omori, Noboru Inoue, Boniface Namangala, Chihiro Sugimoto
    • Journal Title

      PLoS Neglected Tropical Diseases.

      Volume: 13

    • DOI

      10.1371/journal.pntd.0007568

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Achiasmy and sex chromosome evolution2019

    • Author(s)
      Kazuhiro Satomura, Naoki Osada, Toshinori Endo
    • Journal Title

      Ecological Genetics and Genomics

      Volume: 13 Pages: 1000046-1000046

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 日本人ゲノム解析において集団差をどう考えるか2019

    • Author(s)
      河合洋介
    • Journal Title

      IBD Research

      Volume: 13 Pages: 31-34

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 東アジアの人々のゲノム多様性2019

    • Author(s)
      徳永勝士,河合洋介
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 10 Pages: 561-565

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ヤポネシア人の歴史の解明が医学にもたらすもの2019

    • Author(s)
      長田直樹
    • Journal Title

      実験医学

      Volume: 37 Pages: 926-929

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer.2019

    • Author(s)
      Sumiyoshi Takayuki、Mizuno Kei、Yamasaki Toshinari、Miyazaki Yu、Makino Yuki、Okasho Kosuke、Li Xin、Utsunomiya Noriaki、Goto Takayuki、Kobayashi Takashi、Terada Naoki、Inoue Takahiro、Kamba Tomomi、Fujimoto Akihiro、Ogawa Osamu、Akamatsu Shusuke
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 4030-4030

    • DOI

      10.1038/s41598-019-40719-y

    • NAID

      120006709427

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan2019

    • Author(s)
      Kanzawa-Kiriyama H, Jinam TA, Kawai Y, Sato T, Hosomichi K, Tajima A, Adachi N, Matsumura H, Kryukov K, Saitou N and Shinoda K
    • Journal Title

      Anthropological Science

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] POGLUT1, the Putative Effector Gene Driven by rs2293370 in Primary Biliary Cholangitis Susceptibility Locus Chromosome 3q13.33.2019

    • Author(s)
      Hitomi, Y. Ueno, K. Kawai, Y. Nishida, N. , Umemura, T. et al
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 102-102

    • DOI

      10.1038/s41598-018-36490-1

    • NAID

      120006715480

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants2019

    • Author(s)
      Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K.
    • Journal Title

      Cell Mol Gastroenterol Hepatol.

      Volume: 7 Pages: 515-532

    • DOI

      10.1016/j.jcmgh.2018.11.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.2019

    • Author(s)
      Kakuta Yoichi、Kawai Yosuke、Naito Takeo、Hirano Atsushi、Umeno Junji、Fuyuno Yuta、Liu Zhenqiu、Li Dalin、Nakano Takeru、Izumiyama Yasuhiro、Ichikawa Ryo、Okamoto Daisuke、et al.
    • Journal Title

      J Crohns Colotis

      Volume: - Pages: 2019-2019

    • DOI

      10.1093/ecco-jcc/jjy197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate2018

    • Author(s)
      Sakuma Chisato、Sekizuka Tsuyoshi、Kuroda Makoto、Kasai Fumio、Saito Kyoko、Ikeda Masaki、Yamaji Toshiyuki、Osada Naoki、Hanada Kentaro
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 644-644

    • DOI

      10.1038/s41598-017-18934-2

    • NAID

      120006401475

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive phylogenomic analysis reveals a novel cluster of simian endogenous retroviral sequences in Colobinae monkeys2018

    • Author(s)
      Ikeda Masaki、Satomura Kazuhiro、Sekizuka Tsuyoshi、Hanada Kentaro、Endo Toshinori、Osada Naoki
    • Journal Title

      American Journal of Primatology

      Volume: 80

    • DOI

      10.1002/ajp.22882

    • NAID

      120006643589

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole Genome Sequencing of a Vietnamese Family from a Dioxin Contamination Hotspot Reveals Novel Variants in the Son with Undiagnosed Intellectual Disability.2018

    • Author(s)
      Nguyen Dang、Nguyen Hai、Nguyen Thuy、Nguyen Thi、Nakano Kaoru、Maejima Kazuhiro、Sasaki-Oku Aya、Nguyen Van、Nguyen Duy、Le Bach、Wong Jing、Tsunoda Tatsuhiko、Nakagawa Hidewaki、Fujimoto Akihiro、Nong Van
    • Journal Title

      Int J Environ Res Public Health

      Volume: 15 Pages: 2629-2629

    • DOI

      10.3390/ijerph15122629

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis.2018

    • Author(s)
      Shigemizu Daichi、Miya Fuyuki、Akiyama Shintaro、Okuda Shujiro、Boroevich Keith A、Fujimoto Akihiro、Nakagawa Hidewaki、Ozaki Kouichi、Niida Shumpei、Kanemura Yonehiro、Okamoto Nobuhiko、Saitoh Shinji、Kato Mitsuhiro、Yamasaki Mami、Matsunaga Tatsuo、Mutai Hideki、Kosaki Kenjiro、Tsunoda Tatsuhiko
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 10367-10367

    • DOI

      10.1038/s41598-018-23978-z

    • NAID

      120006551758

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer2018

    • Author(s)
      Taniguchi Hiroaki、Fujimoto Akihiro、Kono Hidetoshi、Furuta Mayuko、Fujita Masashi、Nakagawa Hidewaki
    • Journal Title

      Oncotarget

      Volume: 9 Pages: 26144-26156

    • DOI

      10.18632/oncotarget.25456

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy2018

    • Author(s)
      Latt Khun Zaw、Honda Kenjiro、Thiri Myo、Hitomi Yuki、Omae Yosuke、Sawai Hiromi、Kawai Yosuke、Teraguchi Shunsuke、Ueno Kazuko、Nagasaki Masao、Mabuchi Akihiko、Kaga Hajime、Komatsuda Atsushi、Tokunaga Katsushi、Noiri Eisei
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 15576-15576

    • DOI

      10.1038/s41598-018-33612-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project2018

    • Author(s)
      Yasuda Jun、et al.,
    • Journal Title

      BMC Genomics

      Volume: 19 Pages: 551-551

    • DOI

      10.1186/s12864-018-4942-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals.2018

    • Author(s)
      Y Yamaguchi-Kabata, J Yasuda, O Tanabe, Y Suzuki, H Kawame, N Fuse, M Nagasaki, Y Kawai, K Kojima, F Katsuoka, S Saito, I Danjoh, I Motoike, R Yamashita, S Koshiba, D Saigusa, G Tamiya, S Kure, N Yaegashi, Y Kawaguchi, F Nagami, S Kuriyama, J Sugawara, N Minegishi, A Hozawa, T Takai-Igarashi, K Kinoshita, M Yamamoto.
    • Journal Title

      Journal of Human Genetics 21

      Volume: 63 Pages: 213-230

    • DOI

      10.1038/s10038-017-0347-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of chalcone reductase in the soybean isoflavone metabolon: identification of GmCHR5, which interacts with 2- hydroxyisoflavanone synthase2018

    • Author(s)
      Mameda Ryo、Waki Toshiyuki、Kawai Yosuke、Takahashi Seiji、Nakayama Toru
    • Journal Title

      The Plant Journal

      Volume: 96 Pages: 56-74

    • DOI

      10.1111/tpj.14014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population2018

    • Author(s)
      Jia X, Horinouchi T, Hitomi Y, Shono A, Khor SS, Omae Y, Kojima K, Kawai Y, Nagasaki M, Kaku Y, Okamoto T, Ohwada Y, Ohta K, Okuda Y, Fujimaru R, Hatae K, Kumagai N, Sawanobori E, Nakazato H, Ohtsuka Y, Nakanishi K, Shima Y, Tanaka R, Ashida A, Kamei K, Ishikura K, Nozu K, Tokunaga K, Iijima K
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 29 Pages: 2189-2199

    • DOI

      10.1681/asn.2017080859

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 進化遺伝学とがんゲノム解析2018

    • Author(s)
      藤本明洋
    • Journal Title

      実験医学

      Volume: 増刊号 Pages: 105-109

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ゲノムシークエンスデータの情報解析2018

    • Author(s)
      藤本明洋
    • Journal Title

      生物物理

      Volume: 58 Pages: 001-003

    • NAID

      130007378613

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 肝癌の全ゲノムシークエンス解析2018

    • Author(s)
      藤本明洋
    • Journal Title

      医学のあゆみ

      Volume: 8月4日号 Pages: 399-404

    • Related Report
      2018 Annual Research Report
  • [Presentation] Demographic inference of human population from haplotype sharing information. The 2019 SMBE conference2019

    • Author(s)
      Yosuke Kawai
    • Organizer
      SMBE 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Mutations and Protein Stability on Human Mitochondrial DNA Haplogroups2019

    • Author(s)
      Kazumichi Fujiwara, Toshinori Endo, Naoki Osada
    • Organizer
      SMBE 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハプロタイプ共有長の分布から推定する東アジア人の集団史2019

    • Author(s)
      河合洋介
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Identification of structural variations and analysis of their functional roles2019

    • Author(s)
      藤本明洋
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Genetic diversity of wild house mice (Mus musculus) using whole-genome sequences of multiple samples2019

    • Author(s)
      藤原一道,長田直樹,鈴木仁
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The negative selection pressure on autosomal recessive congenital ichthoyosis is weaker in African population2019

    • Author(s)
      東野俊英,長田直樹
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Temporal change of protein stability in human mitochondria during out-of-Africa migration2019

    • Author(s)
      藤原一道,里村和浩,遠藤俊徳,長田直樹
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of structural variations and analysis of their functional roles2019

    • Author(s)
      藤本明洋
    • Organizer
      日本癌学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 長鎖シークエンス技術を用いた癌の全ゲノムシークエンス2019

    • Author(s)
      藤本明洋
    • Organizer
      日本人類遺伝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Population Genetics2019

    • Author(s)
      Akihiro Fujimoto
    • Organizer
      InCoB
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of structural variations and analysis of their functional roles2019

    • Author(s)
      Akihiro Fujimoto
    • Organizer
      InCoB
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリア塩基配列から推定された日本人集団特異的な有効集団サイズの増加2019

    • Author(s)
      五條堀 淳,日笠 幸一郎,松田 文彦,石谷 孔司,水野 文月,熊谷 真彦,植田 信太郎
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハツカネズミ(Mus musculus)亜種を用いた全ゲノム集団解析ハツカネズミ(Mus musculus)亜種を用いた全ゲノム集団解析2019

    • Author(s)
      藤原一道,河合洋介,斎藤成也,長田直樹,鈴木仁
    • Organizer
      第91回日本遺伝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 構造異常/構造多型の検出と機能的意義の解析2019

    • Author(s)
      藤本明洋
    • Organizer
      ナノポア現場の会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 情報解析と人類遺伝学2019

    • Author(s)
      藤本明洋
    • Organizer
      遺伝統計学・夏の学校
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] がんゲノム配列決定と今後の課題 -B型・C型肝炎に由来する肝癌の全ゲノム配列解析を例に-2019

    • Author(s)
      藤本明洋
    • Organizer
      京大小児科血液腫瘍研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「港川人骨のミトコンドリア DNA 全塩基配列からわかること」2019

    • Author(s)
      五條堀淳,水野文月
    • Organizer
      日本学術会議シンポジウム「日本旧石器人研究の発展:沖縄の現場から」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒトゲノムの多様性をどのように解析するのか2019

    • Author(s)
      長田直樹
    • Organizer
      BI人材育成講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ソフトウェア講習2019

    • Author(s)
      長田直樹
    • Organizer
      第3回木村資生記念進化学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Big data in biology: perspectives of genomic diversity studies2019

    • Author(s)
      Naoki Osada
    • Organizer
      Winter International Symposium on Big-Data, Cybersecurity and IoT
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 性による移住率の偏りをゲノムデータから推定する2018

    • Author(s)
      長田直樹
    • Organizer
      第72回日本人類学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアDNAハプログループに注目した,ヒトミトコンドリアタンパク質複合体IVにおける突然変異とタンパク質構造安定性に関する研究2018

    • Author(s)
      藤原一道,遠藤俊徳,長田直樹
    • Organizer
      第72回日本人類学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミトコンドリアタンパク質複合体IVでの突然変異とそのタンパク質の構造安定性が与える影響について2018

    • Author(s)
      藤原一道,遠藤俊徳,長田直樹
    • Organizer
      第90回日本遺伝学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 霊長類ミトコンドリア遺伝子における多重置換に対する自然選択2018

    • Author(s)
      里村和浩,長田直樹,遠藤俊徳
    • Organizer
      第90回日本遺伝学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Understanding the relationship among the structural and functional properties of amino acid changes to predict the effect of mutations on human beta globin gene2018

    • Author(s)
      Sangeetha Udani Ratnayake, Toshinori Endo, Naoki Osada
    • Organizer
      第90回日本遺伝学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Predicting disease causality of mutations in human beta globin gene2018

    • Author(s)
      Sangeetha Udani Ratnayake, Toshinori Endo, Naoki Osada
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hybrid type of nuclear and plastid DNAs suggests the hypothesis for ancient propagation of American bottle gourd (Lagenaria siceraria)2018

    • Author(s)
      Dai Watabe, Hiroshi Yuasa, Naoki Osada, Kazuhiro Satomura, Toshinori endo
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Search for the factors related to HCV replication in the HuH-7 cell line lineages2018

    • Author(s)
      Masaki Kawamoto, Toshinori Endo, Masayoshi Fukasawa, Kentaro Hanada, Naoki Osada
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Compensatory back mutations in mitochondrial genome of primates2018

    • Author(s)
      Kazuhiro Satomura, Naoki Osada, Toshinori Endo
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全ゲノム塩基配列を用いたヤポネシアとその周辺集団の解析2018

    • Author(s)
      五條堀淳
    • Organizer
      第72回日本人類学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genome-wide genetic variation of people in Japan and its implication of demographic history2018

    • Author(s)
      Kawai Y, Mimori T, Hitomi Y, Khor SS, Gervais O, Nagasaki M and Tokunaga K
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types2018

    • Author(s)
      藤本明洋
    • Organizer
      アメリカ人類遺伝学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of structural variations and analysis of their functional roles2018

    • Author(s)
      藤本明洋
    • Organizer
      日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒトのゲノム配列の解析と今後の課題;ゲノム解析の基礎、がんゲノム.研究、リキッドバイオプシーの個別化医療への応用2018

    • Author(s)
      藤本明洋
    • Organizer
      薬物動態談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒト肝癌のゲノム異常の包括的解析と今後の課題2018

    • Author(s)
      藤本明洋
    • Organizer
      関西肝癌局所療法研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 進化で読み解く バイオインフォマティクス入門2019

    • Author(s)
      長田 直樹
    • Total Pages
      232
    • Publisher
      森北出版
    • ISBN
      9784627261419
    • Related Report
      2019 Annual Research Report
  • [Remarks] ヤポネシアゲノム

    • URL

      http://www.yaponesian.jp/

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] New development of human genome diversity studies2019

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-07-20   Modified: 2021-01-27  

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