ヤポネシア人の人口推定を中心とした巨大データ解析

• Project Area: Deciphering Origin and Establishment of Japonesians mainly based on genome sequence data
• Project/Area Number: 18H05511
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Hokkaido University
• Principal Investigator: 長田 直樹 北海道大学, 情報科学研究院, 准教授 (70416270)
• Co-Investigator(Kenkyū-buntansha): 五條堀 淳 総合研究大学院大学, 先導科学研究科, 講師 (00506800) ; 河合 洋介 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (30435515) ; 藤本 明洋 東京大学, 大学院医学系研究科(医学部), 教授 (30525853)
• Project Period (FY): 2018-06-29 – 2023-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000); Fiscal Year 2021: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2020: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2019: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2018: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
• Keywords: ゲノム / 進化 / 日本人 / 集団遺伝学 / ヤポネシア人 / ゲノム配列 / 人口動態

Outline of Annual Research Achievements

本年度は新学術領域研究「ヤポネシアゲノム」の計画研究班として，以下のような研究を行った．
１）Admixture Graphや，Fstから計算されたQ値を用いて，性染色体の分化様式から性に偏った移住様式を推定する手法を開発し，パイロット的に霊長類（旧世界ザル）ゲノムデータに適用した．その結果，性に偏った移住が現在の集団の遺伝構成に大きな影響を及ぼしたことが明らかになった．また，その手法をヤポネシア人集団と東アジア集団の集団ゲノムデータに適用した．2）ハプロタイプ共有長の情報を用いて，集団間の分岐年代をシミュレーションを用いて推定する手法を確立し，本土日本人集団と古代人を含む他の集団との分岐年代推定に応用した．３）マイクロサテライト配列の多型をゲノムワイドに推定する手法を開発し，手法の正確性や，日本人集団内での多様性について検討した．４）長鎖シークエンス技術を用いて発見された変異についての検証を行った．5）集団内に稀にしか存在しない希少変異の情報を用いて，古代人を含む東アジア集団の関係についての推測を行った．6）約2000人のヤポネシア人集団mtDNAのデータから，Bayesian Skyline Plot法を用いて，旧石器時代から弥生時代にかけての人口動態推定を行った．
また，領域内の他の研究班と，縄文人ゲノム解析や動植物（ハツカネズミやヒグマ）のゲノム解析などにおいて，多方面の共同研究を行った．11編の英語論文，4編の日本語解説記事/著書，22回の学会等発表を行った．

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

本年度は5年間の研究計画の2年目に位置する．研究開始当初にあげた目的を着実に達成しているだけでなく，データ解析の結果から新しい知見が得られ始めている．また，個別の研究テーマの推進だけではなく，領域内での共同研究を円滑に進めるためのデータ共有システムの構築も行い，領域内研究者間の共同研究も進みつつある．さらに，縄文人ゲノム解析や動植物のゲノム解析などにおいて，他研究班との多方面の共同研究を行った．また，研究に参画している大学院生がいくつかの賞を受けるなど，若手研究者の育成も着実に進んでいる．これらの点を考慮し，(1)当初の計画以上に進展している，とした．

Strategy for Future Research Activity

今後は，引き続き，ゲノムワイドデータを用いたヤポネシア人集団の歴史の探索を，他班との協力関係をつづけながら進めていく．また，本課題において新たに開発された手法を用いて，今後新しく得られるデータについての解析を行っていく．具体的には，以下の研究計画をあげる（1）日本人集団の成立にあたっての移住時の性比の偏りについて，ゲノムワイドデータとシミュレーションを用いて検証を行う．（2）ハプロタイプデータを用いた人口動態推定について，領域研究で得られたあらたなデータをもとに行う．(3)希少変異を用いた集団間の関連に関する研究を引き続き行い，古代人集団と東アジア人集団との関連をさらに高解像度で判別する．(4)マイクロサテライトデータを用いた日本人集団の遺伝的構造解析を行う．

Research Products

• [Int'l Joint Research] University College Dublin(アイルランド)
• [Int'l Joint Research] Trinity Collage Dublin(アイルランド)
• [Journal Article] Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations. (2020)
  • Author(s): Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H.
  • Journal Title: EBioMedicine. Volume: 53 Pages: 102659-102659
  • DOI: 10.1016/j.ebiom.2020.102659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types (2020)
  • Author(s): Fujimoto A*, Fujita M, Hasegawa T, Wong JH, Maejima K, Oku-Sasaki A, Nakano K, Shiraishi Y, Miyano S, Yamamoto G, Akagi K, Imoto S, and Nakagawa H
  • Journal Title: Genome Res Volume: 30 Pages: 2020-2020
  • DOI: 10.1101/gr.255026.119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pan-cancer analysis of whole genomes (2020)
  • Author(s): The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
  • Journal Title: Nature Volume: 578 Pages: 82-93
  • DOI: 10.1038/s41586-020-1969-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Implications of HLA diversity among regions for bone marrow donor searches in Japan (2020)
  • Author(s): Hashimoto S, Nakajima F, Imanishi T, Kawai Y, Kato K, Kimura T, Miyata S, Takanashi M, Nishio M, Tokunaga K, Satake M
  • Journal Title: HLA Volume: in press
  • DOI: 10.1111/tan.13881
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. (2020)
  • Author(s): Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H
  • Journal Title: Ann Rheum Dis. Volume: 79(1) Pages: 164166-164166
  • DOI: 10.1136/annrheumdis-2019-216044
  • Peer Reviewed / Open Access
• [Journal Article] 港川人のミトコンドリア DNA全塩基配列からわかること (2020)
  • Author(s): 水野文月，五條堀淳
  • Journal Title: 学術の動向 Volume: 25 Pages: 2-2
• [Journal Article] eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA (2019)
  • Author(s): Mizuno Kei、Akamatsu Shusuke、Sumiyoshi Takayuki、Wong Jing Hao、Fujita Masashi et al.
  • Journal Title: Sci Rep. Volume: 9 Pages: 15017-15017
  • DOI: 10.1038/s41598-019-51459-4
  • Peer Reviewed / Open Access
• [Journal Article] Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan (2019)
  • Author(s): Kanzawa-Kiriyama Hideaki、Jinam Timothy A.、Kawai Yosuke、Sato Takehiro、Hosomichi Kazuyoshi、Tajima Atsushi、Adachi Noboru、Matsumura Hirofumi、Kryukov Kirill、Saitou Naruya、Shinoda Ken-Ichi
  • Journal Title: AS Volume: 127 Issue: 2 Pages: 83-108
  • DOI: 10.1537/ase.190415
  • NAID: 130007696474
  • ISSN: 0918-7960, 1348-8570
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A key metabolic gene for recurrent freshwater colonization and radiation in fishes. (2019)
  • Author(s): Asano Ishikawa, Naoki Kabeya, Koki Ikeya, Ryo Kakioka, Jennifer N. Cech, Naoki Osada, Miguel C. Leal, Jun Inoue, Manabu Kume, Atsushi Toyoda, Ayumi Tezuka, Atsushi J. Nagano, Yo Y. Yamasaki, Yuto Suzuki, Tomoyuki Kokita, Hiroshi Takahashi, Kay Lucek, David Marques, Yusuke Takehana, Kiyoshi Naruse, Catherine L. Peichel, Ole Seehausen, Goro Yoshizaki, Jun Kitano, et al.
  • Journal Title: Science Volume: 364 Issue: 6443 Pages: 886-889
  • DOI: 10.1126/science.aau5656
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic diversity and population structure of Glossina morsitans morsitans in the active foci of human African trypanosomiasis in Zambia and Malawi (2019)
  • Author(s): Yukiko Nakamura, Junya Yamagishi, Kyoko Hayashida, Naoki Osada, Elisha Chatanga, Cornelius Mweempwa, Kalinga Chilongo, John Chisi, Jenelisa Musaya, Ryosuke Omori, Noboru Inoue, Boniface Namangala, Chihiro Sugimoto
  • Journal Title: PLoS Neglected Tropical Diseases. Volume: 13
  • DOI: 10.1371/journal.pntd.0007568
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Achiasmy and sex chromosome evolution (2019)
  • Author(s): Kazuhiro Satomura, Naoki Osada, Toshinori Endo
  • Journal Title: Ecological Genetics and Genomics Volume: 13 Pages: 1000046-1000046
  • Peer Reviewed / Open Access
• [Journal Article] 日本人ゲノム解析において集団差をどう考えるか (2019)
  • Author(s): 河合洋介
  • Journal Title: IBD Research Volume: 13 Pages: 31-34
• [Journal Article] 東アジアの人々のゲノム多様性 (2019)
  • Author(s): 徳永勝士，河合洋介
  • Journal Title: 腎臓内科・泌尿器科 Volume: 10 Pages: 561-565
• [Journal Article] ヤポネシア人の歴史の解明が医学にもたらすもの (2019)
  • Author(s): 長田直樹
  • Journal Title: 実験医学 Volume: 37 Pages: 926-929
• [Journal Article] Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer (2019)
  • Author(s): Sumiyoshi Takayuki、Mizuno Kei、Yamasaki Toshinari、Miyazaki Yu、Makino Yuki、Okasho Kosuke、Li Xin、Utsunomiya Noriaki、Goto Takayuki、Kobayashi Takashi、Terada Naoki、Inoue Takahiro、Kamba Tomomi、Fujimoto Akihiro、Ogawa Osamu、Akamatsu Shusuke
  • Journal Title: Sci Rep Volume: 9 Pages: 4030-4030
  • DOI: 10.1038/s41598-019-40719-y
  • NAID: 120006709427
  • Peer Reviewed / Open Access
• [Journal Article] Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan (2019)
  • Author(s): Kanzawa-Kiriyama H, Jinam TA, Kawai Y, Sato T, Hosomichi K, Tajima A, Adachi N, Matsumura H, Kryukov K, Saitou N and Shinoda K
  • Journal Title: Anthropological Science Volume: -
  • Peer Reviewed
• [Journal Article] POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33 (2019)
  • Author(s): Hitomi, Y. Ueno, K. Kawai, Y. Nishida, N. , Umemura, T. et al
  • Journal Title: Sci Rep. Volume: 9 Pages: 102-102
  • DOI: 10.1038/s41598-018-36490-1
  • NAID: 120006715480
  • Peer Reviewed / Open Access
• [Journal Article] NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants. (2019)
  • Author(s): Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K.
  • Journal Title: Cell Mol Gastroenterol Hepatol. Volume: 7 Pages: 515-532
  • DOI: 10.1016/j.jcmgh.2018.11.006
  • Peer Reviewed / Open Access
• [Journal Article] A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals (2019)
  • Author(s): Kakuta Yoichi、Kawai Yosuke、Naito Takeo、Hirano Atsushi、Umeno Junji、Fuyuno Yuta、Liu Zhenqiu、Li Dalin、Nakano Takeru、Izumiyama Yasuhiro、Ichikawa Ryo、Okamoto Daisuke、et al.
  • Journal Title: J Crohns Colotis Volume: - Pages: 2019-2019
  • DOI: 10.1093/ecco-jcc/jjy197
  • Peer Reviewed / Open Access
• [Journal Article] Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate (2018)
  • Author(s): Sakuma Chisato、Sekizuka Tsuyoshi、Kuroda Makoto、Kasai Fumio、Saito Kyoko、Ikeda Masaki、Yamaji Toshiyuki、Osada Naoki、Hanada Kentaro
  • Journal Title: Scientific Reports Volume: 8 Pages: 644-644
  • DOI: 10.1038/s41598-017-18934-2
  • NAID: 120006401475
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive phylogenomic analysis reveals a novel cluster of simian endogenous retroviral sequences in Colobinae monkeys (2018)
  • Author(s): Ikeda Masaki、Satomura Kazuhiro、Sekizuka Tsuyoshi、Hanada Kentaro、Endo Toshinori、Osada Naoki
  • Journal Title: American Journal of Primatology Volume: 80
  • DOI: 10.1002/ajp.22882
  • NAID: 120006643589
  • Peer Reviewed
• [Journal Article] Whole Genome Sequencing of a Vietnamese Family from a Dioxin Contamination Hotspot Reveals Novel Variants in the Son with Undiagnosed Intellectual Disability (2018)
  • Author(s): Nguyen Dang、Nguyen Hai、Nguyen Thuy、Nguyen Thi、Nakano Kaoru、Maejima Kazuhiro、Sasaki-Oku Aya、Nguyen Van、Nguyen Duy、Le Bach、Wong Jing、Tsunoda Tatsuhiko、Nakagawa Hidewaki、Fujimoto Akihiro、Nong Van
  • Journal Title: Int J Environ Res Public Health Volume: 15 Pages: 2629-2629
  • DOI: 10.3390/ijerph15122629
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis (2018)
  • Author(s): Shigemizu Daichi、Miya Fuyuki、Akiyama Shintaro、Okuda Shujiro、Boroevich Keith A、Fujimoto Akihiro、Nakagawa Hidewaki、Ozaki Kouichi、Niida Shumpei、Kanemura Yonehiro、Okamoto Nobuhiko、Saitoh Shinji、Kato Mitsuhiro、Yamasaki Mami、Matsunaga Tatsuo、Mutai Hideki、Kosaki Kenjiro、Tsunoda Tatsuhiko
  • Journal Title: Sci Rep Volume: 8 Pages: 10367-10367
  • DOI: 10.1038/s41598-018-23978-z
  • NAID: 120006551758
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss-of-function mutations in Zn-finger DNA-binding domain of <i>HNF4A</i> cause aberrant transcriptional regulation in liver cancer (2018)
  • Author(s): Taniguchi Hiroaki、Fujimoto Akihiro、Kono Hidetoshi、Furuta Mayuko、Fujita Masashi、Nakagawa Hidewaki
  • Journal Title: Oncotarget Volume: 9 Pages: 26144-26156
  • DOI: 10.18632/oncotarget.25456
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy (2018)
  • Author(s): Latt Khun Zaw、Honda Kenjiro、Thiri Myo、Hitomi Yuki、Omae Yosuke、Sawai Hiromi、Kawai Yosuke、Teraguchi Shunsuke、Ueno Kazuko、Nagasaki Masao、Mabuchi Akihiko、Kaga Hajime、Komatsuda Atsushi、Tokunaga Katsushi、Noiri Eisei
  • Journal Title: Scientific Reports Volume: 8 Pages: 15576-15576
  • DOI: 10.1038/s41598-018-33612-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project (2018)
  • Author(s): Yasuda Jun、et al.,
  • Journal Title: BMC Genomics Volume: 19 Pages: 551-551
  • DOI: 10.1186/s12864-018-4942-0
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2,049 individuals (2018)
  • Author(s): Y Yamaguchi-Kabata, J Yasuda, O Tanabe, Y Suzuki, H Kawame, N Fuse, M Nagasaki, Y Kawai, K Kojima, F Katsuoka, S Saito, I Danjoh, I Motoike, R Yamashita, S Koshiba, D Saigusa, G Tamiya, S Kure, N Yaegashi, Y Kawaguchi, F Nagami, S Kuriyama, J Sugawara, N Minegishi, A Hozawa, T Takai-Igarashi, K Kinoshita, M Yamamoto.
  • Journal Title: Journal of Human Genetics 21 Volume: 63 Pages: 213-230
  • DOI: 10.1038/s10038-017-0347-1
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of chalcone reductase in the soybean isoflavone metabolon: identification of GmCHR5, which interacts with 2-hydroxyisoflavanone synthase (2018)
  • Author(s): Mameda Ryo、Waki Toshiyuki、Kawai Yosuke、Takahashi Seiji、Nakayama Toru
  • Journal Title: The Plant Journal Volume: 96 Pages: 56-74
  • DOI: 10.1111/tpj.14014
  • Peer Reviewed
• [Journal Article] Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population. (2018)
  • Author(s): Jia X, Horinouchi T, Hitomi Y, Shono A, Khor SS, Omae Y, Kojima K, Kawai Y, Nagasaki M, Kaku Y, Okamoto T, Ohwada Y, Ohta K, Okuda Y, Fujimaru R, Hatae K, Kumagai N, Sawanobori E, Nakazato H, Ohtsuka Y, Nakanishi K, Shima Y, Tanaka R, Ashida A, Kamei K, Ishikura K, Nozu K, Tokunaga K, Iijima K
  • Journal Title: Journal of the American Society of Nephrology Volume: 29 Pages: 2189-2199
  • DOI: 10.1681/asn.2017080859
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 進化遺伝学とがんゲノム解析 (2018)
  • Author(s): 藤本明洋
  • Journal Title: 実験医学 Volume: 増刊号 Pages: 105-109
• [Journal Article] ゲノムシークエンスデータの情報解析 (2018)
  • Author(s): 藤本明洋
  • Journal Title: 生物物理 Volume: 58 Pages: 001-003
  • NAID: 130007378613
• [Journal Article] 肝癌の全ゲノムシークエンス解析 (2018)
  • Author(s): 藤本明洋
  • Journal Title: 医学のあゆみ Volume: 8月4日号 Pages: 399-404
• [Presentation] Demographic inference of human population from haplotype sharing information. The 2019 SMBE conference (2019)
  • Author(s): Yosuke Kawai
  • Organizer: SMBE 2019
  • Int'l Joint Research
• [Presentation] Analysis of Mutations and Protein Stability on Human Mitochondrial DNA Haplogroups (2019)
  • Author(s): Kazumichi Fujiwara, Toshinori Endo, Naoki Osada
  • Organizer: SMBE 2019
  • Int'l Joint Research
• [Presentation] ハプロタイプ共有長の分布から推定する東アジア人の集団史 (2019)
  • Author(s): 河合洋介
  • Organizer: 日本進化学会第21回大会
  • Invited
• [Presentation] Identification of structural variations and analysis of their functional roles (2019)
  • Author(s): 藤本明洋
  • Organizer: 日本進化学会第21回大会
  • Invited
• [Presentation] Genetic diversity of wild house mice (Mus musculus) using whole-genome sequences of multiple samples (2019)
  • Author(s): 藤原一道，長田直樹，鈴木仁
  • Organizer: 日本進化学会第21回大会
  • Invited
• [Presentation] The negative selection pressure on autosomal recessive congenital ichthoyosis is weaker in African population (2019)
  • Author(s): 東野俊英，長田直樹
  • Organizer: 日本進化学会第21回大会
• [Presentation] Temporal change of protein stability in human mitochondria during out-of-Africa migration (2019)
  • Author(s): 藤原一道，里村和浩，遠藤俊徳，長田直樹
  • Organizer: 日本進化学会第21回大会
• [Presentation] Identification of structural variations and analysis of their functional roles (2019)
  • Author(s): 藤本明洋
  • Organizer: 日本癌学会
  • Invited
• [Presentation] 長鎖シークエンス技術を用いた癌の全ゲノムシークエンス (2019)
  • Author(s): 藤本明洋
  • Organizer: 日本人類遺伝学会
• [Presentation] Population Genetics (2019)
  • Author(s): Akihiro Fujimoto
  • Organizer: InCoB
  • Int'l Joint Research / Invited
• [Presentation] Identification of structural variations and analysis of their functional roles (2019)
  • Author(s): Akihiro Fujimoto
  • Organizer: InCoB
  • Int'l Joint Research / Invited
• [Presentation] ミトコンドリア塩基配列から推定された日本人集団特異的な有効集団サイズの増加 (2019)
  • Author(s): 五條堀 淳，日笠 幸一郎，松田 文彦，石谷 孔司，水野 文月，熊谷 真彦，植田 信太郎
  • Organizer: 第73回日本人類学会大会
• [Presentation] ハツカネズミ（Mus musculus）亜種を用いた全ゲノム集団解析ハツカネズミ（Mus musculus）亜種を用いた全ゲノム集団解析 (2019)
  • Author(s): 藤原一道，河合洋介，斎藤成也，長田直樹，鈴木仁
  • Organizer: 第91回日本遺伝学会
• [Presentation] 構造異常／構造多型の検出と機能的意義の解析 (2019)
  • Author(s): 藤本明洋
  • Organizer: ナノポア現場の会
  • Invited
• [Presentation] 情報解析と人類遺伝学 (2019)
  • Author(s): 藤本明洋
  • Organizer: 遺伝統計学・夏の学校
  • Invited
• [Presentation] がんゲノム配列決定と今後の課題 -B型・C型肝炎に由来する肝癌の全ゲノム配列解析を例に- (2019)
  • Author(s): 藤本明洋
  • Organizer: 京大小児科血液腫瘍研究会
  • Invited
• [Presentation] 「港川人骨のミトコンドリア DNA 全塩基配列からわかること」 (2019)
  • Author(s): 五條堀淳，水野文月
  • Organizer: 日本学術会議シンポジウム「日本旧石器人研究の発展:沖縄の現場から」
  • Invited
• [Presentation] ヒトゲノムの多様性をどのように解析するのか (2019)
  • Author(s): 長田直樹
  • Organizer: BI人材育成講座
  • Invited
• [Presentation] ソフトウェア講習 (2019)
  • Author(s): 長田直樹
  • Organizer: 第3回木村資生記念進化学セミナー
  • Invited
• [Presentation] Big data in biology: perspectives of genomic diversity studies (2019)
  • Author(s): Naoki Osada
  • Organizer: Winter International Symposium on Big-Data, Cybersecurity and IoT
  • Int'l Joint Research / Invited
• [Presentation] 性による移住率の偏りをゲノムデータから推定する (2018)
  • Author(s): 長田直樹
  • Organizer: 第72回日本人類学会大会
  • Invited
• [Presentation] ミトコンドリアDNAハプログループに注目した，ヒトミトコンドリアタンパク質複合体IVにおける突然変異とタンパク質構造安定性に関する研究 (2018)
  • Author(s): 藤原一道，遠藤俊徳，長田直樹
  • Organizer: 第72回日本人類学会大会
• [Presentation] ミトコンドリアタンパク質複合体IVでの突然変異とそのタンパク質の構造安定性が与える影響について (2018)
  • Author(s): 藤原一道，遠藤俊徳，長田直樹
  • Organizer: 第90回日本遺伝学会大会
• [Presentation] 霊長類ミトコンドリア遺伝子における多重置換に対する自然選択 (2018)
  • Author(s): 里村和浩，長田直樹，遠藤俊徳
  • Organizer: 第90回日本遺伝学会大会
• [Presentation] Understanding the relationship among the structural and functional properties of amino acid changes to predict the effect of mutations on human beta globin gene (2018)
  • Author(s): Sangeetha Udani Ratnayake, Toshinori Endo, Naoki Osada
  • Organizer: 第90回日本遺伝学会大会
• [Presentation] Predicting disease causality of mutations in human beta globin gene (2018)
  • Author(s): Sangeetha Udani Ratnayake, Toshinori Endo, Naoki Osada
  • Organizer: SMBE2018
  • Int'l Joint Research
• [Presentation] Hybrid type of nuclear and plastid DNAs suggests the hypothesis for ancient propagation of American bottle gourd (Lagenaria siceraria) (2018)
  • Author(s): Dai Watabe, Hiroshi Yuasa, Naoki Osada, Kazuhiro Satomura, Toshinori endo
  • Organizer: SMBE2018
  • Int'l Joint Research
• [Presentation] Search for the factors related to HCV replication in the HuH-7 cell line lineages (2018)
  • Author(s): Masaki Kawamoto, Toshinori Endo, Masayoshi Fukasawa, Kentaro Hanada, Naoki Osada
  • Organizer: SMBE2018
  • Int'l Joint Research
• [Presentation] Compensatory back mutations in mitochondrial genome of primates (2018)
  • Author(s): Kazuhiro Satomura, Naoki Osada, Toshinori Endo
  • Organizer: SMBE2018
  • Int'l Joint Research
• [Presentation] 全ゲノム塩基配列を用いたヤポネシアとその周辺集団の解析 (2018)
  • Author(s): 五條堀淳
  • Organizer: 第72回日本人類学会大会
• [Presentation] Genome-wide genetic variation of people in Japan and its implication of demographic history (2018)
  • Author(s): Kawai Y, Mimori T, Hitomi Y, Khor SS, Gervais O, Nagasaki M and Tokunaga K
  • Organizer: SMBE2018
  • Int'l Joint Research
• [Presentation] Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types (2018)
  • Author(s): 藤本明洋
  • Organizer: アメリカ人類遺伝学会
  • Int'l Joint Research
• [Presentation] Identification of structural variations and analysis of their functional roles (2018)
  • Author(s): 藤本明洋
  • Organizer: 日本分子生物学会
  • Invited
• [Presentation] ヒトのゲノム配列の解析と今後の課題；ゲノム解析の基礎、がんゲノム.研究、リキッドバイオプシーの個別化医療への応用 (2018)
  • Author(s): 藤本明洋
  • Organizer: 薬物動態談話会
  • Invited
• [Presentation] ヒト肝癌のゲノム異常の包括的解析と今後の課題 (2018)
  • Author(s): 藤本明洋
  • Organizer: 関西肝癌局所療法研究会
  • Invited
• [Book] 進化で読み解く バイオインフォマティクス入門 (2019)
  • Author(s): 長田 直樹
  • Total Pages: 232
  • Publisher: 森北出版
  • ISBN: 9784627261419
• [Remarks] ヤポネシアゲノム
  • URL: http://www.yaponesian.jp/
• [Funded Workshop] New development of human genome diversity studies (2019)