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Generation and Collapse of Time Processing and its Emotional Value

Planned Research

Project AreaChronogenesis: how the mind generates time
Project/Area Number 18H05525
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

Ikegaya Yuji  東京大学, 大学院薬学系研究科(薬学部), 教授 (10302613)

Co-Investigator(Kenkyū-buntansha) 河村 満  昭和大学, 医学部, 名誉教授 (20161375)
藤澤 茂義  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (20589395)
梅田 聡  慶應義塾大学, 文学部(三田), 教授 (90317272)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥324,090,000 (Direct Cost: ¥249,300,000、Indirect Cost: ¥74,790,000)
Fiscal Year 2022: ¥63,440,000 (Direct Cost: ¥48,800,000、Indirect Cost: ¥14,640,000)
Fiscal Year 2021: ¥63,440,000 (Direct Cost: ¥48,800,000、Indirect Cost: ¥14,640,000)
Fiscal Year 2020: ¥63,440,000 (Direct Cost: ¥48,800,000、Indirect Cost: ¥14,640,000)
Fiscal Year 2019: ¥63,440,000 (Direct Cost: ¥48,800,000、Indirect Cost: ¥14,640,000)
Fiscal Year 2018: ¥70,330,000 (Direct Cost: ¥54,100,000、Indirect Cost: ¥16,230,000)
Keywords時間 / 脳 / 疾患 / 記憶 / 時間判断 / アルツハイマー型認知症 / パーキンソン病 / 海馬 / 楔前部 / 神経 / 認知
Outline of Final Research Achievements

Unlike physical time, "mental time" as perceived by the brain can expand, contract, and segment at will depending on internal conditions such as attention, motivation, and context. This mental time is often inappropriately transformed and sometimes deeply implicated in disease. This project will bring together a comprehensive team of neuroscientists, cognitive neuroscientists, and clinical neuropsychologists to elucidate how psychological time disintegrates and becomes disease. We will reveal the contours of normal and pathological temporal functions of the brain through human clinical trials and animal studies.

Academic Significance and Societal Importance of the Research Achievements

遊具等がない部屋に入れられることで、遊具のある部屋では避けてしまうような嫌悪的な空気刺激を自ら受けに行くようになることを発見した。こうしたマウスの中には頻繁に空気刺激を受けに行く中毒状態になる個体が20%程度存在し、一度中毒状態になると、遊具のある部屋に戻しても、頻繁に空気刺激を受けに行くことがわかった。
嗅周皮質の多数の神経細胞の活動を同時にイメージングした結果、ヒスタミンH3受容体拮抗薬ピトリサントが、嗅周皮質の一部の神経細胞の活動、特に同期活動を上昇させることがわかった。

Report

(6 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (27 results)

All 2024 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 7 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] ニューヨーク大学(米国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 原著・過去の論文から学ぶ2024

    • Author(s)
      河村満
    • Journal Title

      Brain and Nerve

      Volume: in press

    • Related Report
      2022 Annual Research Report
  • [Journal Article] ヒトの時間認知機構と神経疾患overview. ,2024

    • Author(s)
      河村満, 越智隆太, 二村明徳, 花塚優貴, 菊池雷太.
    • Journal Title

      脳神経内科

      Volume: 100 Pages: 6-6

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 症例報告 視覚性運動失調を呈し,微小な硬膜下膿瘍と軟膜炎の局在診断につながった細菌性髄膜炎の1例2024

    • Author(s)
      邉見 光、森 友紀子、黒田 岳志、柿沼 佑樹、石代 優美香、加藤 悠太、久保田 怜美、河村 満、村上 秀友
    • Journal Title

      BRAIN and NERVE

      Volume: 76 Pages: 289-294

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 時間の神経学の創生2023

    • Author(s)
      河村満, 二村明徳, 花塚優貴, 越智隆太.
    • Journal Title

      Clinical Neuroscience

      Volume: 41

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesolimbic dopamine release precedes actively sought aversive stimuli in mice2023

    • Author(s)
      Yawata Yosuke、Shikano Yu、Ogasawara Jun、Makino Kenichi、Kashima Tetsuhiko、Ihara Keiko、Yoshimoto Airi、Morikawa Shota、Yagishita Sho、Tanaka Kenji F.、Ikegaya Yuji
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 2433-2433

    • DOI

      10.1038/s41467-023-38130-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hippocampal sharp wave ripples underlie stress susceptibility in male mice2023

    • Author(s)
      Kuga Nahoko、Nakayama Ryota、Morikawa Shota、Yagishita Haruya、Konno Daichi、Shiozaki Hiromi、Honjoya Natsumi、Ikegaya Yuji、Sasaki Takuya
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 2105-2105

    • DOI

      10.1038/s41467-023-37736-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coexistence of thought types as an attentional state during a sustained attention task2023

    • Author(s)
      Shinagawa Kazushi、Itagaki Yu、Umeda Satoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 1581-1581

    • DOI

      10.1038/s41598-023-28690-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Memory and Time2022

    • Author(s)
      河村 満、梅田 聡
    • Journal Title

      Japanese Journal of Neuropsychology

      Volume: 38 Issue: 4 Pages: 248-250

    • DOI

      10.20584/neuropsychology.17163

    • ISSN
      0911-1085, 2189-9401
    • Year and Date
      2022-12-25
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neural mechanisms of time perception2022

    • Author(s)
      二村 明徳、本間 元康、小野 賢二郎、河村 満
    • Journal Title

      Japanese Journal of Neuropsychology

      Volume: 38 Issue: 4 Pages: 258-264

    • DOI

      10.20584/neuropsychology.17165

    • ISSN
      0911-1085, 2189-9401
    • Year and Date
      2022-12-25
    • Related Report
      2022 Annual Research Report
  • [Journal Article] Symptomatology and Neuropathology of patients presenting with focal cortical signs2022

    • Author(s)
      Ishihara Kenji、Fukui Toshiya、Kawamura Mitsuru、Shiota Jun‐ichi、Nakano Imaharu
    • Journal Title

      Neuropathology

      Volume: 43 Issue: 1 Pages: 27-43

    • DOI

      10.1111/neup.12854

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frontotemporal Lobar Degeneration With Unclassifiable 4-Repeat Tauopathy Mimicking Globular Glial Tauopathy2022

    • Author(s)
      Shimizu Ai、Akagi Akio、Ishida Chiho、Sakai Kenji、Komai Kiyonobu、Kawamura Mitsuru、Hasegawa Masato、Ikeuchi Takeshi、Yamada Masahito
    • Journal Title

      Journal of Neuropathology & Experimental Neurology

      Volume: 81 Issue: 7 Pages: 581-584

    • DOI

      10.1093/jnen/nlac039

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition allocates spikes during hippocampal ripples2022

    • Author(s)
      Noguchi Asako、Huszar Roman、Morikawa Shota、Buzsaki Gyeorgy、Ikegaya Yuji
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 1280-1280

    • DOI

      10.1038/s41467-022-28890-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Towards threshold invariance in defining hippocampal ripples2021

    • Author(s)
      Watanabe Yusuke、Okada Mami、Ikegaya Yuji
    • Journal Title

      Journal of Neural Engineering

      Volume: 18 Issue: 6 Pages: 066012-066012

    • DOI

      10.1088/1741-2552/ac3266

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Savant Syndrome and an" Oshikuramanju Hypothesis2020

    • Author(s)
      Kawamura, M., Hanazuka, Y., & Midorikawa, A.
    • Journal Title

      Brain and nerve

      Volume: 44 Pages: 193-201

    • NAID

      40022181795

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories2019

    • Author(s)
      Nomura H, Mizuta H, Norimoto H, Masuda F, Miura Y, Kubo A, Kojima H, Ashizuka A, Matsukawa N, Baraki Z, Hitora-Imamura N, Nakayama D, Ishikawa T, Okada M, Orita K, Saito R, Yamauchi N, Sano Y, Kusuhara H, Minami M, Takahashi H, Ikegaya Y
    • Journal Title

      Biological Psychiatry

      Volume: 印刷中 Issue: 3 Pages: 230-239

    • DOI

      10.1016/j.biopsych.2018.11.009

    • NAID

      120006876277

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous Activation of Event Details in Episodic Future Simulation.2019

    • Author(s)
      Ito, Y., Terasawa, Y., Umeda, S., & Kawaguchi, J.
    • Journal Title

      Frontiers in Psychology,

      Volume: 10, Pages: 625-625

    • DOI

      10.3389/fpsyg.2019.00625

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons2018

    • Author(s)
      Sakaguchi Tetsuya、Iwasaki Satoshi、Okada Mami、Okamoto Kazuki、Ikegaya Yuji
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 00-00

    • DOI

      10.1038/s41467-018-05894-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Left Posterior Orbitofrontal Cortex Is Associated With Odor-Induced Autobiographical Memory: An fMRI Study. Frontiers in Psychology2018

    • Author(s)
      Watanabe K, Masaoka Y, Kawamura M, Yoshida M, Koiwa N, Yoshikawa A, Kubota S, Ida M, Ono K, Izumizaki M
    • Journal Title

      Frontiers in Psychology

      Volume: 9 Pages: 687-687

    • DOI

      10.3389/fpsyg.2018.00687

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 連合野概念の成立と展開.2022

    • Author(s)
      河村満
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] テンスのない言語における時間2022

    • Author(s)
      梅田 聡
    • Organizer
      第14回時間言語フォーラム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Insular activity during disgusting sound listening evaluated by heartbeat evoked magnetic fields2018

    • Author(s)
      Kato, Y., Takei, Y., Umeda, S., Goto, Y., Mimura, M., & Fukuda, M
    • Organizer
      The Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Insular function with emotional experience and interoceptive awareness using the awake surgery.2018

    • Author(s)
      Motomura, K., Umeda, S., Terasawa, Y., Natsume, A., & Wakabayashi, T.
    • Organizer
      The Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Age-related decline of the insular cortex and emotion recognition2018

    • Author(s)
      Terasawa, Y., Umeda, S., Nishikata, S., Kikuchi, T., Maeda, T., & Den, R.
    • Organizer
      The Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性頭痛患者における内受容感覚2018

    • Author(s)
      朝比奈正人・田仲祐登・辻 幸樹・伊藤友一・寺澤悠理・梅田 聡
    • Organizer
      第46回日本頭痛学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 非腫瘍性疾患病理アトラス2024

    • Author(s)
      黒田岳志, 村上秀友, 河村満.
    • Total Pages
      2
    • Publisher
      文光堂
    • Related Report
      2022 Annual Research Report
  • [Remarks] 時間生成学 時を生み出すこころの仕組み

    • URL

      https://www.chronogenesis.org/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-07-20   Modified: 2025-01-30  

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