| Budget Amount *help |
¥112,840,000 (Direct Cost: ¥86,800,000、Indirect Cost: ¥26,040,000)
Fiscal Year 2022: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2021: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2020: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2019: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2018: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
|
|---|
| Outline of Final Research Achievements |
Gene expression is regulated in a multilevel hierarchical manner at the nucleosome level, the cell nucleus level, and the intermediate levels of "chromatin domains" and "nuclear compartments," which are megabases (Mb) of chromatin higher-order structure. This higher-order chromatin structure fluctuates during cell differentiation and is thought to be closely related to changes in the potential transcriptional susceptibility of chromatin. In this study, through biochemical approaches and analysis of genome structure using early embryos and mouse embryonic stem (ES) cells, we have elucidated some of the mechanisms of chromatin structural regulation at the Mb unit level that occur during cell differentiation.
|
