| Budget Amount *help |
¥207,870,000 (Direct Cost: ¥159,900,000、Indirect Cost: ¥47,970,000)
Fiscal Year 2022: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2021: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2020: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2019: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2018: ¥58,110,000 (Direct Cost: ¥44,700,000、Indirect Cost: ¥13,410,000)
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| Outline of Final Research Achievements |
In eukaryotes, genomic DNA is compacted into chromatin with nuclear nucleosome-binding proteins. Recent studies suggest that diversity of chromatin structure and dynamics are crucial for gene regulation. In this study, we aimed to understand diverse chromatin structures and dynamics, which are regulated by a variety of epigenetic factors. We reconstituted chromatin in vitro and performed structural and biochemical analyses. We then determined structures of various nucleosomes, and their complexes with chromatin binding proteins. Furthermore, we elucidated the mechanisms by which transcription elongation complexes regulate transcription in chromatin.
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