| Budget Amount *help |
¥95,420,000 (Direct Cost: ¥73,400,000、Indirect Cost: ¥22,020,000)
Fiscal Year 2022: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2021: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2020: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2019: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2018: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
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| Outline of Final Research Achievements |
We aim to adapt in vitro gametogenesis technology, which has been rapidly developed in mice in recent years, to various animal species for future industrial and medical applications. Here we use rats and rabbits, the second most common experimental animals next to mice. As one of the major achievements, we could successfully develop a method for inducing primordial germ cells (PGCs), founder cells of sperm and oocytes, from pluripotent stem cells in rats and rabbits, respectively. In particular, in rats, the induced rat PGC-like cells are fully functional to complete spermatogenesis leading to the birth of offspring, for the first time other than mice.
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