| Budget Amount *help |
¥68,120,000 (Direct Cost: ¥52,400,000、Indirect Cost: ¥15,720,000)
Fiscal Year 2022: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2021: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2020: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2019: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2018: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
|
|---|
| Outline of Final Research Achievements |
One of the most important factors for oocyte integrity is the normality of chromosome number. Ocytes produced by in vitro gametogenesis and oocytes from older organisms have a high frequency of chromosome number abnormalities, reflecting their low integrity. Chromosome number abnormalities in oocytes are a major cause of miscarriages and congenital diseases such as Down syndrome. In this study, we conducted cell biological study of oocyte integrity with techniques of chromosome imaging. We found spindle stability as an important factor for oocyte integrity and elucidated molecular mechanisms required for the integrity. We also identified chromosomal factors that decrease with age.
|
