| Budget Amount *help |
¥36,000,000 (Direct Cost: ¥36,000,000)
Fiscal Year 2010: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2007: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Research Abstract |
We investigated the possibility of photo-control of the action or the speed in synthetic or biological molecular machines. In the synthetic molecular machines we synthesized compounds cyclically connected a photoisomerizable azobenzene and an aromatic ring as a rotor unit via spacers. By tuning the spacer lengths and the bulkiness of the rotor unit, it is for the first time accomplished to demonstrate the complete ON-OFF switching of the intra-molecular rotation of the rotor by the action of lights. In the kinesin/microtubuline system as one of motor proteins, it was demonstrated that reversible photo-regulations of the motility velocity were possible by the introduction of azobenzene moiety on surface of the substrate, in an inhibitor, or in the ATP structure.
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