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Utilization of Cdk5/p35 and its role as a negative modulator in signal transduction pathways in neurons.

Planned Research

Project AreaCell Proliferation Control
Project/Area Number 19057007
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan University

Principal Investigator

HISANAGA Shin-ichi  首都大学東京, 大学院理工学研究科, 教授 (20181092)

Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥82,900,000 (Direct Cost: ¥82,900,000)
Fiscal Year 2011: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2010: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2009: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2008: ¥17,300,000 (Direct Cost: ¥17,300,000)
Fiscal Year 2007: ¥28,800,000 (Direct Cost: ¥28,800,000)
Keywordsサイクリン依存性キナーゼ / 分化 / 増殖 / 神経細胞 / 細胞死 / シグナル伝達 / 脳・神経 / 酵素 / タンパク質 / リン酸化 / Cdk5 / p35
Research Abstract

Subcellular localization of Cdk5 is a molecular mechanism that prevents cell death of neurons even when Cdk5 is expressed in post-mitotic neurons. It was shown here that Cdk5 bound to membrane organelles in the cytoplasm through myristoylated p35 Cdk5 activator and Cdk5 activity promoted export of the active Cdk5-p35 complex from the nucleus. We confirmed that Cdk5 suppressed excitation of neurons. One of the molecular mechanisms is phosphorylation of Sept5, which inhibited interaction with syntaxin1 SNARE protein. We also found a novel function of Cdk5, which was suppression of neurite outgrowth through LMTK1 neuron abundant novel Ser/Thr protein kinase.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (81 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (39 results) (of which Peer Reviewed: 13 results) Presentation (23 results) Book (9 results) Remarks (10 results)

  • [Journal Article] Regulation of mitochondrial transport and inter-microtubule spacing by Tau phosphorylation at the sites hyperphosphorylated in Alzheimer’s disease.2012

    • Author(s)
      Shahpasand, S., Uemura, I., Saito, T., Asano, T., Hata, K., Shibata, K., Toyoshima, Y., Hasegawa, M., and Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: 32 Pages: 2430-2441

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phos-tag を用いたCdk5制御サブユニットp35のin vivo リン酸化の定量的解析2012

    • Author(s)
      久永眞市
    • Journal Title

      生物物理化学

      Volume: 56

    • NAID

      130004809458

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation of mitochondrial transport and inter-microtubule spacing by Tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease2012

    • Author(s)
      Shahpasand, et al
    • Journal Title

      J.Neurosci

      Volume: 32 Pages: 2430-2441

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcellular localization of active Cdk5 is determined by its own kinase activity2012

    • Author(s)
      Asada, et al
    • Journal Title

      J.Cell Sci.

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.2011

    • Author(s)
      Sato, K., Minegishi, S., Takano, J., Plattner, F., Saito, T., Asada, A., Kawahara, H., Iwata, N., Saido, T. C., Hisanaga, S.
    • Journal Title

      J. Neurochem.

      Volume: 117 Pages: 504-515

    • Related Report
      2011 Final Research Report
  • [Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p252011

    • Author(s)
      Sato, et al
    • Journal Title

      J.Neurochem.

      Volume: 117 Issue: 3 Pages: 504-515

    • DOI

      10.1111/j.1471-4159.2011.07222.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation and role of Cdk5 kinase activity in neuronal survival and death.2010

    • Author(s)
      Hisanaga, S., and Endo, E.
    • Journal Title

      J. Neurochem.

      Volume: 115 Pages: 1309-1321

    • Related Report
      2011 Final Research Report
  • [Journal Article] Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.2010

    • Author(s)
      Minegishi, S., Asada, A., Miyauchi, S., Fuchigami, T., Saito, T., and Hisanaga, S.
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 5482-5493

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Quantitative Measurement of In Vivo Phosphorylation States of Cdk5 Activator p35 by Phos-tag SDS-PAGE.2010

    • Author(s)
      Hosokawa, T., Saito, T., Asada, A., Fukunaga, K., and Hisanaga, S.
    • Journal Title

      Mol. Cell. Proteomics.

      Volume: 9 Pages: 1133-1143

    • Related Report
      2011 Final Research Report
  • [Journal Article] AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway.2010

    • Author(s)
      Takano, T., Tsutsumi, K., Saito, T., Asada, A., Tomomura, M., Fukuda, M., Hisanaga, S.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 783-797

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.2010

    • Author(s)
      Tsutsumi, K., Takano, T., Endo, R., Fukuda, M., Ohshima, T., Tomomura, M., and Hisanaga, S.
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.2010

    • Author(s)
      Tsutsumi, K., et al.
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator.2009

    • Author(s)
      Endo, R., Saito, T., Asada, A., Kawahara, H., Ohshima, T., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 26029-26039

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Yotsumoto, K., Saito, T., Asada, A., Oikawa, T., Kimura, T., Uchida, C., Ishiguro, K., Uchida, T., Hasegawa, M., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 16840-16847

    • Related Report
      2011 Final Research Report
  • [Journal Article] Novel axonal distribution of neurofilament-H phosphorylated at the GSK3β-phosphorylation site in its E-segment.2009

    • Author(s)
      Sasaki, T., Ishiguro, K., and Hisanaga, S.
    • Journal Title

      J. Neurosci. Res.

      Volume: 87 Pages: 3088-3097

    • Related Report
      2011 Final Research Report
  • [Journal Article] Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator.2009

    • Author(s)
      Endo, R., Saito, T., Asada, A., Kawahara, H., Ohshima, T., Hisanaga, S.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 26029-26039

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Effect of pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Yotsumoto, K., Saito, T., Asada, A., Oikawa, T., Kimura, T., Uchida, C., Ishiguro, K., Uchida, T., Hasegawa, M., Hisanaga, S.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 16840-16847

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Effect of pinl or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Yotsumoto, et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 16840-16847

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pinl or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Sasaki, et al.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 3088-3097

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator.2009

    • Author(s)
      Endo, et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 26029-26039

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008

    • Author(s)
      Kaminosono, S., Saito, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N., and Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: 28 Pages: 8747-8755

    • Related Report
      2011 Final Research Report
  • [Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes.2008

    • Author(s)
      Asada, A., Yamamoto, N., Gohda, M., Saito, T., Hayashi, N., and Hisanaga, S.
    • Journal Title

      J. Neurochem.

      Volume: 106 Pages: 1325-1336

    • Related Report
      2011 Final Research Report
  • [Journal Article] Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src.2008

    • Author(s)
      Tsutsumi, K., Tomomura, M., Furuichi, T., and Hisanaga, S.
    • Journal Title

      Genes to Cells

      Volume: 13 Pages: 949-964

    • Related Report
      2011 Final Research Report
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008

    • Author(s)
      Kaminosono, S., Saito, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N., Hisanaga, S.
    • Journal Title

      J. Neurosci 28

      Pages: 8747-8755

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes.2008

    • Author(s)
      Asada, A., Yamamoto, N., Gohda, M., Saito, T., Hayashi, N., Hisanaga, S.
    • Journal Title

      J. Neuroche 106

      Pages: 1325-1336

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability2008

    • Author(s)
      Kaminosono, et.al.
    • Journal Title

      J. Neurosci 28

      Pages: 8747-8755

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src2008

    • Author(s)
      Tsutsumi, et.al.
    • Journal Title

      Gene to Cell 13

      Pages: 949-964

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes2008

    • Author(s)
      Asada, et.al.
    • Journal Title

      J. Neurochem 106

      Pages: 1325-1336

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p25/Cdk5 promotes the progression of cell death in nucleus of ER-stressed neurons.2007

    • Author(s)
      Saito, T., Konno, T., Asada, A. and Hisanaga, S.
    • Journal Title

      J. Neurochem.

      Volume: 102 Pages: 133-140

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.2007

    • Author(s)
      Sato, Y., Taoka, M., Sugiyama, N., Kubo, K., Fuchigami, T., Asada, A., Saito, T., Nakajima, K., Isobe, T. and Hisanaga, S.
    • Journal Title

      Genes Cells

      Volume: 12 Pages: 1315-1327

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation of the membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007

    • Author(s)
      Sato, K., Zhu, Y-S., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M. and Hisanaga, S.
    • Journal Title

      J. Neurosci. Res.

      Volume: 85 Pages: 3071-3078

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phosphorylation of adult type sept5 (cdcrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1.2007

    • Author(s)
      Taniguchi, T., Taoka, M., Itakura, M., Asada, A., Saito, T., Kinoshita, M., Takahashi, M., Isobe, T., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 282 Pages: 7869-7876

    • Related Report
      2011 Final Research Report
  • [Journal Article] Supression of calpain-dependent cleavage of the cdk5 activator p35 to p25 by site-specific phosphorylation.2007

    • Author(s)
      Kamei, H., Saito, T, Ozawa, O., Fujita, Y., Asada, A., Bibb, J. A., Saido, T. C., Sorimachi, S., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 282 Pages: 1687-1694

    • Related Report
      2011 Final Research Report
  • [Journal Article] p25/Cdk5 promotes the progression of cell death in nucleus of ER-stressed neurons.2007

    • Author(s)
      Saito, T., Konno, T., Asada, A., Hisanaga, S.
    • Journal Title

      J. Neurochem 102

      Pages: 133-140

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Cdk5-p39 is a labile complex with the similar substrate specificity to Cdk5-p352007

    • Author(s)
      Yamada, et. al.
    • Journal Title

      J.Neurochem 102

      Pages: 1477-1487

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the membrane association and kinase activity of Cdk5-p35 by phosphorylation of p352007

    • Author(s)
      Sato K., et. al.
    • Journal Title

      J.Neurosci.Res. 85

      Pages: 3071-3078

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cvclin-denendent kinase 52007

    • Author(s)
      Sato Y., et. al.
    • Journal Title

      Genes Cells 12

      Pages: 1315-1327

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcellular localization of active Cdk5 is determined by its own kinase activity.

    • Author(s)
      Asada, A., Saito, T., and Hisanaga, S.
    • Journal Title

      J. Cell Sci.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] LMTK1/AATYK1 Is a Novel Regulator of Axonal Outgrowth That Acts via Rab11 in a Cdk5-Dependent Manner.

    • Author(s)
      Takano, T., Tomomura, M., Yoshioka, N., Tsutsumi, K., Terasawa, Y., Saito, T., Kawano, H., Kamiguchi, H., Fukuda, M., Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Presentation] Phos-tag SDS-PAGEによって新しく出来たこと2011

    • Author(s)
      久永眞市
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of the kinase activity and function of Cyclin-dependent kinase 5 in post-mitotic neurons.2011

    • Author(s)
      Hisanaga, S.
    • Organizer
      第23回国際神経化学会シンポジウム
    • Place of Presentation
      アテネ
    • Related Report
      2011 Final Research Report
  • [Presentation] Phos-tag SDS-PAGEによって新しく出来たこと2011

    • Author(s)
      久永眞市
    • Organizer
      日本生化学会フォーラム
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Cdk5 and neuron cell death.2011

    • Author(s)
      Hisanaga, S., Asada, A., and Saito, T.
    • Organizer
      Pep Con-2010
    • Place of Presentation
      北京
    • Related Report
      2011 Final Research Report
  • [Presentation] Normal and abnormal phosphorylation of Tau by Cyclin-dependent kinase 5.2010

    • Author(s)
      Hisanaga, S.
    • Organizer
      Aging, Tau Protein and Dementias.
    • Place of Presentation
      東京
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Normal and abnormal phosphorylation of Tau by Cyclin-dependent kinase 5.2010

    • Author(s)
      Hisanaga, S.
    • Organizer
      Aging, Tau Protein and Dementias
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] フォスタグSDS-PAGEを用いたタンパク質リン酸化の解析-Cdk5活性化サブユニットp35の場合-2009

    • Author(s)
      久永眞市, 他3名
    • Organizer
      第7回日本ヒトプロテオーム学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] dk5 and Microtubules in Neurodegenerative Diseases.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      The International Symposium on “Cell Cycle and Cell Architecture”
    • Place of Presentation
      名古屋
    • Year and Date
      2009-02-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Reconsideration of the activation mechanism of Cdk5 by p35 and p39.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      2^<nd> International Symposium on Cdk5
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of PIN1 and microtubules binding on dephosphorylation of FTDP-17 mutant Tau.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      2009 International Conference on Alzheimer’s Disease
    • Place of Presentation
      ウィーン
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質リン酸化研究へのフォスタグSDS-PAGEの応用2009

    • Author(s)
      久永眞市, 細川智永, 浅田明子, 斎藤太郎
    • Organizer
      第4回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] Pro-survival and pro-apoptotic activity of neuron-specific protein kinase Cdk5.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      27th Annual conference of Indian Academy of Neuroscience
    • Place of Presentation
      インド
    • Related Report
      2011 Final Research Report 2009 Self-evaluation Report
  • [Presentation] Effect of PIN1 and micro- tubules binding on dephosphorylation of FTDP-17 mutant Tau.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      ウィーン
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2008

    • Author(s)
      久永眞市, 淺田明子, 斎藤太郎
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2008

    • Author(s)
      久永眞市, 淺田明子, 斎藤太郎
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Related Report
      2009 Self-evaluation Report 2008 Annual Research Report
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永真市, ら
    • Organizer
      第30回分子生物学会ワークショツプ
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Filament assembly abnormality of neurofilament-L with Charcot-Marie-Tooth disease mutation2007

    • Author(s)
      Hisanaga, S., Gotow, T., Shiozaki, M., Sasaki, T., Asada, A., Saito, T., Uchiyama, Y., Yasuki, J.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永真市, 浅田明子, 斉藤太郎
    • Organizer
      第30回分子生物学会ワークショップ
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2009 Self-evaluation Report
  • [Presentation] フォスタグSDS-PAGEを用いたタンパク質リン酸化の解析-Cdk5活性化サブユニットp35の場合-

    • Author(s)
      久永眞市, 細川智永, 浅田明子, 斎藤太郎
    • Organizer
      第7回ヒトプロテオーム学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] サイクリン依存性キナーゼ5(Cdk5)の異常活性化と神経変性疾患

    • Author(s)
      久永眞市
    • Organizer
      「筋萎縮性側索硬化症の病態に基づく画期的治療法の開発」班のワークショップ
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuronal development and neurodegeneration on Cdk5 and related signaling.

    • Author(s)
      Hisanaga, S.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] アルツハイマー病でみられるタウの異常リン酸化とプロテインフォスファターゼ

    • Author(s)
      久永眞市, 斎藤太郎
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuronal development and neurodegeneration on Cdk5 and related signaling.

    • Author(s)
      Hisanaga, S.
    • Organizer
      第32回日本神経科学大会シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2009 Self-evaluation Report
  • [Book] 細胞機能.「第3版分子生物学」第12章 田沼靖一編2011

    • Author(s)
      久永真市
    • Publisher
      丸善
    • Related Report
      2011 Final Research Report
  • [Book] Neurofilaments in aged amimals. Cytoskeleton of the Nervous System. pp325-345. Advances in Neurobiology 3. Eds. By R. Nixon and A Yuan.2011

    • Author(s)
      Hisanaga, S., Sasaki, T., and Uchida, A.
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report
  • [Book] 第3版分子生物学、第12章「細胞機能」2011

    • Author(s)
      久永眞市
    • Total Pages
      14
    • Publisher
      丸善
    • Related Report
      2011 Annual Research Report
  • [Book] 神経細胞におけるCdk5-p35の活用戦略.「細胞周期フロンティア」, 佐方功幸, 稲垣昌樹, 岸本健雄 編集, pp242-2472010

    • Author(s)
      久永眞市, 遠藤良
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Book] Neurofilaments in aged amimals. Cytoskeleton of the Nervous System.2010

    • Author(s)
      Hisanaga, S., et al.
    • Total Pages
      11
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] 蛋白質 核酸 酵素(多様な神経機能を制御するキナーゼCdk5, 特集にあたって)2009

    • Author(s)
      久永眞市
    • Related Report
      2009 Self-evaluation Report
  • [Book] Cdk5 book(N. and Tsai, L-H., The Kinase Activity of Cdk5 and Its Regulation.)2008

    • Author(s)
      Hisanaga, S., Ishiguro, K.
    • Publisher
      Splinger
    • Related Report
      2009 Self-evaluation Report
  • [Book] The Kinase Activity of Cdk5 and Its Regulation. In Cdk5 book2008

    • Author(s)
      Hisanaga, S. and Ishiguro, K.
    • Total Pages
      13
    • Publisher
      SDlinger, NY
    • Related Report
      2008 Annual Research Report
  • [Book] Cyclin-dependent kinase 5: preparation and measurement of kinase activity. In Protein kinase technologies. Neuromethods (Ed., H. Mukai)

    • Author(s)
      Minegishi, S., Hisanaga, S.
    • Publisher
      Springer(in press)
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.comp.tmu.ac.jp/mnc/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biol.se.tmu.ac.jp/labo.asp?ID=neumol

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.excite.co.jp/News/release/Dprp_975.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://must6.somee.com/surf.aspx?dec=1&url=uh4QwdELmS4FtSBQsqNMw8VGwcZOmPAT03==B6X!

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.sci.tmu.ac.jp/mnc/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.sci.metro-u.ac.jp/mnc/

    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.sci.metro-u.ac.jp/mnc/

    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.sci.metro-u.ac.jp/mnc/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.sci.metro-u.ac.jp/mnc/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.sci.metro-u.ac.jp/mnc/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2018-03-28  

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