Study on the mechanism underlying segregation of proliferative and differentiative activities into daughter cells during stem cell asymmetric divisions
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057009
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATSUZAKI Fumio 独立行政法人理化学研究所, 非対称細胞分裂研究グループ, グループディレクター (10173824)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥59,700,000 (Direct Cost: ¥59,700,000)
Fiscal Year 2011: ¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2010: ¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2009: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2007: ¥8,700,000 (Direct Cost: ¥8,700,000)
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| Keywords | 非対称分裂 / 幹細胞 / 細胞極性 / ショウジョウバエ / マウス / 脳発生 / 神経幹細胞 / 上皮極性 / 分裂軸 / 運命決定因子 / 神経発生 / 分化 / 増殖 |
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| Research Abstract |
The mode of asymmetric division of neural stem cells in Drosophila and mouse was investigated. In Drosophila neural stem cell, cell polarity and division axis is parallel to each other such that cell fate determinants are segregated into one daughter cell to ensure division asymmetry. In contrast, we found that mouse neural stem cells undergo divisions that makes the mitotic axis perpendicular to the long epithelial axis so that one daughter inherits the entire epithelial structure, which is a prerequisite for self-renewability.
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Report
(7 results)
Research Products
(89 results)
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[Journal Article] Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix jacchus2011
Author(s)
Kelava I, Reillo I, Murayama AY, Kalinka AT, Stenzel D, Tomancak P, Matsuzaki F, Lebrand C, Sasaki E, Schwamborn JC, Okano H, Huttner WB, Borrell V.
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Journal Title
Cereb Cortex.
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts2011
Author(s)
Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia-Alvarez G, Gwee SS, Soon SB, Sidhu HK, Yu F, Matsuzaki F, Gonzalez C, and Wang H.
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Journal Title
Dev Cell
Volume: 21
Pages: 520-533
Related Report
Peer Reviewed
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[Journal Article]2008
Author(s)
K awaguchi A, Ikawa T, Kasukawa T, Ueda HR, Kurimoto K, Saitou M, Matsuzaki F.
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Journal Title
Development. 135(18)
Pages: 3113-24
Related Report
Peer Reviewed
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