| Budget Amount *help |
¥59,700,000 (Direct Cost: ¥59,700,000)
Fiscal Year 2011: ¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2010: ¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2009: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2007: ¥8,700,000 (Direct Cost: ¥8,700,000)
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| Research Abstract |
The mode of asymmetric division of neural stem cells in Drosophila and mouse was investigated. In Drosophila neural stem cell, cell polarity and division axis is parallel to each other such that cell fate determinants are segregated into one daughter cell to ensure division asymmetry. In contrast, we found that mouse neural stem cells undergo divisions that makes the mitotic axis perpendicular to the long epithelial axis so that one daughter inherits the entire epithelial structure, which is a prerequisite for self-renewability.
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