Mechanisms of cell cycle arrest and its interaction with cell differentiation during development
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057011
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tottori University (2008-2011)
Mitsubishi Kagaku Institute of Life Sciences (2007) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥114,500,000 (Direct Cost: ¥114,500,000)
Fiscal Year 2011: ¥22,600,000 (Direct Cost: ¥22,600,000)
Fiscal Year 2010: ¥22,600,000 (Direct Cost: ¥22,600,000)
Fiscal Year 2009: ¥23,100,000 (Direct Cost: ¥23,100,000)
Fiscal Year 2008: ¥23,100,000 (Direct Cost: ¥23,100,000)
Fiscal Year 2007: ¥23,100,000 (Direct Cost: ¥23,100,000)
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| Keywords | 細胞周期、 / 増殖停止 / 細胞分化 / 発生 / 再生 / マウス / イモリ / 分子遺伝学 / 発生・分化 / 細胞増殖 / 心筋細胞 / 形態形成 / クロマチン制御 / ノックアウト / 転写制御 / 細胞周期 / 分化 / 蛋白質分解 / エピジェネテックス / 遺伝子操作動物 |
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| Research Abstract |
We have analyzed how cell cycle arrests and how cell proliferation interacts with cell differentiation during development. We showed that silencing of cycin D1 expression is required for maintenance of the cardiomyocyte cell cycle arrest, and that cycin D1 represses cardiomyocyte differentiation. These results are important for understanding tissue morphogenesis, homeostasis, and oncogenesis.
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Report
(7 results)
Research Products
(82 results)
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[Journal Article] Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice2010
Author(s)
Wang H., Bauzon F., Ji P., Xu X., Sun D., Locker J., Sellers R.S., Nakayama K, Nakayama KI., Cobrinik D., and Zhu L
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Journal Title
Nat Genet
Volume: 42
Issue: 1
Pages: 83-88
DOI
Related Report
Peer Reviewed
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[Journal Article] A Jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K92009
Author(s)
Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., and Takeuchi, T
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Journal Title
J. Biol. Chem
Volume: 284
Issue: 3
Pages: 733-739
DOI
Related Report
Peer Reviewed
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[Journal Article] Mice lacking the schizophrenia-associated protein FEZ1 manifest hyper- activity and enhanced responsive- ness to psychostimulants2008
Author(s)
Sakae N., Yamasaki N., Kitaichi K., Fukuda T., Yamada M., Yoshikawa H., Hiranita T., Tatsumi Y., Kira J., Yamamoto T., Miyakawa T., and Nakayama KI
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Journal Title
Hum Mol Genet
Volume: 17
Issue: 20
Pages: 3191-203
DOI
Related Report
Peer Reviewed
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