| Budget Amount *help |
¥109,900,000 (Direct Cost: ¥109,900,000)
Fiscal Year 2011: ¥23,100,000 (Direct Cost: ¥23,100,000)
Fiscal Year 2010: ¥23,100,000 (Direct Cost: ¥23,100,000)
Fiscal Year 2009: ¥23,100,000 (Direct Cost: ¥23,100,000)
Fiscal Year 2008: ¥23,100,000 (Direct Cost: ¥23,100,000)
Fiscal Year 2007: ¥17,500,000 (Direct Cost: ¥17,500,000)
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| Research Abstract |
We found two kinds of new membrane chaperones. pspA repairs the leaks of ions through damaged membranes, and uncI assists membrane integration of hydrophobic c-subunit of ATP synthase. DnaK-DnaJ-DafA turns out to be inactive complex. As temperature raises, the complex dissociates and Dnak and DnaJ start to work as disaggregation chaperone in cooperation with ClpB. Polypeptide in the GroEL cage capped by GroES spends most time as tethered state. Then, it is released into the chaperonin cage or outside.
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