Elucidation of the yeast systems that achieve and maintain functions and organizations of mitochondrial and ER proteins
Project Area | Protein community: organization and maintenance of protein functions |
Project/Area Number |
19058005
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
|
Research Institution | Nagoya University |
Principal Investigator |
ENDO Toshiya 名古屋大学, 理学研究科, 教授 (70152014)
|
Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA Shuh-ichi 名古屋大学, 大学院・理学研究科, 准教授 (10252222)
|
Co-Investigator(Renkei-kenkyūsha) |
YOSHIHIA Tohru 名古屋大学, 物質科学国際研究センター, 准教授 (60212312)
|
Project Period (FY) |
2007 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥198,000,000 (Direct Cost: ¥198,000,000)
Fiscal Year 2011: ¥39,600,000 (Direct Cost: ¥39,600,000)
Fiscal Year 2010: ¥39,600,000 (Direct Cost: ¥39,600,000)
Fiscal Year 2009: ¥39,600,000 (Direct Cost: ¥39,600,000)
Fiscal Year 2008: ¥39,600,000 (Direct Cost: ¥39,600,000)
Fiscal Year 2007: ¥39,600,000 (Direct Cost: ¥39,600,000)
|
Keywords | ミトコンドリア / 酵母 / トランスロケータ / 小胞体 / 膜透過 / 品質管理 |
Research Abstract |
We have revealed the mechanisms of various aspects of protein transport into mitochondria, including cooperation of translocators, driving force for protein translocation, roles of multiple targeting signals in the presequence, mapping of subunit arrangements in the translocator complex, assembly of β-barrel proteins etc. We have also revealed the mechanisms of protein quality control in the ER, including roles of interactions between Mnl1 and PDI, ER retention of aberrant proteins by Yos9, roles of Hsp70 in plant sexual reproduction etc.
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Report
(7 results)
Research Products
(275 results)
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[Journal Article] Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria2013
Author(s)
Y. Tamura, Y. Harada, S. Nishikawa, K. Yamano, M. Kamiya, T. Shiota, T. Kuroda, O. Kuge, H. Sesaki, K. Imai, K. Tomii, T. Endo
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Journal Title
Cell Metab.
Volume: (印刷中)(未定)
Related Report
Peer Reviewed
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[Journal Article] Dual role of the receptor Tom20in specificity and efficiency of protein import into mitochondria2011
Author(s)
H. Yamamoto, N. Itoh, S. Kawano, Y. Yatsukawa, T. Momose, T. Makio, M. Matsunaga, M. Yokota, M. Esaki, T. Shodai, D. Kohda, A.E.A. Hobbs, R.E. Jensen, and T.Endo
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 108
Issue: 1
Pages: 91-96
DOI
Related Report
Peer Reviewed
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[Journal Article] Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria2011
Author(s)
H.Yamamoto, N.Itoh, S.Kawano, Y.Yatsukawa, T.Momose, T.Makio, M.Matsunaga, M.Yokota, M.Esaki, T.Shodai, D.Kohda, A.E.A.Hobbs, R.E.Jensen, T.Endo
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Journal Title
Proc.Natl.Acad.Sci.USA
Volume: 108
Pages: 91-96
Related Report
Peer Reviewed
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[Journal Article] Roles of TOM70 in import of presequence-containing mitochondrial proteins2009
Author(s)
H. Yamamoto, K. Fukui, H. Takahashi, S.Kitamura, T. Shiota, K. Terao, M. Uchida, M.Esaki, S. Nishikawa, T. Yoshihisa, K. Yamano, and T. Endo
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Journal Title
J. Biol. Chem
Volume: 284
Issue: 46
Pages: 31635-31646
DOI
Related Report
Peer Reviewed
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[Presentation] Analysis of the protein interaction mapping of Tom22, a component of the mitochondrial outer membrane translocator, by using in vivo site-specific photocrosslinking2011
Author(s)
Takuya Shiota, Hide Mabuchi, Sachiko Tanaka- Yamano, Koji Yamano, Toshiya Endo
Organizer
EMBO Conference on protein transport systems structures, mechanisms, and medical aspects
Place of Presentation
Santa Margherita di Pula, Sardegna, Italy
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