Maintenance of the endoplasmic reticulum function by the unfolded protein response (UPR)
| Project Area | Protein community: organization and maintenance of protein functions |
|---|
| Project/Area Number |
19058009
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
MORI Kazutoshi 京都大学, 大学院・理学研究科, 教授 (70182194)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森 博幸 京都大学, ウイルス研究所, 准教授 (10243271)
|
|---|
| Project Period (FY) |
2007 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥119,200,000 (Direct Cost: ¥119,200,000)
Fiscal Year 2011: ¥26,400,000 (Direct Cost: ¥26,400,000)
Fiscal Year 2010: ¥26,400,000 (Direct Cost: ¥26,400,000)
Fiscal Year 2009: ¥26,400,000 (Direct Cost: ¥26,400,000)
Fiscal Year 2008: ¥26,400,000 (Direct Cost: ¥26,400,000)
Fiscal Year 2007: ¥13,600,000 (Direct Cost: ¥13,600,000)
|
|---|
| Keywords | 小胞体 / 高次構造形成 / 分子シャペロン / タンパク質分解 / 品質管理 / 転写誘導 / 翻訳抑制 / 遺伝子ノックアウト / メダカ / 初期発生 / 脊索 / ニワトリ細胞 / オルガネラ / スプライシング / 翻訳 / 転写 / 脂質 / プロテアソーム / 分解 / フォールディング / 転写透導 / オルガネラ形成 / 生体膜 / リン脂質 / B細胞分化 |
|---|
| Research Abstract |
We discovered that unfolded proteins accumulate in the endoplasmic reticulum (ER) of the notochord during medaka early embryonic development, that medaka refolds the accumulated unfolded proteins by activating sensor proteins designated ATF6α and ATF6β and thereby inducing ER-localized molecular chaperones, and that medaka deficient in both ATF6α and ATF β dies due to notochord abnormality. Thus, the unfolded protein response plays a critical role in the homeostasis of the cell and body.
|
Report
(7 results)
Research Products
(42 results)
-
[Journal Article] A thrombospondin-dependent pathway for a protective ER stress response2012
Author(s)
J. M. Lynch, M. Maillet, D. Vanhoutte, A. Schloemer, M. A. Sargent, N. S. Blair, K. A. Lynch, T. Okada, B. J. Aronow, H. Osinska, R. Prywes, J. N. Lorenz, K. Mori, J. Lawler, J. Robbins and J. D. Molkentin
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells.2010
Author(s)
S.Shimasaki, T.Koga, T.Shuto, MA.Suico, T.Sato, K.Watanabe, S.Morino-Koga, M.Taura, S.Okada, K.Mori, H.Kai
-
Journal Title
Biochem.Biophys.Res.Commun.
Volume: 402
Pages: 235-240
Related Report
Peer Reviewed
-
-
-
[Journal Article] Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow2009
Author(s)
L. Zeng, A. Zampetaki, A. Margariti, A. E. Pepe, S. Alam, D. Martin, Q. Xiao, W. Wang, Z. Jin, G. Cockerill, K. Mori, Y. J. Li, Y. Hu, S. Chien and Q. Xu
-
Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 106
Issue: 20
Pages: 8326-8331
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. L. Zeng2009
Author(s)
A. Zampetaki, A. Margariti, A.E. Pepe, S. Alam, D. Martin, Q. Xiao, W. Wang, Z. Jin, G. Cockerill, K. Mori, Y.J. Li, Y. Hu, S. Chien, Q. Xu
-
Journal Title
Proc. Natl. Acad. Sci. USA 106
Pages: 8326-8331
Related Report
Peer Reviewed
-
-
-
[Journal Article] Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow.2009
Author(s)
L.Zeng, A.Zampetaki, A.Margariti, A.E.Pepe, S.Alam, D.Martin, Q.Xiao, W.Wang, Z.Jin, G.Cockerill, K.Mori, Y.J.Li, Y.Hu, S.Chien, Q.Xu
-
Journal Title
Proc.Natl.Acad.Sci. USA 106
Pages: 8326-8331
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
