| Budget Amount *help |
¥71,000,000 (Direct Cost: ¥71,000,000)
Fiscal Year 2011: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2010: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2009: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2008: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2007: ¥17,000,000 (Direct Cost: ¥17,000,000)
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| Research Abstract |
We found that, in the gut-associated lymphoid tissue (GALT), naturally occurring TNF/iNOS-producing DCs (Tip-DCs) regulate both T cell-dependent and -independent IgA induction, and pDCs play a prominent role in T cell-independent IgA induction. In the peripheral lymphoid tissues under severe infection, monocyte-derived DCs (Mo-DCs) perform hemophagocytosis to fine-tune excessive immune responses. Furthermore, in the BM, we identified a clonogenic progenitor with prominent pDC developmental potential.
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