Mucosal Immunology and self‐discrimination

• Project Area: Immunological Self Recognition and its Disorders
• Project/Area Number: 19059003
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: KIYONO Hiroshi 東京大学, 医科学研究所, 教授 (10271032)
• Co-Investigator(Kenkyū-buntansha): SIDONIA Fagarasan 理化学研究所, 免疫アレルギーセンター科学総合研究センター, チームリーダー (00391970)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥144,000,000 (Direct Cost: ¥144,000,000); Fiscal Year 2011: ¥28,800,000 (Direct Cost: ¥28,800,000); Fiscal Year 2010: ¥28,800,000 (Direct Cost: ¥28,800,000); Fiscal Year 2009: ¥28,800,000 (Direct Cost: ¥28,800,000); Fiscal Year 2008: ¥28,800,000 (Direct Cost: ¥28,800,000); Fiscal Year 2007: ¥28,800,000 (Direct Cost: ¥28,800,000)
• Keywords: 共生細菌 / パイエル板 / Alcaligenes / フコシル化 / IgA / 孤立リンパ濾胞 / M細胞 / Tfh細胞 / 腸管IgA / 胚中心 / 濾胞性ヘルパーT細胞 / Foxp3+制御性T細胞 / PD-1 / 絨毛上皮細胞 / 自然免疫担当細胞 / 濾胞性樹状細胞 / レチノイン酸 / Alcaligrnes / 孤立性リンパ濾胞 / FoxP3^+制御性T細胞 / 樹状細胞

Research Abstract

In this study, we found some gut commensal bacteria, which habit at the inside of gut-associated lymphoid tissue such as Peyer’s patches. To make a cohabitation niche in the tissue, the mucosal immune system plays a critical role. It was also suggested that a breakdown of symbiotic relationship between host and microbes led to chronic inflammation such as inflammatory bowel diseases. We also demonstrated that a mutual relationship between commensal microbiota, mucosal immunocompetent cells and intestinal epithelial cells strictly regulated a homeostasis of not only mucosal but also systemic immunity.

Research Products

• [Journal Article] Impaired selection of IgA and intestinal dysbiosis associated with PD-1-deficiency (2013)
  • Author(s): Maruya, M., Kawamoto, S., Kato, LM., and Fagarasan, S
  • Journal Title: Gut Microbes Volume: 4(2) Pages: 65-71
• [Journal Article] Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development (2013)
  • Author(s): Takase, M., Iida, R., Maruya, M., Sakaue-Sawano, A., Miyawaki, A., Wakayama, T., Nishigami, S., Fagarasan, S. and Kanagawa O
  • Journal Title: Int Immunol Volume: 25(3) Pages: 145-56
• [Journal Article] Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development. (2013)
  • Author(s): Takase M, Iida R, Maruya M, Sakaue-Sawano A, Miyawaki A, Wakayama T, Nishigami S, Fagarasan S, Kanagawa O.
  • Journal Title: International immunology Volume: 25 Issue: 3 Pages: 145-156
  • DOI: 10.1093/intimm/dxs095
  • Peer Reviewed
• [Journal Article] Impaired selection of IgA and intestinal dysbiosis associated with PD-1-deficiency (2013)
  • Author(s): Maruya M, Kawamoto S, Kato LM, Fagarasan S
  • Journal Title: Gut Microbes Volume: 4 Issue: 2 Pages: 165-171
  • DOI: 10.4161/gmic.23595
  • Peer Reviewed
• [Journal Article] The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut (2012)
  • Author(s): Kawamoto, S., Tran, TH., Maruya, M., Suzuki, K., Doi, Y., Tsutsui, Y., Kato, LM., and Fagarasan, S
  • Journal Title: Science. Apr Volume: 336(6080) Pages: 485-9
• [Journal Article] The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. (2012)
  • Author(s): Shimpei Kawamoto, Thinh H. Tran, Mikako Maruya, Keiichiro Suzuki, Yasuko Doi, Yumi Tsutsui, Lucia M. Kato, Sidonia Fagarasan
  • Journal Title: Science Volume: 336 Issue: 6080 Pages: 485-489
  • DOI: 10.1126/science.1217718
  • Peer Reviewed
• [Journal Article] The airway antigen sampling system: Respiratory M cells as an alternative gateway for inhaled antigens (2011)
  • Author(s): Kim, D-Y., Sato, A., Fukuyama, S., Sagara, H, Nagatake, T., Kong, IG., Goda, K., Nochi, T., Kunisawa, J., Sato, S., Yokota, Y., Lee, CH., and Kiyono, H
  • Journal Title: J. Immunol Volume: 186 Pages: 4253-4262
• [Journal Article] Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells (2011)
  • Author(s): Maruya M, Suzuki K, Fujimoto H, Miyajima M, Kanagawa O, Wakayama T, and Fagarasan, S
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108(2) Pages: 722-7
• [Journal Article] Epithelial cell microRNAs in gut immunity (2011)
  • Author(s): Goto, Y., and Kiyono, H
  • Journal Title: Nat Immunol Volume: 12 Pages: 195-197
• [Journal Article] Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis (2011)
  • Author(s): Kunisawa, J., and Kiyono, H
  • Journal Title: Cell Host Microbe Volume: 9 Pages: 83-84
• [Journal Article] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress (2011)
  • Author(s): Terahara, K., Nochi, T., Yoshida, M., Takahashi, Y., Goto, Y., Hatai, H., Kurokawa, S., Jang, H-M., Kweon, M-N, Domino, SE., Hiroi, T., Yuki, Y., Tsunetsugu-Yokota, Y., Kobayashi, K., and Kiyono, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 404 Pages: 822-828
• [Journal Article] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. (2011)
  • Author(s): Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 404 Pages: 822-8
  • Peer Reviewed
• [Journal Article] Peaceful mutualism in the gut : revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. (2011)
  • Author(s): Kunisawa J, Kiyono H.
  • Journal Title: Cell Host Microbe. Volume: 17 Pages: 83-4
  • Peer Reviewed
• [Journal Article] Epithelial cell microRNAs in gut immunity. (2011)
  • Author(s): Goto Y, Kiyono H.
  • Journal Title: Nat Immunol. Volume: 12 Pages: 195-7
  • Peer Reviewed
• [Journal Article] Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells. (2011)
  • Author(s): Maruya M, Suzuki K, Fujimoto H, Miyajima M, Kanagawa O, Wakayama T, Fagarasan S
  • Journal Title: Proc Nat1 Acad Sci U S A. Volume: 108 Pages: 722-7
  • Peer Reviewed
• [Journal Article] Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis (2010)
  • Author(s): Fagarasan, S., Kawamoto, S., Kanagawa, O and Suzuki, K
  • Journal Title: Annu Rev Immunol Volume: 28 Pages: 243-73
• [Journal Article] The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut (2010)
  • Author(s): Suzuki, K., Maruya, M., Kawamoto, S., Sitnik, K., Kitamura, H., Agace, WW and Fagarasan, S
  • Journal Title: Immunity. Jul Volume: 33(1) Pages: 71-83
• [Journal Article] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines (2010)
  • Author(s): Nochi, T., Yuki, Y., Takahashi, H., Sawada, SI., Mejima, M., Kohda, T., Harada, N., Kong, IG., Sato, A., Kataoka, N., Tokuhara, D., Kurokawa, S., Takahashi, Y., Tsukada, H., Kozaki, S., Akiyoshi, K., and Kiyono, H
  • Journal Title: Nature Mater Volume: 9 Pages: 572-578
• [Journal Article] Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine (2010)
  • Author(s): Tokuhara, D., Yuki, Y., Nochi, T., Kodama, T., Mejima, M., Kurokawa, S., Takahashi, Y., Nanno, M., Nakanishi, U., Takaiwa, F., Honda, T., and Kiyono, H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Pages: 8794-8799
• [Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis (2010)
  • Author(s): Obata, T., Goto, Y., Kunisawa, J., Sato, S., Sakamoto, M., Setoyama, H., Matsuki, T., Nonaka, K., Shibata, N., Gohda, M., Kagiyama, Y., Nochi, T., Yuki, Y., Fukuyama, Y., Mukai, A., Shinzaki, S., Fujihashi, K., Sasakawa, C., Iijima, H., Goto, M., Umesaki, Y., Benno, Y., and Kiyono, H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Pages: 7419-7424
• [Journal Article] Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis (2010)
  • Author(s): Fagarasan, S. et al.
  • Journal Title: Adv Immunol Volume: 107
• [Journal Article] B cell-specific and stimulation-responsive enhancers derepress (2010)
  • Author(s): Tran, TH., Nakata, M., Suzuki, K., Begum, NA., Shinkura, R., Fagarasan, S. and Honjo, T and Nagaoka H
  • Journal Title: Aicda by overcoming the effects of silencers Volume: 11(2) Pages: 148-54
• [Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. (2010)
  • Author(s): Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107 Pages: 7419-24
  • Peer Reviewed
• [Journal Article] Secretory IgA-mediated protection against V.cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. (2010)
  • Author(s): Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107 Pages: 8794-9
  • Peer Reviewed
• [Journal Article] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. (2010)
  • Author(s): Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H.
  • Journal Title: Nat Mater. Volume: 9 Pages: 572-8
  • Peer Reviewed
• [Journal Article] IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. (2010)
  • Author(s): Malamut G, El Machhour R, Montcuquet N, Martin-Lanneree S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B.
  • Journal Title: J Clin Invest. Volume: 120 Pages: 2131-43
  • Peer Reviewed
• [Journal Article] In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. (2010)
  • Author(s): Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H.
  • Journal Title: J Immunol. Volume: 185 Pages: 5436-43
  • Peer Reviewed
• [Journal Article] Mucosal regulatory cells in the gastrointestinal tract and periodontium. (2010)
  • Author(s): Takahashi I, Fujihashi K, Kiyono H.
  • Journal Title: Periodontol Volume: 54 Pages: 247-56
  • Peer Reviewed
• [Journal Article] Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. (2010)
  • Author(s): Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S.
  • Journal Title: J Virol. Volume: 84 Pages: 12703-12
  • Peer Reviewed
• [Journal Article] High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. (2010)
  • Author(s): Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 30427-35
  • Peer Reviewed
• [Journal Article] Aberrant interaction of the gut immune system with environmental factors in the development of food allergies. (2010)
  • Author(s): Kunisawa J, Kiyono H.
  • Journal Title: Curr Allergy Asthma Rep. Volume: 10 Pages: 215-21
  • Peer Reviewed
• [Journal Article] The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. (2010)
  • Author(s): Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace WW, Fagarasan S.
  • Journal Title: Immunity. Volume: 33 Pages: 71-83
  • Peer Reviewed
• [Journal Article] Adaptive immune regulation in the gut : T cell-dependent and Tcell-independent IgA synthesis. (2010)
  • Author(s): Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K.
  • Journal Title: Annu Rev Immunol Volume: 28 Pages: 243-73
  • Peer Reviewed
• [Journal Article] Advances in Immunology.Mucosal immunity.Preface. (2010)
  • Author(s): Fagarasan S, Cerutti A.
  • Journal Title: Adv Immunol. Volume: 107
  • Peer Reviewed
• [Journal Article] GALT : organization and dynamics leading to IgA synthesis. (2010)
  • Author(s): Suzuki K, Kawamoto S, Maruya M, Fagarasan S.
  • Journal Title: Adv Immunol Volume: 107 Pages: 153-85
  • Peer Reviewed
• [Journal Article] Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity. (2010)
  • Author(s): Suzuki K, Maruya M, Kawamoto S, Fagarasan S.
  • Journal Title: Immunol Rev. Volume: 237 Pages: 180-90
  • Peer Reviewed
• [Journal Article] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. (2010)
  • Author(s): Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.
  • Journal Title: Nat Immunol. Volume: 12 Pages: 264-70
  • Peer Reviewed
• [Journal Article] Secretory IgA-mediated protection against V.cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine (2010)
  • Author(s): Tokuhara, D., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press)
  • Peer Reviewed
• [Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis (2010)
  • Author(s): Obata, T., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press)
  • Peer Reviewed
• [Journal Article] Adaptive immune regulation in the gut : T cell-dependent and T cell-in dependent IgA synthesis (2010)
  • Author(s): Fagarasan, et al.
  • Journal Title: Annu Rev Immunol 28 Pages: 243-273
  • Peer Reviewed
• [Journal Article] B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers (2010)
  • Author(s): Tran TH, et al.
  • Journal Title: Nat Immunol 11 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches (2009)
  • Author(s): Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S and Fagarasan, S
  • Journal Title: Science Volume: 13;323(5920) Pages: 1488-92
• [Journal Article] Diverse regulatory pathways for IgA synthesis in the gut (2009)
  • Author(s): Suzuki, K., and Fagarasan, S
  • Journal Title: Mucosal Immunol Volume: 2(6) Pages: 468-71
• [Journal Article] A Rice-based oral cholera vaccine induces macaque-specific systemic neutralizing Abs but does not influence pre-existing intestinal immunity (2009)
  • Author(s): Nochi, T., Yuki,Y., Katakai, Y., Shibata, H., Tokuhara,D., Mejima, M., Kurokawa,S., Takahashi,Y., Nakanishi, U., Ono, F., Mimuro, H., Sasakawa, S., Takaiwa, F., Terao, K., and Kiyono, H
  • Journal Title: J. Immunol Volume: 183 Pages: 6538-6544
• [Journal Article] Expression of newly identified secretory CEACAM1(a) isoforms in the intestional epithelium (2009)
  • Author(s): Terahara, K., Yoshida, M., Taguchi, F., Igarashi, O., Nochi, T., Gotoh, Y., Yamamoto, T., Tsunetsugu-Yokota, Y., Beauchemin, N., and Kiyono, H
  • Journal Title: Biochem Biophys Res Commun Volume: 383 Pages: 340-346
• [Journal Article] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium (2009)
  • Author(s): Knoop, KA., Kumar, N., Butler, BR., Sakthivel, SK., Taylor, RT., Nochi, T., Akiba, H., Yagita, H., Kiyono, H., and Williams, IR
  • Journal Title: J. Immunol Volume: 183 Pages: 5738-5747
• [Journal Article] Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response (2009)
  • Author(s): Hase, K., Kawano, K., Nochi, T., Pontes, GS., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Yabashi, A., Waguri, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S., Lowe, AW., Itoh, K., Kiyono, H., and Ohno, H
  • Journal Title: Nature Volume: 462 Pages: 226-230
• [Journal Article] Mucosal immunosenescence : New developments and vaccines to control infectious diseases (2009)
  • Author(s): Fujihashi, K. and Kiyono, H
  • Journal Title: Trends Immunol Volume: 30 Pages: 334-343
• [Journal Article] Id2-, RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity (2009)
  • Author(s): Nagatake, T., Fukuyama, S, Kim. D-Y., Goda, K., Igarashi.O., Sato,S., Nochi, T., Sagara, H.,Yokota, Y., Jetten, AM., Kaisho, T., Akira, A., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., and Kiyono, H
  • Journal Title: J. Exp. Med Volume: 206 Pages: 2351-2364
• [Journal Article] Id2-, RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity (2009)
  • Author(s): Nagatake, T., et al.
  • Journal Title: J.Exp.Med 206 Pages: 2351-2364
  • Peer Reviewed
• [Journal Article] Mucosal immunosenescence : New developments and vaccines to contr-olinfectious diseases (2009)
  • Author(s): Fujihashi, K., Kiyono, H.
  • Journal Title: Trends Immunol 30 Pages: 334-343
  • Peer Reviewed
• [Journal Article] New Horizon of mucosal immunity and vaccine (2009)
  • Author(s): Takahashi, T., et al.
  • Journal Title: Curr.Opin.Immunol 21 Pages: 352-358
  • Peer Reviewed
• [Journal Article] Uptake through glycoprotein 2 of FimH(+)bacteria by M cells initiates mucosal immune response (2009)
  • Author(s): Hase, K., et al.
  • Journal Title: Nature 462 Pages: 226-230
  • Peer Reviewed
• [Journal Article] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium (2009)
  • Author(s): Knoop, K.A., et al.
  • Journal Title: J.Immunol 183 Pages: 5738-5747
  • Peer Reviewed
• [Journal Article] Expression of newly identified secretory CEACAMI(a)isoforms in the intestional epithelium. (2009)
  • Author(s): Terahara, K., et al.
  • Journal Title: Biochem Biophys Res Commun 383 Pages: 340-346
  • Peer Reviewed
• [Journal Article] A Rice-based oral cholera vaccine induces macaque-specific systemic neutralizing Abs but does not influence pre-existing intestinal immunity (2009)
  • Author(s): Nochi, T., et al
  • Journal Title: J.Immunol 183 Pages: 6538-6544
  • Peer Reviewed
• [Journal Article] Mucosal vaccines : novel advances in technology and delivery (2009)
  • Author(s): Yuki, Y., Kiyono, H.
  • Journal Title: Expert Rev Vaccines 8 Pages: 1083-1097
  • Peer Reviewed
• [Journal Article] Diverse regulatory pathways for IgA synthesis in the gut (2009)
  • Author(s): Suzuki K, Fagarasan S.
  • Journal Title: Mucosal Immunol 2 Pages: 468-471
  • Peer Reviewed
• [Journal Article] Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches (2009)
  • Author(s): Tsuji M, et al.
  • Journal Title: Science 323 Pages: 1488-1492
  • Peer Reviewed
• [Journal Article] Peyer's patches are required for intestinal IgA responses to Salmonella (2008)
  • Author(s): Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, MN., Kiyono, H. and Yamamoto, M
  • Journal Title: Infect. Immun Volume: 76 Pages: 927-934
• [Journal Article] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity (2008)
  • Author(s): Chang, SY., Cha, HR., Uematsu, S., Akira, S., Igarashi, O., Kiyono, H., and Kweon, M-N
  • Journal Title: J. Immunol Volume: 180 Pages: 1609-18
• [Journal Article] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 (2008)
  • Author(s): Uematsu, S., Fujimoto, K., Jang, MH., Yang, BG., Jung, YJ., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., Kiyono, H., Miyasaka, M., Ishii, KJ., and Akira, S
  • Journal Title: Nature Immunol Volume: 9 Pages: 769-776
• [Journal Article] Comprehensive gene expression analysis among Peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis (2008)
  • Author(s): Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, GS., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, AW. and Kiyono, H
  • Journal Title: J. Immunol Volume: 180 Pages: 7840-7846
• [Journal Article] The mucosa: at the frontlines of immunity (2008)
  • Author(s): Fehervari1, Z., and Kiyono, H
  • Journal Title: Trends Immunol Volume: 29 Pages: 503-504
• [Journal Article] Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFκB-inducing kinase in stromal cells. (2008)
  • Author(s): Kunisawa, J., Gohda, M., Kurashima, Y., Ishikawa, I., Higuchi, M. and Kiyono, H.
  • Journal Title: Blood. 111 Pages: 4646-4652
  • Peer Reviewed
• [Journal Article] Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. (2008)
  • Author(s): Gohda, M., Kunisawa, J., Miura, F., Kagiyama, Y., Kurashima, Y., Higuchi, M., Ishika wa, I., Ogahara, I. and Kiyono, H.
  • Journal Title: J. Immunol. 180 Pages: 5335-5343
  • Peer Reviewed
• [Journal Article] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. (2008)
  • Author(s): Uematsu, S., Fujimoto, K., Jang, MH., Yang, BG., Jung, YJ., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., Kiyono, H., Miyasaka, M., Ishii, KJ., Akira, S.
  • Journal Title: Nat Immunol 9 Pages: 769-776
  • Peer Reviewed
• [Journal Article] Cutting edge : Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. (2008)
  • Author(s): Chang, SY., Cha, HR., Igarashi, O., Rennert, PD., Kissenpfennig, A., Malissen, B., Nanno, M., Kiyono, H., and Kweon, MN.
  • Journal Title: J. Immunol. 180 Pages: 4361-4365
  • Peer Reviewed
• [Journal Article] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. (2008)
  • Author(s): Sun-Young Chang, Hye-Ran Cha, Uematsu, S., Akira, S., Igarashi, 0., Kiyono, H., and Mi-Na Kweon
  • Journal Title: J. Immunol. 180 Pages: 1609-1618
  • Peer Reviewed
• [Journal Article] Comprehensive gene expression analysis among peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis. (2008)
  • Author(s): Terahara, T., Igarashi, O., Yoshida, M., Nochi, T., Kurokawa, S., Takayama, N., Yuki, Y., Low, AW. and Kiyono, H.
  • Journal Title: J. Immunol. 180 Pages: 7840-7846
  • Peer Reviewed
• [Journal Article] Peyer's patches are required for intestinal IgA responses to Salmonella. (2008)
  • Author(s): Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, M.N., Kiyono, H. and Yamamoto, M.
  • Journal Title: Infect Immun. 76 Pages: 927-934
  • Peer Reviewed
• [Journal Article] Nasal Vaccination with the 40-Kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces lomg-term protective immunity with reduced levels of immunoglobulin E antibodies. (2008)
  • Author(s): Momoi, F., Hashizume, T., Kurita-Ochiai, T., Yuki, Y., Kiyono, H., and Yamamoto, M.
  • Journal Title: Infect Immun. 76 Pages: 7840-7846
  • Peer Reviewed
• [Journal Article] Tonic B cell activation by radioprotective105/MD-1 promotes diseaseprogression in MRL/lpr mice. (2008)
  • Author(s): Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, and Miyake K.
  • Journal Title: Int Immunol. 20 Pages: 881-891
  • Peer Reviewed
• [Journal Article] The mucosa : at the frontlines of immunity. (2008)
  • Author(s): Fehervaril, Z., and Kiyono, H.
  • Journal Title: Trends Immunol 29 Pages: 503-504
  • Peer Reviewed
• [Journal Article] Immunological commonalities and distinctions between airway and digestive immunity. (2008)
  • Author(s): Kunisawa, J., Nochi, T. and Kiyono, H.
  • Journal Title: Trends Immunol. 29 Pages: 505-513
  • Peer Reviewed
• [Presentation] IgA synthesis : a form of functional immune adaptation extending beyond gut (2013)
  • Author(s): Sidonia Fagarasan
  • Organizer: 1. Keystone symposia. XI 2013, B Cell Development & Function
  • Place of Presentation: Colorado, USA(招待講演)
  • Year and Date: 2013-02-12
• [Presentation] PD-1 Defeciency Skews the Gut Microbiota by altering the IgA Selection in Gut (2012)
  • Author(s): Sidonia Fagarasan
  • Organizer: The 2012 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2012-04-13
• [Presentation] Mucosal Decisions of Mutualisum and Elimination for Surface barrier system (2012)
  • Author(s): Invited Speaker
  • Organizer: The 6^<th> Annual International Symposium in Institute of Dermatological Science(IDS)
  • Place of Presentation: Seoul, Korea
• [Presentation] PD-1 Defeciency Skews the Gut Microbiota by altering the IgA Selection in Gut (2012)
  • Author(s): Fagarasan, S
  • Organizer: The 2012 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea
• [Presentation] Chaperon-Like Antigen Presentaion by Nanogel-Based Vaccine at Nasal Epithelium (2011)
  • Author(s): HIROSHI KIYONO
  • Organizer: Avison Biomedical Symposium 2011
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-02-25
• [Presentation] The Mucosal Gateway System for Antigen-sampling and Homestatic Niche (2011)
  • Author(s): Invited Speaker
  • Organizer: The 15^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Paris, France
• [Presentation] New Prospects on the Aerodigestive Immunity for Mucosal Vaccine Development (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: Prato Conference on the Pathogenesis of Bacterial Diseases of Animals
  • Place of Presentation: Prato, Italy
  • Year and Date: 2010-10-09
• [Presentation] Mucosal Nanogel-based Chaperon Vaccine for the induction of protective immunity (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: 4^<th> Vaccine and ISV Annuals Global Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-10-04
• [Presentation] Intra-Tissue habitation of commensal bacteria in Peyer's patches for gut immunity (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: 8^<th> German-Japanease Symposium, Regulation of immune response and diseases
  • Place of Presentation: Cuxhahen, Germany.
  • Year and Date: 2010-09-27
• [Presentation] Intra-tissue habitation of intestinal opportunistic bacteria in mammalian gut-associated lymphoid tissues for the creation of a mucosal antibody-mediated symiosis (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: 40^<th> Annual Meeting DGFI German Society for Immunology
  • Place of Presentation: Leipzig, Germany
  • Year and Date: 2010-09-26
• [Presentation] Mucosal chaperoning nanogel vaccine for the induction of protective immunity (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: The 10^<th> Awaji International Forum on Infection and Immunity (United states-Japan Cooperative Medical Science Program 23^<rd> Joint Meeting of the AIDS Panels
  • Place of Presentation: Awaji, Japan.淡路夢舞台国際会議場
  • Year and Date: 2010-09-08
• [Presentation] Role of Intestinal Glycosylation for the Mucosal Immne System and Mucosal Vaccine Development (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: 1^<st> Asia Pacific Workshop on Neurovirology Seoul 2010
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2010-07-16
• [Presentation] Craniofacial Mucosal Immune Sysem : Uniqueness of lymphoid Organogenesis and Immunological Function for NALT and TALT (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: The 7^<th> Intenational Symposium on Tonsils and Mucosal Barriers of the Upper Airways
  • Place of Presentation: Asahikawa, Hokkaido旭川グランドホテル
  • Year and Date: 2010-07-08
• [Presentation] Mucosal Immunity in the Control of Infectious Diseases (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: Pasteur-Areva Course Anti-Viral Imjmunity
  • Place of Presentation: Shanghai, China
  • Year and Date: 2010-05-28
• [Presentation] Basic principals of immune responces : innate versus adaptive immunity (2010)
  • Author(s): HIROSHI KIYONO
  • Organizer: The 10^<th> International Advanced Course on Vaccinology in Asia Pacific Region
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-05-10
• [Presentation] New Prospect for Mucosal Vaccine Development : MucoRiceTM for Refrigeration-and Needle/Shiringe-free vaccine (2010)
  • Author(s): 清野宏
  • Organizer: The 2nd International Symposium of Innovative B-ioproduction Kobe(iBioK)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-01-22
• [Presentation] Novel Strategy for Mucosal Vaccine Development : MucoRice and MucoNanogel (2010)
  • Author(s): 清野宏
  • Organizer: Adaptive and Innate Immune Resposes to Neglected Tropical Disease Conference
  • Place of Presentation: SanDiego, USA
  • Year and Date: 2010-01-10
• [Presentation] Intra-Tissue Habitation of Commensal Bacteria in Peyer's patches for Gut Immunity (2010)
  • Author(s): Invited Speaker
  • Organizer: The 8^<th> German-Japanease International Symposium, Regulation of Immune Response and Diseases
  • Place of Presentation: Cuxhahen, Germany
• [Presentation] Mucosal Decision of Immunity and Tolerance (2010)
  • Author(s): Invited Speaker
  • Organizer: The 83^<rd> Annunal Meeting of Japanese Society for Bacteriology
  • Place of Presentation: Yokohama, Japan
• [Presentation] MucoRice : New Horizon for the Development of Oral Vaccine (2009)
  • Author(s): 清野宏
  • Organizer: 12th Asia Pacific-International Molecular Biology Network(A-IMBN)Symposium
  • Place of Presentation: Penang, Malaysia
  • Year and Date: 2009-10-27
• [Presentation] New Prospect for Vaccine Development : MucoRice and MucoNanogel (2009)
  • Author(s): 清野宏
  • Organizer: 3rd Vaccine Global Congress
  • Place of Presentation: Singapore Singapore
  • Year and Date: 2009-10-04
• [Presentation] The Craniofacial and Mucosal Immune System (2009)
  • Author(s): 清野宏
  • Organizer: Japanese Journal of Rhinology
  • Place of Presentation: 島根, 日本
  • Year and Date: 2009-10-03
• [Presentation] Mucosal Harmony for Immunity and Tolerance in Vaccine Development (2009)
  • Author(s): 清野宏
  • Organizer: 2nd European Congress of Immunology
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-14
• [Presentation] 粘膜免疫による腸内細菌共生機構の構築 (2009)
  • Author(s): 清野宏
  • Organizer: 第63回日本細菌学会東北支部総会
  • Place of Presentation: 盛岡, 日本
  • Year and Date: 2009-08-20
• [Presentation] Rice-Based Vaccine : New Generation of Mucosal Vacine (2009)
  • Author(s): 清野宏
  • Organizer: 14th International Congress of Mucosal Immunol-ogy
  • Place of Presentation: Boston, USA.
  • Year and Date: 2009-07-08
• [Presentation] 粘膜免疫による腸内細菌共生の構築 (2009)
  • Author(s): 清野宏
  • Organizer: 第91回日本消化器病学会中国支部例会
  • Place of Presentation: 岡山, 日本
  • Year and Date: 2009-06-13
• [Presentation] Mucosal Decision of Immunity and Tolerance for Creation of Symbiosis (2009)
  • Author(s): 清野宏
  • Organizer: The 6th Extraordinary International Symposium on Recent Advances in Otitis Media
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-06
• [Presentation] Mucosal Immunity : A Driving Force for the Development of New Generation of Oral Vaccine (2009)
  • Author(s): 清野宏
  • Organizer: The 13th International Conference on Emerging In fection Dieseases of the Pacific Rum : Focus on Enteric Diseases
  • Place of Presentation: Kolkata, India
  • Year and Date: 2009-04-06
• [Presentation] Session 1"Id2, RORγt, and LTβR independent initiation of TALT genesis in ocular immunity."and Session 2" Indigenous Opportunistic Bacteria Inhabit Mammalian Gut-associated Lymphoid Tissues for Gut Immunity" (2009)
  • Organizer: Trudeau Institute Mucosal Immunology Workshop
  • Place of Presentation: New York, USA
• [Presentation] Development of Intestinal Symbiosis by the Mucosal Immune System (2009)
  • Author(s): Invited Speaker
  • Organizer: The 63^<th> Japanese Society for Bacteriology Tohoku District Research Conference
  • Place of Presentation: Morioka, Japan
• [Presentation] The Mucosal Immune System for the Creation of Gut Symbiosis (2009)
  • Organizer: The 91^<st> Japanese Association of Gastroenteology, Chugoku Division Meeting
  • Place of Presentation: Okayama, Japan
• [Presentation] Mucosal Decision of Immunity and Tolerance for Creation of Symbiosis (2009)
  • Author(s): Invited Speaker
  • Organizer: The 6^<th> Extraordinary International Symposium on Recent Advances in Otitis Media
  • Place of Presentation: Seoul, Korea
• [Presentation] T-dependent and T-independent IgA responses in the gut (2009)
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Osaka
• [Presentation] T-dependent and T-independent IgA responses in the gut (2009)
  • Organizer: Microanatomy of the Immune Responses in Health and Disease
  • Place of Presentation: University of Birmingham, UK
• [Presentation] Sessionl "Id2, RORgt, and LTbR independent initiation of TALT genesis in ocular immunity." and Sessionl "Indigenous opportunistic bacteria inhabit mammalian gut associated lymphoid tissues for gut immunity." (2009)
  • Author(s): 清野宏
  • Organizer: Mucosal immunology Workshop at Trudeau Institute
  • Place of Presentation: New York, USA
• [Presentation] T-dependent and T-independent IgA responses in the gut (2009)
  • Author(s): Fagarasan Sidonia
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪
• [Book] 臨床粘膜免疫学 (2010)
  • Author(s): 清野宏
  • Total Pages: 722
  • Publisher: 株式会社シナジー
• [Book] 臨床粘膜免疫学
  • Author(s): 清野宏
  • Publisher: (株)シナジー