| Project Area | Immunological Self Recognition and its Disorders |
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| Project/Area Number |
19059004
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUI Yoshinori 九州大学, 生体防御医学研究所, 教授 (60243961)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Shinichi 金沢大学, 医薬保健研究域, 特任教授 (00313099)
KURACHI Makoto 東京大学, 大学院・医学系研究科, 助教 (00396722)
UEHA Satoshi 東京大学, 大学院・医学系研究科, 助教 (00447385)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥126,400,000 (Direct Cost: ¥126,400,000)
Fiscal Year 2011: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2010: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2009: ¥28,800,000 (Direct Cost: ¥28,800,000)
Fiscal Year 2008: ¥28,800,000 (Direct Cost: ¥28,800,000)
Fiscal Year 2007: ¥28,800,000 (Direct Cost: ¥28,800,000)
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| Keywords | 免疫寛容 / 細胞動態 / ケモカイン / シグナル / 樹状細胞 / シグナル伝達 / リンパ球 / DOCK2 / 遊走 / regulatory T cells / CCR7 / リンパ節 |
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| Research Abstract |
In this project, we aimed to clarify the trafficking of immune cells that are responsible for peripheral immune tolerance. We also addressed the mechanisms and immunological significance of such cellular trafficking. Following results were obtained through this project: 1) CCR7 and CXCR4 regulate the migration of nTreg into lymph node paracortex and medulla, respectively, 2) MDSC are composed of monocytic cells and neutrophils, and balance between these cell types are critically regulated by a chemokine receptor CCR2, 3) niche size of antibody-producing cells in lymph nodes are likely regulated by B-cell mediated remodeling of the niche, 4) novel mechanisms controlling DOCK2-mediated migration and activation of leukocytes were elucidated.
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