| Budget Amount *help |
¥192,600,000 (Direct Cost: ¥192,600,000)
Fiscal Year 2011: ¥45,000,000 (Direct Cost: ¥45,000,000)
Fiscal Year 2010: ¥45,000,000 (Direct Cost: ¥45,000,000)
Fiscal Year 2009: ¥34,200,000 (Direct Cost: ¥34,200,000)
Fiscal Year 2008: ¥34,200,000 (Direct Cost: ¥34,200,000)
Fiscal Year 2007: ¥34,200,000 (Direct Cost: ¥34,200,000)
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| Research Abstract |
I discovered a novel type of follicular CD4+ T cells that are increased in normal aged animals, termed senescence-associated T (SA-T) cells. SA-T cells showed compromised proliferation but produced massive amounts of osteopontin in response to TCR-stimulation. During leukemia development, there was a robust increase of SA-T cells irrespective of age in association with the progressive immunodepression. The study suggest that the increase of SA-T cells underlie the global immunodepression in senescence and leukemia.
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