Immune Response to Malignant Cells and its Regulation

• Project Area: Immunological Self Recognition and its Disorders
• Project/Area Number: 19059008
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: MINATO Nagahiro 京都大学, 医学研究科, 教授 (40137716)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥192,600,000 (Direct Cost: ¥192,600,000); Fiscal Year 2011: ¥45,000,000 (Direct Cost: ¥45,000,000); Fiscal Year 2010: ¥45,000,000 (Direct Cost: ¥45,000,000); Fiscal Year 2009: ¥34,200,000 (Direct Cost: ¥34,200,000); Fiscal Year 2008: ¥34,200,000 (Direct Cost: ¥34,200,000); Fiscal Year 2007: ¥34,200,000 (Direct Cost: ¥34,200,000)
• Keywords: 自己認識 / 免疫制御 / 胸腺 / 自己免疫病 / 炎症 / がん / 免疫老化 / 白血病 / 全身性自己免疫病 / T細胞 / がん免疫 / アナジー / G蛋白

Research Abstract

I discovered a novel type of follicular CD4+ T cells that are increased in normal aged animals, termed senescence-associated T (SA-T) cells. SA-T cells showed compromised proliferation but produced massive amounts of osteopontin in response to TCR-stimulation. During leukemia development, there was a robust increase of SA-T cells irrespective of age in association with the progressive immunodepression. The study suggest that the increase of SA-T cells underlie the global immunodepression in senescence and leukemia.

Research Products

• [Journal Article] Rap G protein signal in normal and disordered lymphohematopoiesis. (2013)
  • Author(s): Minato, N
  • Journal Title: Exp. Cell Res. Volume: (Epub ahead of print) Pages: 2323-232
  • DOI: 10.1016/j.yexcr.2013.04.009
  • Peer Reviewed
• [Journal Article] Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells (2013)
  • Author(s): Sugie, T., Murata-Hirai, K., Iwasaki, M., Morita, C. T., Li, W., Okamura, H., Minato, N., Toi, M., Tanaka, Y.
  • Journal Title: Cancer Immunol Immunother Volume: (印刷中) Pages: 677-687
  • DOI: 10.1007/s00262-012-1368-4
  • Peer Reviewed
• [Journal Article] Comparison of gammadelta T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid (2013)
  • Author(s): Idrees, AM., Sugie, T., Inoue, C., Murata-Hirai, K., Okamura, H., Morita, CT. Minato, N., Toi, M., Tanaka, Y
  • Journal Title: Cancer Sci Volume: (印刷中) Pages: 536-42
  • DOI: 10.1111/cas.12124
  • Peer Reviewed
• [Journal Article] Rap G protein signal in normal and disordered lymphohematopoiesis. (Review article) (2013)
  • Author(s): Minato, N.
  • Journal Title: Exp. Cell Res. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] E2A and CBP/p300 act in synergy topromote chromatin accessibility of the immunoglobulin κ locus (2012)
  • Author(s): Sakamoto, S., Wakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Myyazaki, K.,Romanow, W.J., Ikawa, T., Kitamura, D.,Yanagihira, I., Minato, N., Murre, C., and Agata, Y
  • Journal Title: J. Immunol Volume: 188(11) Pages: 5547-60
• [Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus (2012)
  • Author(s): Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
  • Journal Title: J. Immunol. Volume: 188 Pages: 5547-5560
  • DOI: 10.4049/jimmunol.1002346
  • Peer Reviewed
• [Journal Article] Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis (2012)
  • Author(s): Fujita, H., Hamazaki, Y. , Noda, Y., Oshima, M., Minato, N.
  • Journal Title: PLoS One. Volume: 7
  • DOI: 10.1371/journal.pone.0052272
  • Peer Reviewed
• [Journal Article] Increased c-Myc activity and DNA damage inhematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency (2011)
  • Author(s): Tanaka H, Tamura A, Sekai M, Hamazaki Y, Minato N
  • Journal Title: Cancer Sci. Volume: 102 Pages: 784-791
  • DOI: 10.1111/j.1349-7006.2011.01850.x
  • Peer Reviewed
• [Journal Article] SPA-1 controls the invasion and metastasis of human prostate cancer. (2011)
  • Author(s): Shimizu Y, Hamazaki Y, Hattori M, Doi K,Terada Y, Kobayashi T, Toda Y, Yamasak T,Inoue T, Kajita Y, Atsushi M, Kamba T, MikamiY, Kamoto T, Yamada T, Ogawa O, Minato Nand Nakamura E
  • Journal Title: Cancer Sci Volume: 102 Pages: 828-36
  • DOI: 10.1111/j.1349-7006.2011.01876.x
  • NAID: 10029292527
  • Peer Reviewed
• [Journal Article] *Both authors contributed equally to this work.Claudin-4 induction by E protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency. (2011)
  • Author(s): Kawai. K. Hamazaki, Y., Fujita, H., Fujita,A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto,T., Agata, Y. and Minato, N
  • Journal Title: Proc Natl Acad Sci USA Volume: 108(10) Pages: 4075-4080
  • DOI: 10.1073/pnas.1014178108
  • Peer Reviewed
• [Journal Article] Claudin-4 is induced in thymocytes of late CD4/CD8 double positive stage by E2A and promotes αβT cell receptor-mediated positive selection (2011)
  • Author(s): Kawai, K.Hamazaki, Y., Fujita, H., Fujita, A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto, T., Agata, Y., Minato, N.
  • Journal Title: Proc.Nat.Acad.Sci.USA Volume: 108 Pages: 4075-4080
  • Peer Reviewed
• [Journal Article] Expression and function of PD-1 in human gd T cell responses to tumor cells (2011)
  • Author(s): Iwasaki, M., Tanaka, Y., Kobayashi, H., Hirai K., Sugie, T., Toi, M., Minato, N.
  • Journal Title: Eur.J.Immunol. Volume: 41 Pages: 345-4080
  • Peer Reviewed
• [Journal Article] Regulation of T cell receptor Vg2 gene rearrangement by the helix-loop-helix protein E2A (2011)
  • Author(s): Nozaki, M., Wakae, K., Tamaki, N., Sakamoto, S., Ohnishi, K., Uejima, T., Minato, N., Yanagihara, I., Agata, Y.
  • Journal Title: Int.Immunol. Volume: 23 Pages: 297-305
  • Peer Reviewed
• [Journal Article] Phase I/II study of adoptive transfer of gd T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma (2011)
  • Author(s): Kobayashi, H., Tanaka, Y., Yagi, J., Minato, N., Tanabe, K
  • Journal Title: Cancer Immunol.Immunotherap Volume: 60 Pages: 1075-1084
  • Peer Reviewed
• [Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of l NZB/W F1mice (2010)
  • Author(s): Kasagi, S, Kawano, S, Okazaki, T, Honjo, T, Morinobu, A, Hatachi, S, Shimatani, K, Tanaka,Y, Minato, N, and Kumagai, S
  • Journal Title: J.Immunol Volume: 184 Pages: 2337-2347
  • DOI: 10.4049/jimmunol.0901652
• [Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of INZB/W F1 mice (2010)
  • Author(s): Kasagi, S, Kawano, S, Okazaki, T, Honjo, T, Morinobu, A, Hatachi, S, Shimatani, K, Tanaka, Y, Minato, N, Kumagai, S
  • Journal Title: J.Immunol Volume: 184 Pages: 2337-2347
  • Peer Reviewed
• [Journal Article] Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gamma delta T-cells in a patient with renal cell carcinoma (2010)
  • Author(s): Kobayashi H, Tanaka Y, Shimmura H, Minato N, Tanabe K., (2010)Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gamma delta T-cells in a patient with renal cell carcinoma
  • Journal Title: Anticancer Res. Volume: 30 Pages: 575-579
  • Peer Reviewed
• [Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of l NZB/W F1 mice. (2010)
  • Author(s): Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, Kumagai S
  • Journal Title: J. Immunol. 184 Pages: 2337-2347
  • Peer Reviewed
• [Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of 1 NZB/W F1 mice. (2010)
  • Author(s): Kasagi, S, Kawano, S, Okazaki, T, Honjo, T, Morinobu, A, Hatachi, S, Shimatani, K, Tanaka, Y, Minato. N, Kumagai, S.
  • Journal Title: J.Immunol. 184 Pages: 2337-2347
  • Peer Reviewed
• [Journal Article] Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. (2010)
  • Author(s): Kobayashi H, Tanaka Y, Shimmura H, Minato N, Tanahe K.
  • Journal Title: Anticancer Res. 30 Pages: 575-579
  • Peer Reviewed
• [Journal Article] Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis (2009)
  • Author(s): Minato, N., and Hattori, M
  • Journal Title: Cancer Science Volume: 100 Pages: 17-23
  • DOI: 10.1007/s11748-008-0294-z
• [Journal Article] Rap signaling in normallymphocyte development and leukemia genesis (2009)
  • Author(s): Minato, N
  • Journal Title: Immune Network Volume: 9 Pages: 35-40
  • DOI: 10.4110/in.2009.9.2.35
• [Journal Article] Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells (2009)
  • Author(s): Katayama, Y., Sekai, M., Hattori, M.,Miyoshi, I., Hamazaki, Y, and Minato, N
  • Journal Title: Blood. Volume: 114 Pages: 1768-1775
  • DOI: 10.1182/blood-2009-03-213371
• [Journal Article] PD-1^+ memory phenotype CD4^+ T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia (2009)
  • Author(s): Shimatani, K., Nakashima, Y., Hattori, M., Hamazaki, Y., and Minato, N
  • Journal Title: Proc Natl Acad Sci USA Volume: 106 Pages: 15807-12
  • DOI: 10.1073/pnas.0908805106
  • Peer Reviewed
• [Journal Article] Memory phenotype PD-1+ CD4+ T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia. (2009)
  • Author(s): Shimatani K, Nakashima Y, Hattori M, Hamazaki Y, Minato N
  • Journal Title: Proc. Nat. Acad. Sci. USA. 106 Pages: 15807-15812
  • Peer Reviewed
• [Journal Article] Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells. (2009)
  • Author(s): Katayama Y, Sekai M, Hattori M, Miyoshi I, Hamazaki Y, Minato N
  • Journal Title: Blood 114 Pages: 1768-1775
  • Peer Reviewed
• [Journal Article] Memory phenotype PD-1^+ CD4^+ T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia. (2009)
  • Author(s): Shimatani, K., Nakashima, Y., Hattori, M., Hamazaki, Y., Minato. N
  • Journal Title: Proc.Nat.Acad.Sci. USA 106 Pages: 15807-15812
  • Peer Reviewed
• [Journal Article] Spa-1 (Sipal) and Rap signaling in leukemia and cancer metastasis. (2009)
  • Author(s): Minato, N., Hattori, M
  • Journal Title: Cancer Science 100 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes. (2009)
  • Author(s): Hiasa, A., Nishikawa, H., Hirasawa, M., Kitano, S., Chono, H., Yu, S.S., Mineno, J., Tanaka, Y., Minato. N., Kato I., Shiku, H.
  • Journal Title: Gene Therapy 16 Pages: 620-628
  • Peer Reviewed
• [Journal Article] Notch activation in thymic epithelial cells induces development of thymic microenvironments. (2009)
  • Author(s): Masuda, K, Germeraad, W, Satoh, R, Itoi, M, Ikawa, T, Minato. N, Katsura, Y, van Ewijk, W, Kawamoto, H.
  • Journal Title: Mol.Immunol 46 Pages: 1756-1767
  • Peer Reviewed
• [Journal Article] Identification of ON bipolar cell-specific genes. (2009)
  • Author(s): Nakajima, Y., Moriyama, M., Hattori, M., Minato. N., Nakanishi, S.
  • Journal Title: J.Biochem. 145 Pages: 811-818
  • Peer Reviewed
• [Journal Article] Rap signaling in normal lymphocyte development and leukemia genesis. (2009)
  • Author(s): Minato. N
  • Journal Title: (Review article) Immune Network 9 Pages: 35-40
  • Peer Reviewed
• [Journal Article] Involvement of Rap-1 activation and early termination of immune synapse in CT LA-4-mediated negative signal. (2009)
  • Author(s): Hara S, Nakaseko C, Yamasaki S, Hattori M, Bos JL, Saito Y, Minato N, Saito T.
  • Journal Title: Hematology Jun ; 14(3) Pages: 150-158
  • Peer Reviewed
• [Journal Article] Development ofNotch-dependent T cell leukemia by deregulated Rap1 signaling (2008)
  • Author(s): Wang, S-F, Aoki, M., Shinozuka, Y.,Nakashima, Y., Tanaka, H., Taniwaki, F., Hattori,M., and Minato, N
  • Journal Title: Blood Volume: 111 Pages: 3011-3016
  • DOI: 10.1182/blood-2007-07-103119
• [Journal Article] Structureof the human programmed death (PD)-1 ligand and its complex with PD-1 that inhibits immune responses (2008)
  • Author(s): Lin, D. Y., Tanaka, Y., Iwasaki, M., Gitttis, A. G., Su, H-P., Mikami, B., Okazaki, T., Honjo, T.,Minato, N., and Garboczi, D, N
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 105 Pages: 3011-3016
  • DOI: 10.1073/pnas.0712278105
• [Journal Article] Essential role of Rapsignal in pre-TCR mediated b-selection in ab Tcell development (2008)
  • Author(s): Kometani, K, Moriyama, M, Nakashima, Y,Katayama, Y, Wang, S-F, Saito, T, Hattori, Mand Minato, N
  • Journal Title: Blood Volume: 112 Pages: 4565-4573
  • DOI: 10.1182/blood-2008-06-164517
• [Journal Article] Essential role of Rap signal in pre-TCR mediatedα-selection inαβT cell development. (2008)
  • Author(s): Kometani K, Moriyama M, Nakashima Y, Katayama Y, Wang S-F, Saito T, Hattori M, Minato N
  • Journal Title: Blood 112 Pages: 4565-4573
  • Peer Reviewed
• [Journal Article] Structure of the human programmed death (PD)-1 ligand and its complex with PD-1 that inhibits immune responses. (2008)
  • Author(s): Lin D Y, Tanaka Y, Iwasaki M, Gitttis A G, Su H-P, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi D N
  • Journal Title: Proc. Natl. Acad. Sci. USA. 105 Pages: 3011-3016
  • Peer Reviewed
• [Journal Article] Development of Notch-dependent T cell leukemia by deregulated Rap1 signaling. (2008)
  • Author(s): Wang S-F, Aoki M, Shinozuka Y, Nakashima Y, Tanaka H, Taniwaki F, Hattori M, Minato N
  • Journal Title: Blood 111 Pages: 3011-3016
  • Peer Reviewed
• [Journal Article] Development of Notch-dependent T cell leukemia by deregulated Rapl signaling (2008)
  • Author(s): Wang, S-F, Aoki, M.(中略5名) and Minato. N.
  • Journal Title: Blood 111 Pages: 3011-3016
  • Peer Reviewed
• [Journal Article] Structure of the human programmed death (PD)-1 ligand and itscomplex with PD-1 that inhibits immune responses (2008)
  • Author(s): Lin, D. Y.(中略7名) Minato. N., and Garboczi, D, N.
  • Journal Title: Proc-Natl. Acad. Sci. USA 105 Pages: 3011-3016
  • Peer Reviewed
• [Journal Article] Essential role of Rap signal in pre-TCR mediated β-selection in α β T cell development (2008)
  • Author(s): Kometani, K, Moriyama, M,(中略5名) and Minato. N.
  • Journal Title: Blood 112 Pages: 4565-4573
  • Peer Reviewed
• [Journal Article] Development of Notch-dependent T cell leukemia by deregulated Rapl signaling. (2008)
  • Author(s): Wang, S-F, 他7名
  • Journal Title: Blood 111 Pages: 3011-3016
  • Peer Reviewed
• [Journal Article] Structure of the human programmed death (PD)-1 1igand and its comlex with PD-1 that inhibits immune responses (2008)
  • Author(s): Lin, D. Y., 他9名
  • Journal Title: Proc. Natl.Acad. Sci. USA 105 Pages: 3011-3016
  • Peer Reviewed
• [Journal Article] Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from claudin-expressing cells (2007)
  • Author(s): Hamazaki, Y, Fujita, H, Kobayashi, T, Choi, Y, H. Scott, Matsumoto, M, and Minato, N
  • Journal Title: Nature Immunol Volume: 8 Pages: 304-311
• [Journal Article] Regulation of immune responses and hematopoiesis by the Rap1 signal. (Review) (2007)
  • Author(s): Minato, N, K.Kometani, and M.Hattori
  • Journal Title: Adv. Immunol Volume: 93 Pages: 229-264
• [Journal Article] Intestinal tumorsinactivated in TGF-b signaling secrete CCL9 and recruit CCR1+ myeloid cells that help invasion (2007)
  • Author(s): Kitamura, T., Kometani, K., Hashiba, H.,Matsunaga, A., Miyoshi. H., Hosogi, H., Aoki, M.,Oshima, M., Hattori, M., Takabayashi, A., Minato,N., and Taketo, M
  • Journal Title: Nature Gen Volume: 39 Pages: 467-475
• [Journal Article] PD-L1 and tumor-infiltratingCD8+ T lymphocytes are independent prognostic factors of human ovarian cancer (2007)
  • Author(s): Hamanishi J., Mandai, M., Iwasaki, M., Okazaki. T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K, Minato, N., Honjo, T., and Fujii, S
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 104 Pages: 3360-3365
• [Journal Article] Impaired T lymphocyte trafficking in micedeficient in an actin-nucleating protein mDial (2007)
  • Author(s): Sakata D, Taniguchi H, Yasuda S,Adachi-Morishima A, Hamazaki Y, Nakayama R,Miki T, Minato N, and Narumiya S
  • Journal Title: J. Exp. Med Volume: 204 Pages: 2031-2038
• [Journal Article] T cell lineage determination precedes the initiation of TCRb gene rearrangement (2007)
  • Author(s): Masuda, K, Kakugawa, K, Nakayama, T, Minato, N, Katsura, Y, and Kawamoto, H
  • Journal Title: J. Immunol Volume: 179 Pages: 3699-3706
• [Journal Article] PD-L1 and tumor-infiltrating CD8+ T lymphocytes are independent prognostic factors of human ovarian cancer. (2007)
  • Author(s): Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, Fujii S.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 104 Pages: 3360-3365
  • Peer Reviewed
• [Journal Article] Intestinal tumors inactivated in TGF-b signaling secrete CCL9 and recruit CCR1+ myeloid cells that help invasion. (2007)
  • Author(s): Kitamura T, Kometani K, Hashiba H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo M.
  • Journal Title: Nature Gen. 39 Pages: 467-475
  • Peer Reviewed
• [Journal Article] Regulation of immune responses and hematopoiesis by the Rap1 signal. (2007)
  • Author(s): Minato N, Kometani K, Hattori M.
  • Journal Title: Adv. Immunol. 93(Review) Pages: 229-264
  • Peer Reviewed
• [Journal Article] Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from claudin-expressing cells. (2007)
  • Author(s): Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott H, Matsumoto M, Minato N.
  • Journal Title: Nature Immunol. 8 Pages: 304-311
  • Peer Reviewed
• [Journal Article] Medullary thymic epithelial cells expressing Aire represent aunique lineage derived from claudin-expressing cells (2007)
  • Author(s): Hamazaki, Y, 他6名
  • Journal Title: Nature Immunol 8 Pages: 304-311
  • Peer Reviewed
• [Journal Article] Rap signaling is crucial for the competence of IL-7 response and the development of B-lineaee cells (2006)
  • Author(s): Katayama, Y., Sekai, M., Hattori, M., Miyoshi, I., Hamazaki, Y, Minato. N.
  • Journal Title: Blood 114 Pages: 1768-1775
  • Peer Reviewed
• [Presentation] Rap signaling in normal hematoiesisand hematologic malignancy (2012)
  • Author(s): Minato, N
  • Organizer: IFOM-Kyoto Symposium
  • Place of Presentation: Milan
  • Year and Date: 2012-10-25
• [Presentation] Rap G protein: Biology and roles inmalignancy (2012)
  • Author(s): Minato, N
  • Organizer: Invited Lecture Series
  • Place of Presentation: Stockholm
  • Year and Date: 2012-05-15
• [Presentation] Immunosenescence and Autoimmunity (2012)
  • Author(s): Minato, N
  • Organizer: International Congree on Autoimmune Diseases
  • Place of Presentation: Tokyo
  • Year and Date: 2012-04-17
• [Presentation] The impact of leukemia on immunesystem (2011)
  • Author(s): Minato, N
  • Organizer: International Symposium ofJapanese Hematology Society
  • Place of Presentation: Yokohama
  • Year and Date: 2011-10-14
• [Presentation] Immunosenescence in leukemia (2011)
  • Author(s): Minato, N
  • Organizer: 日本血液学会総会シンポジウム
  • Place of Presentation: 名古屋(名古屋国際会議場)(招待講演)
  • Year and Date: 2011-10-14
• [Presentation] Cancer immunotherapy (2011)
  • Author(s): Minato, N
  • Organizer: Science in Japan Forum
  • Place of Presentation: Washington DC (Cosmos Club), U.S.A(招待講演)
  • Year and Date: 2011-06-21
• [Presentation] Immunity and malignancy (2011)
  • Author(s): Minato, N
  • Organizer: Forum Science in Japan
  • Place of Presentation: Washington DC
  • Year and Date: 2011-06-20
• [Presentation] Senescence-related T cells; Role insystemic autoimmunity and malignancy (2011)
  • Author(s): Minato, N
  • Organizer: International Conference on Autoimmunity
  • Place of Presentation: Tokyo
  • Year and Date: 2011-04-17
• [Presentation] Lymphoid stree-surveillanceresponse (2010)
  • Author(s): Minato, N
  • Organizer: International Workshop on Cancer Biology
  • Place of Presentation: Kanazawa
  • Year and Date: 2010-08-28
• [Presentation] gdT cells in cancer immunotherapy (2010)
  • Author(s): Minato, N
  • Organizer: International Symposium on Cancer Biology
  • Place of Presentation: Kanazawa (KKR Hotel Kanazawa)(招待講演)
  • Year and Date: 2010-08-23
• [Presentation] 免疫老化 (2010)
  • Author(s): Minato, N
  • Organizer: 抗加齢医学学会シンポジウム
  • Place of Presentation: Kyoto(国立京都国際会館)(招待講演)
  • Year and Date: 2010-06-11
• [Presentation] gd-T cells and cancerimmunotherapy (2009)
  • Author(s): Minato, N
  • Organizer: International Symposium of Japanese Immunology Society
  • Place of Presentation: Kobe
  • Year and Date: 2009-12-04
• [Presentation] Human gamma delta T cells and cancer immunotherapy (2009)
  • Organizer: 日本免疫学会シンポジウム
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-03
• [Presentation] Human gamma delta T cells and cancer immunotherapy (2009)
  • Author(s): Minato, N
  • Organizer: 日本免疫学会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Rap GTPase in normal lymphohematopoiesis and leukemia (2009)
  • Author(s): Minato, N
  • Organizer: Invited Lecture Series
  • Place of Presentation: China
  • Year and Date: 2009-11-02
• [Presentation] Memory phenotype PD-1 CD4 Tcells expressing C/EBPs underlies the global Tcell immunodepression in senescence andmalignancy (2009)
  • Author(s): Minato, N
  • Organizer: International KTCC Worshop
  • Place of Presentation: Kyoto
  • Year and Date: 2009-06-01
• [Presentation] Memory phenotype PD-1^+ CD4^+ T cells expressing C/EBPa underlie the global T cell immunodepression in senescence and malignancy (2009)
  • Organizer: KTCC国際シンポジウム
  • Place of Presentation: 京都大学医学部芝蘭会館(京都市)
  • Year and Date: 2009-06-01
• [Presentation] Memory phenotype PD-1^+ CD4^+ T cells expressing C/EBPa underlie the global T cell immunodepression in senescence and malignancy. (2009)
  • Author(s): Minato, N
  • Organizer: KTCC国際シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2009-06-01
• [Presentation] Rap signaling in lymphocyte development and leukemia (2008)
  • Author(s): N. Minato
  • Organizer: FASEB Summer Research Conference
  • Place of Presentation: Vermont, USA
• [Book] Rap1 and Spa-1, "Encyclopedia of Cancer" the second edition (2008)
  • Author(s): Minato, N
  • Publisher: Springer Press
• [Book] Janeway's免疫生物学(原書第7版)
  • Publisher: 南江堂
• [Remarks]
• [Remarks]
  • URL: http://immself.umin.jp/
• [Remarks]
  • URL: http://immself.umin.jp/
• [Patent(Industrial Property Rights)] ビスフォスホン酸誘導体を含む医薬組成物 (2009)
  • Inventor(s): 田中義正、林衡佑、松本健司、湊長博
  • Industrial Property Rights Holder: 京都大学、アステラス製薬
  • Filing Date: 2009-09-09
• [Patent(Industrial Property Rights)] 新規リンパ球処理剤 (2009)
  • Inventor(s): 田中義正、湊長博
  • Industrial Property Rights Holder: 京都大学、アステラス製薬
  • Filing Date: 2009-07-09
• [Patent(Industrial Property Rights)] 新規リンパ球処理剤 (2009)
  • Inventor(s): 田中義正、湊長博
  • Industrial Property Rights Holder: 京都大学、アステラス
  • Filing Date: 2009-07-09
  • Overseas
• [Patent(Industrial Property Rights)] 細胞表面機能分子の細胞外領域多量体 (2007)
  • Inventor(s): 田中義正、湊長博
  • Industrial Property Rights Holder: 京都大学、小野薬品
  • Filing Date: 2007-03-02
• [Patent(Industrial Property Rights)] 細胞表面機能分子の細胞外領域多量体 (2007)
  • Inventor(s): 田中義正、湊長博
  • Industrial Property Rights Holder: 京都大学、小野薬品
  • Filing Date: 2007-03-02
  • Overseas
• [Patent(Industrial Property Rights)] 細胞表面機能分子の細胞外領域多量体 (2007)
  • Inventor(s): 湊 長博、田中義正、柴山史朗
  • Industrial Property Rights Holder: 小野薬品工業株式会社
  • Filing Date: 2007-03-02
  • Overseas