| Budget Amount *help |
¥184,500,000 (Direct Cost: ¥184,500,000)
Fiscal Year 2011: ¥45,000,000 (Direct Cost: ¥45,000,000)
Fiscal Year 2010: ¥45,000,000 (Direct Cost: ¥45,000,000)
Fiscal Year 2009: ¥31,500,000 (Direct Cost: ¥31,500,000)
Fiscal Year 2008: ¥31,500,000 (Direct Cost: ¥31,500,000)
Fiscal Year 2007: ¥31,500,000 (Direct Cost: ¥31,500,000)
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| Research Abstract |
Ｔ lymphocytes are the cells that play an essential role in distinguishing non-self from self. T lymphocytes acquirｅ this ability through shaping a ｒｅｐｅｒtｏirｅ of recognition specificity ｄｕring the development in the thymus. However, how T lymphocytes are generated and selected in the thymus is still not well understood. This study identified (1) chemokines that are produced by thymic medullary epithelial cells and are essential for establishment of sｅlf-tolerance, (2) cytokines that are essential for the growth and development of thymic medullary epithelial cells, (3) proteasomes that are ｅxpressed in thymic cortical epithelial cells and are essential for positive selection of immunocompetent CD8 T lymphocytes. In addition, (4) we revealed that Airｅ regulates the development of thymic medullary epithelial cells, and (5) we begun the analysis how medullary and cortical thymic epithelial cells are generated from common epithelial progenitor cells.
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