| Budget Amount *help |
¥105,600,000 (Direct Cost: ¥105,600,000)
Fiscal Year 2011: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2010: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2009: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2008: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2007: ¥25,200,000 (Direct Cost: ¥25,200,000)
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| Research Abstract |
T cells are activated through forming TCR-microclusters (MC) upon antigen recognition. Self-peptides cannot induce TCR-MCs, and only the agonist peptides are accumulated into TCR-MCs when agonist and self-peptides are mixed. Thymocytes form TCR-MCs upon self-peptide recognition, and only the strong-stimulus of negative selecting peptides induces cSMAC formation. We clarified spatiotemporal regulation by positive (CD28) and negative (CTLA-4) costimulation and cytoskeletal regulation.
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