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Self recognition and activation regulation

Planned Research

Project AreaImmunological Self Recognition and its Disorders
Project/Area Number 19059013
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

SAITO Takashi  独立行政法人理化学研究所, 免疫シグナル研究グループ, グループディレクター (50205655)

Co-Investigator(Kenkyū-buntansha) KUROSAKI Tomohiro  独立行政法人理化学研究所, 分化制御研究グループ, グループディレクター (50178125)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥105,600,000 (Direct Cost: ¥105,600,000)
Fiscal Year 2011: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2010: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2009: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2008: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2007: ¥25,200,000 (Direct Cost: ¥25,200,000)
Keywords自己抗原 / 自己認識 / T細胞 / 活性化シグナル / 獲得免疫 / ミクロクラスター / planar bilayer / 抗原認識 / 胸腺選択 / TCRミクロクラスター / 免疫シナプス / co-stimulation / CTLA-4 / c SMAC / 抑制性T細胞 / イメージング解析 / リンパ球活性化 / トニックシグナル / 副刺激 / カルシウムシグナル / シグナル伝達 / 抗原受容体 / 自己識別 / 自己反応性制御 / BCR / 免疫寛容
Research Abstract

T cells are activated through forming TCR-microclusters (MC) upon antigen recognition. Self-peptides cannot induce TCR-MCs, and only the agonist peptides are accumulated into TCR-MCs when agonist and self-peptides are mixed. Thymocytes form TCR-MCs upon self-peptide recognition, and only the strong-stimulus of negative selecting peptides induces cSMAC formation. We clarified spatiotemporal regulation by positive (CD28) and negative (CTLA-4) costimulation and cytoskeletal regulation.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (194 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (88 results) (of which Peer Reviewed: 85 results) Presentation (86 results) Book (4 results) Remarks (6 results) Patent(Industrial Property Rights) (10 results) (of which Overseas: 5 results)

  • [Journal Article] A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD282011

    • Author(s)
      Kong K-F, et al.
    • Journal Title

      Nat. Immunol.

      Volume: 21 Pages: 1105-12

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nanocluster formation: More with memory2011

    • Author(s)
      Saito T.
    • Journal Title

      Immunity

      Volume: 35 Pages: 318-320

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CIN85 regulates the canonical NF-кB pathway and subsequent B cell responses2011

    • Author(s)
      Kometani K, Yamada T, Sasaki Y, Yokosuka T, Saito T, Rajewsky K, Ishiai M, Hikida M, Kurosaki T.
    • Journal Title

      J. Exp. Med.

      Volume: 208 Pages: 1447-1457

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation2011

    • Author(s)
      Hashimoto-Tane A, Yokosuka T, Sakata-Sogawa K, Sakuma M, Ishihara C, Tokunaga M, Saito T.
    • Journal Title

      Immunity

      Volume: 34 Pages: 919-931

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of colonic regulatory T cells by indigenous clostridium species2011

    • Author(s)
      Atarashi K, et al.
    • Journal Title

      Science

      Volume: 331 Pages: 337-341

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD282011

    • Author(s)
      Kong, K-F., Yokosuka, T., Canonigo-Balancio, A.J., et al
    • Journal Title

      Nat.Immunol.

      Volume: 12 Issue: 11 Pages: 1105-1112

    • DOI

      10.1038/ni.2120

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanocluster formation : More with memory2011

    • Author(s)
      Saito, T.
    • Journal Title

      Immunity

      Volume: 35 Pages: 318-320

    • Related Report
      2011 Annual Research Report
  • [Journal Article] CIN85 regulates the canonical NF-κB pathway and subsequent B cell responses2011

    • Author(s)
      Kometani K., Yamada, T., Sasaki, Y., et al
    • Journal Title

      J.Exp.Med.

      Volume: 208 Pages: 1447-1457

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A heat-stable extract from mucuna stimulates the differentiation of bone marrow cells into dendritic cells and induces apoptosis in cancer cells2011

    • Author(s)
      Kurokawa, K., Ishii, T., et al
    • Journal Title

      Nutr.Cancer

      Volume: 63 Pages: 100-108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid2011

    • Author(s)
      Yabu, M., Shime, H., et al
    • Journal Title

      Int.Immunol.

      Volume: 23 Pages: 29-41

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.2011

    • Author(s)
      Masahiko Yabu
    • Journal Title

      International Immunology

      Volume: 23 Pages: 4865-4871

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A heat-stable extract from mucuna stimulates the differentiation of bone marrow cells into dendritic cells and induces apoptosis in cancer cells.2011

    • Author(s)
      Kazuhiko Kurokawa
    • Journal Title

      Nutrition and Cancer

      Volume: 63 Pages: 100-108

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of colonic regulatory T cells by indigenous clostridium species.2011

    • Author(s)
      Koji Atarashi
    • Journal Title

      Science

      Volume: 331 Pages: 337-341

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters2010

    • Author(s)
      Saito T, Yokosuka T, Hashimoto-Tane A.
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 4865-4871

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation2010

    • Author(s)
      Ishikawa E, et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 19979-19984

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation2010

    • Author(s)
      Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T.
    • Journal Title

      Immunity

      Volume: 33 Pages: 326-339

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell receptor-microclusters critical for T-cell activation are formed independently of lipid raft clustering2010

    • Author(s)
      Hashimoto-Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W, Saito T.
    • Journal Title

      Mol. Cel. Biol.

      Volume: 30 Pages: 3421-3429

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans2010

    • Author(s)
      Saijo S, et al.
    • Journal Title

      Immunity

      Volume: 32 Pages: 681-691

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell differentiation and tumor cell apoptosis induced by components of a poly-phenylpropanoid polysaccharide complex2010

    • Author(s)
      An Wei-Wei
    • Journal Title

      Anticancer Research

      Volume: 30 Pages: 613-622

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells.2010

    • Author(s)
      Takayoshi Owada
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 87 Pages: 425-432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 cell dfferentiation is essential for host defense against Candida albicans.2010

    • Author(s)
      Shinobu Saijo
    • Journal Title

      Immunity

      Volume: 32 Pages: 681-691

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T cell receptor-microclusters critical for T-cell activation are formed independently of lipid raft clustering.2010

    • Author(s)
      Akiko Hashimoto-Tane
    • Journal Title

      Molecular and Cellular Biology

      Volume: 30 Pages: 3421-3429

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.2010

    • Author(s)
      Tadashi Yokosuka
    • Journal Title

      Immunity

      Volume: 33 Pages: 326-339

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.2010

    • Author(s)
      Eri Ishikawa
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 107 Pages: 19979-19984

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters.2010

    • Author(s)
      Takashi Saito
    • Journal Title

      FEBS Letters

      Volume: 584 Pages: 4865-4871

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B cell signaling and fate decision2010

    • Author(s)
      Kurosaki, T., Shinohara, H., Baba, Y.
    • Journal Title

      Ann.Rev.Immunol. 28(in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] CRTAM confers late-stage activation of CD8^+ T cells to regulate retention within lymph node2009

    • Author(s)
      Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, Saito T.
    • Journal Title

      J. Immunol.

      Volume: 183 Pages: 4220-4228

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters2009

    • Author(s)
      Yokosuka T, Saito T.
    • Journal Title

      Immunol. Rev.

      Volume: 229 Pages: 27-40

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CARD9 versus CARMA1 in innate and adaptive immunity.2009

    • Author(s)
      Hara H, Saito T.
    • Journal Title

      Trends Immunol.

      Volume: 30 Pages: 234-242

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia2009

    • Author(s)
      Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 10 Pages: 1897-1902

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils2009

    • Author(s)
      Hida S, et al.
    • Journal Title

      Nat Immunol.

      Volume: 10 Pages: 214-222

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PLC-・2 is essential for formation and maintenance of memory B cells2009

    • Author(s)
      Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T.
    • Journal Title

      J. Exp. Med.

      Volume: 206 Pages: 681-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PLC-γ2 is essential for formation and maintenance of memory B cells.2009

    • Author(s)
      Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T.
    • Journal Title

      J. Exp. Med. 206

      Pages: 681-9

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] PLC-γ2 is essential for formation and maintenance of memory B cells2009

    • Author(s)
      Hikida, M., et al.
    • Journal Title

      J.Exp.Med. 206

      Pages: 681-689

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain2009

    • Author(s)
      Sato, I., et al.
    • Journal Title

      J.Cell Sci. 122

      Pages: 965-975

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of NF-κB-dependent T cell activation and development by MEKK32009

    • Author(s)
      Shinohara, H., et al.
    • Journal Title

      Int.Immunol. 21

      Pages: 393-401

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naturally occurring regulatory dendritic cells regulate murine cutaneou chronic graft-versus-host disease2009

    • Author(s)
      Sato, K., et al.
    • Journal Title

      Blood 113

      Pages: 4780-4789

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization2009

    • Author(s)
      Takahashi, A., et al.
    • Journal Title

      Exp.Cell Res. 315

      Pages: 1117-1141

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CARD9 versus CARMA1 in innate and adaptive immunity2009

    • Author(s)
      Hara, H., Saito, T.
    • Journal Title

      Trends Immunol. 30

      Pages: 234-242

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The global thymus network : past, present and future2009

    • Author(s)
      Takahama, Y., et al.
    • Journal Title

      Trends Immunol. 30

      Pages: 191-192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation cf T-cell costimulation through TCR-CD28 microclusters2009

    • Author(s)
      Yokosuka, T., Saito, T.
    • Journal Title

      Immunol.Rev. 229

      Pages: 27-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal2009

    • Author(s)
      Hara, S., et al.
    • Journal Title

      Hematology 14

      Pages: 150-158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRTAM confers late-stage activation of CD8+T cells to regulate retention within lymph node2009

    • Author(s)
      Takeuchi, A., et al.
    • Journal Title

      J.Immunol. 183

      Pages: 4220-4228

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fc receptor c-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils2009

    • Author(s)
      Hida, S.
    • Journal Title

      Nat. Immunol. 10

      Pages: 214-222

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.2009

    • Author(s)
      Yamasaki, S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential trafficking of c-Src, Lyn, c-Yes, and Fyn is specified by the state of palmitoylation in the SH4 domain.2009

    • Author(s)
      Sato, I.
    • Journal Title

      J. Cell Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of NF-kappa B-dependent T cell activation and development by MEKK3.2009

    • Author(s)
      Shinohara, H.
    • Journal Title

      Int. Immunol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease.2009

    • Author(s)
      Sato, K.
    • Journal Title

      Blood (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization.2009

    • Author(s)
      Takahashi, A.
    • Journal Title

      Exp. Cell Res. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of NF-κB-dependent T cell activation and development by MEKK3.2009

    • Author(s)
      Shinohara, H.
    • Journal Title

      Int. Immunol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLCγ2 is essential for formation and maintenance of memory B cells.2009

    • Author(s)
      Hikida, M.
    • Journal Title

      J. Exp. Med. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation2008

    • Author(s)
      Yokosuka T, Kobayashi W, Sakata-Sogawa, K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T.
    • Journal Title

      Immunity.

      Volume: 29 Pages: 589-601

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mincle is an ITAM-coupled activating receptor that senses damaged cells2008

    • Author(s)
      Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T.
    • Journal Title

      Nat. Immunol.

      Volume: 9 Pages: 1179-1188

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic selection determines γδ T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ2008

    • Author(s)
      Jensen KD, et al.
    • Journal Title

      Immunity.

      Volume: 29 Pages: 90-100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A lysosomal protein negatively regulate surface T cell antigen receptor expression by promoting CD3ζ-chain degradation2008

    • Author(s)
      Ouchida R, et al.
    • Journal Title

      Immunity.

      Volume: 29 Pages: 33-43

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion2008

    • Author(s)
      Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T.
    • Journal Title

      Immunity

      Volume: 28 Pages: 499-508

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses2008

    • Author(s)
      Baba Y, Nishida K, Fujii Y, Hirano T, Hikida M, Kurosaki T.
    • Journal Title

      Nat. Immunol.

      Volume: 9 Pages: 81-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of B- cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase2008

    • Author(s)
      Aiba Y, Kameyama M, Yamazaki T, Tedder TF, Kurosaki T.
    • Journal Title

      Blood

      Volume: 111 Pages: 1497-1503

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mincle is an ITAM-coupled activating receptor that senses damaged cells.2008

    • Author(s)
      Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T
    • Journal Title

      Nat. Immunol. 9

      Pages: 1179-1188

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation.2008

    • Author(s)
      Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T
    • Journal Title

      Immunity 29

      Pages: 589-601

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A lysosomal protein negatively regulate surface T cell antigeh receptor expression by promoting CD3ζ degradation2008

    • Author(s)
      Ouchida, R.
    • Journal Title

      Immunity 29

      Pages: 33-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic selection determines γδ T cell effector fate : antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ.2008

    • Author(s)
      Jensen, K. D.
    • Journal Title

      Immunity 29

      Pages: 90-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell type-specific regulation of ITAM-mediated NF-κB activation by the adaptors, CARMA1 and CARD9.2008

    • Author(s)
      Hara, H.
    • Journal Title

      J. Immunol. 181

      Pages: 918-930

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LFA-1 decreases the antigen dose for T cell activation in vivo.2008

    • Author(s)
      Wang, Y.
    • Journal Title

      Int. Immunol. 20

      Pages: 1119-1127

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A : T mutations.2008

    • Author(s)
      Ouchida, R.
    • Journal Title

      DNA Repair (Amst) 7

      Pages: 1392-1398

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective impairment of FcεRI-mediated allergic reaction in Gads-deficient mice.2008

    • Author(s)
      Yamasaki, S.
    • Journal Title

      Int. Immunol. 20

      Pages: 1289-1297

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mincle is an ITAM-coupled activating receptor that senses damaged cells.2008

    • Author(s)
      Yamasaki, S.
    • Journal Title

      Nat. Immunol. 9

      Pages: 1179-1188

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C θ translocation.2008

    • Author(s)
      Yokosuka, T.
    • Journal Title

      Immunity 29

      Pages: 589-601

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Rap signal in pre-TCR-mediated β-selection checkpoint in αβ T cell development.2008

    • Author(s)
      Kometani, K.
    • Journal Title

      Blood 112

      Pages: 4565-4573

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early development of human hematopoietic and aquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells.2008

    • Author(s)
      Okada, S.
    • Journal Title

      Int. J. Hematol. 88

      Pages: 476-482

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.2008

    • Author(s)
      Yasuda, T.
    • Journal Title

      Immunity 28

      Pages: 499-508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.2008

    • Author(s)
      Weber, M.
    • Journal Title

      J. Exp. Med. 205

      Pages: 853-868

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced NK-cell development and function in BCAP-deficient mice.2008

    • Author(s)
      MacFarlane IV, A. W.
    • Journal Title

      Blood 112

      Pages: 131-140

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3z-chain degradation.2008

    • Author(s)
      Ouchida, R.
    • Journal Title

      Immunily 29

      Pages: 33-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential contribution of three activating IgG Fc receptors (FcγRI,FcγRIII and FcγRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice.2008

    • Author(s)
      Baudino, L.
    • Journal Title

      J. Immunol. 180

      Pages: 1948-1953

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR2 directly triggers Th1 effector functions2007

    • Author(s)
      Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S, Saito T.
    • Journal Title

      J. Immunol.

      Volume: 178 Pages: 6715-6719

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors2007

    • Author(s)
      Hara H, et al.
    • Journal Title

      Nat. Immunol.

      Volume: 8 Pages: 619-629

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival2007

    • Author(s)
      Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 27 Pages: 4406-4415

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] I・B kinase ・-induced phosphorylation of CARMA1 contributes to CARMA1-Bc110-MALT1 complex formation in B cells2007

    • Author(s)
      Shinohara H, Maeda S, Watarai H, Kurosaki T.
    • Journal Title

      J Exp Med.

      Volume: 204 Pages: 3285-3293

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation.2007

    • Author(s)
      Suzuki, J-I.
    • Journal Title

      Blood 109

      Pages: 168-175

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (Molecular basis for pre-TCR-mediated autonomous signaling.2007

    • Author(s)
      Yamasaki, S.
    • Journal Title

      Trends. Immunol. 28

      Pages: 39-43

    • Related Report
      2007 Annual Research Report
  • [Journal Article] LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.2007

    • Author(s)
      Yamasaki, S.
    • Journal Title

      Mol. Cel. Biol. 27

      Pages: 4406-4415

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The adaptor protein CARD9 is essential for activation of myeloid cells through ITAM-associated and Toll-like receptors.2007

    • Author(s)
      Hara, H.
    • Journal Title

      Nature Immunol. 8

      Pages: 619-629

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR2 directly triggers Th1 effector functions.2007

    • Author(s)
      Imanishi T.
    • Journal Title

      J. Immunol. 178

      Pages: 6715-6719

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diverging signaling events control the pathway of GPVI downregulation in vivo.2007

    • Author(s)
      Rabie, T.
    • Journal Title

      Blood 110

      Pages: 529-535

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells.2007

    • Author(s)
      Hijikata, A.
    • Journal Title

      Bioinformatics 23

      Pages: 2934-2941

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning of B-cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function.2007

    • Author(s)
      Suenaga, T.
    • Journal Title

      Eur. J. Immunol. 37

      Pages: 3197-3207

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

    • Author(s)
      Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T.
    • Journal Title

      J. Exp. Med.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Negative regulation of TCR signaling by PD-1 microcluster2012

    • Author(s)
      Yokosuka, T., Saito, T.
    • Organizer
      Keystone Symposia-Regulation of Lymphocyte Signaling
    • Place of Presentation
      Keystone, CO. USA.
    • Year and Date
      2012-03-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Negative regulation of TCR signaling by PD-1 microcluster2012

    • Author(s)
      Yokosuka, T., Saito, T.
    • Organizer
      Keystone Symposia-Regulation of Lymphocyte Signaling
    • Place of Presentation
      Keystone, CO, USA(招待講演)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] SH3-Guk domain regulating Carma1 micro-cluster formation is essential for antigen receptor-induced NF-κB activation2011

    • Author(s)
      Hara, H., Yokosuka, T., et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of target genes regulated by MafK in T cells2011

    • Author(s)
      Tsukumo, S.I., Unno, M., et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 免疫シナプスにおけるダイニンによるT細胞受容体ミクロクラスター運搬の分子機構2011

    • Author(s)
      多根(橋本)彰子、横須賀忠、斉藤隆
    • Organizer
      第40回日本免疫学会総会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] T細胞における核酸認識機構の解明2011

    • Author(s)
      今西貴之、竹内理、河合太郎、審良静男、斉藤隆
    • Organizer
      第40回日本免疫学会総会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] The PD-1 microclusters : negative costimulatory signalosomes directly targeting TCR downstream2011

    • Author(s)
      Yokosuka, T., Saito, T.
    • Organizer
      第40回日本免疫学会総会学術集会
    • Place of Presentation
      千葉(招待講演)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] イメージング解析が拓くT細胞活性化の制御機構2011

    • Author(s)
      斉藤隆
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spatiotemporal regulation of T cell activation and costimulation2011

    • Author(s)
      Saito, T., Yokosuka, T., Tane-Hashimoto, A.
    • Organizer
      1^<st> POSTECH International Symposium of Bio-Imaging
    • Place of Presentation
      Pophang, Korea(招待講演)
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spatiotemporal regulation of T cell co-stimulation2011

    • Author(s)
      Saito, T., Yokosuka, T., Tane-Hashimoto, A.
    • Organizer
      FASEB Summer Conferences-Signal Transduction in the Immune System
    • Place of Presentation
      Snowmass Village, CO
    • Year and Date
      2011-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Spatiotemporal regulation of T cell co-stimulation2011

    • Author(s)
      Saito, T., Yokosuka, T., Tane-Hashimoto, A.
    • Organizer
      FASEB Summer Conferences-Signal Transduction in the Immune System
    • Place of Presentation
      Snowmass Village, CO, USA(招待講演)
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Visualising the dynamics of immune synapse by TIRF2011

    • Author(s)
      Saito, T., Yokosuka, T., Tane-Hashimoto, A.
    • Organizer
      XXVI Congress of the International Society for Advancement of Cytometry (CYTO2011)
    • Place of Presentation
      Baltimore, MD, USA(招待講演)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immune cell activation under the microscope2011

    • Author(s)
      Saito, T.
    • Organizer
      World Immune Regulation Meeting-V (WIRM) “Innate and Adaptive Immune Response and Role of Tissue in Immune Regulation"
    • Place of Presentation
      Davos, Switzerland
    • Year and Date
      2011-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Immune cell activation under the microscope2011

    • Author(s)
      Takashi Saito
    • Organizer
      World Immune regulation Meeting-V
    • Place of Presentation
      Davos(スイス)
    • Year and Date
      2011-03-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamic regulation of positive/negative T cell co-stimulation2010

    • Author(s)
      Takashi Saito
    • Organizer
      CSI-IFReC Joint Symposium on Immunology
    • Place of Presentation
      杭州(中国)
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Direct regulation of T cell activation by TLR ligands2010

    • Author(s)
      Takashi Saito
    • Organizer
      第10回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spatio-temporal regulation of T cell activation2010

    • Author(s)
      Saito, T.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Spatio-temporal regulation of T cell activation2010

    • Author(s)
      Takashi Saito
    • Organizer
      14th International Congress of Immunology(第14回国際免疫学会議)
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular dynamics for T cell activation and costimulation2010

    • Author(s)
      Saito, T.
    • Organizer
      Keystone Symposia, Lymphocyte Activation and Gene Expression
    • Place of Presentation
      Breckenridge, CO.
    • Year and Date
      2010-03-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular Dynamics for T Cell Activation and Costimulation2010

    • Author(s)
      斉藤隆
    • Organizer
      Keystone Symposia Lymphocyte Activation and Gene Expression
    • Place of Presentation
      Breckenridge(USA)
    • Year and Date
      2010-03-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynein-mediated translocation of TCR microclusters along microtubules to form cSMAC2010

    • Author(s)
      橋本(多根)彰子
    • Organizer
      Keystone Symposia Lymphocyte Activation and Gene Expression
    • Place of Presentation
      Breckenridge(USA)
    • Year and Date
      2010-03-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic regulation of T-cell costimulation by TCR microclusters and the c-SNAG2010

    • Author(s)
      Tadashi Yokosuka
    • Organizer
      第13回国際細胞膜研究フォーラム/第6回iCeMS国際シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-01-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dual specificity receptor for damaged cells and pathogen2010

    • Author(s)
      斉藤隆
    • Organizer
      US-Japan Joint Immunology Board & Parasitic Disease Panel Conference
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transcription factor Bach2 controls tissue-specific homing of naive T cells by regulating CCR4 and CCR9 gene expressions2009

    • Author(s)
      Shin-ichi Tsukumo
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic regulation of T-cell costimulation by TCR microclusters and the c-SNAG2009

    • Author(s)
      Tadashi Yokosuka
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞活性化及びcSMAC形成につながる微小管モーター・ダイニンによるTCRミクロクラスターの移動/Dynein-mediated translocation of TCR micro-clusters along microtubules to form cSMAC during T cell activation2009

    • Author(s)
      橋本(多根)彰子
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nucleic acid-mediated T cell costimulation is independent of TLR2009

    • Author(s)
      Takayuki Imanishi
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] CARD9 and innate immunity2009

    • Author(s)
      斉藤隆
    • Organizer
      Center for the Study of Inflammatory Bowel Disease 19th Annual Workshop-Integrating Innate an Adaptive Immunity in Complex Human Diseases
    • Place of Presentation
      Boston(USA)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞活性化シグナルの時空間的制御2009

    • Author(s)
      斉藤隆
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成21年度第1回班会議
    • Place of Presentation
      阿蘇(熊本県)
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic regulation of T-cell costimulation by TCR microclusters2009

    • Author(s)
      Tadashi Yokosuka
    • Organizer
      FASEB Summer Research Conferences -Signal Transduction in the Immune System
    • Place of Presentation
      Snowmass Village(USA)
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sensing self and non-self danger by ITAM-coupled innate receptor Mincle2009

    • Author(s)
      Saito, T., Yamasaki, S.
    • Organizer
      FASEB Summer Research Conferences-Signal Transduction in the Immune System
    • Place of Presentation
      Snowmass Village, CO.
    • Year and Date
      2009-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Sensing self and non-self danger by ITAM-coupled innate receptor Mincle2009

    • Author(s)
      斉藤隆
    • Organizer
      FASEB Summer Research Conferences -Signal Transduction in the Immune System
    • Place of Presentation
      Snowmass Village(USA)
    • Year and Date
      2009-06-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualization of T cell activation and co-stimulation2009

    • Author(s)
      斉藤隆
    • Organizer
      The 1st Joint SIgN-iFReC Symposium-Integrating Immune Networks with Immuno-imaging
    • Place of Presentation
      Singapore(Singapore)
    • Year and Date
      2009-06-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic assembly of signaling complex for positive and negative costimulation of T cell activation2009

    • Author(s)
      斉藤隆
    • Organizer
      The 5th International Workshop of Kyoto T Cell Conference 2009
    • Place of Presentation
      京都
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spatiotemporal regulation of lymphocyte activation2009

    • Author(s)
      斉藤隆
    • Organizer
      The 2nd RIKEN-University of Edinburgh Joint Workshop for Computational and Systems Biology
    • Place of Presentation
      東京
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Recognition of damaged self and non-self pathogens by ITAM-coupled C-type lectin, Mincle.2009

    • Author(s)
      Saito, T.
    • Organizer
      World Immune Regulation Meeting-III
    • Place of Presentation
      Davos, Switzerland
    • Year and Date
      2009-03-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] C型レクチンMincleによる自己・非自己リガンドの認識とその意義2009

    • Author(s)
      山崎晶
    • Organizer
      第18回東京免疫フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2009-03-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] ITAM受容体による免疫系の形成・維持と生体防御の制御機構2009

    • Author(s)
      山崎晶
    • Organizer
      慶応医学会例会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Self and non-self recognition by ITAM-coupled C-type lectin receptor, Mincle2009

    • Author(s)
      Yamasaki, S.
    • Organizer
      The 2^<nd> International Symposium of WPI Immunology Frontier Research Center
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamic assembly of signaling unit for antigen recognition and activation of immune cells2009

    • Author(s)
      Saito, T.
    • Organizer
      Symposium on Meso Control of the cells, by the cells, for the cells
    • Place of Presentation
      京都
    • Year and Date
      2009-01-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamic regulation of T cell co-stimulation by TCR-CD28 microclusters2009

    • Author(s)
      Yokosuka, T.
    • Organizer
      LIAI-RCAI Joint Workshop 2009
    • Place of Presentation
      横浜
    • Year and Date
      2009-01-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Calcium signaling in immune cells2009

    • Author(s)
      Kurosaki, T.
    • Organizer
      IUPS International Conference of Physiological Sciences.
    • Place of Presentation
      Pusan, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Physiological function for store-operated calcium entry in immune response.2009

    • Author(s)
      Baba, Y.
    • Organizer
      The 2^<nd> International Symposium of WPI Immunology Frontier Research Center
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mincle is an ITAM-coupled activating receptor that senses damaged cells.2008

    • Author(s)
      Yamasaki, S.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamic Regulation of Immunological Synapse and T cell Activation.2008

    • Author(s)
      Saito, T.
    • Organizer
      17th Annual Meeting of Bioimaging Society
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamic regulation of TCRand costimulatory signals via microclusters2008

    • Author(s)
      Saito, T.
    • Organizer
      Cantoblanco Workshops on Biology-Initiation of Antigen Receptor Signaling
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2008-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynamic regulation of TCR-and costimulatory signals via microclusters.2008

    • Author(s)
      Saito, T.
    • Organizer
      Cantoblanco Workshops on Biology, Initiation of Antigen Receptor Signaling.
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2008-10-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Macrophage-inducible C-type lectin is an ITAM-eoupled activating receptor that senses damaged cells.2008

    • Author(s)
      Saito, T.
    • Organizer
      第10回国際樹状細胞シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] C-type lectin Mincle is an ITAM-coupled activating receptor sensing damaged cells.2008

    • Author(s)
      Saito, T.
    • Organizer
      The 8th Awaji International Forum of Infection and Immunity
    • Place of Presentation
      淡路
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 免疫応答の始まりと維持の分子機構-T細胞活性化のダイナミズム-2008

    • Author(s)
      斉藤隆
    • Organizer
      日本免疫学会免疫サマースクール2008
    • Place of Presentation
      南あわじ
    • Year and Date
      2008-08-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamic Regulation of T Cell Co-stimulation by TCR-CD28 Microclusters2008

    • Author(s)
      Saito, T.
    • Organizer
      RCAI-JSI International Symposium on Immunology 2008
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] T細胞初期分化におけるNFκBの役割2008

    • Author(s)
      山崎晶
    • Organizer
      第18回 Kyoto T Cell Conference 学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] PLC-γ/calcium signaling in immune cells.2008

    • Author(s)
      Kurosaki, T.
    • Organizer
      Immunology Interest Group Series of seminars at NIH
    • Place of Presentation
      Bethesda, MD, USA
    • Year and Date
      2008-05-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Imaging of initiation of T cell activation2008

    • Author(s)
      Saito, T.
    • Organizer
      Kick-off Symposium of WPI IFReC, Immunology and Imaging
    • Place of Presentation
      大阪
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Spatiotemporal regulation of T cell activation and co-stimulation by microclusters2008

    • Author(s)
      Saito, T.
    • Organizer
      The First iCeMS International Symposium: The Eleventh Membrane Research Forum
    • Place of Presentation
      京都
    • Year and Date
      2008-02-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differential cellular adaptors mediating innate and adaptive immunity2008

    • Author(s)
      Saito, T.
    • Organizer
      Hepatic Inflammation and Immunity 2008
    • Place of Presentation
      Galveston, USA
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] CRTAM regulates retention of T cells within lymph node and delivery to effecter tissues2008

    • Author(s)
      Saito, T.
    • Organizer
      Keystone Symposia/ Novel Modulators of Leukocyte Traffic
    • Place of Presentation
      Keystone, CO. USA
    • Year and Date
      2008-01-16
    • Related Report
      2011 Final Research Report
  • [Presentation] CRTAM regulates retention of T cells within lymph node and delivery to effecter tissues2008

    • Author(s)
      Saito, T.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Keystone, USA
    • Year and Date
      2008-01-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] C-type lectin Mincle is an ITAM-coupled activating receptor sensing damaged cells2008

    • Author(s)
      Yamasaki, S.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      New Haven, CT、USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] C-type lectin Mincle is an ITAM-coupled activating receptor sensing damaged cells2008

    • Author(s)
      Yamasaki, S.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of a region in immunological synapse critical for T cell co-stimulation.2008

    • Author(s)
      Yokosuka, T.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] CRTAM regulate CD8^+ T cell proliferation in regional lymph nodes through the interaction with CD8α^+ dendritic cell.2008

    • Author(s)
      Takeuchi, A.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative analysis of TCR microclusters in CD3zetaGFP knock-in T cells2008

    • Author(s)
      Hashimoto-Tane, A.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] pre-TCRα-chain knock-in mice lacking charged residues.2008

    • Author(s)
      Ishikawa, E.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] The PLCγ/calcium system as a regulator of immune cells.2008

    • Author(s)
      Kurosaki, T.
    • Organizer
      RCAI-JSI Intemational Symposium on Immunology 2008
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Initiation of Antigen Receptor Signaling.2008

    • Author(s)
      Kurosaki, T.
    • Organizer
      Cantoblanco Workshops on Biology
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2008 Annual Research Report
  • [Presentation] Calcium signaling in immune cells.2008

    • Author(s)
      Kurosaki, T.
    • Organizer
      The 57^<th> Fall Conference of the Korean Association of Immunobiologists.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] B cell signaling and fate decision.2008

    • Author(s)
      Kurosaki, T.
    • Organizer
      The 38^<th> Annual Meeting of the Japanese Society for Immunology.
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] PLCγ2 is essential for formation and maintenance of memory B cells.2008

    • Author(s)
      Hikida, M.
    • Organizer
      The 38^<th> Annual Meeting of the Japanese Society for Immunology.
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] TCRミクロクラスターによる抗原認識と活性化の動的制御2007

    • Author(s)
      斉藤 隆
    • Organizer
      BMB2007第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] TLR3/9 directly augments naive/memory CD4+ T cell survival independently of Myd88/IRAK-42007

    • Author(s)
      Imanishi, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] T cell recognition and activation through TCR microclusters2007

    • Author(s)
      Saito, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] TCR-CD28マイクロクラスターとc-SMACによるT細胞活性化の時空間的制御2007

    • Author(s)
      横須賀 忠
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differential regulation of innate immune signaling through CARMA1 and CARD9 adaptors.2007

    • Author(s)
      Hara, H.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] CARD 9-mediated innate signaling in myeloid cells2007

    • Author(s)
      Saito, T.
    • Organizer
      The 20th Naito Conference-Innate Immunity in Medicine and Biology [III]
    • Place of Presentation
      葉山
    • Year and Date
      2007-10-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dynamic regulation of T cell activation through TCR micloclusters2007

    • Author(s)
      Saito, T.
    • Organizer
      13^<th> International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2007-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Physiological role of CRTAM expression in vivo immunity2007

    • Author(s)
      Takeuchi, A.
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2007-08-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Spatiotemporal regulation of T cell activation by TCR-CD28-microclusters2007

    • Author(s)
      Yokosuka, T.
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2007-08-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Positive selectionに選択的なシグナル伝達経路の解析2007

    • Author(s)
      山崎 晶
    • Organizer
      第17回Kyoto T Cell Coference(KTCC)学術集会
    • Place of Presentation
      京都
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Initiation and sustenance of T cell activation by TCR microclusters2007

    • Author(s)
      Saito, T.
    • Organizer
      4th International Leukocyte Signal Transduction Workshop
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2007-06-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] TCR microclusters and co-stimulation for T cell activation2007

    • Author(s)
      Saito, T.
    • Organizer
      EMBO Conference Series on “Signaling in the immune system” Lymphocyte antigen receptor and coreceptor signaling
    • Place of Presentation
      Siena, Italy
    • Year and Date
      2007-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] TCR microclusters and co-stimulation for T cell activation2007

    • Author(s)
      Saito, T.
    • Organizer
      EMBO Conference Series on "Signaling in the immune system"
    • Place of Presentation
      Siena, Italy
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Spatiotemporal regulation of T cell activation by TCR-CD28-microclusters2007

    • Author(s)
      Yokosuka, T.
    • Organizer
      第7回日本蛋白質科学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dynamic regulation of T cell activation through TCR micloclusters2007

    • Author(s)
      Saito, T.
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2009 Self-evaluation Report 2007 Annual Research Report
  • [Presentation] Differential regulation of pre-TCR- and αβTCR-mediated signaling2007

    • Author(s)
      Yamasaki, S.
    • Organizer
      FASEB Summer Research Conferences-Signal Transduction in the Immune System
    • Place of Presentation
      Snowmass, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation-stage-specific differential functions of toll-like receptors on T cells for T cell activation and survival.2007

    • Author(s)
      Imanishi, T.
    • Organizer
      The 20th Naito Conference-Innate Immunity in Medicine and Biology [III]
    • Place of Presentation
      葉山
    • Related Report
      2007 Annual Research Report
  • [Book] The immunological synapse, TCR microclusters, and T cell activation In: Chap. 5, Immunologial Synapse, Curr. Top. Microbiol. Immunol. T. Saito and F. D. Batista (eds.) 3402010

    • Author(s)
      Yokosuka T, Saito T.
    • Publisher
      Springer-Verlag Berlin Heidelberg
    • Related Report
      2011 Final Research Report
  • [Book] Ann. Rev. Immunol.(B cell signaling and fate decision, 28)2010

    • Author(s)
      Kurosaki T, Shinohara H, Baba Y
    • Related Report
      2009 Self-evaluation Report
  • [Book] Curr. Top. Microbiol. Immunol.(T. Saito and F. D. Batista (eds.), The immunological synapse, TCR microclusters,and T cell activation.)2010

    • Author(s)
      Yokosuka T, Saito T.
    • Publisher
      Springer-Verlag
    • Related Report
      2009 Self-evaluation Report
  • [Book] Immunological Synapse(Current Topics in Microbiology and Immunology)2010

    • Author(s)
      Tadashi Yokosuka
    • Publisher
      Springer-Verlag Berlin Heidelberg
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.rcai.riken.go.jp/group/signaling/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks] 「炎症もたらす仕組みを解明-理研、米誌に論文」(2008. 9. 8. 日本経済新聞他6紙)

    • Related Report
      2009 Self-evaluation Report
  • [Remarks] 「皮膚にすむカビたんぱく質が認識理研など炎症治療へ応用も」(2009. 1. 20. 日本経済新聞他3紙)

    • Related Report
      2009 Self-evaluation Report
  • [Remarks] (独)理化学研究所科学講演会「免疫が未来を開拓する。」(2008. 2. 2. )

    • Related Report
      2009 Self-evaluation Report
  • [Remarks] 日本免疫学会「免疫ふしぎ未来」「なんでも認識できる免疫のしくみ」(東京, 2009. 5. 2-3. )

    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.rcai.riken.jp/group/signaling/index.html

    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] T細胞受容体機能調節剤及びそのスクリーニング方法2009

    • Inventor(s)
      黒崎知博, 篠原久明
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Number
      2009-053968
    • Filing Date
      2009-03-06
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] T細胞受容体機能調節剤及びそのスクリーニング方法2009

    • Inventor(s)
      黒崎知博、篠原久明
    • Industrial Property Rights Holder
      (独)理化学研究所
    • Industrial Property Number
      2009-053968
    • Filing Date
      2009-03-06
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途2008

    • Inventor(s)
      斉藤隆, 山崎晶
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Number
      2008-186570
    • Filing Date
      2008-07-17
    • Related Report
      2011 Final Research Report 2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途2008

    • Inventor(s)
      斉藤隆, 山崎晶
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Number
      2008-285948
    • Filing Date
      2008-11-06
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途2008

    • Inventor(s)
      山崎晶、斉藤隆
    • Industrial Property Rights Holder
      独)理化学研究所
    • Industrial Property Number
      2008-186570
    • Filing Date
      2008-07-17
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途2008

    • Inventor(s)
      山崎晶、斉藤隆
    • Industrial Property Rights Holder
      (独)理化学研究所
    • Industrial Property Number
      2008-285948
    • Filing Date
      2008-11-06
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途2008

    • Inventor(s)
      斉藤隆, 山崎晶, 他
    • Industrial Property Rights Holder
      理化学研究所, 千葉大学
    • Industrial Property Number
      2008-285948
    • Filing Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] T細胞分化調節剤(および細胞表面タンパク質間の細胞外領域における相互作用の検出システム)2007

    • Inventor(s)
      斉藤隆, 山崎晶
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Number
      2007-539809
    • Filing Date
      2007-03-04
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 肥満細胞の脱顆粒抑制剤2007

    • Inventor(s)
      黒崎知博, 馬場義裕
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Number
      2007-273055
    • Filing Date
      2007-10-19
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 肥満細胞の脱顆粒抑制剤2007

    • Inventor(s)
      黒崎知博、馬場義裕
    • Industrial Property Rights Holder
      (独)理化学研究所
    • Industrial Property Number
      2007-273055
    • Filing Date
      2007-10-19
    • Related Report
      2009 Self-evaluation Report

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Published: 2007-04-01   Modified: 2018-03-28  

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