Self recognition and activation regulation
| Project Area | Immunological Self Recognition and its Disorders |
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| Project/Area Number |
19059013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAITO Takashi 独立行政法人理化学研究所, 免疫シグナル研究グループ, グループディレクター (50205655)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSAKI Tomohiro 独立行政法人理化学研究所, 分化制御研究グループ, グループディレクター (50178125)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥105,600,000 (Direct Cost: ¥105,600,000)
Fiscal Year 2011: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2010: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2009: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2008: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2007: ¥25,200,000 (Direct Cost: ¥25,200,000)
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| Keywords | 自己抗原 / 自己認識 / T細胞 / 活性化シグナル / 獲得免疫 / ミクロクラスター / planar bilayer / 抗原認識 / 胸腺選択 / TCRミクロクラスター / 免疫シナプス / co-stimulation / CTLA-4 / c SMAC / 抑制性T細胞 / イメージング解析 / リンパ球活性化 / トニックシグナル / 副刺激 / カルシウムシグナル / シグナル伝達 / 抗原受容体 / 自己識別 / 自己反応性制御 / BCR / 免疫寛容 |
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| Research Abstract |
T cells are activated through forming TCR-microclusters (MC) upon antigen recognition. Self-peptides cannot induce TCR-MCs, and only the agonist peptides are accumulated into TCR-MCs when agonist and self-peptides are mixed. Thymocytes form TCR-MCs upon self-peptide recognition, and only the strong-stimulus of negative selecting peptides induces cSMAC formation. We clarified spatiotemporal regulation by positive (CD28) and negative (CTLA-4) costimulation and cytoskeletal regulation.
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Report
(7 results)
Research Products
(194 results)
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[Journal Article] CRTAM confers late-stage activation of CD8^+ T cells to regulate retention within lymph node2009
Author(s)
Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, Saito T.
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Journal Title
J. Immunol.
Volume: 183
Pages: 4220-4228
Related Report
Peer Reviewed
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[Journal Article] C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia2009
Author(s)
Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
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Journal Title
Proc. Natl. Acad. Sci. USA.
Volume: 10
Pages: 1897-1902
Related Report
Peer Reviewed
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