• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Generation and application of artificial lymphoid tissues

Planned Research

Project AreaImmunological Self Recognition and its Disorders
Project/Area Number 19059015
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University (2008-2011)
The Institute of Physical and Chemical Research (2007)

Principal Investigator

WATANABE Takeshi  京都大学, 医学研究科, 研究員 (40028684)

Co-Investigator(Kenkyū-buntansha) 小林 由佳  京都大学, 理化学研究所, 特別研究員 (00433590)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥58,100,000 (Direct Cost: ¥58,100,000)
Fiscal Year 2011: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2010: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2009: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2008: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2007: ¥12,700,000 (Direct Cost: ¥12,700,000)
Keywords人工免疫組織 / 人工リンパ節 / ストローマ細胞 / インデューサー細胞 / 抗原特異的二次免疫反応 / 感染防御 / 腫瘍免疫 / 人工脾臓 / 生体適合材料 / 抗体産生 / ヒト化マウス / メモリー細胞 / 免疫学 / 再生医学 / 感染症 / バイオテクノロジー / 人工組織 / 濾胞性ヘルパーT細胞 / リンパ節 / 再生医療 / 感染症治療 / モノクローナル抗体 / 免疫組織再生 / 癌治療
Research Abstract

The generation of functional artificial lymphoid tissue will be a major focus of future research in Immunology. In human, this will be an alternative tool which induces specific immune responses at ectopic sites and offers a novel way to restore the immune status and to treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection and immunodeficiency caused by primary defect or aging. Artificially synthesized lymphoid tissue may also provide us with a highly informative method to further study development and physiological functions of lymphoid tissues and organs. We recently reported successful generation of artificial lymph node-like tissues at ectopic sites in mouse. They showed a remarkable ability to induce secondary immune responses upon antigen stimulation, especially when transplanted into naive or immuno-deficient hosts. It was found that a large numbers of memory T cells and follicular helper T cells besides of memory B cells are highly enrich … More ed in our artificial lymph nodes, supporting their ability to induce a strong antigen-specific immune response. In our previous trial, we have utilized a mouse lymphoid stromal cell line and dendritic cells as an organizer for formation of lymphoid tissues and collagen sponge as a scaffold. Recently, we have also succeeded to synthesize artificial lymph nodes, instead of using stromal cells, by using a combination of various kinds of soluble chemokines and cytokines, which are attached to slow-releasing biomaterial (soft gel). The structure of newly synthesized artificial lymphoid tissues is stable in vivo more than one month. Antigen specific immune response could be induced in the tissues. Thus, we have successfully generated a complete structure of lymph node-like tissues without using any stromal cell component. We plan to apply this new method to generate human type secondary lymphoid tissues, which display immunological function, in humanized mice. We have also established the novel method to generate a complete structure of mouse spleen by using “single stromal cell-aggregates” derived from spleen capsules of newborn mice (3-6days after birth). We are now trying to identify and analyze the cells responsible for generation of adult type spleen from newborn mouse spleen capsules. Less

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (61 results)

All 2012 2011 2010 2009 2008 2007 2006 2003 Other

All Journal Article (42 results) (of which Peer Reviewed: 42 results) Presentation (7 results) Remarks (1 results) Patent(Industrial Property Rights) (11 results) (of which Overseas: 4 results)

  • [Journal Article] Synthesis of functional artificial lymphoid tissues2011

    • Author(s)
      Y. Kobayashi, K. Kato and T. Watanabe
    • Journal Title

      Discovery Medicine

      Volume: vol.12, No.65 Pages: 351-362

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity2011

    • Author(s)
      大塚篤司、中島沙恵子, 他
    • Journal Title

      Plos One

      Volume: 6 Issue: 9 Pages: 229-233

    • DOI

      10.1371/journal.pone.0025538

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dys-regulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice2011

    • Author(s)
      N. Aoki, M. Kido, S. Iwamoto, H. Nishiura, R. Maruoka, J. Tanaka, T. Watanabe, Y. Tanaka, T. Okazaki, T. Chiba, N. Watanabe
    • Journal Title

      Gastroenterology

      Volume: vol.140, No.4 Issue: 4 Pages: 1322-1333

    • DOI

      10.1053/j.gastro.2011.01.002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of antihistamines on innate immune responses to severe bacterial infection in mice2011

    • Author(s)
      M. Metz, E. Doyle, C. B.Jensen, T. Watanabe, T. Zuberbier, M. Maurer
    • Journal Title

      Int. Arch. of Allergy and Immunology

      Volume: vol.155 Issue: 4 Pages: 355-360

    • DOI

      10.1159/000321614

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of artificial lymphoid tissues with immunological immunological function2011

    • Author(s)
      Y. Kobayashi and T. Watanabe
    • Journal Title

      Trends in Immunology

      Volume: vol.31 Issue: 11 Pages: 422-428

    • DOI

      10.1016/j.it.2010.09.002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulated generation of ffollicular helper T cells in the spleen triggers fatal hepatitis in mice2011

    • Author(s)
      N.Aoki, 他10名、7番目
    • Journal Title

      Gastroenterology

      Volume: 140 Pages: 1322-1333

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of functional artificial lymphoid tissues2011

    • Author(s)
      Y.Kobayashi, K.Kato, T.Watanabe
    • Journal Title

      Discovery Medicine

      Volume: 65 Pages: 351-362

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dys-regulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.2011

    • Author(s)
      N Aoki, M Kido, S Iwamoto, H Nishiura, R Maruoka, J Tanaka, T Watanabe, 他4名
    • Journal Title

      Gastroenterology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial engineering of secondary lymphoid organs2010

    • Author(s)
      JKH Tan and T. Watanabe
    • Journal Title

      Advance in Immunology

      Volume: vol.105 Pages: 133-150

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histamine regulation in glucose and lipid metabolism via histamine receptors :Model for nonalcoholic steatohepatitis in mice2010

    • Author(s)
      Ke-Y Wang, A. Tanimoto, S. Yamada, X Guo, Y Ding, T. Watanabe, T. Watanabe, K. Kohno, K-I Hirano, H. Tsukada and Y. Sasaguri
    • Journal Title

      American J. Pathology

      Volume: vol.177 Issue: 2 Pages: 713-723

    • DOI

      10.2353/ajpath.2010.091198

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin I receptor IP promoted Th1- differentiation through camp2010

    • Author(s)
      S. Nakajima, T. Honda, D. Sakata, G. Egawa, H. Tanizaki, A. Otsuka, C.S. Morinaga, T. Watanabe, Y. Miyachi, S. Narumiya, K. Kabashima
    • Journal Title

      J. Immunol.

      Volume: vol.184 Issue: 10 Pages: 5595-5603

    • DOI

      10.4049/jimmunol.0903260

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states2010

    • Author(s)
      M. Hondo, K. Nagai, K. Ohno, Y. Kisanuki, J.T. Willie, T. Watanabe, M. Yanagisawa, T. Sakurai
    • Journal Title

      Acta Physiologica

      Volume: vol.198 Pages: 287-294

    • NAID

      120001938913

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activated Regulatory T cells are the major T cell type emigrating from sensitized skin.2010

    • Author(s)
      M. Tomura, T. Honda, H. Tanizaki, A. Otsuka, G. Egawa, Y. Tokura, S. hori, J. G. Cyster, T. Watanabe, Y. Miyachi, O. Kanagawa, K. Kabashima
    • Journal Title

      J. Clin. Invest.

      Volume: vol.120 Issue: 3 Pages: 883-893

    • DOI

      10.1172/jci40926

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of artificial lymphoid tissues with immunological function.2010

    • Author(s)
      Y.Kobayashi, T.Watanabe
    • Journal Title

      Trends in Immunology

      Volume: 31 Pages: 422-428

    • NAID

      120002647324

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial Engineering of Secondary Lymphoid Organs. Advance in Immunology2010

    • Author(s)
      Jonathan KH Tan, T.Watanabe
    • Journal Title

      Advance in Immunology

      Volume: 105 Pages: 133-150

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activated Regulatory T cells are the major T cell type emigrating from sensitized skin.2010

    • Author(s)
      M.Tomura, T.Honda, H.Tanizaki, A.Otsuka, G.Egawa, Y.Tokura, S.hori, J.G.Cyster, T.Watanabe, 他3名
    • Journal Title

      Journal of Clinical.Investigation.

      Volume: 120 Pages: 883-893

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of antihistamines on innate immune responses to severe bacterial infection in mice.2010

    • Author(s)
      M.Metz, E.Doyle, C.B.Jensen, T.Watanabe, T.Zuberbier, M.Maurer
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 155 Pages: 422-428

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine regulation in glucose and lipid metabolism via histamine receptors : Model for nonalcoholic steatohepatitis in mice2010

    • Author(s)
      Ke-Y Wang, A.Tanimoto, S.Yamada, X Guo, Y Ding, T.Watanabe, T.Watanabe, 他4名
    • Journal Title

      American J.Pathology

      Volume: 177 Pages: 723-813

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin I receptor IP promoted Th1-differentiation through camp.2010

    • Author(s)
      S.Nakajima, T.Honda, D.Sakata, G.Egawa, H.Tanizaki, A.Otsuka, C.S.Moniaga, T.Watanabe, 他3名
    • Journal Title

      Journal of Immunology

      Volume: 184 Pages: 5595-5603

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintainance of basal sleep/wake states.2010

    • Author(s)
      M.Hondo, K.Nagai, K.Ohno, Y.Kisanuki, J.T.Willie, T.Watanabe, 他3名
    • Journal Title

      Acta Physiologica

      Volume: 198 Pages: 287-294

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of tissue-engineered lymphoid tissues.2010

    • Author(s)
      Tan J., Watanabe T.
    • Journal Title

      Advances in Immunology (review, in press)

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Histamine regulation in glucose and lipid metabolism via histamine receptors: Model for nonalcoholic steatohepatitis in mice.2010

    • Author(s)
      Ke-Y Wang, A. Tanimoto, S. Yamada, X Guo, Y Ding, T. Watanabe, T. Watanabe, K. Kohno, K-I Hirano, H. Tsukada, Y. Sasaguri
    • Journal Title

      American J. Pathology (in press)

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintainance of basal sleep/wake states.2010

    • Author(s)
      M. Hondo, K. Nagai, K. Ohno, Y. Kisanuki, J.T. Willie, T. Watanabe, M. Yanagisawa, T. Sakurai
    • Journal Title

      Acta Physiologica 198

      Pages: 287-294

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Activated Regulatory T cells are the major T cell type emigrating from sensitized skin.2010

    • Author(s)
      M. Tomura, T. Honda, H. Tanizaki, A. Otsuka, G. Egawa, Y. Tokura, S. hori, J.G. Cyster, T. Watanabe, Y. Miyachi, O. Kanagawa, K. Kabashima.
    • Journal Title

      J. Clin. Invest. 120(3)

      Pages: 883-893

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Synthesis of tissue-engineered lymphoid tissues.2010

    • Author(s)
      Tan J., Watanabe T..
    • Journal Title

      Advances in Immunology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine regulation in glucose and lipid metabolism via histamine receptors : Model for nonalcoholic steatohepatitis in mice.2010

    • Author(s)
      Ke-Y Wang, T.Watanabe, Y.Sasaguri, ほか8名
    • Journal Title

      American J.Pathology 198(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintainance of basal sleep/wake states2010

    • Author(s)
      M.Hondo, K.Nagai, K.Ohno, Y.Kisanuki, J.T.Willie, T.Watanabe, M.Yanagisawa, T.Sakurai.
    • Journal Title

      Acta Physiologica

      Pages: 287-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activated Regulatory T cells are the major T cell type emigrating from sensitized skin.2010

    • Author(s)
      M.Tomura, T.Watanabe, K.Kabashima., ほか9名
    • Journal Title

      J.Clin.Invest. 120

      Pages: 883-893

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis2009

    • Author(s)
      N. Rajasekaran, S. Solomon, T. Watanabe, H. Ohtsu, R. Gajda, H. Illges
    • Journal Title

      Int. Immunol.

      Volume: vol.21 Issue: 11 Pages: 1263-1268

    • DOI

      10.1093/intimm/dxp092

    • NAID

      10027390338

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of histamine and histamine receptors in the pathogenesis of Malaria2009

    • Author(s)
      W. Beghdadi, A. Porcherie, BS. Schneider, D. Dubayle, R. Peronet, M. Huerre, T. Watanabe, H.Ohtsu, J.Louis, S.Mecheri
    • Journal Title

      Med. Science (Paris)

      Volume: vol.25 Pages: 377-381

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse model of disease.2009

    • Author(s)
      W.Beghdadi, T.Watanabe, H.S.Mecheri, ほか7名
    • Journal Title

      Medical Science (Paris) 25

      Pages: 377-381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis.2009

    • Author(s)
      N.Rajasekaran, Solomon S., Watanabe T., Ohtsu H., Gajda R., Illges H
    • Journal Title

      International Immunology 21

      Pages: 1263-1268

    • NAID

      10027390338

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of histaminemediated signaling confers significant protection against severe malaria in mouse model of disease2008

    • Author(s)
      W. Beghdadi, A. Porcherie, D. Dubayle, R. Peronet, M. Huerre, T. Watanabe, H. Ohtsu, J. Louis, S. Mecheri
    • Journal Title

      J. Exp. Med.

      Volume: vol.205 Issue: 2 Pages: 395-408

    • DOI

      10.1084/jem.20071548

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse model of disease.2008

    • Author(s)
      Beghdadi W., Porcherie A., Dubayle D., Peronet R., Huerre M., Watanabe T., Ohtsu. H., Louis, J., Mecheri S.
    • Journal Title

      J. Exp. Med. 205

      Pages: 395-408

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse model of disease2008

    • Author(s)
      W. Beghdadi, A. Porcherie, D. Dubayle, R. Peronet, M. Huerre, T. Watanabe, H. Ohtsu
    • Journal Title

      Journal of Experimental Medicine 205

      Pages: 395-408

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of both UVB irradiation and histamine receptor function on allergic responses to an inhaled antigen2007

    • Author(s)
      P McGlade, S Gorman , JC Lenzo, JW Tan, T Watanabe, JJ Finlay-Jones, WR Thomas, PH Hart
    • Journal Title

      J Immunol

      Volume: vol.178 Pages: 2794-802

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice2007

    • Author(s)
      N. Okamoto, S. Nishimoto, R. Chihara, C. Shimizu and T. Watanabe
    • Journal Title

      J. Clin. Invest.

      Volume: vol.117 Issue: 4 Pages: 997-1007

    • DOI

      10.1172/jci30379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of both UVB irradiation and histamine receptor function on allergic responses to an inhaled antigen.2007

    • Author(s)
      McGlade P, Gorman S., Lenzo JC., Tan JW., Watanabe T., Finlay-Jones JJ., Thomas WR., Hart PH.
    • Journal Title

      J Immunol. 178

      Pages: 2794-802

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice.2007

    • Author(s)
      Okamoto N., Nishimoto S., Chihara R., Shimizu C. Watanabe T.
    • Journal Title

      J. Clin. Invest. 117

      Pages: 997-1007

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice2007

    • Author(s)
      N. Okamoto, T. Watanabe他3名
    • Journal Title

      Journal of Clinical Investigation 117

      Pages: 997-1007

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid hematopoietic progenitor mobilization by sulfated colominic acid2007

    • Author(s)
      S. Kubonishi, T. Watanabe他9名
    • Journal Title

      Biochem. Bioph. Res. Communication 355

      Pages: 970-975

    • NAID

      120001384686

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interfering with histamine-mediated signaling results in significant protection against severe malaria in mice.

    • Author(s)
      W. Beghdadi, T. Watanabe他7名
    • Journal Title

      Journal of Experimental Medicine In press

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Trial of generation of artificial lymph nodes by cell-free methods2011

    • Author(s)
      小林由佳、渡邊武
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉・幕張メッセ
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] A trial to generate the artificial lymph nodes (aLNs) by cell-free method2010

    • Author(s)
      Y.Kobayashi, T Watanabe
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Generation of Artificial Lymph Nodes as a synthetic immunology.2009

    • Author(s)
      渡邊武
    • Organizer
      第2回ヨーロッパ免疫学会議
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Generation of artificial lymph nodes and their application2009

    • Author(s)
      渡邊武
    • Organizer
      第2回ヨーロッパ免疫学連合総会Synthetic Immunology
    • Place of Presentation
      ドイツ、ベルリン
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation of Artificial Lymph Nodes as a synthetic immunology.2009

    • Organizer
      第2回ヨーロッパ免疫学会議
    • Place of Presentation
      ドイツ、ベルリン
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Generation of transplantable lymph node-like tissues and induction of immune responses2008

    • Author(s)
      渡邊武
    • Organizer
      第38回に本免疫学会(シンポジウム)
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation of artificial transplantable lymph node tissues and their immunological function2007

    • Author(s)
      T. Watanabe
    • Organizer
      RCAI(RIKEN)-Max-Planc Insitute Joint Symposium
    • Place of Presentation
      Max-Planc Insitute for Infection Biology, Berlin, Germay
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.ak.med.kyoto-u.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] Artificial lymph node treatingcancer(癌治療用人工リンパ節)2012

    • Inventor(s)
      渡邊武、田中功二
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2012-01-24
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 人工リンパ節の作製方法(ストローマ細胞を用いない新規技術)2010

    • Inventor(s)
      渡邊武、小林由佳
    • Industrial Property Rights Holder
      国立大学法人京都大学、アステラス製薬株式会社
    • Industrial Property Number
      2010-179889
    • Filing Date
      2010-08-11
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 人工リンパ節の作成法2010

    • Inventor(s)
      渡邊武, 小林由佳
    • Industrial Property Rights Holder
      京都大学アステラス
    • Filing Date
      2010-08-11
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 人工リンパ節2008

    • Inventor(s)
      渡邊武、末松佐知子
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Acquisition Date
      2008-03-21
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 人工リンパ節を用いた効率的な抗原特異的ハイブリドーマの作成法2008

    • Inventor(s)
      渡邊武
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      2006-331114
    • Filing Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 人工リンパ節2008

    • Inventor(s)
      渡邊武, 末松佐知子
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Acquisition Date
      2008-03-21
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌治療用人工リンパ節2007

    • Inventor(s)
      渡邊武
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2007
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 癌治療用人工リンパ節2007

    • Inventor(s)
      渡邊 武
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      2007-315574
    • Filing Date
      2007-12-06
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌治療用人工リンパ節2006

    • Inventor(s)
      渡邊武
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      2006-331114
    • Filing Date
      2006-12-07
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 人工リンパ節2003

    • Inventor(s)
      渡邊武、末松佐知子
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2003-02-27
    • Acquisition Date
      2008-03-21
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Method for production of antigenspecific hybridoma using artificial lymph node with good efficiency

    • Inventor(s)
      渡邊武
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Related Report
      2011 Final Research Report
    • Overseas

URL: 

Published: 2007-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi